Volume 12 Supplement 5
Troponin can discriminate the most severe septic patients and should be included as an early routine test in Surviving Sepsis Campaign patients
© Fernandes et al; licensee BioMed Central Ltd. 2008
Published: 18 November 2008
Myocardial injury can now be easily recognized in critically ill septic patients and is associated with increased ICU mortality. Troponin I is recognized nowadays as a highly sensitive and specific serum marker of sepsis-induced myocardial injury/depression and can predict outcome in the critical care setting.
In order to confirm this prediction power we included troponin I evaluations in our cohort of 100 patients within 24 hours of admission to our institutional protocol with strict adherence to the Surviving Sepsis Campaign guidelines within a tertiary care hospital, therefore eliminating heterogeneous population bias.
Cumulative survival curves were constructed using the Kaplan–Meier method and were compared with the log-rank test. Results were considered significant at P < 0.05.
Demographic and clinical features of the study population
Acute Physiology and Chronic Health Evaluation II score
Mean arterial pressure (mmHg)
ICU length of stay (days)
The elevations of troponin observed were mostly small to modest, reflecting minor cardiac injury, but they nonetheless presaged increased mortality very early in the course of the disease. Others have postulated that increased-troponin patients can probably benefit most from drotrecogin-α administration with mortality reduction, thereby rendering troponin determination mandatory in critically ill septic patients. Troponin should therefore probably be included as an early routine test in the Surviving Sepsis Campaign.
This article is published under license to BioMed Central Ltd.