Renal failure in the intensive care unit: acute kidney injury compared to end-stage renal failure

Patients with advanced acute kidney injury (AKI) and end-stage dialysis dependent renal failure (ESRF) are characterized by loss of renal function as well as significant associated co-morbidities. However, prognosis appears to differ when they are admitted to the intensive care unit (ICU). Patients with advanced AKI have a reported ICU mortality between 25% and 90%, depending on the specific patient population and the definition of AKI [1, 2], whereas ICU mortality in ESRF patients has been reported to be 9% to 26% [3–5]. In contrast, Uchino and coworkers [5] found no difference in outcome between 32 ESRF patients in an ICU and 32 diagnosis and severity score matched patients with AKI treated with renal replacement therapy (RRT).

We retrospectively analyzed the Riyadh Intensive Care Program database of 41,972 adult patients admitted to ICUs in 19 hospitals in the UK and three hospitals in Germany between 1989 to 1999, and we compared ESRF patients and patients with advanced AKI (defined by serum creatinine ≥ 354 μmol/l, treatment with RRT or a rise in serum creatinine by >300% from baseline). A total of 797 patients had pre-existing ESRF and 2,782 patients had advanced AKI, of whom 66.4% were treated with RRT. ESRF patients had a significantly lower ICU and hospital mortality and shorter stay in ICU compared with patients with advanced AKI (Table 1). In both groups the ICU mortality rate rose with increasing number of associated failed organ systems (Figure 1). However, patients with AKI had significantly more associated organ failures during their stay in the ICU; 75.4% of patients with AKI on RRT and 54.5% of patients with advanced AKI not on RRT had two or more other failed organ systems, in contrast to only 25.6% of ESRF patients. In addition, significantly more patients with AKI on RRT needed mechanical ventilation compared with ESRF patients (91.3% versus 60.9%, P < 0.0001).

Figure 1

Associated maximum organ failure and impact on outcome. Shown are (a) incidence (%) and (b) ICU mortality (%). AKI, acute kidney injury; ESRF, end-stage renal failure; ICU, intensive care unit; OF, maximum associated organ failure during stay in ICU (excluding renal failure); RRT, renal replacement therapy.

In a multivariate analysis, mechanical ventilation (odds ratio (OR) = 3.3), maximum number of failed organs (OR = 2.93) and nonsurgical admission (OR = 2.1) were the strongest independent risk factors for ICU mortality, followed by emergency surgery (OR = 1.75), pre-existing chronic disease (OR = 1.2), SOFA score on admission to ICU (OR = 1.05) and age (OR = 1.03).

Our study confirms that patients with ESRF admitted to ICU had a significantly better prognosis than did ICU patients with advanced AKI. The main reasons were due to differences in co-morbid risk factors, in particular need for mechanical ventilation and associated organ failure while in the ICU.