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Early diagnosis of sepsis is vital to the clinical course and ... evaluate the accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients.
Tumor necrosis factor-alpha (TNF-α), an early mediator in the systemic inflammatory response to infection, is a potential therapeutic target in sepsis. The primary objective of this study was ... -α Fab preparati...
This prospective study investigated the predictive value of procalcitonin (PCT) for survival in 242 adult patients with severe sepsis and septic shock treated in intensive care.
Major trauma is characterized by an overwhelming pro-inflammatory response and an accompanying anti-inflammatory response that lead to a state of immunosuppression, as observed after septic shock. Diminished mono...
Sepsis is a leading cause of morbidity and ... is characterized by vascular leak. Treatment for sepsis, specifically intravenous fluids, may worsen deterioration ... We therefore sought to quantify vascular leak ...
This review describes current knowledge on the mechanisms that underlie glucocorticoid insufficiency in sepsis and the molecular action of glucocorticoids. In patients with severe sepsis, numerous factors predisp...
The benefits and use of low-dose corticosteroids (LDCs) in severe sepsis and septic shock remain controversial. Surviving sepsis campaign guidelines suggest LDC use for septic ... PROGRESS (PROmoting Global Resea...
We report data from adult and pediatric patients with severe sepsis from studies evaluating drotrecogin alfa (activated) ... relatively small proportion of patients presenting with severe sepsis; pooling data acr...
Endothelial activation leading to vascular barrier breakdown denotes a devastating event in sepsis. Angiopoietin (Ang)-2, a circulating ... early time course of Ang-2 release during sepsis in critically ill patie...
Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute brain ... biomarkers indicating neuro...
The early, accurate diagnosis and risk stratification of sepsis remains an important challenge in the critically ... have not yielded a gold standard marker for sepsis, focus is shifting towards novel strategies ...
The design of clinical trials of interventions aimed at reducing mortality in patients with severe sepsis assumes that the relative treatment effect of ... data from phase III clinical studies of severe sepsis to...
There is a clear relationship between quantitative measures of fitness (e.g., VO2...max) and outcomes after surgical procedures. Whether or not fitness is a modifiable risk factor and what underlying biological p...
Mild hypoglycemia is associated with increased mortality in critically ill patients. However, data regarding the association between mild hypoglycemia and patient outcomes among patients with sepsis are limited.
Microvascular dysregulation characterized by hyporesponsive vessels and heterogeneous bloodflow is implicated in the pathogenesis of organ failure in sepsis. The renin-angiotensin system (RAS) affects ... relatio...
Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and ... important clinical trials have improved our understanding of sepsis-associated AKI (SA-AKI) and impacted clinical c...
During septic shock, resistance to the haemodynamic effects of catecholamine vasopressors and inotropes is a well-recognised marker of mortality risk. However, the specific cardiovascular or metabolic response el...
To determine if neighborhood socioeconomic deprivation independently predicts 30-day mortality and readmission for patients with sepsis or critical illness after adjusting for individual...
In septic patients increased central drive and increased metabolic demands combine to increase energy demands on the ventilatory muscles. This occurs at a time when energy supplies are limited and energy produ...
Drotrecogin alfa (activated; recombinant activated protein C) was shown to reduce 28-day all-cause mortality in patients with severe sepsis and to have an acceptable safety profile ... (activated) in 2786 adult p...
In 2006, Critical Care...provided important and clinically relevant research data in the field of multiple organ failure, sepsis, and shock. This review summarizes the...
Sepsis is the leading cause of death in ... limitations of earlier mathematical models used to describe sepsis and predict outcomes, we designed an empirically ... Monte Carlo model that simulates the progression...
We designed a prospective observational study to investigate the independent association of fever and the use of antipyretic treatments with mortality in critically ill patients with and without sepsis. We includ...
The Erratum to this article has been published in Critical Care 2012 16:450
Early fluid management in patients with advanced chronic kidney disease (CKD) and sepsis-induced hypotension is challenging with limited evidence ... an early restrictive versus liberal fluid management for sepsis
Genetic variations may influence clinical outcomes in patients with sepsis. The present study was conducted to evaluate...
A major pathophysiologic mechanism in sepsis is impaired host immunity which results in...
In sepsis, inflammation and thrombosis are both the cause ... . Microparticles may participate in the pathogenesis of sepsis through multiple ways. They are able to...
Despite significant progress in our understanding of the pathophysiology of sepsis and extensive clinical research, there are few ... the literature evaluating immunotherapy in adult patients with sepsis, emphasi...
Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in sepsis. No study has been performed in sepsis by multidrug-resistant (MDR) Gram-negative...
Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum β-lactam concentrations when standard dosages are administered. Previous studies on β-lactam PK have generally excluded th...
The causative role of new hydroxyethyl starch (HES 130/0.4) in renal dysfunction frequency (a > 50% increase in serum creatinine or need for renal replacement therapy (RRT)) remains debated. Using the database of...
Mitochondrial dysfunction has been suggested as a contributing factor to the pathogenesis of sepsis-induced multiple organ failure. Also, restoration ... the recovery of organ function in patients with sepsis. He...
Prior to investing in a large, multicentre randomised controlled trial (RCT), the National Institute for Health Research in the UK called for an evaluation of the feasibility and value for money of undertaking a ...
A relative immunosuppression is observed in patients after sepsis, trauma, burns, or any severe insults...
The global burden of sepsis is concentrated in sub-Saharan Africa, where ... unique. In this context, poor understanding of sepsis immunopathology represents a crucial barrier to development ... inter-individual ...
The nitric oxide pathway plays a critical role in vascular homeostasis. Increased levels of systemic nitric oxide (NO) are observed in preclinical models of sepsis and endotoxemia. This has led to the ... NO may ...
The benefits of extracorporeal membrane oxygenation (ECMO) in children with sepsis remain controversial. Current guidelines on management of ... publications on effectiveness of ECMO in children with sepsis.
The purpose of this bench-to-bedside review is to summarize the literature relating to complement activation in sepsis and other critical illnesses and the role...
It is not well understood whether the process of autophagy is accelerated or blocked in sepsis, and whether it is beneficial or harmful ... immune defense mechanism over a time course during sepsis. Our aim was t...
Severe sepsis is associated with a high mortality rate ... the crucial role of immunologic derangement in severe sepsis, thymosin alpha 1 (Tα1) is considered ... mortality rates and immunofunction in patients wit...
A potential independent association was recently demonstrated between high red blood cell distribution width (RDW) and the risk of all-cause mortality in critically ill patients, although the mechanism underlying...
Sepsis is associated with significant mortality. Yet,...PCSK9...loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin clearance, holds promise as a pot...
Plasma selenium (Se) concentrations are reduced in critically ill surgical patients, and lower plasma Se concentrations are associated with worse outcomes. We investigated whether adjuvant Se supplementation in t...
Systemic inflammation in sepsis is initiated by interactions between pathogen molecular...
Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hy...
Serial alterations in protein C levels appear to correlate with disease severity in patients with severe sepsis, and it may be possible to tailor severe sepsis therapy with the use of this biomarker. ... compared...
Prevention of lymphocyte apoptosis by caspase inhibition has been proposed as a novel treatment approach in sepsis. However, it has not been clearly demonstrated that caspase inhibitors improve survival in sepsis
Immunomodulatory therapies that improve the outcome of sepsis are not available. We sought to determine whether treatment of critically ill patients with sepsis with low-dose erythromycin—a macrolide antibiotic.....
The Correspondence to this article has been published in Critical Care 2023 27:70
The Correspondence to this article has been published in Critical Care 2023 27:52
Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean prompt achievement...in vitro...susceptibility, subsequent de-escalation of antimicrobial therapy should be applied whene...
Critical Care