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  2. Endothelial dysfunction is a hallmark of sepsis, associated with lung transvascular fluid flux and pulmonary dysfunction in septic patients. We tested the hypothesis that methicillin-resistant Staphylococcus aure...

    Authors: Collette C Jonkam, Kamna Bansal, Daniel L Traber, Atsumori Hamahata, Marc O Maybauer, Dirk M Maybauer, Robert A Cox, Matthias Lange, Rhykka L Connelly, Lillian D Traber, Clarisse D Djukom, John R Salsbury, David N Herndon and Perenlei Enkhbaatar
    Citation: Critical Care 2009 13:R19
    Content type: Research Published on:

  4. Interventional lung assist (ILA), based on the use of a pumpless extracorporeal membrane oxygenator, facilitates carbon dioxide (CO2) elimination in acute respiratory distress syndrome (ARDS). It is unclear wheth...

    Authors: Günther Zick, Dirk Schädler, Gunnar Elke, Sven Pulletz, Berthold Bein, Jens Scholz, Inéz Frerichs and Norbert Weiler
    Citation: Critical Care 2009 13:R17
    Content type: Research Published on:

  6. Delirium in the intensive care unit (ICU) is associated with increased morbidity and mortality. Using an assessment tool has been shown to improve the ability of clinicians in the ICU to detect delirium. The c...

    Authors: Valerie J Page, Sachin Navarange, Sibu Gama and Danny F McAuley
    Citation: Critical Care 2009 13:R16
    Content type: Research Published on:

  7. Increasing numbers of cancer patients are being admitted to the intensive care unit (ICU), either for cancer-related complications or treatment-associated side effects, yet there are relatively few data concer...

    Authors: Fabio Silvio Taccone, Antonio A Artigas, Charles L Sprung, Rui Moreno, Yasser Sakr and Jean-Louis Vincent
    Citation: Critical Care 2009 13:R15
    Content type: Research Published on:

  8. Frequency-dependent acceleration of relaxation (FDAR) ensures appropriate ventricular filling at high heart rates and results from accelerated sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) activity...

    Authors: Olivier Joulin, Sylvestre Marechaux, Sidi Hassoun, David Montaigne, Steve Lancel and Remi Neviere
    Citation: Critical Care 2009 13:R14
    Content type: Research Published on:

  9. Maintaining arterial blood glucose within tight limits is beneficial in critically ill patients. Upper and lower limits of detrimental blood glucose levels must be determined.

    Authors: Monika Holbein, Markus Béchir, Silke Ludwig, Jutta Sommerfeld, Silvia R Cottini, Marius Keel, Reto Stocker and John F Stover
    Citation: Critical Care 2009 13:R13
    Content type: Research Published on:

  10. Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is a known complication of sepsis. However, its pathophysiology remains unclear. The present study investigated the effect of com...

    Authors: Michael A Flierl, Philip F Stahel, Daniel Rittirsch, Markus Huber-Lang, Andreas D Niederbichler, L Marco Hoesel, Basel M Touban, Steven J Morgan, Wade R Smith, Peter A Ward and Kyros Ipaktchi
    Citation: Critical Care 2009 13:R12
    Content type: Research Published on:

  11. One of the main causes of death in European and US intensive care units is sepsis. It involves a network of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6. Furthermore, there is an up regulation of t...

    Authors: Stefan Hofer, Jochen Steppan, Tanja Wagner, Benjamin Funke, Christoph Lichtenstern, Eike Martin, Bernhard M Graf, Angelika Bierhaus and Markus A Weigand
    Citation: Critical Care 2009 13:R11
    Content type: Research Published on:

  13. Pumpless interventional lung assist (iLA) is used in patients with acute respiratory distress syndrome (ARDS) aimed at improving extracorporeal gas exchange with a membrane integrated in a passive arteriovenou...

    Authors: Markus Zimmermann, Thomas Bein, Matthias Arlt, Alois Philipp, Leopold Rupprecht, Thomas Mueller, Matthias Lubnow, Bernhard M Graf and Hans J Schlitt
    Citation: Critical Care 2009 13:R10
    Content type: Research Published on:

  16. Interleukin (IL)-18 is a key modulator of the cytokine response that leads to organ dysfunction and prolonged intensive care unit (ICU) stay after cardiopulmonary bypass surgery. We hypothesised that variation...

    Authors: David M Shaw, Ainsley M Sutherland, James A Russell, Samuel V Lichtenstein and Keith R Walley
    Citation: Critical Care 2009 13:R9
    Content type: Research Published on:

  18. The aim of this study was to assess the effects of albumin dialysis on hepatic encephalopathy and circulating levels of amino acids in severe alcoholic hepatitis.

    Authors: Albert Parés, Ramón Deulofeu, Laura Cisneros, Angels Escorsell, Joan Manuel Salmerón, Joan Caballería and Antoni Mas
    Citation: Critical Care 2009 13:R8
    Content type: Research Published on:

  20. Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly in part through an attenuation of the proinflammatory cytokine response and a stimulation of hea...

    Authors: Anne Sofie Andreasen, Theis Pedersen-Skovsgaard, Ole Hartvig Mortensen, Gerrit van Hall, Pope Lloyd Moseley and Bente Klarlund Pedersen
    Citation: Critical Care 2009 13:R7
    Content type: Research Published on:

  21. Reduction of automatic pressure support based on a target respiratory frequency or mandatory rate ventilation (MRV) is available in the Taema-Horus ventilator for the weaning process in the intensive care unit...

    Authors: Corinne Taniguchi, Raquel C Eid, Cilene Saghabi, Rogério Souza, Eliezer Silva, Elias Knobel, Ângela T Paes and Carmen S Barbas
    Citation: Critical Care 2009 13:R6
    Content type: Research Published on:

  22. Intensive insulin therapy (IIT) reduced the incidence of critical illness polyneuropathy and/or myopathy (CIP/CIM) and the need for prolonged mechanical ventilation (MV ≥ 14 days) in two randomised controlled ...

    Authors: Greet Hermans, Maarten Schrooten, Philip Van Damme, Noor Berends, Bernard Bouckaert, Wouter De Vooght, Wim Robberecht and Greet Van den Berghe
    Citation: Critical Care 2009 13:R5
    Content type: Research Published on:

  25. The effect of expiratory endotracheal tube (ETT) resistance on dynamic lung inflation is unknown. We hypothesized that ETT resistance causes dynamic lung hyperinflation by impeding lung emptying. We further hy...

    Authors: Christoph Haberthür, Annekathrin Mehlig, John F Stover, Stefan Schumann, Knut Möller, Hans-Joachim Priebe and Josef Guttmann
    Citation: Critical Care 2009 13:R4
    Content type: Research Published on:

  27. Bacterial meningitis (BM) is a severe complication in patients with aneurysmal subarachnoid haemorrhage (SAH). Clinical signs of meningitis are often masked by SAH-related symptoms, and routine cerebrospinal f...

    Authors: Florian Schlenk, Katja Frieler, Alexandra Nagel, Peter Vajkoczy and Asita S Sarrafzadeh
    Citation: Critical Care 2009 13:R2
    Content type: Research Published on:

  28. Mechanical ventilation (MV) may cause ventilator-induced lung injury (VILI). Present models of VILI use exceptionally large tidal volumes, causing gross lung injury and haemodynamic shock. In addition, animals...

    Authors: Esther K Wolthuis, Alexander PJ Vlaar, Goda Choi, Joris JTH Roelofs, Nicole P Juffermans and Marcus J Schultz
    Citation: Critical Care 2009 13:R1
    Content type: Research Published on:

  30. Bland-Altman analysis is used for assessing agreement between two measurements of the same clinical variable. In the field of cardiac output monitoring, its results, in terms of bias and limits of agreement, a...

    Authors: Maurizio Cecconi, Andrew Rhodes, Jan Poloniecki, Giorgio Della Rocca and R Michael Grounds
    Citation: Critical Care 2009 13:201
    Content type: Review Published on:

  40. Many studies have demonstrated that closed intensive care units (ICUs), staffed by trained intensivists, are associated with improved patient outcomes. However, the mechanisms by which ICU organizational facto...

    Authors: David J Murphy, Eddy Fan and Dale M Needham
    Citation: Critical Care 2009 13:101
    Content type: Commentary Published on:

  41. Our understanding of septic acute kidney injury (AKI) remains incomplete. A fundamental step is the use of animal models designed to meet the criteria of human sepsis. Therefore, we dynamically assessed renal ...

    Authors: Jiri Chvojka, Roman Sykora, Ales Krouzecky, Jaroslav Radej, Veronika Varnerova, Thomas Karvunidis, Ondrej Hes, Ivan Novak, Peter Radermacher and Martin Matejovic
    Citation: Critical Care 2008 12:R164
    Content type: Research Published on:

  42. Drotrecogin alfa (activated) (DrotAA) is licensed in the United States and the European Union for the treatment of severe sepsis with multiple organ failure. Patients with severe sepsis on renal replacement th...

    Authors: Luigi Camporota, Eleonora Corno, Eleonora Menaldo, John Smith, Katie Lei, Richard Beale and Duncan Wyncoll
    Citation: Critical Care 2008 12:R163
    Content type: Research Published on:

  43. Although sodium disturbances are common in hospitalised patients, few studies have specifically investigated the epidemiology of sodium disturbances in the intensive care unit (ICU). The objectives of this stu...

    Authors: Henry Thomas Stelfox, Sofia B Ahmed, Farah Khandwala, David Zygun, Reza Shahpori and Kevin Laupland
    Citation: Critical Care 2008 12:R162
    Content type: Research Published on:

  45. A limitation of pre-hospital monitoring is that vital signs often do not change until a patient is in a critical stage. Blood lactate levels are suggested as a more sensitive parameter to evaluate a patient's ...

    Authors: Tim C Jansen, Jasper van Bommel, Paul G Mulder, Johannes H Rommes, Selma JM Schieveld and Jan Bakker
    Citation: Critical Care 2008 12:R160
    Content type: Research Published on:

  46. Stimulation of beta2-adrenergic receptors (β2-ARs) inhibits tumor necrosis factor-alpha (TNF-α) release in monocytes. In septic shock, endogenous catecholamines induce β2-AR downregulation, leading to an increase...

    Authors: Andreas Link, Simina Selejan, Christoph Maack, Monika Lenz and Michael Böhm
    Citation: Critical Care 2008 12:R159
    Content type: Research Published on:

  47. Sepsis is a leading cause of admission to non-cardiological intensive care units (ICUs) and the second leading cause of death among ICU patients. We present the first extensive dataset on the epidemiology of s...

    Authors: Jesús Blanco, Arturo Muriel-Bombín, Víctor Sagredo, Francisco Taboada, Francisco Gandía, Luís Tamayo, Javier Collado, Ángel García-Labattut, Demetrio Carriedo, Manuel Valledor, Martín De Frutos, María-Jesús López, Ana Caballero, José Guerra, Braulio Álvarez, Agustín Mayo…
    Citation: Critical Care 2008 12:R158
    Content type: Research Published on:

  48. Inflammatory stimuli are causative for insulin resistance in obesity as well as in acute inflammatory reactions. Ongoing research has identified a variety of secreted proteins that are released from immune cel...

    Authors: Michael Lehrke, Uli C Broedl, Ingeborg M Biller-Friedmann, Michael Vogeser, Volkmar Henschel, Kirsten Nassau, Burkhard Göke, Erich Kilger and Klaus G Parhofer
    Citation: Critical Care 2008 12:R157
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535