Page 42 of 139
A decrease of small nerve fibers in skin biopsies during the course of critical illness has been demonstrated recently. However, the diagnostic use of skin biopsies in sepsis and its time course is not known.
Left ventricular diastolic dysfunction is associated with mortality outcomes in severe sepsis and septic shock. There are ongoing issues ... to identify diastolic dysfunction in patients with severe sepsis and se...
This article is part of a Supplement: Volume 5 Supplement 1
This article is part of a Supplement: Volume 28 Supplement 1
This article is part of a Supplement: Volume 6 Supplement 1
This article is part of a Supplement: Volume 25 Supplement 1
One of the therapeutic essentials in severe sepsis and septic shock is an adequate fluid...
Developing dementia is feared by many for its detrimental effects on cognition and independence. Experimental and clinical evidence suggests that sepsis is a risk factor for the later ... We aimed to investigate ...
Sepsis in critically ill patients is almost associated ... discovered marker for muscle degradation in patients with sepsis. The hypothesis of the present study is ... of serum 20S proteasome at early diagnosis o...
This article is part of a Supplement: Volume 26 Supplement 1
Systemic inflammatory response syndrome (SIRS) is a frequent condition after cardiopulmonary bypass (CPB) and makes conventional biological tests fail to detect postoperative sepsis. Biphasic waveform (BPW) analy...
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Elevated plasma B-type natriuretic peptide (BNP) levels in patients with critical sepsis (severe sepsis and septic shock) may indicate septic cardiomyopathy ... addition, the prognostic value of BNP in sepsis rem...
Sepsis is characterized by systemic immune activation and...
A total of 273 patients (197 with sepsis, 76 without sepsis) were studied prospectively upon admission to the...
Sepsis has a high mortality rate, but no ... prompting the development of new drugs. Immunologically, sepsis can involve hyperinflammation, immune paralysis, or ... , but it has never been tested for sepsis.
Severe sepsis, septic shock, and resulting organ failure ... or apoptosis plays the predominant role in severe sepsis. Determining the prevalent mode of cell death ... may improve unsatisfactory outcomes in patie...
On admission to the Medical ICU, 170 patients (122 with sepsis, 48 without sepsis) were studied prospectively and compared with 60...
Impaired T cell function in sepsis is associated with poor outcome, but the ... during acute human infectious disease and in particular sepsis remains unknown. Hypoarginemia is prevalent in sepsis. This study aim...
Bacteremia is recognized as a critical condition that influences the outcome of sepsis. Although large-scale surveillance studies of bacterial...
Gram-negative bacteremia has been associated with severe sepsis, although the exact mechanism and pathophysiological differences...Critical Care..., Abe and colleagues report results of a retrospective study that...
High-mobility group box-1 protein (HMGB1) has been known as a chromosomal protein for many years. HMGB1 has recently been shown to be a proinflammatory cytokine with a role in the immunopathogenesis of sepsis. Li...
Genome-wide expression data were compared between patients with SIRS having negative bacterial cultures (n = 21) and patients with sepsis having positive bacterial cultures (n...= 60). Differentially expressed ge...
C-type natriuretic peptide (CNP) is a paracrine molecule which is mainly synthesized in the vasculature. High levels have been reported in sepsis, and CNP has been proposed as a biomarker predicting sepsis in tra...
The incidence of sepsis can be estimated between 250 and 500 ... of the most relevant global health problems, sepsis is the condition that generates the highest ... information about how changes in the management...
An excessive inflammatory response is thought to account for the pathogenesis of sepsis and multiple organ dysfunction syndrome (MODS) ... polymorphisms with IL-10 production and incidence of sepsis and MODS.
The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect...
Cell death is a central event in the pathogenesis of sepsis and is reflected by circulating nucleosomes. Circulating ... demonstrated to correlate with severity and outcome in sepsis patients. We recently showed ...
The chemokine CXCL10 is produced during infection and inflammation to activate the chemokine receptor CXCR3, an important regulator of lymphocyte trafficking and activation. The goal of this study was to asses...
Innate immune suppression occurs commonly in pediatric critical illness, in which it is associated with adverse outcomes. Less is known about the adaptive immune response in critically ill children with sepsis. W...
Increasing evidence indicates that epidural anesthesia improves postoperative pulmonary function. The underlying mechanisms, however, remain to be determined. Because pulmonary nitric oxide has been identified to...
The role of reactive carbonyl species, such as methylglyoxal (MG), has been overlooked within the context of the sepsis syndrome. The aims of this study were ... early diagnosis as well as prognosis of the sepsis
In almost half of all sepsis patients, acute kidney injury (AKI) develops. However, the pathobiologic differences between sepsis patients with and without AKI are only ... in two clinically relevant large-animal ...
Acute kidney injury (AKI) is a common and feared complication of sepsis. The pathogenesis of sepsis-induced AKI is largely unknown, and therapeutic ... renal function and reduce renal damage in experimental sepsis
Using the database from a large prospective European study, we studied 2,933 patients who had stayed more than 48 hours in the ICU and described patterns of organ failure and their relation to outcome. Patients w...
This article is part of a Supplement: Volume 17 Supplement 3
This article is part of a Supplement: Volume 17 Supplement 3
Experimental studies demonstrate beneficial immunological and hemodynamic effects of estradiol in animal models of sepsis. This raises the question whether estradiol contributes ... sex differences in the inciden...
A reanalysis of the ALBIOS trial suggested that patients with septic shock - defined by vasopressor-dependent hypotension in the presence of severe sepsis (Shock-2) - had a survival...
In this cohort study, we investigated whether monitoring blood levels of immature neutrophils (myelocytes, metamyelocytes and band cells) differentiated patients with sepsis from those with the non-infectious (N....
This article is part of a Supplement: Volume 21 Supplement 1
The Erratum to this article has been published in Critical Care 2017 21:182
Primary causes of death were reviewed from 144 pediatric autopsy reports. Percentages of patients that died from anoxic brain injuries, sepsis, or multi-organ failure were calculated by...P < 0.05.
In a previous study with 96 septic patients, we found that circulating platelets in 6-months surviving septic patients showed higher activity and quantity of cytochrome c oxidase (COX) normalized by citrate synth...
This review examines experimental evidence that the microvascular dysfunction that occurs early in sepsis is the critical first stage in tissue ... However, within hours of the onset of sepsis, a dysfunctional mi...
This article is part of a Supplement: Volume 9 Supplement 4
Great white sharks are responsible for about 10 cases of death annually worldwide, as compared with millions of deaths caused by sepsis. However, the basic principles of avoiding shark attacks and fighting sepsis
This article is part of a Supplement: Volume 19 Supplement 3
The present study was conducted to assess the value of serum concentration of lipopolysaccharide-binding protein (LBP) in patients with systemic inflammatory response syndrome (SIRS), sepsis and septic shock with...
There are minimal data in the medical literature determining thefrequency or outcome of patients with a low SVR that is unrelated to sepsis orthe sepsis syndrome. We retrospectively reviewed and analyzed all...5w...
Severe infection and sepsis are common causes of morbidity and mortality. ... inflammatory response syndrome (SIRS) and those with sepsis in patients suffering from a broad range...
This article is part of a Supplement: Volume 14 Supplement 2
This article is part of a Supplement: Volume 12 Supplement 2
Critical Care