Effect of vasoactive drugs on the response of the baroreceptor and regulation of heart rate variability in patients with septic shock
© Nogueira et al; licensee BioMed Central Ltd. 2013
Published: 19 June 2013
We evaluated the action of vasoactive drugs on baroreceptor regulation and the interaction of this in regulation of heart rate variability (HRV) in patients with septic shock.
A prospective observational study of patients with severe sepsis or septic shock. Collected data were analyzed retrospectively, separating patients according to their clinical evolution: survival or death. We monitored troponin I, vasoactive drug dose, HRV and blood pressure variability.
64 ± 5
Patients with septic shock have impaired baroreceptor function, and this is correlated with progression to death. Dobutamine is related to higher levels of cardiac damage and higher doses of dobutamine interfere with the responsiveness of the baroreceptor. Moreover, norepinephine has a positive effect on the integration of baroreceptor.
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