Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the united states from 1979 through 2000. New Engl J Med 2003, 348: 1546-1554. 10.1056/NEJMoa022139
Article
PubMed
Google Scholar
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the united states: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29: 1303-1310. 10.1097/00003246-200107000-00002
Article
CAS
PubMed
Google Scholar
Baskurt OK, Gelmont D, Meiselman HJ: Red blood cell deformability in sepsis. Am J Resp Crit Care Med 1998, 157: 421-427. 10.1164/ajrccm.157.2.9611103
Article
CAS
PubMed
Google Scholar
Kempe DS, Akel A, Lang PA, Hermle T, Biswas R, Muresanu J, Friedrich B, Dreischer P, Wolz C, Schumacher U, Peschel A, Gotz F, Doring G, Wieder T, Gulbins E, Lang F: Suicidal erythrocyte death in sepsis. J Mol Med (Berl) 2007, 85: 273-281. 10.1007/s00109-006-0123-8
Article
CAS
Google Scholar
Machiedo GW, Powell RJ, Rush BF Jr, Swislocki NI, Dikdan G: The incidence of decreased red blood cell deformability in sepsis and the association with oxygen free radical damage and multiple-system organ failure. Arch Surg 1989, 124: 1386-1389. 10.1001/archsurg.1989.01410120032007
Article
CAS
PubMed
Google Scholar
Piagnerelli M, Boudjeltia KZ, Vanhaeverbeek M, Vincent JL: Red blood cell rheology in sepsis. Intens Care Med 2003, 29: 1052-1061. 10.1007/s00134-003-1783-2
Article
CAS
Google Scholar
Billings FT, Ball SK, Roberts LJ 2nd, Pretorius M: Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. Free Radic Biol Med 2011, 50: 1480-1487. 10.1016/j.freeradbiomed.2011.02.011
Article
PubMed Central
CAS
PubMed
Google Scholar
Vermeulen Windsant IC, Snoeijs MG, Hanssen SJ, Altintas S, Heijmans JH, Koeppel TA, Schurink GW, Buurman WA, Jacobs MJ: Hemolysis is associated with acute kidney injury during major aortic surgery. Kidney Int 2010, 77: 913-920. 10.1038/ki.2010.24
Article
PubMed
Google Scholar
Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM: Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA 2008, 299: 2304-2312. 10.1001/jama.299.19.jrv80007
Article
CAS
PubMed
Google Scholar
Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO 3rd, Schechter AN, Gladwin MT: Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002, 8: 1383-1389. 10.1038/nm1202-799
Article
CAS
PubMed
Google Scholar
Meyer C, Heiss C, Drexhage C, Kehmeier ES, Balzer J, Muhlfeld A, Merx MW, Lauer T, Kuhl H, Floege J, Kelm M, Rassaf T: Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular function. J Am Coll Cardiol 2010, 55: 454-459. 10.1016/j.jacc.2009.07.068
Article
CAS
PubMed
Google Scholar
Gladwin MT, Kim-Shapiro DB: Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis. Curr Opin Hematol 2009, 16: 515-523. 10.1097/MOH.0b013e32833157f4
Article
PubMed
Google Scholar
Minneci PC, Deans KJ, Zhi H, Yuen PS, Star RA, Banks SM, Schechter AN, Natanson C, Gladwin MT, Solomon SB: Hemolysis-associated endothelial dysfunction mediated by accelerated no inactivation by decompartmentalized oxyhemoglobin. J Clin Invest 2005, 115: 3409-3417. 10.1172/JCI25040
Article
PubMed Central
CAS
PubMed
Google Scholar
Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT: Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation 2011, 124: 465-476. 10.1161/CIRCULATIONAHA.110.008698
Article
PubMed Central
CAS
PubMed
Google Scholar
Baek JH, D’Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW: Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest 2012, 122: 1444-1458. 10.1172/JCI59770
Article
PubMed Central
CAS
PubMed
Google Scholar
Graca-Souza AV, Arruda MA, de Freitas MS, Barja-Fidalgo C, Oliveira PL: Neutrophil activation by heme: Implications for inflammatory processes. Blood 2002, 99: 4160-4165. 10.1182/blood.V99.11.4160
Article
CAS
PubMed
Google Scholar
Reeder BJ, Svistunenko DA, Cooper CE, Wilson MT: The radical and redox chemistry of myoglobin and hemoglobin: from in vitro studies to human pathology. Antioxid Redox Signal 2004, 6: 954-966.
Article
CAS
PubMed
Google Scholar
Janz DR, Bastarache JA, Peterson JF, Sills G, Wickersham N, May AK, Roberts LJ 2nd, Ware LB: Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study*. Crit Care Med 2013, 41: 784-790. 10.1097/CCM.0b013e3182741a54
Article
PubMed Central
CAS
PubMed
Google Scholar
Adamzik M, Hamburger T, Petrat F, Peters J, de Groot H, Hartmann M: Free hemoglobin concentration in severe sepsis: methods of measurement and prediction of outcome. Crit Care 2012, 16: R125. 10.1186/cc11425
Article
PubMed Central
PubMed
Google Scholar
Melamed-Frank M, Lache O, Enav BI, Szafranek T, Levy NS, Ricklis RM, Levy AP: Structure-function analysis of the antioxidant properties of haptoglobin. Blood 2001, 98: 3693-3698. 10.1182/blood.V98.13.3693
Article
CAS
PubMed
Google Scholar
Tolosano E, Altruda F: Hemopexin: structure, function, and regulation. DNA Cell Biology 2002, 21: 297-306. 10.1089/104454902753759717
Article
CAS
PubMed
Google Scholar
Arredouani MS, Kasran A, Vanoirbeek JA, Berger FG, Baumann H, Ceuppens JL: Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology 2005, 114: 263-271. 10.1111/j.1365-2567.2004.02071.x
Article
PubMed Central
CAS
PubMed
Google Scholar
Yang F, Haile DJ, Berger FG, Herbert DC, Van Beveren E, Ghio AJ: Haptoglobin reduces lung injury associated with exposure to blood. Am J Physiol Lung Cell Mol Physiol 2003, 284: L402-L409.
Article
CAS
PubMed
Google Scholar
Larsen R, Gozzelino R, Jeney V, Tokaji L, Bozza FA, Japiassu AM, Bonaparte D, Cavalcante MM, Chora A, Ferreira A, Marguti I, Cardoso S, Sepulveda N, Smith A, Soares MP: A central role for free heme in the pathogenesis of severe sepsis. Sci Transl Med 2010, 2: 51ra71. 10.1126/scitranslmed.3001118
Article
PubMed
Google Scholar
Chavez-Bueno S, Beasley JA, Goldbeck JM, Bright BC, Morton DJ, Whitby PW, Stull TL: Haptoglobin concentrations in preterm and term newborns. J Perinatol 2011, 31: 500-503. 10.1038/jp.2010.197
Article
CAS
PubMed
Google Scholar
Kalenka A, Feldmann RE Jr, Otero K, Maurer MH, Waschke KF, Fiedler F: Changes in the serum proteome of patients with sepsis and septic shock. Anesth Analg 2006, 103: 1522-1526. 10.1213/01.ane.0000242533.59457.70
Article
CAS
PubMed
Google Scholar
Philip AG: Haptoglobin in diagnosis of sepsis. J Perinatol 2012, 32: 312. author reply 313 10.1038/jp.2011.189
Article
CAS
PubMed
Google Scholar
Philip AG, Hewitt JR: Early diagnosis of neonatal sepsis. Pediatrics 1980, 65: 1036-1041.
CAS
PubMed
Google Scholar
Thongboonkerd V, Chiangjong W, Mares J, Moravec J, Tuma Z, Karvunidis T, Sinchaikul S, Chen ST, Opatrny K, Matejovic M: Altered plasma proteome during an early phase of peritonitis-induced sepsis. Clin Sci (Lond) 2009, 116: 721-730. 10.1042/CS20080478
Article
CAS
Google Scholar
Siew ED, Ikizler TA, Gebretsadik T, Shintani A, Wickersham N, Bossert F, Peterson JF, Parikh CR, May AK, Ware LB: Elevated urinary il-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol 2010, 5: 1497-1505. 10.2215/CJN.09061209
Article
PubMed Central
CAS
PubMed
Google Scholar
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The accp/sccm consensus conference committee. American college of chest physicians/society of critical care medicine. Chest 1992, 101: 1644-1655. 10.1378/chest.101.6.1644
Article
CAS
PubMed
Google Scholar
Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM: Hemolysis and free hemoglobin revisited: Exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood 2013, 121: 1276-1284. 10.1182/blood-2012-11-451229
Article
PubMed Central
CAS
PubMed
Google Scholar
Tanaka K, Kanamori Y, Sato T, Kondo C, Katayama Y, Yada I, Yuasa H, Kusagawa M: Administration of haptoglobin during cardiopulmonary bypass surgery. ASAIO Trans 1991, 37: M482-M483.
CAS
PubMed
Google Scholar