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Fever is prevalent in the majority of patients after aneurysmal subarachnoid hemorrhage and is associated with worse outcome. Treatment of fever is highly recommended, but with low-grade evidence in current gu...
The discharge of patients from the intensive care unit (ICU) to a hospital ward is a common transition of care that is associated with error and adverse events. Risk stratification tools may help identify high...
Glucocorticoid use in sepsis is controversial. In contrast to other extracellular signaling molecules, glucocorticoid receptors (GRs) are intra-cytoplasmic. Several GR isoforms have been identified. A study in Cr...
This article is part of a Supplement: Volume 17 Supplement 1
The original article was published in Critical Care 2013 17:S6
We hypothesized that mechanical ventilation per se increases abdominal edema and inflammation in sepsis and tested this in experimental endotoxemia.
After numerous negative randomized trials testing drugs for severe sepsis and/or septic shock, the blood purification approach remains one possibility. Many techniques have been proposed, having in common the ...
The largest cohort of critically ill patients evaluating intragastric and small intestinal delivery of nutrients was recently reported. This systematic review included recent data to compare the effects of sma...
The Erratum to this article has been published in Critical Care 2014 18:R138
Physician-staffed helicopter emergency medical services (HEMS) are a well-established component of prehospital trauma care in Germany. Reduced rescue times and increased catchment area represent presumable spe...
The Berlin definition divides acute respiratory distress syndrome (ARDS) into three severity categories. The relationship between these categories and pulmonary microvascular permeability as well as extravascu...
Glucagon-like peptide-1 (GLP-1) originates from the gastrointestinal system in response to the presence of nutrition in the intestinal lumen and potentiates postprandial insulin secretion. Also, it acts as an ...
Obesity is an increasingly common comorbidity in critically ill patients. Whether obesity alters sepsis outcome, susceptibility, treatment, and response is not completely understood.
Hemodynamic management in intensive care patients guided by blood pressure and flow measurements often do not sufficiently reveal common hemodynamic problems. Trans-esophageal echocardiography (TEE) allows for...
Studies indicate that mechanically ventilated patients develop significant diaphragm muscle weakness, but the etiology of weakness and its clinical impact remain incompletely understood. We assessed diaphragm ...
Critically ill patients can develop acute respiratory failure requiring endotracheal intubation. Swallowing dysfunction after liberation from mechanical ventilation, also known as post-extubation dysphagia, is...
Enteral feeding can be given either through the nasogastric or the nasojejunal route. Studies have shown that nasojejunal tube placement is cumbersome and that nasogastric feeding is an effective means of prov...
Cardiac troponins are sensitive and specific biomarkers of myocardial necrosis. We evaluated troponin, CK, and ECG abnormalities in patients with septic shock and compared the effect of vasopressin (VP) versus...
The Erratum to this article has been published in Critical Care 2017 21:98
The peripheral perfusion index (PI) is a noninvasive numerical value of peripheral perfusion, and the transcutaneous oxygen challenge test (OCT) is defined as the degree of transcutaneous partial pressure of o...
Close monitoring and repeated risk assessment of sepsis patients in the intensive care unit (ICU) is important for decisions regarding care intensification or early discharge to the ward. We studied whether co...
Neutrophil recovery has been implicated in deterioration of oxygenation and exacerbation of preexisting acute lung injury (ALI). The aim of this study was to investigate whether imatinib or nilotinib was effec...
The reliability of pulse pressure analysis to estimate cardiac output is known to be affected by arterial load changes. However, the contribution of each aspect of arterial load could be substantially differen...
The urine output criterion of 0.5 ml/kg/hour for 6 hours for acute kidney injury (AKI) has not been prospectively validated. Urine output criteria for AKI (AKIUO) as predictors of in-hospital mortality or dialysi...
To validate the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) scoring system in patients with severe sepsis, we conducted a multicenter, prospective study at 15 cr...
Severe trauma with concomitant chest injury is frequently associated with acute lung failure (ALF). This report summarizes our experience with extracorporeal lung support (ELS) in thoracic trauma patients trea...
Continuous renal replacement therapy (CRRT) is a widely used but resource-intensive treatment. Despite its broad adoption in intensive care units (ICUs), it remains challenging to identify patients who would b...
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
Critical Care