Articles
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Citation: Critical Care 2016 20:347
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Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study
Ventriculitis is a complication of temporary intraventricular drains. The limited penetration of meropenem into the cerebrospinal fluid (CSF) is well known. However, ventricular CSF pharmacokinetic data in pat...
Citation: Critical Care 2016 20:343 -
Survey of the training and use of echocardiography and lung ultrasound in Australasian intensive care units
Citation: Critical Care 2016 20:339 -
Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis
Ventilator-associated event (VAE) is a new surveillance paradigm for monitoring complications in mechanically ventilated patients in intensive care units (ICUs). The National Healthcare Safety Network replaced...
Citation: Critical Care 2016 20:338 -
Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome
Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during the influenza season. The objective of the study was to assess the impact of a...
Citation: Critical Care 2016 20:337 -
The modified SAVE score: predicting survival using urgent veno-arterial extracorporeal membrane oxygenation within 24 hours of arrival at the emergency department
Although many risk models have been tested in patients who undergo extracorporeal membrane oxygenation, few have been assessed for patients who received veno-arterial extracorporeal membrane oxygenation (VA-EC...
Citation: Critical Care 2016 20:336 -
Bioavailable estradiol concentrations are elevated and predict mortality in septic patients: a prospective cohort study
Experimental studies demonstrate beneficial immunological and hemodynamic effects of estradiol in animal models of sepsis. This raises the question whether estradiol contributes to sex differences in the incid...
Citation: Critical Care 2016 20:335 -
Regulation of blood flow and volume exchange across the microcirculation
Oxygen delivery to cells is the basic prerequisite of life. Within the human body, an ingenious oxygen delivery system, comprising steps of convection and diffusion from the upper airways via the lungs and the...
Citation: Critical Care 2016 20:319 -
Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study
Identifying patients in the immunosuppressive phase of sepsis is essential for development of immunomodulatory therapies. Little data exists comparing the ability of the two most well-studied markers of sepsis...
Citation: Critical Care 2016 20:334 -
Communicating with conscious and mechanically ventilated critically ill patients: a systematic review
Ventilator-dependent patients in the ICU often experience difficulties with one of the most basic human functions, namely communication, due to intubation. Although various assistive communication tools exist,...
Citation: Critical Care 2016 20:333 -
Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis
The dysbiosis of intestinal microbiota plays an important role in the development of gut-derived infections, making it a potential therapeutic target against multiple organ dysfunction syndrome (MODS) after se...
Citation: Critical Care 2016 20:332 -
The digestive tract as the origin of systemic inflammation
Failure of gut homeostasis is an important factor in the pathogenesis and progression of systemic inflammation, which can culminate in multiple organ failure and fatality. Pathogenic events in critically ill p...
Citation: Critical Care 2016 20:279 -
N-acetylcysteine plus deferoxamine for patients with prolonged hypotension does not decrease acute kidney injury incidence: a double blind, randomized, placebo-controlled trial
The aim was to test the primary hypothesis that in patients suffering from shock, treatment with N-acetylcysteine (NAC) plus deferoxamine (DFX) decreases the incidence of acute kidney injury (AKI).
Citation: Critical Care 2016 20:331 -
Pharmacokinetics of anidulafungin during venovenous extracorporeal membrane oxygenation
Citation: Critical Care 2016 20:325 -
Consensus development of core competencies in intensive and critical care medicine training in China
The aim of this study is to develop consensus on core competencies required for postgraduate training in intensive care medicine.
Citation: Critical Care 2016 20:330 -
Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial
Authors of recent meta-analyses have reported that prolonged glucocorticoid treatment is associated with significant improvements in patients with severe pneumonia or acute respiratory distress syndrome (ARDS)...
Citation: Critical Care 2016 20:329 -
Risk factors, host response and outcome of hypothermic sepsis
Hypothermia is associated with adverse outcome in patients with sepsis. The objective of this study was to characterize the host immune response in patients with hypothermic sepsis in order to determine if an ...
Citation: Critical Care 2016 20:328 -
Management of delayed cerebral ischemia after subarachnoid hemorrhage
For patients who survive the initial bleeding event of a ruptured brain aneurysm, delayed cerebral ischemia (DCI) is one of the most important causes of mortality and poor neurological outcome. New insights in...
Citation: Critical Care 2016 20:277 -
What is the value of regional cerebral saturation in post-cardiac arrest patients? A prospective observational study
The aim of this study was to elucidate the possible role of cerebral saturation monitoring in the post-cardiac arrest setting.
Citation: Critical Care 2016 20:327 -
Nurse-performed screening for postextubation dysphagia: a retrospective cohort study in critically ill medical patients
Swallowing difficulties are common, and dysphagia occurs frequently in intensive care unit (ICU) patients after extubation. Yet, no guidelines on postextubation swallowing assessment exist. We aimed to investi...
Citation: Critical Care 2016 20:326 -
Response to: influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation
Citation: Critical Care 2016 20:324 -
Understanding the complex host response in sepsis: is diabetes the key?
Citation: Critical Care 2016 20:321 -
Positive impact of a clinical goal-directed protocol on reducing cardiac arrests during potential brain-dead donor maintenance
The disproportion between the large organ demand and the low number of transplantations performed represents a serious public health problem worldwide. Reducing the loss of transplantable organs from deceased ...
Citation: Critical Care 2016 20:323 -
Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study
Sepsis is a prominent reason for intensive care unit (ICU) admission in patients with HIV. We aimed to investigate the impact of HIV infection on presentation, outcome and host response in sepsis.
Citation: Critical Care 2016 20:322 -
Nomenclature for renal replacement therapy in acute kidney injury: basic principles
This article reports the conclusions of a consensus expert conference on the basic principles and nomenclature of renal replacement therapy (RRT) currently utilized to manage acute kidney injury (AKI). This mu...
Citation: Critical Care 2016 20:318 -
Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications
This article reports the conclusions of the second part of a consensus expert conference on the nomenclature of renal replacement therapy (RRT) techniques currently utilized to manage acute kidney injury and o...
Citation: Critical Care 2016 20:283 -
Preoperative plasma growth-differentiation factor-15 for prediction of acute kidney injury in patients undergoing cardiac surgery
Growth-differentiation factor-15 (GDF-15) is an emerging humoral marker for risk stratification in cardiovascular disease. Cardiac-surgery-associated acute kidney injury (CSA-AKI), an important complication in...
Citation: Critical Care 2016 20:317 -
Noninvasive ventilation for avoidance of reintubation in patients with various cough strength
Reintubation is associated with high mortality. Identification of methods to avoid reintubation is needed. The aim of this study was to assess whether prophylactic noninvasive ventilation (NIV) would benefit p...
Citation: Critical Care 2016 20:316 -
Fundamentals of aerosol therapy in critical care
Drug dosing in critically ill patients is challenging due to the altered drug pharmacokinetics–pharmacodynamics associated with systemic therapies. For many drug therapies, there is potential to use the respir...
Citation: Critical Care 2016 20:269 -
Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients
Acute kidney injury and hyperchloremia are commonly present in critically ill septic patients. Our study goal was to evaluate the association of hyperchloremia and acute kidney injury in severe sepsis and sept...
Citation: Critical Care 2016 20:315 -
Urine biomarkers give early prediction of acute kidney injury and outcome after out-of-hospital cardiac arrest
Post-resuscitation care after out-of-hospital cardiac arrest (OHCA) is challenging due to the threat of organ failure and difficult prognostication. Our aim was to examine whether urine biomarkers could give a...
Citation: Critical Care 2016 20:314 -
Spinal cord injury: is monitoring from the injury site the future?
This paper challenges the current management of acute traumatic spinal cord injury based on our experience with monitoring from the injury site in the neurointensive care unit. We argue that the concept of bon...
Citation: Critical Care 2016 20:308 -
Decatecholaminisation during sepsis
Citation: Critical Care 2016 20:309 -
Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates
Severe sepsis is a challenge for healthcare systems, and epidemiological studies are essential to assess its burden and trends. However, there is no consensus on which coding strategy should be used to reliabl...
Citation: Critical Care 2016 20:313 -
Should we treat pyrexia? And how do we do it?
The concept of pyrexia as a protective physiological response to aid in host defence has been challenged with the awareness of the severe metabolic stress induced by pyrexia. The host response to pyrexia varie...
Citation: Critical Care 2016 20:303 -
Dramatic reduction of mortality in pneumococcal meningitis
Acute bacterial meningitis is still a life threatening disease.
Citation: Critical Care 2016 20:312 -
Near-infrared spectroscopy for assessing tissue oxygenation and microvascular reactivity in critically ill patients: a prospective observational study
Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome. The aim of this study was to detect alterations in tissue oxygenation or microvascular re...
Citation: Critical Care 2016 20:311 -
New aspects in the management of pneumonia
Despite improvements in the management of community-acquired pneumonia (CAP), morbidity and mortality are still high, especially in patients with more severe disease. Early and appropriate antibiotics remain t...
Citation: Critical Care 2016 20:267 -
Real-time point of care microcirculatory assessment of shock: design, rationale and application of the point of care microcirculation (POEM) tool
Despite over a decade of research and technological advances, sublingual microcirculatory monitoring has not yet reached clinical utility. Offline analysis is time consuming and occurs away from the patient. A...
Citation: Critical Care 2016 20:310 -
The value of poly-urethane cuffed endotracheal tubes
Citation: Critical Care 2016 20:290 -
Iron supplementation to treat anaemia in adult critical care patients: a systematic review and meta-analysis
Anaemia affects 60–80 % of patients admitted to intensive care units (ICUs). Allogeneic red blood cell (RBC) transfusions remain the mainstay of treatment for anaemia but are associated with risks and are cost...
Citation: Critical Care 2016 20:306 -
Post-cardiac arrest mortality is declining in the UK
Citation: Critical Care 2016 20:304 -
Pre-emptive antibiotic therapy to reduce ventilator-associated pneumonia: “thinking outside the box”
Mechanically ventilated, intubated patients are at increased risk for tracheal colonization with bacterial pathogens that may progress to heavy bacterial colonization, ventilator-associated tracheobronchitis (...
Citation: Critical Care 2016 20:300 -
Bleeding complications of anticoagulant therapy in sepsis-induced disseminated intravascular coagulation
Citation: Critical Care 2016 20:307 -
Can diaphragmatic ultrasonography performed during the T-tube trial predict weaning failure? The role of diaphragmatic rapid shallow breathing index
The rapid shallow breathing index (RSBI), which is the ratio between respiratory rate (RR) and tidal volume (VT), is one of the most widely used indices to predict weaning outcome. Whereas the diaphragm plays ...
Citation: Critical Care 2016 20:305 -
Adrenaline use is associated with excess organ injury and mortality in cardiogenic shock: facts and fiction
Citation: Critical Care 2016 20:292 -
Vasopressors and inotropes in cardiogenic shock: is there room for “adrenaline resuscitation”?
Citation: Critical Care 2016 20:302 -
Stress hyperglycaemia in critically ill patients and the subsequent risk of diabetes: a systematic review and meta-analysis
Hyperglycaemia occurs frequently in critically ill patients without diabetes. We conducted a systematic review and meta-analysis to evaluate whether this ‘stress hyperglycaemia’ identifies survivors of critica...
Citation: Critical Care 2016 20:301 -
Acute kidney injury 2016: diagnosis and diagnostic workup
Acute kidney injury (AKI) is common and is associated with serious short- and long-term complications. Early diagnosis and identification of the underlying aetiology are essential to guide management. In this ...
Citation: Critical Care 2016 20:299 -
Real-life use of vasopressors and inotropes in cardiogenic shock—observation is necessarily ‘theory-laden’
Citation: Critical Care 2016 20:293
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- ISSN: 1364-8535 (electronic)