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Correction to: Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry
Critical Care volume 24, Article number: 660 (2020)
Correction to: Critical Care (2020) 24:535 https://doi.org/10.1186/s13054-020-03245-2
Following publication of the original article [1], the authors reported a misalignment error of the x-axis in Fig. 1b; in addition, there were two typos and two formatting errors. The revised Fig. 1b and revised text is indicated hereafter. The changes have been highlighted in bold typeface.
The sentence currently reads:
The metabolic profiles differed between survivors and non-survivors (Fig. 1a). Both groups had negative energy balance during fasting state. Survivors transitioned to a hypermetabolic state following feeding initiation, achieving positive energy balance. Non-survivors remained hypometabolic despite feeding.
The sentence should read:
The metabolic profiles differed between survivors and non-survivors (Fig. 1a). Both groups had negative energy balance during fasting state. Survivors transitioned to a hypermetabolic state following feeding initiation, achieving positive energy balance. Non-survivors remained hypometabolic despite feeding.
The sentence currently reads:
Our study advances the understanding of energy balance and substrate utilization in sepsis. During fasting, low insulin with elevated counter-regulatory hormones promotes lipolysis; muscle glycogen is depleted at an exponential rate greater than athletes running marathons [4]. The predominant energy substrate switches from carbohydrates to lipids—the hallmark of fasting physiology. This explains the low RQ in early sepsis, when patients are preferentially utilizing lipids (RQ ≤ 0.8) during permissive underfeeding [5]. The hypermetabolic state and inability for non-survivors to transit to carbohydrate utilization suggest ongoing debilitating mitochondrial dysfunction, consistent with associated multi-organ failure [6]. However, whether adjusting the feeding types and regimen to alter these patterns and improve outcomes remain unknown.
The sentence should read:
Our study advances the understanding of energy balance and substrate utilization in sepsis. During fasting, low insulin with elevated counter-regulatory hormones promotes lipolysis; muscle glycogen is depleted at an exponential rate greater than athletes running marathons [4]. The predominant energy substrate switches from carbohydrates to lipids—the hallmark of fasting physiology. This explains the low RQ in early sepsis, when patients are preferentially utilizing lipids (RQ ≤ 0.8) during relative underfeeding [5]. The hypometabolic state and inability for non-survivors to transit to carbohydrate utilization suggest on-going debilitating mitochondrial dysfunction, consistent with associated multi-organ failure [6]. However, whether adjusting the feeding types and regimen to alter these patterns to improve outcomes remain unknown.
This has now been included in this correction article.
References
Li A, Mukhopadhyay A. Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry. Crit Care. 2020;24:535. https://doi.org/10.1186/s13054-020-03245-2.
Wischmeyer PE, San-Millan I. Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology. Crit Care. 2015;19(Suppl 3):S6.
Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, et al. Permissive underfeeding or standard enteral feeding in critically ill adults. N Engl J Med. 2015;372:2398–408.
Leverve XM. Mitochondrial function and substrate availability. Crit Care Med. 2007;35(9 Suppl):S454–60.
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Li, A., Mukhopadhyay, A. Correction to: Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry. Crit Care 24, 660 (2020). https://doi.org/10.1186/s13054-020-03391-7
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DOI: https://doi.org/10.1186/s13054-020-03391-7