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  1. Critically ill patients require complex care and experience unique needs during and after their stay in the intensive care unit (ICU). Discharging or transferring a patient from the ICU to a hospital ward or b...

    Authors: Kara M. Plotnikoff, Karla D. Krewulak, Laura Hernández, Krista Spence, Nadine Foster, Shelly Longmore, Sharon E. Straus, Daniel J. Niven, Jeanna Parsons Leigh, Henry T. Stelfox and Kirsten M. Fiest
    Citation: Critical Care 2021 25:438
  2. The measurement of circulating substrate concentrations does not provide information about substrate kinetics. It, therefore, remains unclear if a decrease in plasma concentration of albumin, as seen during cr...

    Authors: Keisuke Omiya, Hiroaki Sato, Tamaki Sato, Linda Wykes, Mengyin Hong, Roupen Hatzakorzian, Arnold S. Kristof and Thomas Schricker
    Citation: Critical Care 2021 25:436
  3. Authors: Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer…
    Citation: Critical Care 2021 25:435

    The original article was published in Critical Care 2021 25:331

  4. While targeted temperature management (TTM) has been recommended in patients with shockable cardiac arrest (CA) and suggested in patients with non-shockable rhythms, few data exist regarding the impact of the ...

    Authors: Jean-Baptiste Lascarrou, Elie Guichard, Jean Reignier, Amélie Le Gouge, Caroline Pouplet, Stéphanie Martin, Jean-Claude Lacherade and Gwenhael Colin
    Citation: Critical Care 2021 25:434
  5. Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide despite correct antibiotic use. Corticosteroids have long been evaluated as a treatment option, but heterogeneous effe...

    Authors: A. Ceccato, A. Russo, E. Barbeta, P. Oscanoa, G. Tiseo, A. Gabarrus, P. Di Giannatale, S. Nogas, C. Cilloniz, F. Menichetti, M. Ferrer, M. Niederman, M. Falcone and A. Torres
    Citation: Critical Care 2021 25:432
  6. We hypothesized that as CARDS may present different pathophysiological features than classic ARDS, the application of high levels of end-expiratory pressure is questionable. Our first aim was to investigate th...

    Authors: Davide Chiumello, Matteo Bonifazi, Tommaso Pozzi, Paolo Formenti, Giuseppe Francesco Sferrazza Papa, Gabriele Zuanetti and Silvia Coppola
    Citation: Critical Care 2021 25:431
  7. Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate wi...

    Authors: Ilse Vanhorebeek, Inge Derese, Jan Gunst, Pieter J. Wouters, Greet Hermans and Greet Van den Berghe
    Citation: Critical Care 2021 25:430
  8. Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) represent leading causes of trauma-induced mortality, especially when co-occurring in pre-hospital settings where standard...

    Authors: Andrew R. Mayer, Andrew B. Dodd, Julie G. Rannou-Latella, David D. Stephenson, Rebecca J. Dodd, Josef M. Ling, Carissa J. Mehos, Cidney R. Robertson-Benta, Sharvani Pabbathi Reddy, Rachel E. Kinsler, Meghan S. Vermillion, Andrew P. Gigliotti, Veronik Sicard, Amy L. Lloyd, Erik B. Erhardt, Jessica M. Gill…
    Citation: Critical Care 2021 25:428
  9. Flow Index, a numerical expression of the shape of the inspiratory flow-time waveform recorded during pressure support ventilation, is associated with patient inspiratory effort. The aim of this study was to a...

    Authors: Filippo Albani, Federica Fusina, Gianni Ciabatti, Luigi Pisani, Valeria Lippolis, Maria Elena Franceschetti, Alessia Giovannini, Rossella di Mussi, Francesco Murgolo, Antonio Rosano, Salvatore Grasso and Giuseppe Natalini
    Citation: Critical Care 2021 25:427
  10. The preferential use of the oral/enteral route in critically ill patients over gut rest is uniformly recommended and applied. This article provides practical guidance on enteral nutrition in compliance with re...

    Authors: Jean-Charles Preiser, Yaseen M. Arabi, Mette M. Berger, Michael Casaer, Stephen McClave, Juan C. Montejo-González, Sandra Peake, Annika Reintam Blaser, Greet Van den Berghe, Arthur van Zanten, Jan Wernerman and Paul Wischmeyer
    Citation: Critical Care 2021 25:424
  11. Autoptic pulmonary findings have been described in severe COVID-19 patients, but evidence regarding the correlation between clinical picture and lung histopathologic patterns is still weak.

    Authors: Maddalena Alessandra Wu, Gianluca Lopez, Manuela Nebuloni, Davide Ottolina, Jonathan Montomoli, Luca Carsana, Tommaso Fossali, Antonio Castelli, Roberto Rech, Chiara Cogliati, Emanuele Catena and Riccardo Colombo
    Citation: Critical Care 2021 25:423
  12. Severity scores are commonly used for outcome adjustment and benchmarking of trauma care provided. No specific models performed only with critically ill patients are available. Our objective was to develop a n...

    Authors: Luis Serviá, Juan Antonio Llompart-Pou, Mario Chico-Fernández, Neus Montserrat, Mariona Badia, Jesús Abelardo Barea-Mendoza, María Ángeles Ballesteros-Sanz and Javier Trujillano
    Citation: Critical Care 2021 25:420
  13. The present study was performed to investigate the impacts of type 2 diabetes mellitus (T2DM) on severe community-acquired pneumonia (SCAP) and to develop a novel prediction model for mortality in SCAP patient...

    Authors: Dong Huang, Dingxiu He, Linjing Gong, Wen Wang, Lei Yang, Zhongwei Zhang, Yujun Shi and Zongan Liang
    Citation: Critical Care 2021 25:419
  14. Data in the literature about HSV reactivation in COVID-19 patients are scarce, and the association between HSV-1 reactivation and mortality remains to be determined. Our objectives were to evaluate the impact of

    Authors: Antoine Meyer, Niccolò Buetti, Nadhira Houhou-Fidouh, Juliette Patrier, Moustafa Abdel-Nabey, Pierre Jaquet, Simona Presente, Tiphaine Girard, Faiza Sayagh, Stephane Ruckly, Paul-Henri Wicky, Etienne de Montmollin, Lila Bouadma, Romain Sonneville, Diane Descamps and Jean-Francois Timsit
    Citation: Critical Care 2021 25:417
  15. Several clinical guidelines recommend monitoring blood lactate levels and central venous oxygen saturation for hemodynamic management of patients with sepsis. We hypothesized that carbon dioxide production (VCO2)...

    Authors: Ichiro Hirayama, Toshifumi Asada, Miyuki Yamamoto, Naoki Hayase, Takahiro Hiruma and Kent Doi
    Citation: Critical Care 2021 25:416
  16. Although the combination of rehabilitation and nutrition may be important for the prevention of intensive care unit (ICU)-acquired weakness, a protocolized intervention of this combination has not yet been rep...

    Authors: Hidehiko Nakano, Hiromu Naraba, Hideki Hashimoto, Masaki Mochizuki, Yuji Takahashi, Tomohiro Sonoo, Yasuhiro Ogawa, Yujiro Matsuishi, Nobutake Shimojo, Yoshiaki Inoue and Kensuke Nakamura
    Citation: Critical Care 2021 25:415
  17. Although non-invasive respiratory management strategies have been implemented to avoid intubation, patients with de novo acute hypoxaemic respiratory failure (AHRF) are high risk of treatment failure. In the p...

    Authors: Masaaki Sakuraya, Hiromu Okano, Tomoyuki Masuyama, Shunsuke Kimata and Satoshi Hokari
    Citation: Critical Care 2021 25:414
  18. Sepsis is often associated with multiple organ failure; however, changes in brain volume with sepsis are not well understood. We assessed brain atrophy in the acute phase of sepsis using brain computed tomogra...

    Authors: Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Yasuo Murai, Eigo Kodani, Geoffrey Warnock, Hidetaka Sato, Akio Morita, Hiroyuki Yokota and Shoji Yokobori
    Citation: Critical Care 2021 25:411
  19. There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most stu...

    Authors: Jonathan Rilinger, Klara Krötzsch, Xavier Bemtgen, Markus Jäckel, Viviane Zotzmann, Corinna N. Lang, Klaus Kaier, Daniel Duerschmied, Alexander Supady, Christoph Bode, Dawid L. Staudacher and Tobias Wengenmayer
    Citation: Critical Care 2021 25:410
  20. The International Liaison Committee on Resuscitation recommends that dispatchers provide instructions to perform compression-only cardiopulmonary resuscitation (CPR) to callers responding to adults with out-of...

    Authors: Yoshikazu Goto, Akira Funada, Tetsuo Maeda and Yumiko Goto
    Citation: Critical Care 2021 25:408
  21. The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems. In this study, we combine the ultrasound approach...

    Authors: Stefan Schmidt, Jana-Katharina Dieks, Michael Quintel and Onnen Moerer
    Citation: Critical Care 2021 25:405
  22. Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative a...

    Authors: Katherine D. Wick, Daniel F. McAuley, Joseph E. Levitt, Jeremy R. Beitler, Djillali Annane, Elisabeth D. Riviello, Carolyn S. Calfee and Michael A. Matthay
    Citation: Critical Care 2021 25:404
  23. Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this stud...

    Authors: Lauro Damonti, Andreas Kronenberg, Jonas Marschall, Philipp Jent, Rami Sommerstein, Marlieke E. A. De Kraker, Stephan Harbarth, Michael Gasser and Niccolò Buetti
    Citation: Critical Care 2021 25:403
  24. This study investigated temporal trends in the treatment and mortality of patients with cardiogenic shock (CS) in Taiwan in relation to acute myocardial infarction (AMI) accreditation implemented in 2009 and t...

    Authors: Shih-Chieh Chien, Chien-Yi Hsu, Hung-Yi Liu, Chao-Feng Lin, Chung-Lieh Hung, Chun-Yao Huang and Li-Nien Chien
    Citation: Critical Care 2021 25:402
  25. The coronavirus disease-19 (COVID-19) pandemic had a relatively minimal direct impact on critical illness in children compared to adults. However, children and paediatric intensive care units (PICUs) were affe...

    Authors: Hari Krishnan Kanthimathinathan, Hannah Buckley, Peter J. Davis, Richard G. Feltbower, Caroline Lamming, Lee Norman, Lyn Palmer, Mark J. Peters, Adrian Plunkett, Padmanabhan Ramnarayan, Barnaby R. Scholefield and Elizabeth S. Draper
    Citation: Critical Care 2021 25:399
  26. We assessed the prognostic accuracy of the standardized electroencephalography (EEG) patterns (“highly malignant,” “malignant,” and “benign”) according to the EEG timing (early vs. late) and investigated the E...

    Authors: Youn-Jung Kim, Min-Jee Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Dong Hoon Lee and Won Young Kim
    Citation: Critical Care 2021 25:398
  27. Authors: Jean-Louis Vincent, Mervyn Singer, Sharon Einav, Rui Moreno, Julia Wendon, Jean-Louis Teboul, Jan Bakker, Glenn Hernandez, Djillali Annane, Angélique M. E. de Man, Xavier Monnet, V. Marco Ranieri, Olfa Hamzaoui, Jukka Takala, Nicole Juffermans, Jean-Daniel Chiche…
    Citation: Critical Care 2021 25:397
  28. Authors: William Xu, Armen A. Gharibans, Ian P. Bissett, Gregory O’Grady, Cameron I. Wells, Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson and Sarah Vollam
    Citation: Critical Care 2021 25:394

    The original article was published in Critical Care 2021 25:351

  29. Prognostic assessments of the mortality of critically ill patients are frequently performed in daily clinical practice and provide prognostic guidance in treatment decisions. In contrast to several sophisticat...

    Authors: Eline G. M. Cox, Marisa Onrust, Madelon E. Vos, Wolter Paans, Willem Dieperink, Jacqueline Koeze, Iwan C. C. van der Horst and Renske Wiersema
    Citation: Critical Care 2021 25:393
  30. Enrollment problems are common among randomized controlled trials conducted in the ICU. However, little is known about actual trial enrollment rates and influential factors. We set out to determine the overall...

    Authors: Dustin C. Krutsinger, Kuldeep N. Yadav, Michael O. Harhay, Karsten Bartels and Katherine R. Courtright
    Citation: Critical Care 2021 25:392
  31. Extubation failure is an important issue in ventilated patients and its risk factors remain a matter of research. We conducted a systematic review and meta-analysis to explore factors associated with extubatio...

    Authors: Flavia Torrini, Ségolène Gendreau, Johanna Morel, Guillaume Carteaux, Arnaud W. Thille, Massimo Antonelli and Armand Mekontso Dessap
    Citation: Critical Care 2021 25:391
  32. Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 (COVID-19) is associated with ARDS in the more sever...

    Authors: Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B. Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Peñuelas, Jesús Ruiz-Cabello and Jose L. Izquierdo-Garcia
    Citation: Critical Care 2021 25:390