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The objective of this study was to identify and characterize the most highly cited clinical research articles published on sepsis.
Sepsis is still a leading cause of morbidity ... (depolarization) were found in different tissues during sepsis. Previous work suggests that mitochondrial dysfunction of platelets correlates with clinical disease...
Sepsis represents a dysregulated host response to infection, ... of the biological rationale for using IVIg in sepsis. A literature search was conducted using the ... intravenous immunoglobulin, immunoglobulin, i...
Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of ... patients. Though most studies of AKI in sepsis have focused on tubular epithelial in...
Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The prim...
Activation of inflammation and coagulation was closely related and mutually interdependent in sepsis. Tissue factor (TF) and its endogenous ... TFPI have been related to worse outcome in sepsis. The objective of ...
The purpose of this study was to assess the relation between glycaemic control and the severity of sepsis in a cohort of patients treated with...
Matrix metalloproteinases (MMPs) play a role in infectious diseases through extracellular matrix (ECM) degradation, which favors the migration of immune cells from the bloodstream to sites of inflammation. Althou...
Matrix metalloproteinases (MMPs) have various roles in inflammatory states. They seem to be able to modulate endothelial barriers and regulate the activity of chemokines and cytokines. The timely development of t...
This article is part of a Supplement: Volume 17 Supplement 2
Sepsis represents a major worldwide healthcare burden. However ... is related to the long-term risk of sepsis-related mortality in low- and middle-income...
Fungal sepsis is an increasingly common problem in intensive care unit patients.Mortality from fungal sepsis remains high despite antimicrobial therapy that is ... recognized immunologic defect that occurs in pat...
Measurement of biomarkers is a potential approach to early assessment and prediction of mortality in patients with sepsis. The aim of the present study was...
Sepsis involves the dynamic interplay between a pathogen, ... far. While it is generally accepted that sepsis is very complex indeed, the concepts, ... remain underappreciated. In this perspective we view sepsis ...
Sepsis survivors are at elevated risk for cardiovascular ... -up. Whether diabetes influences cardiovascular risk after sepsis survival remains unknown. We sought to describe ... diabetes with long-term cardiovas...
The aim of this study was to determine if there are differences between patients with pre-existing left ventricular dysfunction and those with normal antecedent left ventricular function during a sepsis episode i...
Pharmacological agents that block beta-adrenergic receptors have been associated with improved outcome in burn injury. It has been hypothesized that injuries leading to a hypermetabolic state, such as septic shoc...
Gene expression profiling was performed via DNA microarrays in leukocytes from critically ill trauma patients nonseptic upon admission to the ICU, who subsequently developed either sepsis (n = 2) or severe sepsis
This article is part of a Supplement: Volume 10 Supplement 1
Implementation of biomarkers in sepsis and septic shock in emergency situations, remains ... day workshop aiming to facilitate the transition of sepsis biomarkers into clinical practice. The authors consist ... t...
This article is part of a Supplement: Volume 11 Supplement 2
Cancer and sepsis share risk factors, and sepsis patients may have impaired immune response and ... care. This study aimed to assess whether sepsis survivors are at increased risk for cancer. ... the incidence of...
This article is part of a Supplement: Volume 12 Supplement 2
Deregulated apoptosis and overshooting neutrophil functions contribute to immune and organ dysfunction in sepsis and multiple organ failure (MOF). In ... posttraumatic neutrophil extrinsic apoptosis and the devel...
Sepsis has been a factor of acute kidney ... dialysis-requiring AKI and the risk of severe sepsis after survival to discharge.
This article is part of a Supplement: Volume 17 Supplement 2
This article is part of a Supplement: Volume 13 Supplement 1
This article is part of a Supplement: Volume 11 Supplement 2
Sepsis-induced immunosuppression may result in death. The ... determine the mechanisms of immune suppression in severe sepsis by repeated detection.
Fungal infection is increasingly common in critical illness with severe sepsis, but the influence of invasive fungal infection (IFI) on severe sepsis is not well understood. The aim of ... outcomes of critically ...
This article is part of a Supplement: Volume 12 Supplement 2
The aim of this study was to evaluate the early diagnostic, risk stratification and prognostic value of neutrophil gelatinase-associated lipocalin (NGAL), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor o...
This article is part of a Supplement: Volume 11 Supplement 2
This article is part of a Supplement: Volume 17 Supplement 2
Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary ext...
The Letter to this article has been published in Critical Care 2019 23:265
The original article was published in Critical Care 2019 23:400
The original article was published in Critical Care 2016 20:229
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at
The Letter to this article has been published in Critical Care 2020 24:16
The original article was published in Critical Care 2018 22:183
The original article was published in Critical Care 2016 20:145
The Letter to this article has been published in Critical Care 2016 20:409
Sepsis is estimated to affect more than 30 ... million deaths every year worldwide. Prevention of sepsis, as well as early recognition, diagnosis...SAVE LIVES: Clean Your Hands...campaign on 5 May every year. The...
There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem ... solutions. We offer a conceptual framework for sepsis as a public health problem by adapting...
The Letter to this article has been published in Critical Care 2018 22:247
The original article was published in Critical Care 2016 20:73
We report on the increasingly important need to diagnose and care for the elderly with sepsis as a distinct patient population. We share an overview of age-related changes in sepsis physiology and the potential r...
The original article was published in Critical Care 2017 21:210
The original article was published in Critical Care 2018 22:79
Critical Care