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  1. While numerous randomized controlled trials (RCTs) have been conducted in the field of trauma, a substantial portion of them are yielding negative results. One potential contributing factor to this trend could...

    Authors: Thomas Jeanmougin, Elaine Cole, Baptiste Duceau, Mathieu Raux and Arthur James
    Citation: Critical Care 2023 27:363
  2. This study aims to determine the relationship between spinal cord perfusion pressure (SCPP) and breathing function in patients with acute cervical traumatic spinal cord injuries.

    Authors: Ravindran Visagan, Ellaine Boseta, Argyro Zoumprouli, Marios C. Papadopoulos and Samira Saadoun
    Citation: Critical Care 2023 27:362
  3. Prediction of fluid responsiveness in acutely ill patients might be influenced by a number of clinical and technical factors. We aim to identify variables potentially modifying the operative performance of flu...

    Authors: Jorge Iván Alvarado Sánchez, Juan Daniel Caicedo Ruiz, Juan José Diaztagle Fernández, Luís Eduardo Cruz Martínez, Fredy Leonardo Carreño Hernández, Carlos Andrés Santacruz Herrera and Gustavo Adolfo Ospina-Tascón
    Citation: Critical Care 2023 27:361
  4. Non-ventilator-associated ICU-acquired pneumonia (NV-ICU-AP), a nosocomial pneumonia that is not related to invasive mechanical ventilation (IMV), has been less studied than ventilator-associated pneumonia, an...

    Authors: Louis-Marie Galerneau, Sébastien Bailly, Nicolas Terzi, Stéphane Ruckly, Maité Garrouste-Orgeas, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Jean-Marie Forel, Anaïs Dartevel, Julien Dessajan, Christophe Adrie, Dany Goldgran-Toledano, Virginie Laurent…
    Citation: Critical Care 2023 27:359
  5. Cardiac surgery-associated acute kidney injury (CSA-AKI) is frequent. While two network meta-analyses assessed the impact of pharmacological interventions to prevent CSA-AKI, none focused on non-pharmacologica...

    Authors: Geoffroy Hariri, Lucie Collet, Lucie Duarte, Guillaume L. Martin, Matthieu Resche-Rigon, Guillaume Lebreton, Adrien Bouglé and Agnès Dechartres
    Citation: Critical Care 2023 27:354
  6. Singapore and Osaka in Japan have comparable population sizes and prehospital management; however, the frequency of ECPR differs greatly for out-of-hospital cardiac arrest (OHCA) patients with initial shockabl...

    Authors: Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Taro Irisawa, Tomoki Yamada, Tetsuro Nishimura, Takeyuki Kiguchi, Masafumi Kishimoto, Tasuku Matsuyama, Norihiro Nishioka, Kosuke Kiyohara…
    Citation: Critical Care 2023 27:351
  7. This work provides an epidemiological overview of out-of-hospital cardiac arrest (OHCA) in children in Germany between 2007 and 2021. We wanted to identify modifiable factors associated with survival.

    Authors: Stephan Katzenschlager, Inga K. Kelpanides, Patrick Ristau, Matthias Huck, Stephan Seewald, Sebastian Brenner, Florian Hoffmann, Jan Wnent, Jo Kramer-Johansen, Ingvild B. M. Tjelmeland, Markus A. Weigand, Jan-Thorsten Gräsner and Erik Popp
    Citation: Critical Care 2023 27:349
  8. One of five global deaths are attributable to sepsis. Hyperferritinemic sepsis (> 500 ng/mL) is associated with increased mortality in single-center studies. Our pediatric research network’s objective was to o...

    Authors: Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa…
    Citation: Critical Care 2023 27:347
  9. Retrospective studies have demonstrated that the deep learning-based cardiac arrest risk management system (DeepCARS™) is superior to the conventional methods in predicting in-hospital cardiac arrest (IHCA). T...

    Authors: Kyung-Jae Cho, Jung Soo Kim, Dong Hyun Lee, Sang‑Min Lee, Myung Jin Song, Sung Yoon Lim, Young-Jae Cho, You Hwan Jo, Yunseob Shin and Yeon Joo Lee
    Citation: Critical Care 2023 27:346
  10. Respiratory mechanics is a key element to monitor mechanically ventilated patients and guide ventilator settings. Besides the usual basic assessments, some more complex explorations may allow to better charact...

    Authors: François M. Beloncle, Jean-Christophe Richard, Hamid Merdji, Christophe Desprez, Bertrand Pavlovsky, Elise Yvin, Lise Piquilloud, Pierre-Yves Olivier, Dara Chean, Antoine Studer, Antonin Courtais, Maëva Campfort, Hassene Rahmani, Arnaud Lesimple, Ferhat Meziani and Alain Mercat
    Citation: Critical Care 2023 27:343
  11. Approximately 20% of patients with acute brain injury (ABI) also experience acute kidney injury (AKI), which worsens their outcomes. The metabolic and inflammatory changes associated with AKI likely contribute...

    Authors: Faeq Husain-Syed, Tomonori Takeuchi, Javier A. Neyra, Gonzalo Ramírez-Guerrero, Mitchell H. Rosner, Claudio Ronco and Ashita J. Tolwani
    Citation: Critical Care 2023 27:341
  12. Except in a few retrospective studies mainly including patients under chemotherapy, information regarding the impact of immunosuppressive therapy on the prognosis of patients admitted to the intensive care uni...

    Authors: Julien Vaidie, Edwige Peju, Louise-Marie Jandeaux, Mathieu Lesouhaitier, Jean-Claude Lacherade, Antoine Guillon, Xavier Wittebole, Pierre Asfar, Bruno Evrard, Thomas Daix, Philippe Vignon and Bruno François
    Citation: Critical Care 2023 27:340
  13. The primary aim was to explore the association of global cerebral physiological variables including intracranial pressure (ICP), cerebrovascular reactivity (PRx), cerebral perfusion pressure (CPP), and deviati...

    Authors: Teodor Svedung Wettervik, Erta Beqiri, Stefan Yu Bögli, Michal Placek, Mathew R. Guilfoyle, Adel Helmy, Andrea Lavinio, Ronan O’Leary, Peter J. Hutchinson and Peter Smielewski
    Citation: Critical Care 2023 27:339

    The Matters Arising to this article has been published in Critical Care 2023 27:452

  14. Few specific methods are available to reduce the risk of diaphragmatic dysfunction for patients under mechanical ventilation. The number of studies involving transcutaneous electrical stimulation of the diaphr...

    Authors: Clément Medrinal, Margaux Machefert, Bouchra Lamia, Tristan Bonnevie, Francis-Edouard Gravier, Roger Hilfiker, Guillaume Prieur and Yann Combret
    Citation: Critical Care 2023 27:338
  15. Vascular leakage is a major feature of acute respiratory distress syndrome (ARDS). We aimed to evaluate the efficacy of FX06, a drug under development that stabilizes interendothelial cell junctions, at reduci...

    Authors: Emmanuelle Guérin, Lisa Belin, Guillaume Franchineau, Loïc Le Guennec, David Hajage, Mamadou Hassimiou Diallo, Thomas Frapard, Lucie Le Fèvre, Charles-Edouard Luyt, Alain Combes, Stéphane Germain, Jan Hayon, Pierre Asfar and Nicolas Bréchot
    Citation: Critical Care 2023 27:331
  16. Haloperidol is frequently used in critically ill patients with delirium, but evidence for its effects has been sparse and inconclusive. By including recent trials, we updated a systematic review assessing effe...

    Authors: Nina Christine Andersen-Ranberg, Marija Barbateskovic, Anders Perner, Marie Oxenbøll Collet, Lone Musaeus Poulsen, Mathieu van der Jagt, Lisa Smit, Jørn Wetterslev, Ole Mathiesen and Mathias Maagaard
    Citation: Critical Care 2023 27:329
  17. Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with...

    Authors: Erik Blennow Nordström, Susanna Vestberg, Lars Evald, Marco Mion, Magnus Segerström, Susann Ullén, John Bro-Jeppesen, Hans Friberg, Katarina Heimburg, Anders M. Grejs, Thomas R. Keeble, Hans Kirkegaard, Hanna Ljung, Sofia Rose, Matthew P. Wise, Christian Rylander…
    Citation: Critical Care 2023 27:328
  18. Mechanical ventilation is applied to unload the respiratory muscles, but knowledge about transpulmonary driving pressure (ΔPL) is important to minimize lung injury. We propose a method to estimate ΔPL during neur...

    Authors: Ling Liu, Hong-Liang Li, Cong Lu, Purab Patel, Danqiong Wang, Jennifer Beck and Christer Sinderby
    Citation: Critical Care 2023 27:325
  19. Pneumocystis jirovecii pneumonia (PJP) is an opportunistic, life-threatening disease commonly affecting immunocompromised patients. The distribution of predisposing diseases or conditions in critically ill patien...

    Authors: Daniele Roberto Giacobbe, Silvia Dettori, Vincenzo Di Pilato, Erika Asperges, Lorenzo Ball, Enora Berti, Ola Blennow, Bianca Bruzzone, Laure Calvet, Federico Capra Marzani, Antonio Casabella, Sofia Choudaly, Anais Dartevel, Gennaro De Pascale, Gabriele Di Meco, Melissa Fallon…
    Citation: Critical Care 2023 27:323
  20. Thrombocytopenia, hemorrhage and platelet transfusion are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA ECMO). However, current literature is limited to small single-ce...

    Authors: Senta Jorinde Raasveld, Claudia van den Oord, Jimmy Schenk, Walter M. van den Bergh, Annemieke Oude Lansink - Hartgring, Franciska van der Velde, Jacinta J. Maas, Pablo van de Berg, Roberto Lorusso, Thijs S. R. Delnoij, Dinis Dos Reis Miranda, Erik Scholten, Fabio Silvio Taccone, Dieter F. Dauwe, Erwin De Troy, Greet Hermans…
    Citation: Critical Care 2023 27:321
  21. COVID-19 patients with acute hypoxemic respiratory failure (AHRF) benefit from high flow nasal cannula (HFNC) oxygen therapy. However, delays in initiating invasive ventilation after HFNC failure are associate...

    Authors: Chun En Yau, Dawn Yi Xin Lee, Adithi Vasudevan, Ken Junyang Goh, Evelyn Wong, Andrew Fu Wah Ho and Daniel Yan Zheng Lim
    Citation: Critical Care 2023 27:320
  22. Urinary C–C motif chemokine ligand 14 (CCL14) has been described as an effective marker for delayed recovery of acute kidney injury (AKI), yet its efficacy has been found to vary between different trials. The ...

    Authors: Yih‑Ting Chen, Heng-Chih Pan, Cheng-Kai Hsu, Chiao-Yin Sun, Chun-Yu Chen, Yi-Hung Chen, Heng-Jung Hsu, I-Wen Wu, Vin-Cent Wu and Eric Hoste
    Citation: Critical Care 2023 27:318
  23. This substudy of the randomized IDEAL-ICU trial assessed whether the timing of renal replacement therapy (RRT) initiation has a differential effect on 90-day mortality, according to the criteria used to diagno...

    Authors: Saber Davide Barbar, Abderrahmane Bourredjem, Rémi Trusson, Auguste Dargent, Christine Binquet and Jean-Pierre Quenot
    Citation: Critical Care 2023 27:316
  24. The effects of awake prone position on the breathing pattern of hypoxemic patients need to be better understood. We conducted a crossover trial to assess the physiological effects of awake prone position in pa...

    Authors: Domenico Luca Grieco, Luca Delle Cese, Luca S. Menga, Tommaso Rosà, Teresa Michi, Gianmarco Lombardi, Melania Cesarano, Valentina Giammatteo, Giuseppe Bello, Simone Carelli, Salvatore L. Cutuli, Claudio Sandroni, Gennaro De Pascale, Antonio Pesenti, Salvatore M. Maggiore and Massimo Antonelli
    Citation: Critical Care 2023 27:315