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  1. Dopexamine may be a therapeutic option to improve hepatosplanchnic perfusion in sepsis. To investigate this possibility, we administered dopexamine in an experimental sepsis model in rats.

    Authors: Jürgen Birnbaum, Edda Klotz, Claudia D Spies, Björn Lorenz, Patrick Stuebs, Ortrud Vargas Hein, Matthias Gründling, Dragan Pavlovic, Taras Usichenko, Michael Wendt, Wolfgang J Kox and Christian Lehmann
    Citation: Critical Care 2006 10:R117
  2. Some guidelines to prevent ventilator-associated pneumonia (VAP) do not establish a recommendation for the preferential use of either heat and moisture exchangers (HMEs) or heated humidifiers (HHs), while othe...

    Authors: Leonardo Lorente, María Lecuona, Alejandro Jiménez, María L Mora and Antonio Sierra
    Citation: Critical Care 2006 10:R116
  3. The objective of the present study was to compare the discriminative ability of the Sequential Organ Failure Assessment (SOFA) and Multiple Organ Dysfunction (MOD) scoring systems with respect to hospital mort...

    Authors: David Zygun, Luc Berthiaume, Kevin Laupland, John Kortbeek and Christopher Doig
    Citation: Critical Care 2006 10:R115
  4. Hospital-acquired pneumonia (HAP) due to Pseudomonas aeruginosa is associated with high mortality rates. The metallo-β-lactamases (MBLs) are emerging enzymes that hydrolyze virtually all β-lactams. We aimed to as...

    Authors: Alexandre Prehn Zavascki, Afonso Luís Barth, Juliana Fernandez Fernandes, Ana Lúcia Didonet Moro, Ana Lúcia Saraiva Gonçalves and Luciano Zubaran Goldani
    Citation: Critical Care 2006 10:R114
  5. Shockable rhythms are rare in pediatric cardiac arrest and the results of defibrillation are uncertain. The objective of this study was to analyze the results of cardiopulmonary resuscitation that included def...

    Authors: Antonio Rodríguez-Núñez, Jesús López-Herce, Cristina García, Pedro Domínguez, Angel Carrillo and Jose María Bellón
    Citation: Critical Care 2006 10:R113
  6. Early detection of pneumothorax in multiple trauma patients is critically important. It can be argued that the efficacy of ultrasonography (US) for detection of pneumothorax is enhanced if it is performed and ...

    Authors: Mao Zhang, Zhi-Hai Liu, Jian-Xin Yang, Jian-Xin Gan, Shao-Wen Xu, Xiang-Dong You and Guan-Yu Jiang
    Citation: Critical Care 2006 10:R112
  7. The abdominal compartment syndrome is a state of serious organ dysfunction. The syndrome results from sustained intra-abdominal hypertension, which is indirectly identified by measuring intra-bladder pressures...

    Authors: Chad G Ball and Andrew W Kirkpatrick
    Citation: Critical Care 2006 10:153
  8. The use of pulmonary artery catheters is under debate yet again. We look at two recent trials evaluating their impact on mortality. Our suspicions regarding obesity are proven and we also look at a simple, cos...

    Authors: Hannah Rose and Richard Venn
    Citation: Critical Care 2006 10:152
  9. With the current epidemiology of a growing advanced-age population and the specificities of critical illness in elderly patients, studies on this topic are appropriate. We need more clinical trials and evaluat...

    Authors: Jean-Yves Fagon
    Citation: Critical Care 2006 10:151
  10. Many critically ill patients develop hemostatic abnormalities, ranging from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. Ther...

    Authors: Marcel Levi and Steven M Opal
    Citation: Critical Care 2006 10:222
  11. Genetic variations may influence clinical outcomes in patients with sepsis. The present study was conducted to evaluate the impact on mortality of three polymorphisms after adjusting for confounding variables,...

    Authors: Jose Garnacho-Montero, Teresa Aldabo-Pallas, Carmen Garnacho-Montero, Aurelio Cayuela, Rocio Jiménez, Sonia Barroso and Carlos Ortiz-Leyba
    Citation: Critical Care 2006 10:R111
  12. Postoperative care after oesophageal tumour resection holds a high risk of respiratory complications. We therefore aimed to determine the value of systemic inflammatory markers in predicting arterial hypoxaemi...

    Authors: Lajos Bogar, Zsolt Molnar, Piroska Tarsoly, Peter Kenyeres and Sandor Marton
    Citation: Critical Care 2006 10:R110
  13. The steroid hormone dehydroepiandrosterone (DHEA) exerts protecting effects in the treatment of traumatic and septic complications in several animal models. This effect goes along with reduced amounts of infil...

    Authors: Tanja Barkhausen, Britt-Mailin Westphal, Claudia Pütz, Christian Krettek and Martijn van Griensven
    Citation: Critical Care 2006 10:R109
  14. Patients with acute-on-chronic liver failure show an aggravated hyperdynamic circulation. We evaluated, in a controlled manner, potential changes in systemic haemodynamics induced by the molecular adsorbent re...

    Authors: Wim Laleman, Alexander Wilmer, Pieter Evenepoel, Ingrid Vander Elst, Marcel Zeegers, Zahur Zaman, Chris Verslype, Johan Fevery and Frederik Nevens
    Citation: Critical Care 2006 10:R108
  15. Acute respiratory distress syndrome (ARDS) has heterogeneous etiologies, rapid progressive change and a high mortality rate. To improve the outcome of ARDS, accurate diagnosis is essential to the application o...

    Authors: Kuo-Chin Kao, Ying-Huang Tsai, Yao-Kuang Wu, Ning-Hung Chen, Meng-Jer Hsieh, Shiu-Feng Huang and Chung-Chi Huang
    Citation: Critical Care 2006 10:R106
  16. Etomidate blocks adrenocortical synthesis when it is administered intravenously as a continuous infusion or a single bolus. The influence of etomidate administration on the incidence of relative adrenal insuff...

    Authors: Zulfiqar Mohammad, Bekele Afessa and Javier D Finkielman
    Citation: Critical Care 2006 10:R105
  17. Recombinant activated factor VII (rFVIIa) has been used as adjunctive therapy in trauma patients with severe bleeding. However, its pharmacokinetics profile remains unknown.

    Authors: Thomas Klitgaard, Rene Tabanera y Palacios, Kenneth D Boffard, Philip TC Iau, Brian Warren, Sandro Rizoli, Rolf Rossaint, Yoram Kluger and Bruno Riou
    Citation: Critical Care 2006 10:R104
  18. With the 3100B high-frequency oscillatory ventilator (SensorMedics, Yorba Linda, CA, USA), patients' spontaneous breathing efforts result in a high level of imposed work of breathing (WOB). Therefore, spontane...

    Authors: Marc van Heerde, Karel Roubik, Vitek Kopelent, Frans B Plötz and Dick G Markhorst
    Citation: Critical Care 2006 10:R103
  19. Although most risk-stratification scores are derived from preoperative patient variables, there are several intraoperative and postoperative variables that can influence prognosis. Higgins and colleagues previ...

    Authors: Bonizella Biagioli, Sabino Scolletta, Gabriele Cevenini, Emanuela Barbini, Pierpaolo Giomarelli and Paolo Barbini
    Citation: Critical Care 2006 10:R94
  20. The objective was to study the effects of a lung recruitment procedure by stepwise increases of mean airway pressure upon organ blood flow and hemodynamics during high-frequency oscillatory ventilation (HFOV) ...

    Authors: Matthias David, Hendrik W Gervais, Jens Karmrodt, Arno L Depta, Oliver Kempski and Klaus Markstaller
    Citation: Critical Care 2006 10:R100
  21. We present a consensus report from the SFAR/SLRF (Société Française d'Anesthésie et de Réanimation/Société de Réanimation de Langue Française) Consensus Conference, held on 13 October 2005 in Paris, France. Th...

    Authors: Thierry Pottecher, Sylvie Calvat, Hervé Dupont, Jacques Durand-Gasselin and Patrick Gerbeaux
    Citation: Critical Care 2006 10:311
  22. Translaryngeal intubated and ventilated patients often need sedation to treat anxiety, agitation and/or pain. Current opinion is that tracheotomy reduces sedation requirements. We determined sedation needs bef...

    Authors: Denise P Veelo, Dave A Dongelmans, Jan M Binnekade, Johanna C Korevaar, Margreeth B Vroom and Marcus J Schultz
    Citation: Critical Care 2006 10:R99
  23. Whether it is the primary reason for admission or a complication of critical illness, upper gastrointestinal bleeding is commonly encountered in the intensive care unit. In this setting, in the absence of endo...

    Authors: Yaseen Arabi, Bandar Al Knawy, Alan N Barkun and Marc Bardou
    Citation: Critical Care 2006 10:218
  24. We summarize all original research in the field of respiratory intensive care medicine published in 2005 in Critical Care. Twenty-seven articles were grouped into the following categories and subcategories to fac...

    Authors: Jack J Haitsma, Jesús Villar and Arthur S Slutsky
    Citation: Critical Care 2006 10:217
  25. During 2005 Critical Care published several original papers dealing with resource management. Emphasis was placed on sepsis, especially the coagulation cascade, prognosis and resuscitation. The papers highlighted...

    Authors: André Carlos Kajdacsy-Balla Amaral and Gordon D Rubenfeld
    Citation: Critical Care 2006 10:215
  26. To gain a better understanding of the clinical and economic outcomes associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in patients with early onset ventilator-associated pneumonia (VAP)...

    Authors: Andrew F Shorr, Ying P Tabak, Vikas Gupta, RS Johannes, Larry Z Liu and Marin H Kollef
    Citation: Critical Care 2006 10:R97
  27. Pro-adrenomedullin (proADM) is helpful for individual risk assessment and outcome prediction in sepsis. A major cause of sepsis is community-acquired pneumonia (CAP). The aim of this study was to investigate t...

    Authors: Mirjam Christ-Crain, Nils G Morgenthaler, Daiana Stolz, Christian Müller, Roland Bingisser, Stephan Harbarth, Michael Tamm, Joachim Struck, Andreas Bergmann and Beat Müller
    Citation: Critical Care 2006 10:R96