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  1. Muscle weakness is a complication of critical illness which hampers recovery. In critically ill mice, supplementation with the ketone body 3-hydroxybutyrate has been shown to improve muscle force and to normal...

    Authors: Chloë Goossens, Ruben Weckx, Sarah Derde, Sarah Vander Perre, Inge Derese, Paul P. Van Veldhoven, Bart Ghesquière, Greet Van den Berghe and Lies Langouche
    Citation: Critical Care 2021 25:252
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2021 25:296

  2. A personalized mechanical ventilation approach for patients with adult respiratory distress syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging, and biological phenotypes may i...

    Authors: Paolo Pelosi, Lorenzo Ball, Carmen S. V. Barbas, Rinaldo Bellomo, Karen E. A. Burns, Sharon Einav, Luciano Gattinoni, John G. Laffey, John J. Marini, Sheila N. Myatra, Marcus J. Schultz, Jean Louis Teboul and Patricia R. M. Rocco
    Citation: Critical Care 2021 25:250
    Content type: Review Published on:

  4. Differences in physiology of ARDS have been described between COVID-19 and non-COVID-19 patients. This study aimed to compare initial values and longitudinal changes in respiratory system compliance (CRS), oxygen...

    Authors: François Beloncle, Antoine Studer, Valérie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat and Ferhat Meziani
    Citation: Critical Care 2021 25:248
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2021 25:366

  5. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the association of higher positive end-expiratory pressure (PEEP), as opposed to lower PEEP, with hospital mo...

    Authors: Tommaso Pettenuzzo, Annalisa Boscolo, Alessandro De Cassai, Nicolò Sella, Francesco Zarantonello, Paolo Persona, Laura Pasin, Giovanni Landoni and Paolo Navalesi
    Citation: Critical Care 2021 25:247
    Content type: Research Published on:

  6. While recommended by international societal guidelines in the paediatric population, the use of venoarterial extracorporeal membrane oxygenation (VA ECMO) as mechanical circulatory support for refractory septi...

    Authors: Ryan Ruiyang Ling, Kollengode Ramanathan, Wynne Hsing Poon, Chuen Seng Tan, Nicolas Brechot, Daniel Brodie, Alain Combes and Graeme MacLaren
    Citation: Critical Care 2021 25:246
    Content type: Research Published on:

  9. Septic shock comprises a heterogeneous population, and individualized resuscitation strategy is of vital importance. The study aimed to identify subclasses of septic shock with non-supervised learning algorith...

    Authors: Penglin Ma, Jingtao Liu, Feng Shen, Xuelian Liao, Ming Xiu, Heling Zhao, Mingyan Zhao, Jing Xie, Peng Wang, Man Huang, Tong Li, Meili Duan, Kejian Qian, Yue Peng, Feihu Zhou, Xin Xin…
    Citation: Critical Care 2021 25:243
    Content type: Research Published on:

  11. Bloodstream infections (BSIs) are frequent on veno-arterial extracorporeal membrane oxygenation (V-A ECMO). Performing routine blood cultures (BCs) may identify early paucisymptomatic BSIs. We investigated the...

    Authors: Quentin de Roux, Marie Renaudier, Wulfran Bougouin, Johanna Boccara, Vincent Fihman, Raphaël Lepeule, Chamsedine Cherait, Antonio Fiore, François Hemery, Jean-Winoc Decousser, Olivier Langeron and Nicolas Mongardon
    Citation: Critical Care 2021 25:241
    Content type: Research Published on:

  12. A plasma glutamine concentration outside the normal range at Intensive Care Unit (ICU) admission has been reported to be associated with an increased mortality rate. Whereas hypoglutaminemia has been frequentl...

    Authors: Marie Smedberg, Johan Helleberg, Åke Norberg, Inga Tjäder, Olav Rooyackers and Jan Wernerman
    Citation: Critical Care 2021 25:240
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2021 25:342

  14. Current practices regarding tracheostomy in patients treated with extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome are unknown. Our objectives were to assess the prevalence an...

    Authors: Matthieu Schmidt, Christoph Fisser, Gennaro Martucci, Darryl Abrams, Thomas Frapard, Konstantin Popugaev, Antonio Arcadipane, Bianca Bromberger, Giovanni Lino, Alexis Serra, Sacha Rozencwajg, Matthias Lubnow, Sergey Petrikov, Thomas Mueller, Alain Combes, Tài Pham…
    Citation: Critical Care 2021 25:238
    Content type: Research Published on:

  16. Infectious diseases may affect brain function and cause encephalopathy even when the pathogen does not directly infect the central nervous system, known as infectious disease-associated encephalopathy. The sys...

    Authors: Maria C. Barbosa-Silva, Maiara N. Lima, Denise Battaglini, Chiara Robba, Paolo Pelosi, Patricia R. M. Rocco and Tatiana Maron-Gutierrez
    Citation: Critical Care 2021 25:236
    Content type: Review Published on:

  18. The coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression ...

    Authors: Runzhi Huang, Tong Meng, Qiongfang Zha, Kebin Cheng, Xin Zhou, Junhua Zheng, Dingyu Zhang and Ruilin Liu
    Citation: Critical Care 2021 25:234
    Content type: Research Published on:

  21. The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after ...

    Authors: Jakub Fronczek, Kamil Polok, Dylan W. de Lange, Christian Jung, Michael Beil, Andrew Rhodes, Jesper Fjølner, Jacek Górka, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Steffen Christensen, Michael Joannidis, Susannah Leaver, Brian Marsh, Alessandro Morandi…
    Citation: Critical Care 2021 25:231
    Content type: Research Published on:

  22. Individualized positive end-expiratory pressure (PEEP) by electrical impedance tomography (EIT) has potential interest in the optimization of ventilation distribution in acute respiratory distress syndrome (AR...

    Authors: Huaiwu He, Yi Chi, Yingying Yang, Siyi Yuan, Yun Long, Pengyu Zhao, Inéz Frerichs, Feng Fu, Knut Möller and Zhanqi Zhao
    Citation: Critical Care 2021 25:230
    Content type: Research Published on:

  23. There is no universally accepted method to assess the pressure-generating capacity of inspiratory muscles in children on mechanical ventilation (MV), and no study describing its evolution over time in this pop...

    Authors: Benjamin Crulli, Atsushi Kawaguchi, Jean-Paul Praud, Basil J. Petrof, Karen Harrington and Guillaume Emeriaud
    Citation: Critical Care 2021 25:229
    Content type: Research Published on:

  25. Early sepsis diagnosis has emerged as one of the main challenges in the emergency room. Measurement of sepsis biomarkers is largely used in current practice to improve the diagnosis accuracy. Monocyte distribu...

    Authors: Pierre Hausfater, Neus Robert Boter, Cristian Morales Indiano, Marta Cancella de Abreu, Adria Mendoza Marin, Julie Pernet, Dolores Quesada, Iris Castro, Diana Careaga, Michel Arock, Liliana Tejidor and Laetitia Velly
    Citation: Critical Care 2021 25:227
    Content type: Research Published on:

  26. Rapid response systems aim to achieve a timely response to the deteriorating patient; however, the existing literature varies on whether timing of escalation directly affects patient outcomes. Prior studies ha...

    Authors: Stephen F. Whebell, Emma J. Prower, Joe Zhang, Megan Pontin, David Grant, Andrew T. Jones and Guy W. Glover
    Citation: Critical Care 2021 25:226
    Content type: Research Published on:

  28. Previous studies reporting the causes of death in patients with severe COVID-19 have provided conflicting results. The objective of this study was to describe the causes and timing of death in patients with se...

    Authors: Charles de Roquetaillade, Swann Bredin, Jean-Baptiste Lascarrou, Thibaud Soumagne, Mariana Cojocaru, Benjamin Glenn Chousterman, Maxime Leclerc, Albin Gouhier, Gaël Piton, Frédéric Pène, Annabelle Stoclin and Jean-François Llitjos
    Citation: Critical Care 2021 25:224
    Content type: Research Published on:

  29. Thiamine is a precursor of the essential coenzyme thiamine pyrophosphate required for glucose metabolism; it improves the immune system function and has shown to reduce the risk of several diseases. The role o...

    Authors: Khalid Al Sulaiman, Ohoud Aljuhani, Maram Al Dossari, Asma Alshahrani, Aisha Alharbi, Rahmah Algarni, Majed Al Jeraisy, Shmeylan Al Harbi, Abdulmalik Al Katheri, Fahad Al Eidan, Abdulkareem M. Al Bekairy, Nouf Al Qahtani, Mashael Al Muqrin, Ramesh Vishwakarma and Ghassan Al Ghamdi
    Citation: Critical Care 2021 25:223
    Content type: Research Published on:

  30. Prolonged ventilatory support is associated with poor clinical outcomes. Partial support modes, especially pressure support ventilation, are frequently used in clinical practice but are associated with patient...

    Authors: Xueyan Yuan, Xinxing Lu, Yali Chao, Jennifer Beck, Christer Sinderby, Jianfeng Xie, Yi Yang, Haibo Qiu and Ling Liu
    Citation: Critical Care 2021 25:222
    Content type: Research Published on:

  31. In intensive care units (ICUs), patients experiencing post-extubation respiratory failure have poor outcomes. The use of noninvasive ventilation (NIV) to treat post-extubation respiratory failure may increase ...

    Authors: Arnaud W. Thille, Grégoire Monseau, Rémi Coudroy, Mai-Anh Nay, Arnaud Gacouin, Maxens Decavèle, Romain Sonneville, François Beloncle, Christophe Girault, Laurence Dangers, Alexandre Lautrette, Quentin Levrat, Anahita Rouzé, Emmanuel Vivier, Jean-Baptiste Lascarrou, Jean-Damien Ricard…
    Citation: Critical Care 2021 25:221
    Content type: Research Published on:

  33. A correlation between unsuccessful noninvasive ventilation (NIV) and poor outcome has been suggested in de-novo Acute Respiratory Failure (ARF) patients. Consequently, it is of paramount importance to identify...

    Authors: Giovanna Mercurio, Sonia D’Arrigo, Rossana Moroni, Domenico Luca Grieco, Luca Salvatore Menga, Anna Romano, Maria Giuseppina Annetta, Maria Grazia Bocci, Davide Eleuteri, Giuseppe Bello, Luca Montini, Mariano Alberto Pennisi, Giorgio Conti and Massimo Antonelli
    Citation: Critical Care 2021 25:219
    Content type: Research Published on:

  35. The viral load of asymptomatic SAR-COV-2 positive (ASAP) persons has been equal to that of symptomatic patients. On the other hand, there are no reports of ST-elevation myocardial infarction (STEMI) outcomes i...

    Authors: Raffaele Marfella, Pasquale Paolisso, Celestino Sardu, Luciana Palomba, Nunzia D’Onofrio, Arturo Cesaro, Michelangela Barbieri, Maria Rosaria Rizzo, Ferdinando Carlo Sasso, Lucia Scisciola, Fabrizio Turriziani, Massimiliano Galdiero, Danilo Pignataro, Fabio Minicucci, Maria Consiglia Trotta, Michele D’Amico…
    Citation: Critical Care 2021 25:217
    Content type: Research Published on:

  38. Critically ill COVID-19 patients have pathophysiological lung features characterized by perfusion abnormalities. However, to date no study has evaluated whether the changes in the distribution of pulmonary gas...

    Authors: Lorenzo Ball, Chiara Robba, Jacob Herrmann, Sarah E. Gerard, Yi Xin, Maura Mandelli, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Giulio Bovio, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R. M. Rocco, Maurizio Cereda…
    Citation: Critical Care 2021 25:214
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2021 25:352

  40. The severity of coronavirus disease 2019 (COVID-19) is highly variable between individuals, ranging from asymptomatic infection to critical disease with acute respiratory distress syndrome requiring mechanical...

    Authors: Inès Dufour, Alexis Werion, Leila Belkhir, Anastazja Wisniewska, Marie Perrot, Julien De Greef, Gregory Schmit, Jean Cyr Yombi, Xavier Wittebole, Pierre-François Laterre, Michel Jadoul, Ludovic Gérard and Johann Morelle
    Citation: Critical Care 2021 25:212
    Content type: Research Published on:

  41. There are several reports of extracorporeal membrane oxygenation (ECMO) use in patients with coronavirus disease 2019 (COVID-19) who develop severe acute respiratory distress syndrome (ARDS). We conducted a s...

    Authors: Kollengode Ramanathan, Kiran Shekar, Ryan Ruiyang Ling, Ryan P. Barbaro, Suei Nee Wong, Chuen Seng Tan, Bram Rochwerg, Shannon M. Fernando, Shinhiro Takeda, Graeme MacLaren, Eddy Fan and Daniel Brodie
    Citation: Critical Care 2021 25:211
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2021 25:375

    The Letter to this article has been published in Critical Care 2021 25:285

  43. The effect of awake prone positioning on intubation rates is not established. The aim of this trial was to investigate if a protocol for awake prone positioning reduces the rate of endotracheal intubation com...

    Authors: Jacob Rosén, Erik von Oelreich, Diddi Fors, Malin Jonsson Fagerlund, Knut Taxbro, Paul Skorup, Ludvig Eby, Francesca Campoccia Jalde, Niclas Johansson, Gustav Bergström and Peter Frykholm
    Citation: Critical Care 2021 25:209
    Content type: Research Published on:

  44. Despite considerable progress, it remains unclear why some patients admitted for COVID-19 develop adverse outcomes while others recover spontaneously. Clues may lie with the predisposition to hypoxemia or unex...

    Authors: Ludovico Messineo, Elisa Perger, Luciano Corda, Simon A. Joosten, Francesco Fanfulla, Leonardo Pedroni, Philip I. Terrill, Carolina Lombardi, Andrew Wellman, Garun S. Hamilton, Atul Malhotra, Guido Vailati, Gianfranco Parati and Scott A. Sands
    Citation: Critical Care 2021 25:208
    Content type: Research Published on:

  45. Acute kidney injury (AKI) is a common and serious complication after cardiac surgery, and current strategies aimed at treating AKI have proven ineffective. Levosimendan, an inodilatating agent, has been shown ...

    Authors: Maria Tholén, Sven-Erik Ricksten and Lukas Lannemyr
    Citation: Critical Care 2021 25:207
    Content type: Research Published on:

  47. Postoperative complications impact on early and long-term patients’ outcome. Appropriate perioperative fluid management is pivotal in this context; however, the most effective perioperative fluid management is...

    Authors: Antonio Messina, Chiara Robba, Lorenzo Calabrò, Daniel Zambelli, Francesca Iannuzzi, Edoardo Molinari, Silvia Scarano, Denise Battaglini, Marta Baggiani, Giacomo De Mattei, Laura Saderi, Giovanni Sotgiu, Paolo Pelosi and Maurizio Cecconi
    Citation: Critical Care 2021 25:205
    Content type: Research Published on:

  48. Combining energy and protein targets during the acute phase of critical illness is challenging. Energy should be provided progressively to reach targets while avoiding overfeeding and ensuring sufficient prote...

    Authors: Pierre Singer, Itai Bendavid, Ilana BenArie, Liran Stadlander and Ilya Kagan
    Citation: Critical Care 2021 25:204
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535