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The association of ageing with increased sepsis mortality is well established. Nonetheless, current ... to plasma cytokine levels while neglecting other pathophysiological sepsis domains like endothelial cell act...
Hepatobiliary elimination of endo- and xenobiotics is affected by different variables including hepatic perfusion, hepatocellular energy state and functional integrity of transporter proteins, all of which are al...
The aim of the study was to evaluate and compare the microcirculatory perfusion during experimental sepsis in different potentially available parts of the...
Inflammation and coagulation are closely interrelated pathophysiologic processes in the pathogenesis of sepsis. However, the diagnostic criteria of sepsis and disseminated intravascular coagulation (DIC) are ... ...
Previous reports suggest that endothelial activation is an important process in sepsis pathogenesis. We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dy...
Sepsis, the dysregulated host response to infection, ... inflammatory molecule makes it an appealing target for sepsis biomarker studies. This meta-analysis aims to ... C (PC) as a biomarker for adult sepsis.
During the course of infection, natural killer (NK) cells contribute to innate immunity by producing cytokines, particularly interferon-gamma (IFN-γ). In addition to their beneficial effects against infection, NK...
Liver dysfunction is a common feature of severe sepsis and is associated with a poor outcome. ... Both liver perfusion and hepatic inflammatory response in sepsis might be affected by sympathetic nerve activity.....
Sepsis is a significant cause of morbidity and ... who develop cardiovascular dysfunction and septic shock. Sepsis is especially devastating in the neonatal population, ... little is known about the cardiovascula...
Culture-negative sepsis is a common but relatively understudied condition. ... outcomes of culture-negative versus culture-positive severe sepsis.
This article is part of a Supplement: Volume 13 Supplement 1
Sepsis has a high mortality despite advances in ... reactivity, would be impaired in proportion to sepsis severity and related to endothelial activation and...
This study involved histopathology and mRNA analyses of postmortem kidney biopsies collected from patients with COVID-19 (n = 6) and bacterial sepsis (n = 27). Normal control renal tissue was obtained from patien...
This article is part of a Supplement: Volume 10 Supplement 1
This article is part of a Supplement: Volume 17 Supplement 2
The aim of this study was to evaluate the diagnostic and prognostic value of presepsin in patients with severe sepsis and septic shock during the first week...
Sepsis is a serious condition with a significant ... mortality. New insight into the immunopathogenesis of sepsis could promote the development of new strategies ... Its role as a pro-inflammatory cytokine in sepsis
Sepsis occurs in 12–27% of patients with ... haematological malignancy within a year of diagnosis. Sepsis mortality has improved in non-cancer patients ... admitted to ICU with a primary diagnosis of sepsis in Au...
Both C-reactive protein (CRP) and procalcitonin (PCT) are accepted sepsis markers. However, there is still some ... concerning the correlation between their serum concentrations and sepsis severity. We hypothesis...
Sepsis is a syndromic illness that has traditionally ... distinct pathophysiologic states may meet diagnostic criteria for sepsis, leading to syndrome heterogeneity. The existence of biologically distinct sepsis ...
Patients with sepsis often demonstrate severely impaired immune responses. The ... cells (DCs) were reported in patients with sepsis. However, little is known about DC phenotype and function in human sepsis. We t...
Eosinopenia is a cheap and forgotten marker of acute infection that has not been evaluated previously in intensive care units (ICUs). The aim of the present study was to test the value of eosinopenia in the diagn...
Down-regulation of ex-vivo...cytokine production is a specific feature in patients with sepsis. Cytokine downregulation was studied focusing on caspase...
Sepsis is characterized by organ dysfunction resulting from ... pivotal role in the onset and progression of sepsis. This review aims to furnish a comprehensive ... of HIF-1α's mechanism of action in sepsis, scru...
This article is part of a Supplement: Volume 13 Supplement 1
We investigated whether steroid profiles before and after corticotropin stimulation can predict the risk of in-hospital death in sepsis.
Rapid detection of, and optimized treatment for, severe sepsis and septic shock is crucial for successful ... HBP in the plasma of patients with severe sepsis and septic shock in the ICU.
This article is part of a Supplement: Volume 9 Supplement 1
The pathophysiology of sepsis-associated delirium is not completely understood and the data on cerebral perfusion in sepsis are conflicting. We tested the hypothesis that ... delirium differ in septic patients wi...
The pathogenesis of sepsis and its progression to multiple organ dysfunction ... with regard to understanding the molecular pathophysiology of sepsis in relation to the complex roles played ... review we categori...
Sepsis is a complex health condition, leading to ... mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid...
To evaluate the utility of urinary cystatin C (uCysC) as a diagnostic marker of acute kidney injury (AKI) and sepsis, and predictor of mortality in critically ill...
Early risk assessment is the mainstay of management of patients with sepsis. APACHE II is the gold standard prognostic...
This article is part of a Supplement: Volume 13 Supplement 1
Hospital-onset sepsis is associated with a higher in-hospital mortality rate than community-onset sepsis. Many hospitals have implemented rapid response teams ... in-hospital mortality in patient with hospital-on...
This article is part of a Supplement: Volume 13 Supplement 1
Although many sepsis biomarkers have shown promise in selected patient ... this study was to evaluate three promising novel sepsis biomarkers in unselected patients at admission to ... binding protein (HBP) in di...
This article is part of a Supplement: Volume 13 Supplement 1
Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechani...
This article is part of a Supplement: Volume 17 Supplement 2
Sepsis is a severe systemic inflammatory response to ... gene variants associated with development and outcomes of sepsis focusing on biological candidates. We conducted the ... of 28-day survival in adult patien...
Infection is an important complication in cancer patients, which frequently leads to or prolongs hospitalization, and can also lead to acute organ dysfunction (severe sepsis) and eventually death. While cancer pa...
Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways ... of host immune responses and the development of sepsis. The objective of th...
Sepsis, a dysregulated host response to infection characterized ... to inhibit or stimulate the immune system in sepsis have failed so far to improve patients’ ... discuss future perspectives for precision medici...
To establish a prognostic model for predicting 14-day mortality in ICU patients with severe sepsis overall and according to place of infection acquisition and to sepsis episode number.
This article is part of a Supplement: Volume 10 Supplement 1
Additional biomarkers in sepsis are needed to tackle the challenges of...
The Erratum to this article has been published in Critical Care 2005 9:169
Sepsis is a life-threatening complication of the ... The financial, medical, and psychological costs of sepsis to individuals and to the healthcare system are high. Most sepsis cases originate in the community, m...
The role of site of infection in sepsis has been poorly characterized. Additionally, sepsis epidemiology has evolved. Early mortality has decreased ... the host response and current epidemiology of surgical sepsis
Severe sepsis is a dreaded consequence of infection and necessitates intensive care treatment. Severe sepsis has a profound impact on mortality and ... to determine the prevalence and incidence of severe sepsis o...
Critical Care