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  1. To summarize knowledge and identify gaps in evidence regarding treatment of right ventricular dysfunction (RVD) in acute respiratory distress syndrome (ARDS).

    Authors: Simran Ganeriwal, Gabriele Alves dos Anjos, Mary Schleicher, Maxwell A. Hockstein, Adriano R. Tonelli, Abhijit Duggal and Matthew T. Siuba
    Citation: Critical Care 2023 27:104
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:133

  2. Limitations of life-sustaining therapies (LST) practices are frequent and vary among intensive care units (ICUs). However, scarce data were available during the COVID-19 pandemic when ICUs were under intense p...

    Authors: Mikhael Giabicani, Christophe Le Terrier, Antoine Poncet, Bertrand Guidet, Jean-Philippe Rigaud, Jean-Pierre Quenot, Marie-France Mamzer, Jérôme Pugin, Emmanuel Weiss and Simon Bourcier
    Citation: Critical Care 2023 27:103
    Content type: Research Published on:

    The Comment to this article has been published in Critical Care 2023 27:195

  3. Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of organ systems, medical interventions and a myriad of other factors. This together results in a complex, dynamic and d...

    Authors: Alex R. Schuurman, Peter M. A. Sloot, W. Joost Wiersinga and Tom van der Poll
    Citation: Critical Care 2023 27:102
    Content type: Perspective Published on:

  7. Prolonged Intermittent Renal Replacement Therapy (PIRRT) is the term used to define ‘hybrid’ forms of renal replacement therapy. PIRRT can be provided using an intermittent hemodialysis machine or a continuous...

    Authors: Edward G. Clark and Anitha Vijayan
    Citation: Critical Care 2023 27:88
    Content type: Perspective Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:165

    The Correspondence to this article has been published in Critical Care 2023 27:159

  8. There is inconclusive evidence regarding the effectiveness of extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) patients. We aimed to evaluate the association betwee...

    Authors: Yeongho Choi, Jeong Ho Park, Joo Jeong, Yu Jin Kim, Kyoung Jun Song and Sang Do Shin
    Citation: Critical Care 2023 27:87
    Content type: Research Published on:

  9. Hyperoxemia may aggravate reperfusion brain injury after cardiac arrest. The aim of this study was to study the associations between different levels of hyperoxemia in the reperfusion period after cardiac arre...

    Authors: Akil Awad, Per Nordberg, Martin Jonsson, Robin Hofmann, Mattias Ringh, Jacob Hollenberg, Jens Olson and Eva Joelsson-Alm
    Citation: Critical Care 2023 27:86
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:434

  10. Management of bleeding trauma patients is still a difficult challenge. Massive transfusion (MT) requires resources to ensure the safety and timely delivery of blood products. Early prediction of MT need may be...

    Authors: Andrea Carsetti, Riccardo Antolini, Erika Casarotta, Elisa Damiani, Francesco Gasparri, Benedetto Marini, Erica Adrario and Abele Donati
    Citation: Critical Care 2023 27:85
    Content type: Research Published on:

  11. Sepsis is a leading cause of preventable death around the world. Population-based estimation of sepsis incidence is lacking in China. In this study, we aimed to estimate the population-based incidence and geog...

    Authors: Li Weng, Yang Xu, Peng Yin, Yi Wang, Yan Chen, Wei Liu, Shan Li, Jin-min Peng, Run Dong, Xiao-yun Hu, Wei Jiang, Chun-yao Wang, Pei Gao, Mai-geng Zhou and Bin Du
    Citation: Critical Care 2023 27:84
    Content type: Research Published on:

  12. This study assessed the mobility levels among critically ill patients and the association of early mobility with incident proximal lower-limb deep-vein thrombosis and 90-day mortality.

    Authors: Hasan M. Al-Dorzi, Samah AlQahtani, Abdulaziz Al-Dawood, Fahad M. Al-Hameed, Karen E. A. Burns, Sangeeta Mehta, Jesna Jose, Sami J. Alsolamy, Sheryl Ann I. Abdukahil, Lara Y. Afesh, Mohammed S. Alshahrani, Yasser Mandourah, Ghaleb A. Almekhlafi, Mohammed Almaani, Ali Al Bshabshe, Simon Finfer…
    Citation: Critical Care 2023 27:83
    Content type: Research Published on:

  13. Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Reportedly, flucloxacillin target attainment in critically ill patients was heterogeneous considering the study population sel...

    Authors: Sjoerd D. Meenks, Nieko Punt, Jos L. M. L. le Noble, Norbert A. Foudraine, Kees Neef and Paddy K. C. Janssen
    Citation: Critical Care 2023 27:82
    Content type: Research Published on:

  14. The Chain of Survival highlights the effectiveness of early recognition of cardiac arrest and call for help, early cardiopulmonary resuscitation and early defibrillation. Most patients, however, remain in card...

    Authors: Gavin D. Perkins and Keith Couper
    Citation: Critical Care 2023 27:81
    Content type: Review Published on:

  15. Severe trauma represents a major global public health burden and the management of post-traumatic bleeding continues to challenge healthcare systems around the world. Post-traumatic bleeding and associated tra...

    Authors: Rolf Rossaint, Arash Afshari, Bertil Bouillon, Vladimir Cerny, Diana Cimpoesu, Nicola Curry, Jacques Duranteau, Daniela Filipescu, Oliver Grottke, Lars Grønlykke, Anatole Harrois, Beverley J. Hunt, Alexander Kaserer, Radko Komadina, Mikkel Herold Madsen, Marc Maegele…
    Citation: Critical Care 2023 27:80
    Content type: Guidelines Published on:

  16. Community-acquired pneumonia (CAP) is the primary cause of death for children under five years of age globally. Hence, it is essential to investigate new early biomarkers and potential mechanisms involved in d...

    Authors: Yi Wang, Xiaolan Huang, Fang Li, Xinbei Jia, Nan Jia, Jin Fu, Shuang Liu, Jin Zhang, Haiyan Ge, Siyuan Huang, Yi Hui, Chunrong Sun, Fei Xiao, Xiaodai Cui, Laurence Don Wai Luu, Dong Qu…
    Citation: Critical Care 2023 27:79
    Content type: Research Published on:

  17. During high-flow nasal cannula (HFNC) therapy, flow plays a crucial role in the physiological effects. However, there is no consensus on the initial flow settings and subsequent titration. Thus, we aimed to sy...

    Authors: Jie Li, Fai A. Albuainain, Wei Tan, J. Brady Scott, Oriol Roca and Tommaso Mauri
    Citation: Critical Care 2023 27:78
    Content type: Review Published on:

  18. Both high mobility group box-1 (HMGB1) and histones are major damage-associated molecular patterns (DAPMs) that mediate lethal systemic inflammation, activation of the complement and coagulation system, endoth...

    Authors: Yupei Li, Yu Chen, Tinghang Yang, Kaixi Chang, Ningyue Deng, Weifeng Zhao and Baihai Su
    Citation: Critical Care 2023 27:77
    Content type: Review Published on:

  19. So far, the few prospective studies on near-death experience (NDE) were carried out only in intensive care unit (ICU) patients with homogeneous aetiologies, such as cardiac arrest or trauma survivors. The aims...

    Authors: Anne-Françoise Rousseau, Laurence Dams, Quentin Massart, Laila Choquer, Héléna Cassol, Steven Laureys, Benoit Misset, Nadia Dardenne, Olivia Gosseries and Charlotte Martial
    Citation: Critical Care 2023 27:76
    Content type: Brief Report Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:185

  20. This paper discusses the use of Artificial Intelligence Chatbot in scientific writing. ChatGPT is a type of chatbot, developed by OpenAI, that uses the Generative Pre-trained Transformer (GPT) language model t...

    Authors: Michele Salvagno, Fabio Silvio Taccone and Alberto Giovanni Gerli
    Citation: Critical Care 2023 27:75
    Content type: Perspective Published on:

    The Correction to this article has been published in Critical Care 2023 27:99

    The Correspondence to this article has been published in Critical Care 2023 27:180

    The Comment to this article has been published in Critical Care 2023 27:148

    The Correspondence to this article has been published in Critical Care 2023 27:120

  21. Previous studies have reported high prognostic accuracy of circulating neurofilament light (NfL) at 24–72 h after out-of-hospital cardiac arrest (OHCA), but performance at earlier time points and after in-hosp...

    Authors: Helena Levin, Anna Lybeck, Attila Frigyesi, Isabelle Arctaedius, Bergthóra Thorgeirsdóttir, Martin Annborn, Marion Moseby-Knappe, Niklas Nielsen, Tobias Cronberg, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Hans Friberg and Niklas Mattsson-Carlgren
    Citation: Critical Care 2023 27:74
    Content type: Research Published on:

  22. This study aimed to assess the effect of different blood pressure levels on global cerebral metabolism in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA).

    Authors: Simon Mølstrøm, Troels Halfeld Nielsen, Carl-Henrik Nordstrøm, Axel Forsse, Søren Møller, Søren Venø, Dmitry Mamaev, Tomas Tencer, Ásta Theódórsdóttir, Thomas Krøigård, Jacob Møller, Christian Hassager, Jesper Kjærgaard, Henrik Schmidt and Palle Toft
    Citation: Critical Care 2023 27:73
    Content type: Perspective Published on:

  23. Severe community-acquired pneumococcal meningitis is a medical emergency. The aim of the present investigation was to evaluate the epidemiology, management and outcomes of this condition.

    Authors: María Martín-Cerezuela, Maialen Aseginolaza-Lizarazu, Patricia Boronat-García, María José Asensio-Martín, Gisela Alamán-Laguarda, Francisco Álvarez-Lerma, David Roa-Alonso, Lorenzo Socias, Paula Vera-Artázcoz and Paula Ramírez-Galleymore
    Citation: Critical Care 2023 27:72
    Content type: Research Published on:

  26. Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut micr...

    Authors: Marius Trøseid, Jan Cato Holter, Kristian Holm, Beate Vestad, Taisiia Sazonova, Beathe K. Granerud, Anne Ma Dyrhol-Riise, Aleksander R. Holten, Kristian Tonby, Anders Benjamin Kildal, Lars Heggelund, Anders Tveita, Simen Bøe, Karl Erik Müller, Synne Jenum, Johannes R. Hov…
    Citation: Critical Care 2023 27:69
    Content type: Research Published on:

  28. The optimal thresholds for the initiation of invasive ventilation in patients with hypoxemic respiratory failure are unknown. Using the saturation-to-inspired oxygen ratio (SF), we compared lower versus higher...

    Authors: Christopher J. Yarnell, Federico Angriman, Bruno L. Ferreyro, Kuan Liu, Harm Jan De Grooth, Lisa Burry, Laveena Munshi, Sangeeta Mehta, Leo Celi, Paul Elbers, Patrick Thoral, Laurent Brochard, Hannah Wunsch, Robert A. Fowler, Lillian Sung and George Tomlinson
    Citation: Critical Care 2023 27:67
    Content type: Research Published on:

  29. In critically ill patients, positive fluid balance is associated with excessive mortality. The POINCARE-2 trial aimed to assess the effectiveness of a fluid balance control strategy on mortality in critically ...

    Authors: Pierre-Edouard Bollaert, Alexandra Monnier, Francis Schneider, Laurent Argaud, Julio Badie, Claire Charpentier, Ferhat Meziani, Michel Bemer, Jean-Pierre Quenot, Marie Buzzi, Hervé Outin, Cédric Bruel, Laurent Ziegler, Sébastien Gibot, Jean-Marc Virion, Camille Alleyrat…
    Citation: Critical Care 2023 27:66
    Content type: Research Published on:

  32. Sepsis is characterized by a dysregulated immune response to infection. The complement system plays an important role in the host defence to pathogens. However, exaggerated complement activation might contribu...

    Authors: Aline H. de Nooijer, Antigone Kotsaki, Eleftheria Kranidioti, Matthijs Kox, Peter Pickkers, Erik J. M. Toonen, Evangelos J. Giamarellos-Bourboulis and Mihai G. Netea
    Citation: Critical Care 2023 27:63
    Content type: Brief Report Published on:

  34. Whether surrogate decision makers regret decisions about the use of life support for incapacitated, critically ill patients remain uncertain. We sought to determine the prevalence of decision regret among surr...

    Authors: Sarah K. Andersen, Rachel A. Butler, Chung-Chou H. Chang, Robert Arnold, Derek C. Angus and Douglas B. White
    Citation: Critical Care 2023 27:61
    Content type: Research Published on:

  35. Pseudomonas aeruginosa pneumonia is commonly treated with systemic antibiotics to ensure adequate treatment of multidrug resistant (MDR) bacteria. However, intravenous (IV) antibiotics often achieve suboptimal pu...

    Authors: Ana Motos, Hua Yang, Gianluigi Li Bassi, Minlan Yang, Andrea Meli, Denise Battaglini, Roberto Cabrera, Joaquim Bobi, Francesco Pagliara, Gerard Frigola, Marta Camprubí-Rimblas, Laia Fernández-Barat, Montserrat Rigol, Antoni Ferrer-Segarra, Kasra Kiarostami, Daniel Martinez…
    Citation: Critical Care 2023 27:60
    Content type: Research Published on:

  36. Acute respiratory distress syndrome (ARDS) patients with different lung morphology have distinct pulmonary mechanical dysfunction and outcomes. Whether lung morphology impacts the association between ventilato...

    Authors: Hui Chen, Qin Sun, Yali Chao, Yue Liu, Qian Yu, Jianfeng Xie, Chun Pan, Ling Liu, Yi Yang and Haibo Qiu
    Citation: Critical Care 2023 27:59
    Content type: Research Published on:

  39. Ethylene glycol (EG) is metabolized into glycolate and oxalate and may cause metabolic acidemia, neurotoxicity, acute kidney injury (AKI), and death. Historically, treatment of EG toxicity included supportive ...

    Authors: Marc Ghannoum, Sophie Gosselin, Robert S. Hoffman, Valery Lavergne, Bruno Mégarbane, Hossein Hassanian-Moghaddam, Maria Rif, Siba Kallab, Steven Bird, David M. Wood and Darren M. Roberts
    Citation: Critical Care 2023 27:56
    Content type: Research Published on:

  40. Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g. sepsis, acute r...

    Authors: Lucy A. Coupland, David J. Rabbolini, Jonathan G. Schoenecker, Philip J. Crispin, Jennene J. Miller, Tony Ghent, Robert L. Medcalf and Anders E. Aneman
    Citation: Critical Care 2023 27:55
    Content type: Research Published on:

  41. The end-tidal alveolar dead space fraction (AVDSf = [PaCO2−PETCO2]/PaCO2) is a metric used to estimate alveolar dead space. Higher AVDSf on the first day of mechanical ventilation is associated with mortality and...

    Authors: Anoopindar K. Bhalla, Ariya Chau, Robinder G. Khemani and Christopher J. L. Newth
    Citation: Critical Care 2023 27:54
    Content type: Research Published on:

  42. Steroids are widely used to modulate the inflammatory reactions associated with coronavirus disease 2019 (COVID-19); however, the optimal upper limit dose of steroid use for acute COVID-19 care remains unclear...

    Authors: Takuhiro Moromizato, Ryoto Sakaniwa, Yasuharu Tokuda, Kiyosu Taniguchi and Kenji Shibuya
    Citation: Critical Care 2023 27:53
    Content type: Research Published on:

  44. Retrospective cohorts have suggested that levosimendan may facilitate the weaning of veno-arterial extracorporeal membrane oxygenation (VA-ECMO). We therefore studied this clinical question by emulating a rand...

    Authors: Julien Massol, Noémie Simon-Tillaux, Joanna Tohme, Geoffroy Hariri, Pauline Dureau, Baptiste Duceau, Lisa Belin, David Hajage, Yann De Rycke, Ahmed Charfeddine, Guillaume Lebreton, Alain Combes and Adrien Bouglé
    Citation: Critical Care 2023 27:51
    Content type: Research Published on:

  45. Sepsis and septic shock remain drivers for morbidity and mortality in critical illness. The clinical picture of patients presenting with these syndromes evolves rapidly and may be characterised by: (a) microbi...

    Authors: Claudio Ronco, Lakhmir Chawla, Faeq Husain-Syed and John A. Kellum
    Citation: Critical Care 2023 27:50
    Content type: Review Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:121

  46. Recent high-quality trials have shown that the anti-inflammatory effects of colchicine reduce the risk of cardiovascular events in patients suffering post-myocardial infarction and chronic coronary disease. Th...

    Authors: Tuo Pan, Chen-Yu Jiang, He Zhang, Xi-Kun Han, Hai-Tao Zhang, Xin-Yi Jiang, Wei Chen, Kuo Wang, Fu-Dong Fan, Jun Pan, Qing Zhou, Chuang-Shi Wang, Li Zhang and Dong-Jin Wang
    Citation: Critical Care 2023 27:49
    Content type: Research Published on:

  47. Health-related quality of life after surviving acute respiratory distress syndrome has come into focus in recent years, especially during the coronavirus disease 2019 pandemic.

    Authors: Alice Bernard, Lina Maria Serna-Higuita, Peter Martus, Valbona Mirakaj, Michael Koeppen, Alexander Zarbock, Gernot Marx, Christian Putensen, Peter Rosenberger and Helene Anna Haeberle
    Citation: Critical Care 2023 27:48
    Content type: Research Published on:

  49. Cumulative evidence has demonstrated that the ventilatory ratio closely correlates with mortality in acute respiratory distress syndrome (ARDS), and a primary feature in coronavirus disease 2019 (COVID-19)-ARD...

    Authors: Mingjia Zheng
    Citation: Critical Care 2023 27:46
    Content type: Review Published on:

  50. Pulse pressure variation (PPV) has been widely used in hemodynamic assessment. Nevertheless, PPV is limited in low tidal volume ventilation. We conducted this systematic review and meta-analysis to evaluate wh...

    Authors: Xiaoying Wang, Shuai Liu, Ju Gao, Yang Zhang and Tianfeng Huang
    Citation: Critical Care 2023 27:45
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535