Open Access

Erratum to: The role of corticosteroids in severe community-acquired pneumonia: a systematic review

  • Jorge IF Salluh1, 2Email author,
  • Pedro Póvoa3,
  • Márcio Soares1,
  • Hugo C Castro-Faria-Neto2,
  • Fernando A Bozza4 and
  • Patrícia T Bozza2
Critical Care200812:434

Published: 7 November 2008

The original article was published in Critical Care 2008 12:R76

Following the publication of the above article [1], we noticed that in Table 1, concerning the data of the study from Garcia-Vidal the dose of methylprednisolone is not 14.5 mg/day but 45 mg/day.
Table 1

Recent literature on the role of corticosteroids in severe community-acquired pneumonia


Study design

Sample size, number

Patient selection

Corticosteroids (drug/regimen)

Primary endpoints

Level of evidence and recommendation

Marik, et al. [21]

Single-center RCT


Severe CAP

Hydrocortisone 10 mg/kg versus placebo 30 minutes before antibiotics

Mortality, clinical course, and serum TNF-α levels

Weak recommendation, moderate-quality evidence

Confalonieri, et al. [6]

Multicenter RCT


Severe CAP

Hydrocortisone 200 mg + hydrocortisone 10 mg/hour, for 7 days versus placebo

Mortality, clinical course, and Systemic inflammation

Strong recommendation, moderate-quality evidence

Mikami, et al. [20]

Open label RCT


Moderate and severe CAP

Prednisolone 40 mg qd, for 3 days versus placebo

Mortality and clinical course

Weak recommendation, low-quality evidence

Garcia-Vidal, et al. [19]

Retrospective cohort study


Severe CAP

Methylprednisolone 45 mg (or equivalent) qd for 11.4 days


Strong recommendation, low-quality evidence

CAP, community-acquired pneumonia; qd, quaque die (every day); RCT, randomized controlled trial; TNF-α, tumor necrosis factor-alpha.



Authors’ Affiliations

Intensive Care Unit, Instituto Nacional de Câncer
Immunopharmacology Laboratory, Instituto Oswaldo Cruz, FIOCRUZ
Medical Intensive Care Unit, Hospital de São Francisco Xavier. Centro Hospitalar de Lisboa Ocidental
Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz


  1. Salluh JI, Povoa P, Soares M, Castro-Faria-Neto HC, Bozza FA, Bozza PT: The role of corticosteroids in severe community-acquired pneumonia: a systematic review. Crit Care. 2008, 12: R76-10.1186/cc6922.PubMed CentralView ArticlePubMedGoogle Scholar


© BioMed Central Ltd 2008