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Citation: Critical Care 2019 23:199
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Post-stroke treatment with argon attenuated brain injury, reduced brain inflammation and enhanced M2 microglia/macrophage polarization: a randomized controlled animal study
In recent years, argon has been shown to exert neuroprotective effects in an array of models. However, the mechanisms by which argon exerts its neuroprotective characteristics remain unclear. Accumulating evid...
Citation: Critical Care 2019 23:198 -
Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis
Septic shock is the most severe form of sepsis, in which profound underlying abnormalities in circulatory and cellular/metabolic parameters lead to substantially increased mortality. A clear understanding and ...
Citation: Critical Care 2019 23:196 -
Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death
Despite the essential functions of the intestinal microbiota in human physiology, little has been reported about the microbiome in neurocritically ill patients. This investigation aimed to evaluate the charact...
Citation: Critical Care 2019 23:195 -
Automated continuous noninvasive ward monitoring: future directions and challenges
Automated continuous noninvasive ward monitoring may enable subtle changes in vital signs to be recognized. There is already some evidence that automated ward monitoring can improve patient outcome. Before aut...
Citation: Critical Care 2019 23:194 -
Acute kidney injury after cardiac arrest: the role of coronary angiography and temperature management
Citation: Critical Care 2019 23:193 -
Continuous monitoring of intrinsic PEEP based on expired CO2 kinetics: an experimental validation study
Quantification of intrinsic PEEP (PEEPi) has important implications for patients subjected to invasive mechanical ventilation. A new non-invasive breath-by-breath method (etCO2D) for determination of PEEPi is eva...
Citation: Critical Care 2019 23:192 -
Albumin infusion rate and plasma volume expansion: a randomized clinical trial in postoperative patients after major surgery
Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is a...
Citation: Critical Care 2019 23:191 -
Procalcitonin levels in candidemia versus bacteremia: a systematic review
Procalcitonin (PCT) is a biomarker used to assess systemic inflammation, infection, and sepsis and to optimize antimicrobial therapies. Its role in the in the differential diagnosis between candidemia and bact...
Citation: Critical Care 2019 23:190 -
Red blood cell transfusion may be more detrimental than anemia for the clinical outcome of patients with severe traumatic brain injury
Citation: Critical Care 2019 23:189 -
Letter on “Sigh maneuver to enhance assessment of fluid responsiveness during pressure support ventilation”
Citation: Critical Care 2019 23:188 -
Identifying patients’ support needs following critical illness: a scoping review of the qualitative literature
Intensive care survivors suffer chronic and potentially life-changing physical, psychosocial and cognitive sequelae, and supporting recovery is an international priority. As survivors’ transition from the inte...
Citation: Critical Care 2019 23:187 -
Describing organ dysfunction in the intensive care unit: a cohort study of 20,000 patients
Multiple organ dysfunction is a common cause of morbidity and mortality in intensive care units (ICUs). Original development of the Sequential Organ Failure Assessment (SOFA) score was not to predict outcome, ...
Citation: Critical Care 2019 23:186 -
Clinically relevant pharmacokinetic knowledge on antibiotic dosing among intensive care professionals is insufficient: a cross-sectional study
Antibiotic exposure in intensive care patients with sepsis is frequently inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the intensive care, as critically ill patients ha...
Citation: Critical Care 2019 23:185 -
Endocan removal during continuous renal replacement therapy: does it affect the reliability of this biomarker?
Citation: Critical Care 2019 23:184 -
How to treat combined respiratory and metabolic acidosis after extracorporeal cardiopulmonary resuscitation?
Citation: Critical Care 2019 23:183 -
An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial
Sepsis remains one of the most important causes of morbidity and mortality worldwide. In approximately 30–50% of cases of suspected sepsis, no pathogen is isolated, disabling the clinician to treat the patient...
Citation: Critical Care 2019 23:182 -
Response
Citation: Critical Care 2019 23:181 -
High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation: a systematic review and meta-analysis
The effect of high-flow nasal cannula (HFNC) therapy in patients after planned extubation remains inconclusive. We aimed to perform a rigorous and comprehensive systematic meta-analysis to robustly quantify th...
Citation: Critical Care 2019 23:180 -
Time course of fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study
Fluid challenge (FC) is one of the most common practices in Intensive Care Unit (ICU). The present study aimed to evaluate whether echocardiographic assessment of the response to FC at the end of the infusion ...
Citation: Critical Care 2019 23:179 -
Are we really preventing lung collapse with APRV?
Citation: Critical Care 2019 23:178 -
How I manage a difficult intubation
Citation: Critical Care 2019 23:177 -
How I ventilate an obese patient
Citation: Critical Care 2019 23:176 -
Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample
Timely initiation of physical, occupational, and speech therapy in critically ill patients is crucial to reduce morbidity and improve outcomes. Over a 5-year time interval, we sought to determine the utilizati...
Citation: Critical Care 2019 23:175 -
Should ECMO be used in cardiogenic shock?
Citation: Critical Care 2019 23:174 -
The challenge of removal of sepsis markers by continuous hemofiltration
Citation: Critical Care 2019 23:173 -
Temporal change in characteristics and outcomes of acute kidney injury on renal replacement therapy in intensive care units: analysis of a nationwide administrative database in Japan, 2007–2016
We aimed to examine recent trends in patient characteristics and mortality in patients with acute kidney injury (AKI) receiving renal replacement therapy (RRT), including continuous RRT (CRRT) and intermittent...
Citation: Critical Care 2019 23:172 -
Near-infrared spectroscopy after out-of-hospital cardiac arrest
Cerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is...
Citation: Critical Care 2019 23:171 -
Is systematic fecal carriage screening of extended-spectrum beta-lactamase-producing Enterobacteriaceae still useful in intensive care unit: a systematic review
Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) are disseminating worldwide leading to increased hospital length of stay and mortality in intensive care units (ICU). ESBL-E dissemination wa...
Citation: Critical Care 2019 23:170 -
Nuclear magnetic resonance-based serum metabolomic analysis reveals different disease evolution profiles between septic shock survivors and non-survivors
Septic shock is the most severe phase of sepsis and is associated with high rates of mortality. However, early stage prediction of septic shock outcomes remains difficult. Metabolomic techniques have emerged a...
Citation: Critical Care 2019 23:169 -
Comparative efficacy of vasoactive medications in patients with septic shock: a network meta-analysis of randomized controlled trials
Catecholamines, especially norepinephrine, are the most frequently used vasopressors for treating patients with septic shock. During the recent decades, terlipressin, vasopressin V1A agonist, and even Ca2+ sensit...
Citation: Critical Care 2019 23:168 -
Letter in response to “Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury”
Citation: Critical Care 2019 23:167 -
Inducible metabolic pathway for citrate metabolism in case of major liver dysfunction: fact or fiction?
Citation: Critical Care 2019 23:166 -
Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders
At least a third of the world’s population consumes alcohol regularly. Patients with alcohol use disorders (AUDs) are frequently hospitalized for both alcohol-related and unrelated medical conditions. It is we...
Citation: Critical Care 2019 23:165 -
Hypothermia after decompressive hemicraniectomy in treatment of malignant middle cerebral artery stroke: comment on the randomized clinical trial
Citation: Critical Care 2019 23:164 -
Renal function after out-of-hospital cardiac arrest; the influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial
To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal func...
Citation: Critical Care 2019 23:163 -
Pyroglutamic acidosis by glutathione regeneration blockage in critical patients with septic shock
The aim of this study was to evaluate oxidative stress from glutathione depletion in critically ill patients with a septic shock through the abnormal presence of pyroglutamic acid (PyroGlu) in the urine (indir...
Citation: Critical Care 2019 23:162 -
The effect of adhesive tape versus endotracheal tube fastener in critically ill adults: the endotracheal tube securement (ETTS) randomized controlled trial
The optimal securement method of endotracheal tubes is unknown but should prevent dislodgement while minimizing complications. The use of an endotracheal tube fastener might reduce complications among critical...
Citation: Critical Care 2019 23:161 -
How I monitor cerebral autoregulation
Citation: Critical Care 2019 23:160 -
Fluid management in patients undergoing cardiac surgery: effects of an acetate- versus lactate-buffered balanced infusion solution on hemodynamic stability (HEMACETAT)
Recent evidence suggests that acetate-buffered infusions result in better hemodynamic stabilization than 0.9% saline in patients undergoing major surgery. The choice of buffer in balanced crystalloid solutions...
Citation: Critical Care 2019 23:159 -
Retrospective cohort study of hospital variation in airway management during in-hospital cardiac arrest and the association with patient survival: insights from Get With The Guidelines-Resuscitation
The optimal approach to airway management during in-hospital cardiac arrest is unknown.
Citation: Critical Care 2019 23:158 -
Does training level affect the accuracy of visual assessment of capillary refill time?
Citation: Critical Care 2019 23:157 -
Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials
Randomised controlled trials (RCTs) enrolling patients with sepsis or acute respiratory distress syndrome (ARDS) generate heterogeneous trial populations. Non-random variation in the treatment effect of an int...
Citation: Critical Care 2019 23:156 -
Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury
Elevated intracranial pressure (ICP) is frequent after traumatic brain injury (TBI) and may cause abnormal pupillary reactivity, which in turn is associated with a worse prognosis. Using automated infrared pup...
Citation: Critical Care 2019 23:155 -
When circulatory death does not come in time in potential organ donors
Citation: Critical Care 2019 23:154 -
Social and economic problems of ICU survivors identified by a structured social welfare consultation
Citation: Critical Care 2019 23:153 -
Influenza and associated co-infections in critically ill immunosuppressed patients
It is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure.
Citation: Critical Care 2019 23:152 -
Procalcitonin is an essential biomarker for hydrocortisone, ascorbic acid, and thiamine (HAT) therapy in patients with sepsis
Citation: Critical Care 2019 23:151 -
The global challenge of Candida auris in the intensive care unit
Citation: Critical Care 2019 23:150 -
Renin-angiotensin-aldosterone system blockers after KDIGO stage 3 acute kidney injury: use and impact on 2-year mortality in the AKIKI trial
Citation: Critical Care 2019 23:148
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- ISSN: 1364-8535 (electronic)