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Citation: Critical Care 2015 19:454
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Judging quality of current septic shock definitions and criteria
Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardio...
Citation: Critical Care 2015 19:445 -
Fluid overload and acute kidney injury: cause or consequence?
There is increasing evidence that fluid overload and acute kidney injury (AKI) are associated but the exact cause-effect relationship remains unclear. Wang and colleagues analysed patients admitted to 30 inten...
Citation: Critical Care 2015 19:443 -
Obituary: Mitchell P. Fink
Citation: Critical Care 2015 19:442 -
Metabolic and coagulation effects of citrate: down to the last detail!
Citation: Critical Care 2015 19:433 -
Predicting acute kidney injury in severe trauma. A biomarker breakthrough?
Citation: Critical Care 2015 19:432 -
Ionized calcium measurements during regional citrate anticoagulation in CRRT: we need better blood gas analyzers
Citation: Critical Care 2015 19:427 -
Timing of tracheotomy in ICU patients: a systematic review of randomized controlled trials
The optimal timing of tracheotomy in critically ill patients remains a topic of debate. We performed a systematic review to clarify the potential benefits of early versus late tracheotomy.
Citation: Critical Care 2015 19:424 -
The course of diaphragm atrophy in ventilated patients assessed with ultrasound: a longitudinal cohort study
Mechanical ventilation and the effect of respiratory muscle unloading on the diaphragm cause ventilator-induced diaphragmatic dysfunction (VIDD). Atrophy of the diaphragmatic muscle is a major part of VIDD, an...
Citation: Critical Care 2015 19:422 -
Neurological outcomes in children dead on hospital arrival
Obtaining favorable neurological outcomes is extremely difficult in children transported to a hospital without a prehospital return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA)...
Citation: Critical Care 2015 19:410 -
What is the right temperature to cool post-cardiac arrest patients?
Niklas Nielsen, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Ã…neman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen...
Citation: Critical Care 2015 19:406 -
Timing of antibiotics, volume and vasoactive infusions in children with sepsis: it is all in the timing
Citation: Critical Care 2015 19:394 -
Qualitative real-time analysis by nurses of sublingual microcirculation in intensive care unit: the MICRONURSE study
We aimed to determine i) the feasibility of nurses taking bedside measurements of microcirculatory parameters in real time in intensive care patients; and ii) whether such measurements would be comparable to t...
Citation: Critical Care 2015 19:388 -
Bioelectrical impedance vector analysis in the critically ill: cool tool or just another ‘toy’?
Assessment of volume and hydration status is far from easy and therefore technology such as bioelectrical impedance vector analysis (BIVA) may complement our examination techniques. This study highlights the f...
Citation: Critical Care 2015 19:387 -
How to understand the results of studies of glutamine supplementation
The lack of understanding of the mechanisms behind possible beneficial and possible harmful effects of glutamine supplementation makes the design of interventional studies of glutamine supplementations difficu...
Citation: Critical Care 2015 19:385 -
Alleviating central venous oxygen saturation (ScvO2): a new approach of kidney protection after cardiac surgery?
Citation: Critical Care 2015 19:359 -
The epidemiology of sepsis: questioning our understanding of the role of race
Race has been identified as an important risk factor for the development of sepsis and as a predictor of poor outcomes in sepsis. For example, black individuals have been demonstrated to be nearly twice as lik...
Citation: Critical Care 2015 19:347 -
Altering the mechanical scenario to decrease the driving pressure
Ventilator settings resulting in decreased driving pressure (ΔP) are positively associated with survival. How to further foster the potential beneficial mediator effect of a reduced ΔP? One possibility is prom...
Citation: Critical Care 2015 19:342 -
Early mobilisation in intensive care units in Australia and Scotland: a prospective, observational cohort study examining mobilisation practises and barriers
Mobilisation of patients in the intensive care unit (ICU) is an area of growing research. Currently, there is little data on baseline mobilisation practises and the barriers to them for patients of all admissi...
Citation: Critical Care 2015 19:336 -
Differential expression of the Nrf2-linked genes in pediatric septic shock
Experimental data from animal models of sepsis support a role for a transcription factor, nuclear erythroid-related factor 2 p45-related factor 2 (Nrf2), as a master regulator of antioxidant and detoxifying ge...
Citation: Critical Care 2015 19:327 -
Daily estimation of the severity of organ dysfunctions in critically ill children by using the PELOD-2 score
Daily or serial evaluation of multiple organ dysfunction syndrome (MODS) scores may provide useful information. We aimed to validate the daily (d) PELOD-2 score using the set of seven days proposed with the pr...
Citation: Critical Care 2015 19:324 -
Lung ultrasound in the critically ill (LUCI) and the lung point: a sign specific to pneumothorax which cannot be mimicked
Citation: Critical Care 2015 19:311 -
Clinical study replicability and the pursuit of excellence
Comparisons of processes of care are common in critical care research. Often, these processes are neither explicit nor replicable and this can result in seemingly irreconcilable results. Here, we briefly revie...
Citation: Critical Care 2015 19:297 -
Loop diuretics in acute heart failure: beyond the decongestive relief for the kidney
Current goals in the acute treatment of heart failure are focused on pulmonary and systemic decongestion with loop diuretics as the cornerstone of therapy. Despite rapid relief of symptoms in patients with acu...
Citation: Critical Care 2015 19:296 -
Physician burnout: can we make a difference together?
West CP, Dyrbye LN, Rabatin JT, Call TG, Davidson JH, Multari A, Romanski SA, Hellyer JMH, Sloan JA, Shanafelt TF. Intervention to promote physician well-being, job satisfaction, and professionalism: a randomi...
Citation: Critical Care 2015 19:273 -
Nebulized colistin for treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: we still need to straighten out the dose!
Citation: Critical Care 2015 19:265 -
Early dynamic left intraventricular obstruction is associated with hypovolemia and high mortality in septic shock patients
Based on previously published case reports demonstrating dynamic left intraventricular obstruction (IVO) triggered by hypovolemia or catecholamines, this study aimed to establish: (1) IVO occurrence in septic ...
Citation: Critical Care 2015 19:262 -
Is fever control or improved survival the ‘risk factor’ for ventilator-associated pneumonia?
Citation: Critical Care 2015 19:208 -
Tetrastarch in cardiac surgery: error, confounding and bias in a meta-analysis of randomized trials
Citation: Critical Care 2015 19:187 -
Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis
Citation: Critical Care 2015 19:176 -
Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study
Vital drugs may be degraded or sequestered in extracorporeal membrane oxygenation (ECMO) circuits, with lipophilic drugs considered to be particularly vulnerable. However, the circuit effects on protein-bound ...
Citation: Critical Care 2015 19:164 -
Systolic blood pressure and short-term mortality in the emergency department and prehospital setting: a hospital-based cohort study
Systolic blood pressure is a widely used tool to assess circulatory function in acutely ill patients. The systolic blood pressure limit where a given patient should be considered hypotensive is the subject of ...
Citation: Critical Care 2015 19:158 -
A physiological sign that mimics lung point in critical care ultrasonography
Citation: Critical Care 2015 19:155 -
Unexpected death within 72 hours of emergency department visit: were those deaths preventable?
We aimed to determine the rate of preventable death in patients who died early and unexpectedly following hospital admission from the emergency department (ED).
Citation: Critical Care 2015 19:154 -
MiR-181a: a potential biomarker of acute muscle wasting following elective high-risk cardiothoracic surgery
Acute muscle wasting in the critically ill is common and associated with significant morbidity and mortality. Although some aetiological factors are recognised and muscle wasting can be detected early with ult...
Citation: Critical Care 2015 19:147 -
Continuous renal replacement therapy in critically ill patients does not affect urinary neutrophil gelatinase-associated lipocalin levels
Citation: Critical Care 2015 19:140 -
Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference is associated with lactate evolution in the hemodynamic resuscitation process in early septic shock
Since normal or high central venous oxygen saturation (ScvO2) values cannot discriminate if tissue perfusion is adequate, integrating other markers of tissue hypoxia, such as central venous-to-arterial carbon dio...
Citation: Critical Care 2015 19:126 -
β-blockers in critically ill patients: from physiology to clinical evidence
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at
Citation: Critical Care 2015 19:119 -
Increase in cerebral oxygenation during advanced life support in out-of-hospital patients is associated with return of spontaneous circulation
By maintaining sufficient cerebral blood flow and oxygenation, the goal of cardiopulmonary resuscitation (CPR) is to preserve the pre-arrest neurological state. To date, cerebral monitoring abilities during CP...
Citation: Critical Care 2015 19:112 -
Aspirin therapy in patients with acute respiratory distress syndrome (ARDS) is associated with reduced intensive care unit mortality: a prospective analysis
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome with high mortality and long-term morbidity. To date there is no effective pharmacological therapy. Aspirin therapy has recently been sh...
Citation: Critical Care 2015 19:109 -
Rapid response systems: are they really effective?
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at
Citation: Critical Care 2015 19:104 -
Long-term sequelae from acute kidney injury: potential mechanisms for the observed poor renal outcomes
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at
Citation: Critical Care 2015 19:102 -
Angiotensin II in septic shock
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at
Citation: Critical Care 2015 19:98 -
The relationship between arterial transducer level and pulse contour waveform-derived measurements
Citation: Critical Care 2015 19:31 -
Efficiency of hydrogen peroxide in improving disinfection of ICU rooms
The primary objective of this study was to determine the efficiency of hydrogen peroxide (H2O2) techniques in disinfection of ICU rooms contaminated with multidrug-resistant organisms (MDRO) after patient dischar...
Citation: Critical Care 2015 19:30 -
Contradictory findings on one-year mortality following ICU delirium
Citation: Critical Care 2015 19:29 -
Passive leg raising: five rules, not a drop of fluid!
Citation: Critical Care 2015 19:18 -
Is there a role for music in the ICU?
Citation: Critical Care 2015 19:17 -
Rs1800625 in the receptor for advanced glycation end products gene predisposes to sepsis and multiple organ dysfunction syndrome in patients with major trauma
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study s...
Citation: Critical Care 2015 19:6 -
Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?
Postoperative acute kidney injury (AKI) is a frequently observed complication after on-pump cardiac surgery (CS) and is associated with adverse patient outcomes. Early identification of patients at risk is ess...
Citation: Critical Care 2015 19:3
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- ISSN: 1364-8535 (electronic)