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Critical Care

Open Access

Parenteral colistin for the treatment of severe infections by multidrug-resistant Gram-negative bacteria

  • C Grion1,
  • MT Tanita1,
  • CM Dantas de Maio Carrilho1,
  • JP Garcia1,
  • J Festti1,
  • LTQ Cardoso1,
  • F Chiquetti1,
  • MM Kanehissa1,
  • CC Branco Lopes1,
  • D Blum1,
  • V Anami1,
  • AR Ruiz1 and
  • PA Rossatto1
Critical Care201317(Suppl 3):P27

Published: 19 June 2013


This study aimed to describe the use of colistin to treat nosocomial infections caused by multidrug-resistant Gram-negative bacteria and to identify risk factors associated with acute kidney injury and mortality in a single center.


This prospective longitudinal study evaluates critically ill patients with nosocomial infections caused by multidrug-resistant Gram-negative bacteria. All adult patients requiring treatment with intravenous colistin (colistimethate sodium) from January to December 2008 were considered eligible for the study. Data include demographics, diagnosis, duration of treatment with colistin and 30-day mortality. Data were analyzed using MedCalc 12 (MedCalc Software, Belgium).


Colistin was used to treat an infection in 109 (13.81%) of the 789 patients admitted to the ICU. Colistin treatment started an average of 10 (6 to 14.25) days after admission to the ICU. The 30-day mortality observed in these patients was 71.56%. Twenty-four (22.02%) patients developed acute kidney injury, and 11 of these patients required dialysis. The variables independently associated with the presence of acute kidney injury were concomitant use of vancomycin (OR 3.10; 95% CI 1.10 to 8.69; P = 0.032) and vasopressors (OR 4.22; 95% CI 1.23 to 14.43; P = 0.022). Age (OR 1.03; 95% CI 1.00 to 1.05; P = 0.027) and vasopressor use (OR 12.48; 95% 4.49 to 34.70; P < 0.001) were independent risk factors for death in the logistic-regression model.


The concomitant use of vancomycin was associated with increased risk of acute kidney injury. Shock and vasopressors were associated with increased risk for acute kidney injury and death.

Authors’ Affiliations

Hospital Universitário - Universidade Estadual de Londrina, Londrina, Brazil


© Grion et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.