Early application of CVVH In the complex treatment of patients with early severe acute pancreatitis
© Aleksandrova et al.; licensee BioMed Central Ltd. 2012
Published: 20 March 2012
A large population-based study of 1,024 deaths from acute pancreatitis (AP) has revealed that the median time lapse between the onset of AP and death was 6 days . A number of authors considered the patients with persistent or progressive early multiple organ failure (MOF) as patients with early severe acute pancreatitis (ESAP) .
42 ± 15
39 ± 13
47 ± 16
31 ± 5
29 ± 4
29 ± 5
APACHE II score
Early mortality (%)
Overall mortality (%)
As compared to reference group 3, significant (P = 0.022) reduction of early mortality (14 days) was observed in the second group, and decreasing tendency (P = 0.093) of mortality rate was detected in the first group. The median time interval between admission and death was 14 days (in the first and second groups) and 5 days in the third group.
The early application of the CVVH increases time interval for care delivery and allows reducing early mortality. The best results were obtained in the group of patients who were treated with the higher dose of CVVH (earlier restoration of homeostasis and decreased severity of early MOF).
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