Articles
Page 57 of 376
-
Citation: Critical Care 2018 22:300
-
Systematic review of incretin therapy during peri-operative and intensive care
Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones. By lowering blood glucose in a glucose-dependent manner, incretin-based therapies represent a novel and...
Citation: Critical Care 2018 22:299 -
Is goal-directed fluid therapy based on dynamic variables alone sufficient to improve clinical outcomes among patients undergoing surgery? A meta-analysis
Whether goal-directed fluid therapy based on dynamic predictors of fluid responsiveness (GDFTdyn) alone improves clinical outcomes in comparison with standard fluid therapy among patients undergoing surgery re...
Citation: Critical Care 2018 22:298 -
Comparison between surgical and percutaneous tracheostomy effects on procalcitonin kinetics in critically ill patients
Available evidence from randomized controlled trials including adult critically ill patients tends to show that percutaneous dilatational tracheostomy (PDT) techniques are performed faster and reduce stoma inf...
Citation: Critical Care 2018 22:297 -
Selective decontamination of the digestive tract in critical care: a teenage angst or coming of age issue?
Selective decontamination of the digestive tract (SDD) has been with us since the early days of our specialty, and in some ways it marks our progression and maturation. How we have dealt with SDD to date range...
Citation: Critical Care 2018 22:296 -
Bright environmental light improves the sleepiness of nightshift ICU nurses
Shift work can disturb circadian homeostasis and result in fatigue, excessive sleepiness, and reduced quality of life. Light therapy has been shown to impart positive effects in night shift workers. We sought ...
Citation: Critical Care 2018 22:295 -
A brief comment on the predictive value of myeloperoxidase-conjugated DNA level in patients with septic shock
Citation: Critical Care 2018 22:294 -
Cost-effectiveness of procalcitonin testing to guide antibiotic treatment duration in critically ill patients: results from a randomised controlled multicentre trial in the Netherlands
Procalcitonin (PCT) testing can help in safely reducing antibiotic treatment duration in intensive care patients with sepsis. However, the cost-effectiveness of such PCT guidance is not yet known.
Citation: Critical Care 2018 22:293 -
Ultrasound-guided vessel puncture: calling for Pythagoras’ help
Citation: Critical Care 2018 22:292 -
Is access to intensive care equitable?
Citation: Critical Care 2018 22:291 -
Clinical benefit of high-volume hemofiltration in severe burn injury: is it removing bad humors or actually avoiding hypervolemia?
Citation: Critical Care 2018 22:290 -
Optimizing micafungin dosing in critically ill patients: what about extracorporeal therapies?
Citation: Critical Care 2018 22:289 -
Angiotensin in ECMO patients with refractory shock
Citation: Critical Care 2018 22:288 -
Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia
Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are still not fully und...
Citation: Critical Care 2018 22:287 -
Multicenter derivation and validation of an early warning score for acute respiratory failure or death in the hospital
Acute respiratory failure occurs frequently in hospitalized patients and often starts before ICU admission. A risk stratification tool to predict mortality and risk for mechanical ventilation (MV) may allow fo...
Citation: Critical Care 2018 22:286 -
Early therapeutic plasma exchange in septic shock: a prospective open-label nonrandomized pilot study focusing on safety, hemodynamics, vascular barrier function, and biologic markers
Given the pathophysiological key role of the host response to an infection rather than the infection per se, an ideal therapeutic strategy would also target this response. This study was designed to demonstrat...
Citation: Critical Care 2018 22:285 -
Development and internal validation of the multivariable CIPHER (Collaborative Integrated Pregnancy High-dependency Estimate of Risk) clinical risk prediction model
Intensive care unit (ICU) outcome prediction models, such as Acute Physiology And Chronic Health Evaluation (APACHE), were designed in general critical care populations and their use in obstetric populations i...
Citation: Critical Care 2018 22:278 -
Hyperchloremia and postoperative acute kidney injury: a retrospective analysis of data from the surgical intensive care unit
Whether perioperative hyperchloremia can induce postoperative acute kidney injury (AKI) is controversial. We investigated the association between perioperative hyperchloremia and postoperative AKI in patients ...
Citation: Critical Care 2018 22:277 -
The global need for essential emergency and critical care
Critical illness results in millions of deaths each year. Care for those with critical illness is often neglected due to a lack of prioritisation, co-ordination, and coverage of timely identification and basic...
Citation: Critical Care 2018 22:284 -
Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation
The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and...
Citation: Critical Care 2018 22:283 -
Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice
Antibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation,...
Citation: Critical Care 2018 22:282 -
Microcirculation in cardiogenic shock supported with extracorporeal membrane oxygenation: the need for a homogeneous population and strict evolution assessment
Citation: Critical Care 2018 22:281 -
Vitamin D deficiency and supplementation in critical illness—the known knowns and known unknowns
The burgeoning literature on vitamin D deficiency and supplementation over the past decade or so has generated a greater understanding of some areas but also an appreciation of the many areas of equipoise. Thi...
Citation: Critical Care 2018 22:276 -
Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials
Metabolic alkalosis is common in patients with respiratory failure and may delay weaning in mechanically ventilated patients. Carbonic anhydrase inhibitors block renal bicarbonate reabsorption, and thus revers...
Citation: Critical Care 2018 22:275 -
Angiotensin converting enzyme defects in shock: implications for future therapy
Citation: Critical Care 2018 22:274 -
Determinants of sepsis knowledge: a representative survey of the elderly population in Germany
Sepsis is a life-threatening medical emergency requiring early diagnosis and urgent treatment. Knowledge is crucial, especially in major risk groups such as the elderly. We therefore assessed sophisticated kno...
Citation: Critical Care 2018 22:273 -
Can probiotics be an alternative to chlorhexidine for oral care in the mechanically ventilated patient? A multicentre, prospective, randomised controlled open trial
Pathogenic enteric bacteria aspirated from the oropharynx are the main cause of ventilator-associated pneumonia (VAP). Using chlorhexidine (CHX) orally or selective decontamination has been shown to reduce VAP...
Citation: Critical Care 2018 22:272 -
Bacterial contamination of platelets for transfusion: strategies for prevention
Platelet transfusions carry greater risks of infection, sepsis, and death than any other blood product, owing primarily to bacterial contamination. Many patients may be at particular risk, including critically...
Citation: Critical Care 2018 22:271 -
Permissive fluid volume in adult patients undergoing extracorporeal membrane oxygenation treatment
Extracorporeal membrane oxygenation (ECMO) is a cardiorespiratory support technique for patients with circulatory or pulmonary failure. Frequently, large-volume fluid resuscitation is needed to ensure sufficie...
Citation: Critical Care 2018 22:270 -
Angiotensin-(1–7) attenuates organ injury and mortality in rats with polymicrobial sepsis
Sepsis and related multiple organ dysfunction result in high morbidity and mortality. Angiotensin (Ang)-(1–7), a biologically active peptide, has various opposing effects of Ang II. Because the effect of Ang-(...
Citation: Critical Care 2018 22:269 -
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The...
Citation: Critical Care 2018 22:268 -
Endocan, sepsis, pneumonia, and acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) are major problems of public health in intensive care units (ICUs), occurring in 15% of critically ill patients. Among the facto...
Citation: Critical Care 2018 22:280 -
The effect of polymyxin B hemoperfusion on modulation of human leukocyte antigen DR in severe sepsis patients
Recent randomized trials have not found that polymyxin B hemoperfusion (PMX-HP) improves outcomes for patients with sepsis. However, it remains unclear whether the therapy could provide benefit for highly sele...
Citation: Critical Care 2018 22:279 -
Impact of a remifentanil supply shortage on mechanical ventilation in a tertiary care hospital: a retrospective comparison
The continuous administration of opioids in critical care patients is a common therapy for the tolerance of mechanical ventilation. Opioid choice has a crucial impact on the length of mechanical ventilation. O...
Citation: Critical Care 2018 22:267 -
Factors associated with recurrence and mortality in central line-associated bloodstream infections: a retrospective cohort study
Central line-associated bloodstream infections (CLABSIs) are associated with increased mortality, hospital length of stay, and cost. Antimicrobial treatment guidelines for CLABSIs are primarily based on expert...
Citation: Critical Care 2018 22:266 -
Differences in attitudes towards end-of-life care among intensivists, oncologists and prosecutors in Brazil: a nationwide survey
Citation: Critical Care 2018 22:265 -
Volutrauma and atelectrauma: which is worse?
Citation: Critical Care 2018 22:264 -
Electrical impedance tomography in acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is a clinical entity that acutely affects the lung parenchyma, and is characterized by diffuse alveolar damage and increased pulmonary vascular permeability. Currentl...
Citation: Critical Care 2018 22:263 -
Extracorporeal techniques for the treatment of critically ill patients with sepsis beyond conventional blood purification therapy: the promises and the pitfalls
Sepsis is one of the leading causes of morbidity and mortality worldwide. It is characterized by a dysregulated immune response to infections that results in life-threatening organ dysfunction and even death. ...
Citation: Critical Care 2018 22:262 -
High protein intake during the early phase of critical illness: yes or no?
The rationale for the provision of nitrogen from proteins given via the enteral route or from intravenous amino acids is to boost the synthesis of muscle proteins, and thereby to limit the severity of intensiv...
Citation: Critical Care 2018 22:261 -
New perspectives on substituted relational autonomy for shared decision-making in critical care
In critical care when unconscious patients are assisted by machines, humanity is mainly ensured by respect for autonomy, realised through advance directives or, mostly, reconstructed by cooperation with relati...
Citation: Critical Care 2018 22:260 -
Epidemiology of subsequent bloodstream infections in the ICU
Subsequent bloodstream infections (sBSI) occur with a delay after removal of the intravascular catheter (IVC) whose tip revealed microbial growth. Here we describe the epidemiology of sBSI in the intensive car...
Citation: Critical Care 2018 22:259 -
Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis
Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary ext...
Citation: Critical Care 2018 22:258 -
The meaning of blood pressure
Measurement of arterial pressure is one of the most basic elements of patient management. Arterial pressure is determined by the volume ejected by the heart into the arteries, the elastance of the walls of the...
Citation: Critical Care 2018 22:257 -
Subclinical acute kidney injury is associated with adverse outcomes in critically ill neonates and children
Research on acute kidney injury (AKI) has focused on identifying early biomarkers. However, whether AKI could be diagnosed in the absence of the classic signs of clinical AKI and whether the condition of subcl...
Citation: Critical Care 2018 22:256 -
Association between diuretics and successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury
Despite aggressive application of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI), there is no consensus on diuretic therapy when discontinuation of CRRT i...
Citation: Critical Care 2018 22:255 -
Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a severe complication of cirrhosis and is defined by organ failure and high rates of short-term mortality. Patients with ACLF are managed with multiorgan support in the...
Citation: Critical Care 2018 22:254 -
Bougie-in-channel intubation technique
Citation: Critical Care 2018 22:253 -
Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients
Citation: Critical Care 2018 22:252 -
Noise in the intensive care unit and its influence on sleep quality: a multicenter observational study in Dutch intensive care units
High noise levels in the intensive care unit (ICU) are a well-known problem. Little is known about the effect of noise on sleep quality in ICU patients. The study aim is to determine the effect of noise on sub...
Citation: Critical Care 2018 22:250
Follow
- ISSN: 1364-8535 (electronic)