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The ideal management of infection includes not only the early identification and start of effective therapy but also the correct categorization of non-infected patients in order to avoid unnecessary use of ant...
This article is part of a Supplement: Volume 18 Supplement 2
Angiopoietin-1 is a Tie-2 receptor agonist that stabilizes vascular endothelium, promoting endothelial maturation and preventing capillary leak. Angiopoietin-2 is largely a competitive partial antagonist that is ...
This article is part of a Supplement: Volume 17 Supplement 4
The original article was published in Critical Care 2022 26:14
The Correspondence to this article has been published in Critical Care 2022 26:342
Myocardial depression in septic patients is well recognized yet still poorly understood. The prognostic significance in terms of overall mortality when it is identified, remains in dispute. Parameters of left ven...
Changes in body temperature are a characteristic feature of sepsis. The study by Kushimoto and colleagues in...Critical Care demonstrates that hypothermia is a very important manifestation of infection associated...
This article is part of a Supplement: Volume 18 Supplement 2
Reversing the immunoparalysis associated with septic shock remains a priority for improving the outcome of patients suffering from sepsis. The efficacy of future therapies may be...
An intact hypothalamic-pituitary-adrenal (HPA) axis with effective intracellular glucocorticoid anti-inflammatory activity is essential for host survival following exposure to an infectious agent. Glucocorticoids...
The original article was published in Critical Care 2021 25:167
The original article was published in Critical Care 2023 27:417
This article is part of a Supplement: Volume 15 Supplement 3
The original article was published in Critical Care 2012 16:R33
Patients with diabetes mellitus have an increased risk of developing infections and sepsis. In this issue of Critical Care...Esper and colleagues report on a large survey, involving 12.5 million sepsis cases, tha...
The hypothalamic-pituitary-adrenal (HPA) axis response in sepsis remains to be elucidated. Apart from corticotropin ... conflicting results of corticosteroid replacement therapy in severe sepsis/septic shock. The...
This article is part of a Supplement: Volume 16 Supplement 3
Sepsis is now understood to affect a variety ... patients suffering from septic disease. In fact, sepsis-related immune suppression has become increasingly recognized...ex vivo...stimulation, and introduce altere...
The multicenter study conducted by Lorente and coworkers published in the previous issue of Critical Care...demonstrates that matrix metalloproteinase (MMP)-9 and MMP-10 and their inhibitor tissue inhibitor of ma...
Severe sepsis is more and more frequent, especially because ... HIV/ADS patients hospitalized in ICU with severe sepsis remained poor. This situation is partly due ... be used in HIV/AIDS patients with severe sepsis
This article is part of a Supplement: Volume 16 Supplement 3
The Correspondence to this article has been published in Critical Care 2022 26:177
The original article was published in Critical Care 2022 26:4
An amendment to this paper has been published and can be accessed via the original article.
The original article was published in Critical Care 2020 24:535
Sepsis with myocardial dysfunction is seen commonly. Beta...
This article is part of a Supplement: Volume 15 Supplement 3
Altered immune status of blood leukocytes is a general phenomenon observed in adult patients with sepsis or septic shock. This is also the...ex vivo cytokine production upon activation by phytohemagglutinin.
Despite the same manufacturer, the same drotrecogin alfa activated dose, and the same placebo-controlled design, the negative result from the PROWESS-SHOCK trial contradicted the survival benefit observed in t...
This article is part of a Supplement: Volume 17 Supplement 4
Research interest in epidural anesthesia during sepsis has grown over the past years and ... whether these alter depending on the phase of sepsis, the spread of epidural anesthesia or additional...
This article is part of a Supplement: Volume 16 Supplement 3
The original article was published in Critical Care 2023 27:432
This article is part of a Supplement: Volume 12 Supplement 5
In this issue of Critical Care..., Patschan and colleagues present a study of endothelial progenitor cells (EPCs) in patients with sepsis. The importance of this study is in ... focusing attention on several freq...
In this issue of Critical Care..., Dutch investigators report that, in a cohort of patients with sepsis/septic shock admitted to three different intensive...2...) was uncommon at the time of ICU admission, and ho...
Dysregulated cell death in several tissues is intimately involved in the pathogenesis of sepsis and contributes to multiple organ failure. Whether cell death during sepsis occurs by necrosis or apoptosis may depe...
This article is part of a Supplement: Volume 16 Supplement 3
The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis.
This article is part of a Supplement: Volume 16 Supplement 3
This article is part of a Supplement: Volume 14 Supplement 1
Abnormal body temperatures (Tb...) are frequently seen in patients with severe sepsis. However, the relationship between Tb abnormalities and the severity of disease is not clear. This study investigated the impa...
The gut microbiome regulates a number of homeostatic mechanisms in the healthy host including immune function and gut barrier protection. Loss of normal gut microbial structure and function has been associated...
This article is part of a Supplement: Volume 14 Supplement 1
Socio-demographic and clinical factors associated with increased sepsis risk, including older age, non-white ... without health insurance have a higher risk of sepsis-associated hospitalization or sepsis-associat...
Sepsis is a medical emergency with potentially life- ... play a crucial role in preventing and recognizing sepsis at an early stage. The understanding of risk groups’ sepsis knowledge and their ability to use thi...
This prospective, observational study comprised a convenience sample of three cohorts of adult patients (age > 17 years) at three urban university emergency departments: (1) a septic shock cohort (systolic blo...
Critical Care