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Sepsis leads to an activation of the immune ... However, studies on platelet aggregation in severe sepsis using impedance aggregometry have not been performed ... biomarker for the diagnosis and prognosis of seve...
It is unknown whether resources necessary to implement the Surviving Sepsis Campaign guidelines and sepsis bundles are available in Africa. This self...vs. South Africa, Mauritius and the Northern African countri...
Hemolysis can be induced in sepsis via various mechanisms, its pathophysiological importance has been demonstrated in experimental sepsis. However, no data on free hemoglobin concentrations in human sepsis are av...
Sepsis biomarkers can have important diagnostic, therapeutic, ... references reporting on 178 different biomarkers related to sepsis. In the present review, we evaluate the progress in the research of sepsis biom...
The potent endogenous antimicrobial peptide human β-defensin 2 (hBD2) is a crucial mediator of innate immunity. In addition to direct antimicrobial properties, different effects on immune cells have been descr...
To evaluate the impact of recent evidence-based treatments for severe sepsis in routine clinical care requires an understanding ... trends in the incidence and mortality of severe sepsis over a nine-year period.
Sepsis is a leading cause of admission to ... first extensive dataset on the epidemiology of severe sepsis treated in ICUs in Spain.
Sepsis is a severe condition characterized by acute ... role of APOH in the immunopathology of paediatric sepsis remains unclear.
Sepsis is typically hallmarked by high plasma (free ... ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely activates the hypothalamus to generate, via...
The gut microbiome plays a pivotal role in the progression of sepsis. However, the specific mechanism of gut ... and its metabolites involved in the process of sepsis remains elusive, which limits its translation...
The Comment to this article has been published in Critical Care 2023 27:147
Sepsis is defined as a systemic hyper-inflammatory ... necrosis factor alpha (TNF-α)- and sepsis-induced mortality in mice. However, it ... trafficking, which contributes to organ damage in sepsis.
Consistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs ... verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the...
This article is part of a Supplement: Volume 13 Supplement 1
Critically ill patients with sepsis are prone to develop cardiac dysrhythmias, most ... outcomes of new-onset AF in patients with sepsis.
In transgenic animal models of sepsis, members of the Bcl-2 family of proteins regulate lymphocyte apoptosis and survival of sepsis. This study investigates the gene regulation of ... of proteins in patients with...
Although sepsis is the leading cause of death in ... unit (ICU) mortality in patients with severe sepsis.
The present review is aimed at elucidating the neonatal 'sepsis redox cycle' - the cascade of inflammatory ... and redox events involved in the pathogenesis of sepsis in neonates. While adult and neonatal sepses ...
Coagulation abnormalities are frequent in sepsis. Conventional coagulation assays, however, have several ... tests to diagnose hypo- and hypercoagulability in sepsis.
Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be determ...
Timely administration of antibiotics is one of the most important interventions in reducing mortality in sepsis. However, administering antibiotics within a strict time threshold in all patients suspected with sepsis
Activation of the sympathetic nervous system has beneficial cardiovascular effects in sepsis, but there is also evidence that sympatholytics have beneficial actions in sepsis. We therefore determined the effect o...
This article is part of a Supplement: Volume 17 Supplement 2
We conducted a study to evaluate the incidence, risk factors and outcomes associated with early acute kidney injury (AKI) in sepsis.
Sepsis, an acute and potentially fatal systemic response ... by affecting millions annually. Prompt identification of sepsis is vital, as treatment delays lead to ... into leveraging Machine Learning (ML) for pre...
Sepsis is a complex immunological response to infection ... differentiation. Pre-clinical research using an equine sepsis model identified a panel of gene expression ... these gene expression biomarkers to distin...
Sepsis, severe sepsis and septic shock are common conditions with ... presenting at the ED with SIRS and suspected sepsis or septic shock.
A recent randomised trial showed that recombinant thrombomodulin did not benefit patients who had sepsis with coagulopathy and organ dysfunction. Several recent ... suggested presence of clinical phenotypes in pa...
Sepsis is known as a complex immunological response ... by immunosuppression. Although aging is crucial in sepsis, the impact of aging on inflammation and ... and immunosuppression in aged patients and mice after...
Individuals who survive sepsis are at high risk of chronic sequelae, ... have focused on aspects of healthcare pathways of sepsis survivors but comprehensive, longitudinal overview of their ... retrospective, lon...
Ultrasound measurements of brachial artery reactivity in response to stagnant ischemia provide estimates of microvascular function and conduit artery endothelial function. We hypothesized that brachial artery rea...
Sepsis is a major health issue in preterm ... are used to diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is ... not predictive at onset of late onset neonatal sepsis (LONS) diagnosis. The...
The combination antiretroviral therapy (cART) has led to decreased opportunistic infections and hospital admissions in human immunodeficiency virus (HIV)-infected patients, but the intensive care unit (ICU) admis...
Clinicians are in need of better diagnostic markers in diagnosing infections and sepsis. We studied the ability of procalcitonin, ... reactive protein to identify patients with infection and sepsis.
Although major changes of the immune system have been described in sepsis, it has never been studied whether these...
Severe sepsis is characterized by an initial hyper-inflammatory ... of samples obtained from patients who died of sepsis has identified expression of specific inhibitory receptors ... and immune cell function in ...
Biomarkers can be useful for identifying or ruling out sepsis, identifying patients who may benefit from specific...
Neuropeptides arginine-vasopressin (AVP), apelin (APL), and stromal-derived factor-1α (SDF-1α) are involved in the dysfunction of the corticotropic axis observed in septic ICU patients. Study aims were: (i)...to ...
Sepsis and trauma are known to disrupt gut...
Although early institution of adequate antimicrobial therapy is lifesaving in sepsis patients, optimal antimicrobial strategy has not been ... describe patterns of empiric antimicrobial therapy in severe sepsis, ...
Sepsis is associated with cardiovascular changes that may ... development of tissue hypoperfusion. Early recognition of sepsis and tissue hypoperfusion is critical to implement ... interventions aimed at optimizi...
This article is part of a Supplement: Volume 10 Supplement 3
Sepsis is common, deadly, and heterogenous. Prior analyses of patients with sepsis and septic shock in New York State ... However, it is unknown if clinically identifiable sepsis subtypes modify these association...
Sepsis is thought to be an abnormal inflammatory ... of drugs that modulate the inflammatory response of sepsis have been unsuccessful. Emerging genomic evidence shows that the host response in sepsis does not co...
Effective removal of pathogenic bacteria is key to improving the prognosis of sepsis. Polymorphonuclear neutrophils (PMNs) are the most ... metabolic characteristics and immunomodulatory pathways of PMNs during sepsis
Ghrelin has been recently identified as a mediator of various beneficial effects in animal models of sepsis. At present, no data are available ... of ghrelin in critically ill patients and human sepsis from a cli...
Hyperglycemia and insulin resistance have been associated with a worse outcome in sepsis. Although tight glycemic control through insulin therapy ... of intensive insulin therapy in patients with severe sepsis is...
The Retraction Note to this article has been published in Critical Care 2016 20:278
Infection control depends on adequate microbe recognition and cell activation, yet inflammatory response may lead to organ dysfunction in sepsis. The aims of this study were to evaluate cell activation in the con...
Early treatment of sepsis improves survival, but early diagnosis of hospital-acquired sepsis, especially in critically ill patients, is ... temperature patterns may be an early indicator of sepsis, but data is li...
The relationships between systemic hemodynamics and renal blood flow and renal microcirculation are poorly known in sepsis. Norepinephrine (NE) infusion may add another...
This article is part of a Supplement: Volume 13 Supplement 1
Management of the early stage of sepsis is a critical issue. As part of...
Critical Care