Evaluation of recognition and signalling receptors on the peripheral blood cells of septic patients and their correlation with clinical outcomes
© Silva et al; licensee BioMed Central Ltd. 2013
Published: 19 June 2013
Monocytes and neutrophils play a key role in host defence by sensing and destroying microorganisms . We evaluated the expression of cellular receptors implicated in pathogen recognition, cell activation and migration on both cell types during sepsis. Blood samples were collected from 77 septic patients (SP) at admission (D0), from 45 patients after 7 days of therapy (D7) and from 40 healthy volunteers (HV).
The expression of recognition and cell signalling receptors is differentially regulated between SP and HV depending on the receptor being evaluated. However, despite these changes, it is likely that the functional changes in monocytes and neutrophils that are observed during sepsis are not directly linked to the modulation of the expression of TLRs .
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