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Reversible myocardial depression occurs early in severe sepsis and septic shock. The question of whether...
Susceptibility and response to infectious disease is, in part, heritable. Initial attempts to identify the causal genetic polymorphisms have not been entirely successful because of the complexity of the genetic, ...
Current criteria for early diagnosis of coagulopathy in sepsis are limited. We postulated that coagulopathy is already complicated with sepsis in the initial phase, and severe coagulopathy ... subsequent developm...
The impact of in vitro...resistance on initially appropriate antibiotic therapy (IAAT) remains unclear. We elucidated the relationship between non-IAAT and mortality, and between IAAT and multi-drug resistance (M...
Sepsis is a life-threatening condition arising from...+...monocyte phenotype with immune suppressive properties termed “monocyte state 1” (MS1) in patients with sepsis. Our objective was to determine the associat...
Sepsis-associated encephalopathy is a severe neurologic syndrome ... a diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of ... patient outcomes deserves to be further inv...
Hyperferritinemia is associated with increased mortality in pediatric sepsis, multiple organ dysfunction syndrome (MODS), ... hypothesized that patients with hyperferritinemia associated secondary HLH/sepsis/MODS...
Most patients with sepsis develop potentially irreversible cerebral dysfunctions. It is ... clear whether cerebral haemodynamics are altered in these sepsis patients at all, and to what extent ... dioxide reactiv...
Early identification of septic patients at high risk of dying remains a challenge. The prognostic role of brain natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) in septic pati...
Different isoforms of nitric oxide synthases (NOS) and determinants of oxidative/nitrosative stress play important roles in the pathophysiology of pulmonary dysfunction induced by acute lung injury (ALI) and sepsis
There is conflicting evidence on association between quick sequential organ failure assessment (qSOFA) and sepsis mortality in ICU patients. The primary aim ... 28-day mortality in ICU patients admitted for sepsis
The Matters Arising to this article has been published in Critical Care 2024 28:59
Increased vascular permeability represents one of the hallmarks of sepsis. In the kidney, vascular permeability is ... the GFB and its glycocalyx are altered during sepsis, no study has specifically addressed thi...
The large, international, randomized controlled NeoPInS trial showed that procalcitonin (PCT)-guided decision making was superior to standard care in reducing the duration of antibiotic therapy and hospitalizatio...
Sepsis is a complex syndrome that develops when ... , the diversity of the clinical presentation of sepsis, the response to current medical treatment, ... patients at high risk for the development of sepsis and o...
Sepsis-related multiple organ dysfunction is a common ... the intensive care unit. The effect of sepsis on markers of tissue repair is only ... measure markers of collagen synthesis and degradation during sepsis ...
Sepsis is characterized by systemic microvascular dysfunction. Endothelial ... endothelial progenitor cell system in patients suffering from sepsis with acute renal dysfunction.
The purpose of the present study was to evaluate the effects of intravenous lornoxicam on haemodynamic and biochemical parameters, serum cytokine levels and patient outcomes in severe sepsis.
Twenty-four anesthetized and mechanically ventilated pigs were randomly assigned (n = 8/group) to a septic control group (septic-CG) without resuscitation until death or one of two groups with resuscitation perfo...
Sepsis is a life-threatening condition characterised by ... role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies...
The impact of gender on outcome in critically ill patients is unclear. Weinvestigated the influence of gender on the epidemiology of severe sepsis andassociated morbidity and mortality in a large...
The aim of this study is to evaluate the effects of emergency department (ED) crowding on the implementation of tasks in the early resuscitation bundle during acute care of patients with severe sepsis and septic ...
Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is a known complication of sepsis. However, its pathophysiology remains unclear. The ... preventing BBB damage and pituitary dysfunc...
Many studies have shown that monocyte human leukocyte antigen-DR (mHLA-DR) expression may be a good predictor for mortality in severe septic patients. On the contrary, other studies found mHLA-DR was not a useful...
Inflammation and coagulation are closely linked, and both can be triggered by endotoxin. Thrombelastometry and impedance aggregometry are of diagnostic and predictive value in critically ill patients. In this ...
To investigate the effects of G-CSF or GM-CSF therapy in non-neutropenic patients with sepsis.
Recent epidemiologic literature indicates that candidal species resistant to azoles are becoming more prevalent in the face of increasing incidence of hospitalizations with candidemia. Echinocandins, a new cla...
Early CVVHDF may improve the prognosis of sepsis-related multiple organ failure. Failure to correct...
The protective effect of glutamine, as a pharmacological agent against lung injury, has been reported in experimental sepsis; however, its efficacy at improving oxygenation...
Meropenem dosing for septic critically patients is difficult due to pathophysiological changes associated with sepsis as well as supportive symptomatic therapies. A...
Circulating histones have been identified as mediators of damage in animal models of sepsis and in patients with trauma-associated lung ... various disease conditions, histone levels in human sepsis, association ...
Of the 8,670 patients with septic shock, 2,882 (33.2%) had height and weight data recorded at ICU admission and constituted the study group. Obese patients were more likely to have skin and soft tissue infections...
Procalcitonin (PCT) algorithms for antibiotic treatment decisions have been studied in adult patients from primary care, emergency department, and intensive care unit (ICU) settings, suggesting that procalcitonin...
The availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perfuse...
Knowledge of the association of hemodynamics with progression of septic acute kidney injury (AKI) is limited. However, some recent data suggest that mean arterial pressure (MAP) exceeding current guidelines (60–6...
Sepsis-associated acute kidney injury (SA-AKI)...
The current shortage of accurate and readily available, validated biomarkers of disease severity in sepsis is an important limitation when attempting to ... cytokine profile in plasma of patients with severe sepsis
Natural killer (NK) cells play a major role in immune tolerance after sepsis, and the programmed cell death 1 ( ... NK cells and the prognosis of patients with sepsis, however, has not been elucidated. Thus ... b...
Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet...
Biomarkers, such as C-reactive protein [CRP] and procalcitonin [PCT], are insufficiently sensitive or specific to stratify patients with sepsis. We investigate the prognostic value of pancreatic...reg) concentrat...
One hundred and sixty consecutive patients were included: 43 SIRS without sepsis and 117 with sepsis. Levels of CRP and PCT, but ... count, were significantly higher in patients with sepsis than in SIRS-no sepsis
It has been proposed that doses of amikacin of >15 mg/kg should be used in conditions associated with an increased volume of distribution (Vd), such as severe sepsis and septic shock. The primary aim of...
Sepsis is a severe and life-threatening systemic ... populations and age groups. The pathophysiology of sepsis is associated with aberrant interaction between leukocytes ... the predictive value of soluble adhesi...
Individuals deficient in mannose-binding lectin (MBL), an important component of the innate immune system, show increased susceptibility to infection. We investigated whether polymorphisms in the MBL2 gene and th...
We administered a mail-based survey with simulated clinical vignettes to a random sample of the Critical Care Assembly of the American Thoracic Society. Vignettes represented a patient with septic shock with mult...
CD40 Ligand (CD40L) and its soluble counterpart (sCD40L) are proteins that exhibit prothrombotic and proinflammatory properties on binding to their cell surface receptor CD40. The results of small clinical studie...
To investigate the significance of changes in regulatory T cells (Tregs) activity and its relationship with sepsis, as well as outcome of patients with...
This study was carried out to determine whether interactions of cell activation, shear stress and platelets at sites of endothelial injury explain the paradoxical maldistribution of activated leukocytes during sepsis
Recombinant human activated protein C (APC) therapy has been shown to reduce short-term mortality in patients with severe sepsis. However, survivors of sepsis may have long-term complications affecting health-...
To test the hypothesis that the administration of antithrombin concentrate improves disseminated intravascular coagulation (DIC), resulting in recovery from DIC and better outcomes in patients with sepsis, we con...
Polymorphonuclear neutrophils (PMNs) play an important role in sepsis-related acute lung injury (ALI). Accumulating ... , the role of PMN-derived exosomes in sepsis-related ALI and the underlying mechanisms remai...
Critical Care