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During the past decade, there have been an increasing number of studies investigating the precise role of T regulatory cells in human disease. First recognized for their ability to prevent autoimmunity, T regu...
Rapid diagnosis, appropriate management, and time are the key factors for improving survival rate in many emergency clinical scenarios such as acute myocardial infarction, pulmonary embolism, cerebral stroke, and...
Molecular biology has not yet fully reached its ambitious goals in clinical bacteriology. Notwithstanding the tremendous technical challenges, the detection of nucleic acids directly from the blood of septic p...
Sepsis is one of the most common conditions ... quality of life are reduced in survivors of sepsis, yet there is little knowledge of the effect of sepsis-specific interventions on either long-term survival ... re...
The early detection and treatment of sepsis are the most important factors in improving ... experience a long delay in the diagnosis of sepsis. Furthermore, it is not uncommon for ... overt septic shock. The earl...
This article is part of a Supplement: Volume 14 Supplement 2
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 15 Supplement 3
Identification of good surrogate end-points can greatly facilitate the design of clinical trials. Using data from PROWESS and ENHANCE, Shorr and colleagues explore the potential value of several plasma biomarkers...
The origins of sepsis-induced hyperlactatemia are still imperfectly understood and...Critical Care, Michaeli and colleagues showed that lactate elevation during mild endotoxemia is due to an increased aerobic pro...
This article is part of a Supplement: Volume 17 Supplement 4
Observational studies usually agree with randomised, controlled trials. It is a logical fallacy, however, to suggest that agreement in one direction implies prediction in the other direction. Observational studie...
The relationship between blood coagulation factors and the promotion or inhibition of the anti-inflammatory response continues to be defined through basic research. The potential key role of blood coagulation fac...
This article is part of a Supplement: Volume 16 Supplement 3
This article is part of a Supplement: Volume 16 Supplement 3
Early prediction of the outcome of patients with sepsis could be helpful in guiding therapies but remains challenging. Presepsin, a new sepsis biomarker whose elevation as early as day...
This article is part of a Supplement: Volume 18 Supplement 2
Chlorhexidine bed baths seem to reduce the incidence of methicillin-resistant Staphylococcus aureus...and vancomycin-resistant enterococcus detected by surveillance cultures. There is also some evidence on the be...
Severe sepsis is a major healthcare problem and the...
Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are ... to or are associated with brain dysfunction in sepsis.
In the previous issue of Critical Care..., Tang and colleagues offer a very novel systematic review of 12 studies of gene expression in blood of human sepsis. The review concludes that there is no ... anti-inflam...
Activated protein C (APC), a physiological coagulation inhibitor, has been shown to reduce mortality in patients with severe sepsis. APC exerts pleiotropic cytoprotection by a mechanism...in vivo...upon pharmacol...
This article is part of a Supplement: Volume 15 Supplement 1
This article is part of a Supplement: Volume 17 Supplement 4
In the previous issue of Critical Care..., Blanco and colleagues contributed to a growing body of literature on the international epidemiology of severe sepsis. Taken together, these studies confirm that the sepsis
Based on several recently completed randomized controlled trials, cortisol replacement is likely to become a standard of care for vasopressor dependent septic shock. Further studies are needed in order to accompl...
The diagnosis of disseminated intravascular coagulation (DIC) based on composite scoring systems using routinely available coagulation tests has been greatly facilitated. Such scoring instruments not only adeq...
Impairment of the inflammatory-immune response is currently accepted as a hallmark of severe sepsis even in the early stages of the...Critical Care indicated that, in patients with septic shock, the B-cell compar...
Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Åneman A, Madsen KR, Møller MH, Elkjær JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, Søe-Jensen P, Bestle M, Strand K, Wiis J, Whi...
Severe sepsis can be a catastrophic condition that is ... accurately confirm the condition, the diagnosis of sepsis is challenging. Even more challenging is the...
The receptor of advanced glycation endproducts (RAGE) is a multiligand receptor that upon activation causes sustained activation of multiple inflammatory pathways. Recent evidence, summarized in a review by Bo...
This article is part of a Supplement: Volume 18 Supplement 2
This article is part of a Supplement: Volume 15 Supplement 3
This article is part of a Supplement: Volume 16 Supplement 3
This article is part of a Supplement: Volume 18 Supplement 2
The Researching Severe Sepsis and Organ Dysfunction in Children: A Global ... adjunctive therapy ever performed in children with severe sepsis. Despite this, the study failed to ... trials in relatively rare cond...
This article is part of a Supplement: Volume 15 Supplement 2
The original article was published in Critical Care 2023 27:50
This article is part of a Supplement: Volume 16 Supplement 3
Endothelium dysfunction is one of the hallmarks of sepsis. Looney and Mattay, in the previous...Critical Care, highlight the role of activated protein C (APC) as a protective endothelial drug in septic situations...
Throughout the last years, several new diagnostic biomarkers have been introduced into clinical routine to identify a systemic inflammatory response syndrome (SIRS) or a septic state and to discriminate between t...
Direct haemoperfusion with polymyxin B-immobilized fibre (PMX-F) is a promising treatment for Gram-negative sepsis in critically ill patients. Indeed, it ... a positive impact on outcome in patients with sepsis, ...
Critical Care