Relationship between clinical and cytokines profile of brain-death donors
© Mello et al; licensee BioMed Central Ltd. 2013
Published: 19 June 2013
Brain death induces a massive inflammatory response. The majority of transplants are derived from donors who suffered from brain injury. The possible relation of clinical profile and cytokines in donors has been poorly explored. The objectives of this study were to analyze clinical characteristics of brain-dead donors and the correlation with cytokine profile in the ICU of a unique tertiary-care hospital.
We evaluated 120 consecutive potential brain-dead organ donors (mean age 34.9 years, 74.2% males) between July 2007 and June 2008. Plasma cytokines (TNF, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IFNγ) were measured in 40 donors immediately after criteria for brain death (or confirmatory tests) and after obtaining consent from families. Cytokines were assessed by cytometric bead array in the plasma and all laboratory personnel were blinded to clinical information.
Levels of proinflammatory and anti-inflammatory cytokines were increased in brain-dead donors and were correlated. There was no difference between cytokines and clinical and laboratory profiles.
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