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Sepsis leads to microcirculatory dysfunction and therefore a disturbed neurovascular coupling in the brain. To investigate if the dysfunction is also present in less severe inflammatory diseases we studied the...
Disseminated intravascular coagulation (DIC) is characterized by the concomitant activation of coagulofibrinolytic disorders and systemic inflammation associated with endothelial dysfunction-induced microvascu...
Ventilator-associated pneumonia (VAP) may contribute to the mortality associated with acute respiratory distress syndrome (ARDS). We aimed to determine the incidence, outcome, and risk factors of bacterial VAP...
Many supposed low-risk intensive care unit (ICU) admissions develop acute organ failure (AOF). Identifying patients at high risk of developing AOF and targeting them with preventative strategies may be effecti...
Apolipoprotein M (apoM) is present in 5% of high-density lipoprotein (HDL) particles in plasma. It is a carrier of sphingosine-1-phosphate (S1P), which is important for vascular barrier protection. The aim was...
During severe sepsis or septic shock, activation of the inflammatory and coagulatory systems can result in microcirculatory dysfunction as well as microvascular thrombosis, culminating in multiple organ dysfun...
The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients.
Candida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.
Critical care medicine is a global specialty and epidemiologic research among countries provides important data on availability of critical care resources, best practices, and alternative options for delivery ...
Hyperglycemia and protein loss are common in critically ill patients. Insulin can be used to lower blood glucose and inhibit proteolysis. The impact of moderate insulin therapy on protein metabolism in critica...
Mechanical ventilators are increasingly used in critical care units. However, they can cause lung injury, including pulmonary edema. Our previous studies indicated that γ-aminobutyric acid (GABA) receptors are...
Prasad M, Holmboe ES, Lipner RS, Hess BJ, Christie JD, Bellamy SL, Rubenfeld GD, Kahn JM. Clinical Protocols and Trainee Knowledge About Mechanical Ventilation. JAMA. 2011; 306(9):935-941. PubMed PMID: 2190013...
Accumulating evidence suggests that, in critically ill patients, a lower hemoglobin transfusion threshold is safe. However, the optimal hemoglobin level and associated transfusion threshold remain unknown in n...
Sepsis is the third largest cause of death in industrialised countries, but treatment remains largely supportive and effective therapeutic interventions are urgently needed. Disruption and dysfunction of the m...
Community-acquired pneumonia (CAP) requiring intensive care unit (ICU) admission remains a severe medical condition, presenting ICU mortality rates reaching 30%. The aim of this study was to assess the value o...
The study by Wassenberg and colleagues shows that rapid diagnostic testing, although not cost-saving, reduces the number of unnecessary isolation days at ICU admission. Here, the strengths and limitations and ...
The original article was published in Critical Care 2010 14:R90
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
This article is part of a Supplement: Volume 16 Supplement 1
Critical Care