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  1. The CytoSorb therapy in COVID-19 (CTC) registry evaluated the clinical performance and treatment parameters of extracorporeal hemoadsorption integrated with veno-venous extracorporeal membrane oxygenation (VV ...

    Authors: J. W. Awori Hayanga, Tae Song, Lucian Durham, Lawrence Garrison, Deane Smith, Zsolt Molnar, Joerg Scheier, Efthymios N. Deliargyris and Nader Moazami
    Citation: Critical Care 2023 27:243
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:421

    The Correspondence to this article has been published in Critical Care 2023 27:297

  3. In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious infections. These studies have led to the inclusion of dose optimization recom...

    Authors: Paul G. Williams, Alexis Tabah, Menino Osbert Cotta, Indy Sandaradura, Salmaan Kanji, Marc H. Scheetz, Sahand Imani, Muhammed Elhadi, Sònia Luque-Pardos, Natalie Schellack, Cristina Sanches, Jean-Francois Timsit, Jiao Xie, Andras Farkas, Kathryn Wilks and Jason A. Roberts
    Citation: Critical Care 2023 27:241
    Content type: Research Published on:

  4. Benefit of early awake prone positioning for COVID-19 patients hospitalised in medical wards and who need oxygen therapy remains to be demonstrated. The question was considered at the time of COVID-19 pandemic...

    Authors: Mai-Anh Nay, Raphaël Hindre, Christophe Perrin, Jérémy Clément, Laurent Plantier, Aymeric Sève, Sylvie Druelle, Marine Morrier, Jean-Baptiste Lainé, Léa Colombain, Grégory Corvaisier, Nicolas Bizien, Xavier Pouget-Abadie, Adrien Bigot, Simon Jamard, Elsa Nyamankolly…
    Citation: Critical Care 2023 27:240
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:393

  5. Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize a porcine model of ARDS induced by pneumonia—the m...

    Authors: Enric Barbeta, Marta Arrieta, Ana Motos, Joaquim Bobi, Hua Yang, Minlan Yang, Giacomo Tanzella, Pierluigi Di Ginnatale, Stefano Nogas, Carmen Rosa Vargas, Roberto Cabrera, Denise Battaglini, Andrea Meli, Kasra Kiarostami, Nil Vázquez, Laia Fernández-Barat…
    Citation: Critical Care 2023 27:239
    Content type: Perspective Published on:

  8. Sepsis is common, deadly, and heterogenous. Prior analyses of patients with sepsis and septic shock in New York State showed a risk-adjusted association between more rapid antibiotic administration and bundled...

    Authors: Anne Yang, Jason N. Kennedy, Katherine M. Reitz, Gary Phillips, Kathleen M. Terry, Mitchell M. Levy, Derek C. Angus and Christopher W. Seymour
    Citation: Critical Care 2023 27:236
    Content type: Research Published on:

  9. Cerebral autoregulation (CA) can be impaired in patients with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). The Pressure Reactivity Index (PRx, correlation of blood pressure and...

    Authors: Nick Kastenholz, Murad Megjhani, Catharina Conzen-Dilger, Walid Albanna, Michael Veldeman, Daniel Nametz, Soon Bin Kwon, Henna Schulze-Steinen, Hani Ridwan, Hans Clusmann, Gerrit Alexander Schubert, Soojin Park and Miriam Weiss
    Citation: Critical Care 2023 27:235
    Content type: Research Published on:

  10. Angiopoietin-2 (Ang-2) is associated with vascular endothelial injury and permeability in the acute respiratory distress syndrome (ARDS) and sepsis. Elevated circulating Ang-2 levels may identify critically il...

    Authors: Carrie M. Rosenberger, Katherine D. Wick, Hanjing Zhuo, Nelson Wu, Yue Chen, Sharookh B. Kapadia, Alessander Guimaraes, Diana Chang, David F. Choy, Hubert Chen, Melicent Peck, Kathryn M. Sullivan, Serena Ke, Alejandra Jauregui, Aleksandra Leligdowicz, Pratik Sinha…
    Citation: Critical Care 2023 27:234
    Content type: Brief Report Published on:

  11. In ARDS, the PEEP level associated with the best respiratory system compliance is often selected; however, intra-tidal recruitment can increase compliance, falsely suggesting improvement in baseline mechanics....

    Authors: Francesco Mojoli, Marco Pozzi, Eric Arisi, Silvia Mongodi, Anita Orlando, Giuseppe Maggio, Federico Capra Marzani and Laurent Brochard
    Citation: Critical Care 2023 27:233
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:306

  12. The appropriate administration regimen of polymyxin B is yet controversial. The present study aimed to explore the optimal dose of polymyxin B under therapeutic drug monitoring (TDM) guidance.

    Authors: Shaohua Liu, Ying Wu, Shaoyan Qi, Huanzhang Shao, Min Feng, Lihua Xing, Hongmei Liu, Yanqiu Gao, Zhiqiang Zhu, Shuguang Zhang, Yuming Du, Yibin Lu, Jing Yang, Pingyan Chen and Tongwen Sun
    Citation: Critical Care 2023 27:232
    Content type: Research Published on:

  14. Sepsis-induced endothelial dysfunction is proposed to cause angiotensin-converting enzyme (ACE) dysfunction and renin–angiotensin–aldosterone system (RAAS) derangement, exacerbating vasodilatory shock and acut...

    Authors: Naomi Pode-Shakked, Giovanni Ceschia, James E. Rose, Stuart L. Goldstein and Natalja L. Stanski
    Citation: Critical Care 2023 27:230
    Content type: Brief Report Published on:

  15. Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due to...

    Authors: Ryoung-Eun Ko, Danbee Kang, Juhee Cho, Soo Jin Na, Chi Ryang Chung, Sung Yoon Lim, Yeon Joo Lee, Sunghoon Park, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Haein Lee, Chae-Man Lim and Gee Young Suh
    Citation: Critical Care 2023 27:229
    Content type: Research Published on:

  16. To evaluate the safety, feasibility, and efficacy of combined adrenergic blockade with propranolol and clonidine in patients with severe traumatic brain injury (TBI).

    Authors: Mina F. Nordness, Amelia W. Maiga, Laura D. Wilson, Tatsuki Koyama, Erika L. Rivera, Shayan Rakhit, Michael de Riesthal, Cari L. Motuzas, Madison R. Cook, Deepak K. Gupta, James C. Jackson, Shawniqua Williams Roberson, William J. Meurer, Roger J. Lewis, Geoffrey T. Manley, Pratik P. Pandharipande…
    Citation: Critical Care 2023 27:228
    Content type: Research Published on:

  17. Critical illness results in subjective financial distress for families, but little is known about objective caregiver finances after a child’s pediatric intensive care unit (PICU) hospitalization. Using statew...

    Authors: Erin F. Carlton, Michelle H. Moniz, John W. Scott, Hallie C. Prescott and Nora V. Becker
    Citation: Critical Care 2023 27:227
    Content type: Brief Report Published on:

  18. A hallmark of acute respiratory distress syndrome (ARDS) is hypoxaemic respiratory failure due to pulmonary vascular hyperpermeability. The tyrosine kinase inhibitor imatinib reversed pulmonary capillary leak ...

    Authors: Leila N. Atmowihardjo, Job R. Schippers, Erik Duijvelaar, Imke H. Bartelink, Pierre M. Bet, Noortje E. L. Swart, Nienke van Rein, Keith Purdy, David Cavalla, Andrew McElroy, Sarah Fritchley, Anton Vonk Noordegraaf, Henrik Endeman, Patricia van Velzen, Matty Koopmans, Harm Jan Bogaard…
    Citation: Critical Care 2023 27:226
    Content type: Research Published on:

  20. The importance of assessing venous congestion in ICU patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool. The Venous Excess Ultrasound Grading System (VExUS), ...

    Authors: Stefan Andrei, Pierre-Alain Bahr, Maxime Nguyen, Belaid Bouhemad and Pierre-Grégoire Guinot
    Citation: Critical Care 2023 27:224
    Content type: Research Published on:

  22. Continuous renal replacement therapy (CRRT) is a widely used standard therapy for critically ill patients with acute kidney injury (AKI). Despite its effectiveness, treatment is often interrupted due to clot f...

    Authors: Zhifeng Zhou, Chen Liu, Yingying Yang, Fang Wang, Ling Zhang and Ping Fu
    Citation: Critical Care 2023 27:222
    Content type: Research Published on:

  25. Bleeding and thrombosis induce major morbidity and mortality in patients under extracorporeal membrane oxygenator (ECMO). Circuit changes can be performed for oxygenation membrane thrombosis but are not recomm...

    Authors: Thibaut Genty, Stanislas Burguburu, Audrey Imbert, Calypso Roman, Wirth Camille, Jacques Thès and François Stéphan
    Citation: Critical Care 2023 27:219
    Content type: Brief Report Published on:

  27. Early mobilisation in critical care is recommended within clinical guidance; however, mobilisation prevalence across the UK is unknown. The study aimed to determine the proportion of patients mobilised out of ...

    Authors: Claire Black, Helen Sanger, Ceri Battle, Allaina Eden and Evelyn Corner
    Citation: Critical Care 2023 27:217
    Content type: Research Published on:

  29. Cytokine adsorption using the CytoSorb® adsorber has been proposed in various clinical settings including sepsis, ARDS, hyperinflammatory syndromes, cardiac surgery or recovery after cardiac arrest. The aim of...

    Authors: Sören Becker, Hannah Lang, Clara Vollmer Barbosa, Zhejia Tian, Anette Melk and Bernhard M. W. Schmidt
    Citation: Critical Care 2023 27:215
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:444

    The Matters Arising to this article has been published in Critical Care 2023 27:357

  30. Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute brain dysfunction. SAE may result ...

    Authors: Barbora Bircak-Kuchtova, Ha-Yeun Chung, Jonathan Wickel, Johannes Ehler and Christian Geis
    Citation: Critical Care 2023 27:214
    Content type: Review Published on:

  31. Findings from preclinical studies and one pilot clinical trial suggest potential benefits of epidural analgesia in acute pancreatitis. We aimed to assess the efficacy of thoracic epidural analgesia, in additio...

    Authors: Matthieu Jabaudon, Alexandra Genevrier, Samir Jaber, Olivier Windisch, Stéphanie Bulyez, Pierre-François Laterre, Etienne Escudier, Achille Sossou, Philippe Guerci, Pierre-Marie Bertrand, Pierre-Eric Danin, Martin Bonnassieux, Leo Bühler, Claudia Paula Heidegger, Russell Chabanne, Thomas Godet…
    Citation: Critical Care 2023 27:213
    Content type: Research Published on:

  32. Patients with community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU) have high mortality rates during the acute infection and up to ten years thereafter. Recommendations from internationa...

    Authors: Luis Felipe Reyes, Esteban Garcia, Elsa D. Ibáñez-Prada, Cristian C. Serrano-Mayorga, Yuli V. Fuentes, Alejandro Rodríguez, Gerard Moreno, Alirio Bastidas, Josep Gómez, Angélica Gonzalez, Christopher R. Frei, Leo Anthony Celi, Ignacio Martin-Loeches and Grant Waterer
    Citation: Critical Care 2023 27:212
    Content type: Research Published on:

  33. The optimal treatment duration and the nature of regimen of antibiotics (monotherapy or combination therapy) for Pseudomonas aeruginosa ventilator‑associated pneumonia (PA-VAP) remain debated. The aim of this stu...

    Authors: Arnaud Foucrier, Thomas Dessalle, Sophie Tuffet, Laura Federici, Claire Dahyot‑Fizelier, François Barbier, Julien Pottecher, Antoine Monsel, Tarik Hissem, Jean‑Yves Lefrant, Alexandre Demoule, Jean‑Michel Constantin, Alexandra Rousseau, Tabassome Simon, Marc Leone and Adrien Bouglé
    Citation: Critical Care 2023 27:211
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:364

  37. The relevance of current consensus threshold to define oliguria has been challenged by small observational studies. We aimed to determine the optimal threshold to define oliguria in critically-ill patients.

    Authors: Nathan Axel Bianchi, Marco Altarelli, Céline Monard, Tatiana Kelevina, Aziz Chaouch and Antoine Guillaume Schneider
    Citation: Critical Care 2023 27:207
    Content type: Research Published on:

  38. Fluid normally exchanges freely between the plasma and interstitial space and is returned primarily via the lymphatic system. This balance can be disturbed by diseases and medications. In inflammatory disease ...

    Authors: Randal O. Dull and Robert G. Hahn
    Citation: Critical Care 2023 27:206
    Content type: Review Published on:

  39. Venous congestion is an under-recognized contributor to mortality in critically ill patients. Unfortunately, venous congestion is difficult to measure, and right heart catheterization (RHC) has been considered...

    Authors: August Longino, Katharine Martin, Katarina Leyba, Gabriel Siegel, Edward Gill, Ivor S. Douglas and Joseph Burke
    Citation: Critical Care 2023 27:205
    Content type: Brief Report Published on:

  41. Since oxygen content and oxygen consumption typically remain unchanged within a short period, variation in central venous oxygen saturation (ΔScvO2) during fluid challenge can theoretically track the changes in c...

    Authors: Jianneng Pan, Yuxiang Sun, Zhaojun Xu, Pingping Dong and Xiaoyang Zhou
    Citation: Critical Care 2023 27:203
    Content type: Research Published on:

  42. Authors: Bairbre A. McNicholas, Emanuele Rezoagli, Andrew J. Simpkin, Sankalp Khanna, Jacky Y. Suen, Pauline Yeung, Daniel Brodie, Gianluigi Li Bassi, Tai Pham, Giacomo Bellani, John F. Fraser and John Laffey
    Citation: Critical Care 2023 27:202
    Content type: Correction Published on:

    The original article was published in Critical Care 2023 27:3

  43. A quantitative assessment of pulmonary edema is important because the clinical severity can range from mild impairment to life threatening. A quantitative surrogate measure, although invasive, for pulmonary ed...

    Authors: Dominik Schulz, Sebastian Rasch, Markus Heilmaier, Rami Abbassi, Alexander Poszler, Jörg Ulrich, Manuel Steinhardt, Georgios A. Kaissis, Roland M. Schmid, Rickmer Braren and Tobias Lahmer
    Citation: Critical Care 2023 27:201
    Content type: Research Published on:

  44.  Circulatory failure is classified into four types of shock (obstructive, cardiogenic, distributive, and hypovolemic) that must be distinguished as each requires a different treatment. Point-of-care ultrasound...

    Authors: Takuo Yoshida, Takuya Yoshida, Hisashi Noma, Takeshi Nomura, Akihiro Suzuki and Takahiro Mihara
    Citation: Critical Care 2023 27:200
    Content type: Review Published on:

  45. Prevalence, risk factors and medical management of persistent pain symptoms after critical care illness have not been thoroughly investigated.

    Authors: Alexandre Bourdiol, Vincent Legros, Fanny Vardon-Bounes, Thomas Rimmele, Paul Abraham, Clément Hoffmann, Claire Dahyot-Fizelier, Maud Jonas, Pierre Bouju, Cédric Cirenei, Yoann Launey, Gregoire Le Gac, Samia Boubeche, Edouard Lamarche, Olivier Huet, Lucillia Bezu…
    Citation: Critical Care 2023 27:199
    Content type: Research Published on:

  48. Ventilator-induced lung injury (VILI) is caused by overdistension of the alveoli by the repetitive recruitment and derecruitment of alveolar units. This study aims to investigate the potential role and mechani...

    Authors: Peng Ding, Rui Yang, Cheng Li, Hai-Long Fu, Guang-Li Ren, Pei Wang, Dong-Yu Zheng, Wei Chen, Li-Ye Yang, Yan-Fei Mao, Hong-Bin Yuan and Yong-Hua Li
    Citation: Critical Care 2023 27:196
    Content type: Research Published on:

  50. A previous retrospective single-centre study suggested that the percentage of time spent with cerebral perfusion pressure (CPP) below the individual lower limit of reactivity (LLR) is associated with mortality...

    Authors: Erta Beqiri, Frederick A. Zeiler, Ari Ercole, Michal M. Placek, Jeanette Tas, Joseph Donnelly, Marcel J. H. Aries, Peter J. Hutchinson, David Menon, Nino Stocchetti, Marek Czosnyka and Peter Smielewski
    Citation: Critical Care 2023 27:194
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:311

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Critical Care

ISSN: 1364-8535