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  1. The timing of initiation of renal replacement therapy (RRT) in severe acute kidney injury (AKI) remains controversial, with early initiation resulting in unnecessary therapy for some patients while expectant t...

    Authors: Nuttha Lumlertgul, Sadudee Peerapornratana, Thananda Trakarnvanich, Wanjak Pongsittisak, Kajbundit Surasit, Anan Chuasuwan, Pleumjit Tankee, Khajohn Tiranathanagul, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong, John A. Kellum and Nattachai Srisawat
    Citation: Critical Care 2018 22:101
    Content type: Research Published on:

  2. The modifiable prehospital system factors, bystander cardiopulmonary resuscitation (CPR), emergency medical services (EMS), response time, and EMS physician attendance, may affect short- and long-term survival...

    Authors: Wenche Torunn Mathiesen, Conrad Arnfinn Bjørshol, Jan Terje Kvaløy and Eldar Søreide
    Citation: Critical Care 2018 22:99
    Content type: Research Published on:

  3. Patients on extracorporeal membrane oxygenation (ECMO) are often among the most severely ill in the intensive care unit. They are often receiving broad-spectrum antibiotics; they have multiple entry points for...

    Authors: Yiorgos Alexandros Cavayas, Hakeem Yusuff and Richard Porter
    Citation: Critical Care 2018 22:98
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2019 23:314

    The Letter to this article has been published in Critical Care 2018 22:145

  4. Admission to the intensive care unit (ICU) outside daytime hours has been shown to be variably associated with increased morbidity and mortality. We aimed to describe the characteristics and outcomes of patien...

    Authors: Adam M. Hall, Henry T. Stelfox, Xioaming Wang, Guanmin Chen, Danny J. Zuege, Peter Dodek, Allan Garland, Damon C. Scales, Luc Berthiaume, David A. Zygun and Sean M. Bagshaw
    Citation: Critical Care 2018 22:97
    Content type: Research Published on:

  5. Sepsis remains a major cause of mortality in critical care, for which specific treatments are lacking. The dysregulated response to infection seen in sepsis includes features of lymphocyte dysfunction and exha...

    Authors: Julie K. Wilson, Yuan Zhao, Mervyn Singer, Jo Spencer and Manu Shankar-Hari
    Citation: Critical Care 2018 22:95
    Content type: Research Published on:

  7. The prevalence and mortality of sepsis are largely unknown in Turkey, a country with high antibiotic resistance. A national, multicenter, point-prevalence study was conducted to determine the prevalence, causa...

    Authors: Nur Baykara, Halis Akalın, Mustafa Kemal Arslantaş, Volkan Hancı, Çiğdem Çağlayan, Ferda Kahveci, Kubilay Demirağ, Canan Baydemir and Necmettin Ünal
    Citation: Critical Care 2018 22:93
    Content type: Research Published on:

  8. Dosing in obese critically ill patients is challenging due to pathophysiological changes derived from obesity and/or critical illness, and it remains fully unexplored. This study estimated the micafungin proba...

    Authors: Emilio Maseda, Santiago Grau, Sonia Luque, Maria-Pilar Castillo-Mafla, Alejandro Suárez-de-la-Rica, Ana Montero-Feijoo, Patricia Salgado, Maria-Jose Gimenez, Carlos A. García-Bernedo, Fernando Gilsanz and Jason A. Roberts
    Citation: Critical Care 2018 22:94
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2018 22:289

    The Letter to this article has been published in Critical Care 2018 22:149

  10. Sepsis is estimated to affect more than 30 million patients with potentially five million deaths every year worldwide. Prevention of sepsis, as well as early recognition, diagnosis and treatment, can’t be over...

    Authors: Romain Martischang, Daniela Pires, Sarah Masson-Roy, Hiroki Saito and Didier Pittet
    Citation: Critical Care 2018 22:92
    Content type: Editorial Published on:

  11. General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to a...

    Authors: Jilske A. Huijben, Victor Volovici, Maryse C. Cnossen, Iain K. Haitsma, Nino Stocchetti, Andrew I. R. Maas, David K. Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W. Steyerberg, Hester F. Lingsma and Mathieu van der Jagt
    Citation: Critical Care 2018 22:90
    Content type: Research Published on:

  13. Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenot...

    Authors: Antoine Néel, Anaïs Wahbi, Benoit Tessoulin, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Cédric Bretonnière and Mohamed Hamidou
    Citation: Critical Care 2018 22:88
    Content type: Research Published on:

  14. The shock index (SI), defined as heart rate (HR) divided by systolic blood pressure (SBP), is reported to be a more sensitive marker of shock than traditional vital signs alone. In previous literature, use of ...

    Authors: Akio Kimura and Noriko Tanaka
    Citation: Critical Care 2018 22:87
    Content type: Research Published on:

  16. Strained intensive care unit (ICU) capacity represents a fundamental supply-demand mismatch in ICU resources. Strain is likely to be influenced by a range of factors; however, there has been no systematic eval...

    Authors: Oleksa G. Rewa, Henry T. Stelfox, Armann Ingolfsson, David A. Zygun, Robin Featherstone, Dawn Opgenorth and Sean M. Bagshaw
    Citation: Critical Care 2018 22:86
    Content type: Research Published on:

  20. Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by progressive loss of lung function and poor prognosis. The so-called acute exacerbation of IPF (AE-IPF) may lead to severe hypoxem...

    Authors: Alessandro Marchioni, Roberto Tonelli, Lorenzo Ball, Riccardo Fantini, Ivana Castaniere, Stefania Cerri, Fabrizio Luppi, Mario Malerba, Paolo Pelosi and Enrico Clini
    Citation: Critical Care 2018 22:80
    Content type: Review Published on:

  22. This study assessed the ability of mid-regional proadrenomedullin (MR-proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate, C-reactive protein) and clinical scores to identify disease...

    Authors: Gunnar Elke, Frank Bloos, Darius Cameron Wilson, Frank Martin Brunkhorst, Josef Briegel, Konrad Reinhart, Markus Loeffler, Stefan Kluge, Axel Nierhaus, Ulrich Jaschinski, Onnen Moerer, Andreas Weyland and Patrick Meybohm
    Citation: Critical Care 2018 22:79
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2019 23:173

  23. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at

    Authors: Nora Suzanne Wolff, Floor Hugenholtz and Willem Joost Wiersinga
    Citation: Critical Care 2018 22:78
    Content type: Review Published on:

  32. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at

    Authors: Anna Hall, Laurence W. Busse and Marlies Ostermann
    Citation: Critical Care 2018 22:69
    Content type: Review Published on:

  33. Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction by mechanisms related to inflammation and oxidative stress. Despite previous studies demonstrating...

    Authors: Juliana Monte Real, Ludmila Rodrigues Pinto Ferreira, Gustavo Henrique Esteves, Fernanda Christtanini Koyama, Marcos Vinícius Salles Dias, João Evangelista Bezerra-Neto, Edécio Cunha-Neto, Flavia Ribeiro Machado, Reinaldo Salomão and Luciano Cesar Pontes Azevedo
    Citation: Critical Care 2018 22:68
    Content type: Research Published on:

  34. Rapid Response Teams (RRTs) are groups of healthcare providers that are used by many hospitals to respond to acutely deteriorating patients admitted to the wards. We sought to identify outcomes of patients ass...

    Authors: Shannon M. Fernando, Peter M. Reardon, Sean M. Bagshaw, Damon C. Scales, Kyle Murphy, Jennifer Shen, Peter Tanuseputro, Daren K. Heyland and Kwadwo Kyeremanteng
    Citation: Critical Care 2018 22:67
    Content type: Research Published on:

  35. Mild therapeutic hypothermia (TH), or targeted temperature management, improves survival and neurological outcomes in patients after out-of-hospital cardiac arrest (OHCA). International guidelines strongly sup...

    Authors: Patrick J. Lindsay, Danielle Buell and Damon C. Scales
    Citation: Critical Care 2018 22:66
    Content type: Research Published on:

  36. Insertion of a central venous catheter (CVC) is common practice in critical care medicine. Complications arising from CVC placement are mostly due to a pneumothorax or malposition. Correct position is currentl...

    Authors: Jasper M. Smit, Reinder Raadsen, Michiel J. Blans, Manfred Petjak, Peter M. Van de Ven and Pieter R. Tuinman
    Citation: Critical Care 2018 22:65
    Content type: Review Published on:

  37. Neuromuscular blockade (NMB) is a therapy for acute respiratory distress syndrome (ARDS). However, the mechanism by which NMB may improve outcome for ARDS patients remains unclear. We sought to determine wheth...

    Authors: Peter D. Sottile, David Albers and Marc M. Moss
    Citation: Critical Care 2018 22:63
    Content type: Research Published on:

    The Editorial to this article has been published in Critical Care 2018 22:132

  41. Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality that imposes a serious medical burden. Antiplatelet therapy is a potential strategy for preventing ARDS in patient...

    Authors: Yingqin Wang, Ming Zhong, Zhichao Wang, Jieqiong Song, Wei Wu and Duming Zhu
    Citation: Critical Care 2018 22:60
    Content type: Research Published on:

  43. Patients with sepsis with a high ratio of visceral adipose tissue (VAT) to subcutaneous adipose tissue (SAT) have increased mortality. Our goal was to investigate the mechanism of this effect, noting that low ...

    Authors: Joseph G. H. Lee, Kelly R. Genga, Chawika Pisitsak, John H. Boyd, Alex K. K. Leung, James A. Russell and Keith R. Walley
    Citation: Critical Care 2018 22:58
    Content type: Research Published on:

  49. Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic, cardiogenic, hemorrhagic, and anaphylactic shock. Its pathophysiology is complex, involving various mechanisms in vascular ...

    Authors: Bruno Levy, Caroline Fritz, Elsa Tahon, Audrey Jacquot, Thomas Auchet and Antoine Kimmoun
    Citation: Critical Care 2018 22:52
    Content type: Review Published on:

    The Letter to this article has been published in Critical Care 2018 22:159

    The Letter to this article has been published in Critical Care 2018 22:104

  50. For healthcare systems, an ageing population poses challenges in the delivery of equitable and effective care. Frailty assessment has the potential to improve care in the intensive care setting, but applying a...

    Authors: Richard J. Pugh, Amy Ellison, Kate Pye, Christian P. Subbe, Chris M. Thorpe, Nazir I. Lone and Andrew Clegg
    Citation: Critical Care 2018 22:49
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535