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Critical Care

Open Access

Erratum to: The role of corticosteroids in severe community-acquired pneumonia: a systematic review

  • Jorge IF Salluh1, 2Email author,
  • Pedro Póvoa3,
  • Márcio Soares1,
  • Hugo C Castro-Faria-Neto2,
  • Fernando A Bozza4 and
  • Patrícia T Bozza2
Critical Care200812:434

Published: 7 November 2008

The original article was published in Critical Care 2008 12:R76

Following the publication of the above article [1], we noticed that in Table 1, concerning the data of the study from Garcia-Vidal the dose of methylprednisolone is not 14.5 mg/day but 45 mg/day.
Table 1

Recent literature on the role of corticosteroids in severe community-acquired pneumonia


Study design

Sample size, number

Patient selection

Corticosteroids (drug/regimen)

Primary endpoints

Level of evidence and recommendation

Marik, et al. [21]

Single-center RCT


Severe CAP

Hydrocortisone 10 mg/kg versus placebo 30 minutes before antibiotics

Mortality, clinical course, and serum TNF-α levels

Weak recommendation, moderate-quality evidence

Confalonieri, et al. [6]

Multicenter RCT


Severe CAP

Hydrocortisone 200 mg + hydrocortisone 10 mg/hour, for 7 days versus placebo

Mortality, clinical course, and Systemic inflammation

Strong recommendation, moderate-quality evidence

Mikami, et al. [20]

Open label RCT


Moderate and severe CAP

Prednisolone 40 mg qd, for 3 days versus placebo

Mortality and clinical course

Weak recommendation, low-quality evidence

Garcia-Vidal, et al. [19]

Retrospective cohort study


Severe CAP

Methylprednisolone 45 mg (or equivalent) qd for 11.4 days


Strong recommendation, low-quality evidence

CAP, community-acquired pneumonia; qd, quaque die (every day); RCT, randomized controlled trial; TNF-α, tumor necrosis factor-alpha.



Authors’ Affiliations

Intensive Care Unit, Instituto Nacional de Câncer, Rio de Janeiro-RJ, Brazil
Immunopharmacology Laboratory, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro-RJ, Brazil
Medical Intensive Care Unit, Hospital de São Francisco Xavier. Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal
Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro-RJ, Brazil


  1. Salluh JI, Povoa P, Soares M, Castro-Faria-Neto HC, Bozza FA, Bozza PT: The role of corticosteroids in severe community-acquired pneumonia: a systematic review. Crit Care. 2008, 12: R76-10.1186/cc6922.PubMed CentralView ArticlePubMedGoogle Scholar


© BioMed Central Ltd 2008