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  2. Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardio...

    Authors: Manu Shankar-Hari, Guido Bertolini, Frank M. Brunkhorst, Rinaldo Bellomo, Djillali Annane, Clifford S. Deutschman and Mervyn Singer
    Citation: Critical Care 2015 19:445
    Content type: Viewpoint Published on:

  3. There is increasing evidence that fluid overload and acute kidney injury (AKI) are associated but the exact cause-effect relationship remains unclear. Wang and colleagues analysed patients admitted to 30 inten...

    Authors: Marlies Ostermann, Heleen M. Oudemans-van Straaten and Lui G. Forni
    Citation: Critical Care 2015 19:443
    Content type: Commentary Published on:

    The original article was published in Critical Care 2015 19:371

  9. Mechanical ventilation and the effect of respiratory muscle unloading on the diaphragm cause ventilator-induced diaphragmatic dysfunction (VIDD). Atrophy of the diaphragmatic muscle is a major part of VIDD, an...

    Authors: Tom Schepens, Walter Verbrugghe, Karolien Dams, Bob Corthouts, Paul M. Parizel and Philippe G. Jorens
    Citation: Critical Care 2015 19:422
    Content type: Research Published on:

  10. Obtaining favorable neurological outcomes is extremely difficult in children transported to a hospital without a prehospital return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA)...

    Authors: Yoshikazu Goto, Akira Funada and Yumiko Nakatsu-Goto
    Citation: Critical Care 2015 19:410
    Content type: Research Published on:

  11. Niklas Nielsen, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Ã…neman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen...

    Authors: Premkumar Nattanmai Chandrasekaran, Cameron Dezfulian and Kees H. Polderman
    Citation: Critical Care 2015 19:406
    Content type: Journal club critique Published on:

  13. We aimed to determine i) the feasibility of nurses taking bedside measurements of microcirculatory parameters in real time in intensive care patients; and ii) whether such measurements would be comparable to t...

    Authors: Sébastien Tanaka, Anatole Harrois, Camille Nicolaï, Mélanie Flores, Sophie Hamada, Eric Vicaut and Jacques Duranteau
    Citation: Critical Care 2015 19:388
    Content type: Research Published on:

  18. Ventilator settings resulting in decreased driving pressure (ΔP) are positively associated with survival. How to further foster the potential beneficial mediator effect of a reduced ΔP? One possibility is prom...

    Authors: João Batista Borges, Göran Hedenstierna, Anders Larsson and Fernando Suarez-Sipmann
    Citation: Critical Care 2015 19:342
    Content type: Letter Published on:

  19. Mobilisation of patients in the intensive care unit (ICU) is an area of growing research. Currently, there is little data on baseline mobilisation practises and the barriers to them for patients of all admissi...

    Authors: Meg E. Harrold, Lisa G. Salisbury, Steve A. Webb and Garry T. Allison
    Citation: Critical Care 2015 19:336
    Content type: Research Published on:

  20. Experimental data from animal models of sepsis support a role for a transcription factor, nuclear erythroid-related factor 2 p45-related factor 2 (Nrf2), as a master regulator of antioxidant and detoxifying ge...

    Authors: Jocelyn R. Grunwell, Scott L. Weiss, Natalie Z. Cvijanovich, Geoffrey L. Allen, Neal J. Thomas, Robert J. Freishtat, Nick Anas, Keith Meyer, Paul A. Checchia, Thomas P. Shanley, Michael T. Bigham, Julie Fitzgerald, Kelli Howard, Erin Frank, Kelli Harmon and Hector R. Wong
    Citation: Critical Care 2015 19:327
    Content type: Research Published on:

  21. Daily or serial evaluation of multiple organ dysfunction syndrome (MODS) scores may provide useful information. We aimed to validate the daily (d) PELOD-2 score using the set of seven days proposed with the pr...

    Authors: Stéphane Leteurtre, Alain Duhamel, Valérie Deken, Jacques Lacroix and Francis Leclerc
    Citation: Critical Care 2015 19:324
    Content type: Research Published on:

  23. Comparisons of processes of care are common in critical care research. Often, these processes are neither explicit nor replicable and this can result in seemingly irreconcilable results. Here, we briefly revie...

    Authors: Michael J. Lanspa, Eliotte L. Hirshberg, Russell R. Miller III and Alan H. Morris
    Citation: Critical Care 2015 19:297
    Content type: Commentary Published on:

  25. West CP, Dyrbye LN, Rabatin JT, Call TG, Davidson JH, Multari A, Romanski SA, Hellyer JMH, Sloan JA, Shanafelt TF. Intervention to promote physician well-being, job satisfaction, and professionalism: a randomi...

    Authors: Matthew Siedsma and Lillian Emlet
    Citation: Critical Care 2015 19:273
    Content type: Journal Club Critique Published on:

  27. Based on previously published case reports demonstrating dynamic left intraventricular obstruction (IVO) triggered by hypovolemia or catecholamines, this study aimed to establish: (1) IVO occurrence in septic ...

    Authors: Jean-Louis Chauvet, Shari El-Dash, Olivier Delastre, Bernard Bouffandeau, Dominique Jusserand, Jean-Baptiste Michot, Fabrice Bauer, Julien Maizel and Michel Slama
    Citation: Critical Care 2015 19:262
    Content type: Research Published on:

  31. Vital drugs may be degraded or sequestered in extracorporeal membrane oxygenation (ECMO) circuits, with lipophilic drugs considered to be particularly vulnerable. However, the circuit effects on protein-bound ...

    Authors: Kiran Shekar, Jason A Roberts, Charles I Mcdonald, Sussan Ghassabian, Chris Anstey, Steven C Wallis, Daniel V Mullany, Yoke L Fung and John F Fraser
    Citation: Critical Care 2015 19:164
    Content type: Research Published on:

  32. Systolic blood pressure is a widely used tool to assess circulatory function in acutely ill patients. The systolic blood pressure limit where a given patient should be considered hypotensive is the subject of ...

    Authors: Anders Kasper Bruun Kristensen, Jon Gitz Holler, Søren Mikkelsen, Jesper Hallas and Annmarie Lassen
    Citation: Critical Care 2015 19:158
    Content type: Research Published on:

  34. We aimed to determine the rate of preventable death in patients who died early and unexpectedly following hospital admission from the emergency department (ED).

    Authors: Hélène Goulet, Victor Guerand, Benjamin Bloom, Patricia Martel, Philippe Aegerter, Enrique Casalino, Bruno Riou and Yonathan Freund
    Citation: Critical Care 2015 19:154
    Content type: Research Published on:

  35. Acute muscle wasting in the critically ill is common and associated with significant morbidity and mortality. Although some aetiological factors are recognised and muscle wasting can be detected early with ult...

    Authors: Susannah AA Bloch, Anna VJ Donaldson, Amy Lewis, Winston AS Banya, Michael I Polkey, Mark JD Griffiths and Paul R Kemp
    Citation: Critical Care 2015 19:147
    Content type: Research Published on:

  37. Since normal or high central venous oxygen saturation (ScvO2) values cannot discriminate if tissue perfusion is adequate, integrating other markers of tissue hypoxia, such as central venous-to-arterial carbon dio...

    Authors: Jaume Mesquida, Paula Saludes, Guillem Gruartmoner, Cristina Espinal, Eva Torrents, Francisco Baigorri and Antonio Artigas
    Citation: Critical Care 2015 19:126
    Content type: Research Published on:

  39. By maintaining sufficient cerebral blood flow and oxygenation, the goal of cardiopulmonary resuscitation (CPR) is to preserve the pre-arrest neurological state. To date, cerebral monitoring abilities during CP...

    Authors: Cornelia Genbrugge, Ingrid Meex, Willem Boer, Frank Jans, René Heylen, Bert Ferdinande, Jo Dens and Cathy De Deyne
    Citation: Critical Care 2015 19:112
    Content type: Research Published on:

  40. Acute respiratory distress syndrome (ARDS) is a common clinical syndrome with high mortality and long-term morbidity. To date there is no effective pharmacological therapy. Aspirin therapy has recently been sh...

    Authors: Andrew J Boyle, Stefania Di Gangi, Umar I Hamid, Linda-Jayne Mottram, Lia McNamee, Griania White, LJ Mark Cross, James J McNamee, Cecilia M O’Kane and Daniel F McAuley
    Citation: Critical Care 2015 19:109
    Content type: Research Published on:

  41. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at

    Authors: Claudio Sandroni, Sonia D’Arrigo and Massimo Antonelli
    Citation: Critical Care 2015 19:104
    Content type: Review Published on:

  43. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at

    Authors: Thiago D Corrêa, Jukka Takala and Stephan M Jakob
    Citation: Critical Care 2015 19:98
    Content type: Review Published on:

  45. The primary objective of this study was to determine the efficiency of hydrogen peroxide (H2O2) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient dischar...

    Authors: Caroline Blazejewski, Frédéric Wallet, Anahita Rouzé, Rémi Le Guern, Sylvie Ponthieux, Julia Salleron and Saad Nseir
    Citation: Critical Care 2015 19:30
    Content type: Research Published on:

  49. The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study s...

    Authors: Ling Zeng, Juan Du, Wei Gu, An-qiang Zhang, Hai-yan Wang, Da-lin Wen, Lin Qiu, Xue-tao Yang, Jian-hui Sun, Mao Zhang, Jiang Hao and Jian-xin Jiang
    Citation: Critical Care 2015 19:6
    Content type: Research Published on:

  50. Postoperative acute kidney injury (AKI) is a frequently observed complication after on-pump cardiac surgery (CS) and is associated with adverse patient outcomes. Early identification of patients at risk is ess...

    Authors: Anna J Wetz, Eva M Richardt, Saskia Wand, Nils Kunze, Hanna Schotola, Michael Quintel, Anselm Bräuer and Onnen Moerer
    Citation: Critical Care 2015 19:3
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535