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We conducted the present study to investigate whether early large-volume crystalloid infusion can restore gut mucosal blood flow and mesenteric oxygen metabolism in severe sepsis.
Survivors from sepsis have presented with long-term cognitive impairment, ... we evaluated the effects of memory enhancers in sepsis-surviving rats.
The Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock recommend that the initial...2...], low central venous pressure [CVP], and high lactate), and higher mortality rates. ...
The usefulness of n-3 fatty acids, γ-linolenic acid and antioxidants in the critically ill is controversial. I propose that adverse outcome in the critically ill is due to excess production of proinflammatory ...
Host immunity should play a principal role in determining both the outcome and recovery of patients with sepsis that originated from a microbial infection. Quantification...
Sepsis-associated encephalopathy (SAE) is a diffuse ... shown to improve mortality in patients with severe sepsis-induced organ failure. We studied the effect...
Procalcitonin (PCT) and C-reactive protein (CRP) are established markers of infection in the general population. In contrast, several studies reported falsely increased PCT levels in patients receiving T-cell ...
Cellular signaling by proteases of the blood coagulation cascade through members of the protease-activated receptor (PAR) family can profoundly impact on the inflammatory balance in sepsis. The coagulation initia...
In our previous studies we demonstrated that CXC chemokine receptor 3 (CXCR3) participates in the regulation of lymphocyte trafficking during cecal ligation and puncture (CLP)-induced sepsis. In this study, we ev...
Early structured resuscitation of severe sepsis has been suggested to improve short term ... in the emergency department (ED) care of sepsis.
Increased serum levels of procalcitonin (ProCT) and its componentpeptides have been reported in humans with sepsis. Using a hamster model ofbacterial peritonitis,...
Severe critical illness-induced immune suppression, termed immunoparalysis, is associated with longer duration of organ dysfunction in septic children. mRNA studies have suggested differential benefit of hydrocor...
The pathogenesis of sepsis-induced multiple organ failure may crucially depend...
Sixteen of the 52 patients investigated died within 3 months of sampling. Nineteen of the 52 patients developed either severe sepsis or septic shock. Plasma DNA was higher ... and was also higher in patients who ...
Administration of dexmedetomidine has been reported to improve inflammatory response in animals. We explored the effects of administering dexmedetomidine on the levels of C-reactive protein (CRP) and procalcitoni...
With the approval from the institutional Research Ethics Board and after obtaining written informed consent from patients or their substitute decision maker, mechanically ventilated patients with sepsis and patie...
Neural networks are new methodological tools based on nonlinear models. They appear to be better at prediction and classification in biological systems than do traditional strategies such as logistic regression. ...
Enrollment problems are common among randomized controlled trials conducted in the ICU. However, little is known about actual trial enrollment rates and influential factors. We set out to determine the overall en...
Sepsis and septic shock are leading causes of ... exchange has the potential to improve survival in sepsis by removing inflammatory cytokines and restoring deficient ... and safety of plasma exchange in patients ...
Neuroinflammation often develops in sepsis along with increasing permeability of the blood- ... autopsy specimens in critically ill patients deceased with sepsis and analyzed the relationship of BBB damage...
We studied the incidence of withholding or withdrawing therapeutic measures in intensive care unit (ICU) patients, as well as the possible implications of sepsis-related organ failure assessment (SOFA) in...
The relationship between oxygen delivery and consumption in sepsis is impaired, suggesting a microcirculatory perfusion defect ... skeletal muscle capillary perfusion and tissue oxygenation in sepsis.
Patients with alcohol use disorders (AUD) are at increased risk of developing sepsis and have higher mortality. AUD are associated...
Albumin has potential endothelial protective effects through antioxidant and anti-inflammatory properties. However, the effect of albumin on peripheral tissue perfusion in human sepsis remains poorly known.
The Matters Arising to this article has been published in Critical Care 2024 28:79
A secondary analysis of a matched case-control study conducted at an oncologic medical-surgical intensive care unit (ICU) was performed, segregating patients with severe sepsis/septic shock. The impact of neutrop...
Sepsis is the main cause of morbidity and ... of infection may improve its usefulness as a sepsis marker. In the present article, we...
In this prospective, randomized controlled study, we aimed to evaluate the effect of IgM-enriched immunoglobulin treatment on progression of organ failure and septic shock in patients with severe sepsis.
Sepsis activates the coagulation system and frequently causes ... has not so far been used to investigate sepsis-induced hypercoagulability. Antithrombin (AT) in plasma...
The purpose of the present study was to evaluate the effects of continuously infused N...-acetyl-L-cystein (NAC) on serum cytokine levels and gastric intramucosal pH in humans suffering from severe sepsis.
The Erratum to this article has been published in Critical Care 2016 20:403
Despite sound basis to suspect that aggressive and early administration of nutritional support may hold therapeutic benefits during sepsis, recommendations for nutritional support have been somewhat ... demonstra...
The Letter to this article has been published in Critical Care 2020 24:254
Lymphocyte apoptosis and monocyte dysfunction play a pivotal role in sepsis-induced immunosuppression. Programmed death-1 (PD1) ... has been shown to improve survival in murine sepsis. However, PD-L1 and PD-1 ......
Activation of the coagulation system is a fundamental host defense mechanism. Microorganisms that have invaded the body are trapped and disposed of in clots. Monocytes/macrophages are widely accepted as the main ...
Chemokines are a superfamily of small peptides involved in leukocyte chemotaxis and in the induction of cytokines in a wide range of infectious diseases. Little is known about their role in meningococcal sepsis i...
We conducted the present study to assess the validity of mortality prediction systems in patients admitted to the intensive care unit (ICU) with severe sepsis and septic shock. We included Acute Physiology...0 an...
Treatment of sepsis is aimed at increasing both the duration ... life (QoL) in clinical trial evaluations of sepsis care should be a priority.
Protein C, because of its central role in hemostasis, plays an integral role in the host response to infection. Protein C depletion, resulting from increased consumption, degradation, and/or decreased synthesis, ...
During sepsis, the liver plays a key role. ... the clearance of the infectious agents/products. Sepsis also induces liver damage through hemodynamic alterations ... through both. Accordingly, liver dysfunction in...
Sepsis is a deadly inflammatory condition that often...
Over the past decade several investigators have applied microarray technology and related bioinformatic approaches to clinical sepsis and septic shock, thus allowing for an ... genomic medicine has meaningfully i...
Myocardial dysfunction frequently accompanies severe sepsis and septic shock. Whereas myocardial depression was ... fraction is present in most patients with severe sepsis and septic shock. Myocardial depression ...
The aim of this study was to derive a novel prognostic score for mortality in paediatric meningococcal sepsis (MS) based on readily available laboratory...
Severe sepsis is characterised by intravascular or extravascular infection...in vivo.... This study aimed to investigate the acute effects of the more stable Ang-1 variant matrilin-1-angiopoietin-1 (MAT.Ang-1) on...
To assess changes in renal blood flow (RBF) in human and experimental sepsis, and to identify determinants of RBF.
The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly...
The Matters Arising to this article has been published in Critical Care 2024 28:9
The Matters Arising to this article has been published in Critical Care 2023 27:480
Previous cost-effectiveness analyses (CEA) reported that Drotrecogin alfa (DrotAA) is cost-effective based on a Phase III clinical trial (PROWESS). There is little evidence on whether DrotAA is cost-effective in ...
In this two-centre randomised clinical trial, critically ill patients with sepsis or septic shock were randomised to AutoKinetics...
On one side, brain dysfunction is a poorly explored complication of sepsis. On the other side, brain dysfunction may actively contribute to the pathogenesis of sepsis. The current review aimed at summarizing the ...
In sepsis, mitochondria have been associated with both initial ... However, the evolvement of mitochondrial function in sepsis over time is largely unknown, and we ... in peripheral blood immune cells (PBICs) in
Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (...
Cecal ligation and puncture (CLP) is an inflammatory condition that leads to multisystemic organ failure. Flavocoxid, a dual inhibitor of cyclooxygenase (COX-2) and 5-lipoxygenase (5-LOX), has been shown in vitro
Critical Care