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Sepsis-associated delirium (SAD) increases morbidity in ... the impairment of cerebrovascular autoregulation (AR) by sepsis, leading to cerebral hypo- or hyperperfusion ... of SAD and the status of AR during sepsis
A biomarker describes a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk ...
The Correspondence to this article has been published in Critical Care 2022 26:100
This article is part of a Supplement: Volume 14 Supplement 1
This article is part of a Supplement: Volume 14 Supplement 1
To evaluate the impact of compliance with a core version of the Surviving Sepsis Campaign 6-hour bundle on 28 days...
Sepsis is a leading cause of preventable death around the world. Population-based estimation of sepsis incidence is lacking in China. In this ... population-based incidence and geographic variation of hospitalize...
Early sepsis diagnosis has emerged as one of the ... challenges in the emergency room. Measurement of sepsis biomarkers is largely used in current practice ... distribution width (MDW) is a recent new sepsis biom...
This article is part of a Supplement: Volume 16 Supplement 3
Apoptosis of neutrophils (polymorphonuclear neutrophils [PMNs]) may limit inflammatory injury in sepsis and acute respiratory distress syndrome (ARDS), but the relationship between the severity of sepsis and exte...
Sepsis, a leading cause of death in critically...
Sepsis is a life-threatening condition accompanied by ... infection. Up to 60% of patients with sepsis develop acute kidney injury (AKI), which ... a poor clinical outcome. The pathophysiology of sepsis-associate...
A strong biologic rationale exists for targeting markers of endothelial cell (EC) activation as clinically informative biomarkers to improve diagnosis, prognostic evaluation or risk-stratification of patients wit...
This article is part of a Supplement: Volume 16 Supplement 3
This article is part of a Supplement: Volume 14 Supplement 1
Hospital- and community-onset sepsis are significant sepsis subgroups. Japanese data comparing these subgroups are ... the epidemiology of hospital- and community-onset sepsis in critical care units in Japan.
Sepsis is defined as a life-threatening syndrome ... receptor (IL-36R) in host response during sepsis remains unknown.
Data on long-term outcomes after sepsis-associated critical illness have mostly come from ... incidence of new disability. We investigated whether sepsis-associated critical illness was independently associated w...
Sepsis is the focus of national quality improvement ... for Medicare and Medicaid Services. However, diagnosing sepsis requires interpreting nonspecific signs and can therefore ... We sought to quantify interobse...
Race has been identified as an important risk factor for the development of sepsis and as a predictor of poor outcomes in sepsis. For example, black individuals have been ... to be nearly twice as likely to devel...
Apolipoprotein M (apoM) is present in 5% of high-density lipoprotein (HDL) particles in plasma. It is a carrier of sphingosine-1-phosphate (S1P), which is important for vascular barrier protection. The aim was to...
Several clinical guidelines recommend monitoring blood lactate levels and central venous oxygen saturation for hemodynamic management of patients with sepsis. We hypothesized that carbon dioxide production (...2)...
Angiopoietin-2 (Ang-2) is associated with vascular endothelial injury and permeability in the acute respiratory distress syndrome (ARDS) and sepsis. Elevated circulating Ang-2 levels may identify ... 2 measured s...
Diabetes mellitus (DM) is one of the most common chronic co-morbid medical conditions in the USA and is frequently present in patients with sepsis. Previous studies reported that people with DM and severe sepsis ...
Gelsolin is an actin-binding plasma protein that is part of an 'actin-scavenging' system. Studies suggest that plasma gelsolin may play a crucial role in the pathophysiology of sepsis. Little is known about the c...
Permeability changes in the blood–brain barrier (BBB) and their possible contribution to brain edema formation have a crucial role in the pathophysiology of septic encephalopathy. Magnesium sulfate has been shown...
The purpose of this study was to clarify the prognostic value of Pentraxin-3 (PTX3) on the mortality of patients with sepsis.
This article is one of ten reviews selected from the Yearbook of Intensive Care and Emergency Medicine 2010 (Springer Verlag) and co-published as a series in Critical Care. Other articles in the series can be fou...
We have developed reproducible and accurate enzyme-linked immunosorbent assays for both Gas6 and sAxl and used them to investigate plasma samples from 70 patients with severe sepsis, 99 patients with sepsis, 42 p...
Cannabinoid receptor 2 (CB2R) expression is upregulated during sepsis. However, there are conflicting results regarding ... within the intestinal microcirculation in two acute experimental sepsis models.
The growing basic and clinical investigations into the extraskeletal effects of vitamin D have revealed roles in the functioning of the immune system, generating interesting questions about this nutrient's connec...
Plasma levels of cell-free hemoglobin are associated with mortality in patients with sepsis; however descriptions of independent associations with free ... hemopexin with in-hospital mortality in adults with sepsis
The objective of the present study was to compare the health-related quality of life (HR-QoL) of survivors from severe sepsis and septic shock with HR-QoL in others who survived critical illness not involving sepsis
Patients with sepsis suffer high morbidity and mortality. We sought...
Multisystem organ failure remains a poorly understood complication of sepsis. During sepsis, reduced excitability contributes to organ failure of ... excitability might also contribute to cardiac failure during sepsis
Resuscitation of septic patients by means of one or more fluid boluses is recommended by guidelines from multiple relevant organizations and as a component of surviving sepsis campaigns. The technique is consider...
Treatment of patients with severe sepsis with agents antagonising the effects of C5a...in vitro studies demonstrating upregulation of the C5a receptor (CD88) on granulocytes by endotoxin.
The aim of this study was to examine whether albumin reduced mortality when employed for the resuscitation of adult patients with severe sepsis and septic shock compared with crystalloid by...
The pathophysiology of sepsis-associated encephalopathy (SAE) is not entirely...
Due to the increasing burden on hospital systems, most elderly patients with non-surgical sepsis are admitted to general internal medicine departments. ... score (SCS), mortality in emergency department sepsis (M...
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be found online at
Established biomarkers for the diagnosis of sepsis are procalcitonin, interleukin 6, and C-reactive protein. Although sepsis evokes changes of coagulation and fibrinolysis, it ... thromboelastometry variables are...
Sepsis and severe sepsis are asociated with high hospital mortality. Little is known about the occurrence of sepsis in general hospital populations. The goal of ... present study was to reveal the epidemiology of...
In a study conducted by Annane, patients with septic shock and unresponsive to adrenocorticotropic hormone stimulation receiving low-dose steroid therapy had prolonged survival but not significantly improved 28-d...
Drotecogin alfa (activated; DrotAA) was approved in 2001 by the US Food and Drug Administration for the treatment of patients with severe sepsis who are at high risk for death. ... DrotAA could be administered to...
This article is part of a Supplement: Volume 11 Supplement 5
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at
Several research papers published in Critical Care...throughout 2007 examined the pathogenesis, diagnosis, treatment and prognosis of sepsis and multiorgan failure. The present review summarizes ... findings and ...
Critical illness polyneuropathy (CIP) is a clinical condition frequently seen in patients being treated in critical care units in the final stage of sepsis. The etiopathology of CIP is still unclear ... alteratio...
The effect of sepsis on epidermal wound healing has not been ... that epidermal wound healing is disturbed in severe sepsis.
Sepsis is characterized by a dysregulated immune response ... infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a ... microbiota play crucial roles in liver inj...
Critical Care