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The aim of this study was to investigate whether in-hospital mortality was associated with the administered fraction of oxygen in inspired air (FiO2) and achieved arterial partial pressure of oxygen (PaO2).
The rate of weaning of vasopressors drugs is usually an empirical choice made by the treating in critically ill patients. We applied fuzzy logic principles to modify intravenous norepinephrine (noradrenaline) ...
Acute renal failure after cardiac surgery increases in-hospital mortality. We evaluated the effect of intra- and postoperative tight control of blood glucose levels on renal function after cardiac surgery base...
Bacterial virulence factors enable a host to replicate and disseminate within a host in part by subverting or eluding host defenses. The use of genomic techniques has led to the identification of new virulence...
The use of prophylactic antibiotics in patients with severe acute pancreatitis remains an intensely debated topic. Although animal studies consistently demonstrated an advantage of antibiotic prophylaxis, the ...
Patients who have suffered aneurysmal subarachnoid haemorrhage (SAH) often have derangements in blood volume, contributing to poor outcome. To guide fluid management, regular assessments of volume status must ...
The purpose of this study was to evaluate sedation practice in UK intensive care units (ICUs), particularly the implementation of daily sedation holding, written sedation guidelines, sedation scoring tools and...
The goal of personalised medicine in the intensive care unit (ICU) is to predict which diagnostic tests, monitoring interventions and treatments translate to improved outcomes given the variation between patie...
End expiratory lung volume (EELV) measurement in the clinical setting is routinely performed using the helium dilution technique. A ventilator that implements a simplified version of the nitrogen washout/washi...
The Erratum to this article has been published in Critical Care 2009 13:405
The original article was published in Critical Care 2008 12:R90
Metformin-associated lactic acidosis (MALA) is a classic side effect of metformin and is known to be a severe disease with a high mortality rate. The treatment of MALA with dialysis is controversial and is the...
Patients with community-acquired pneumonia (CAP) in the hospital setting exhibit markedly abnormal levels of various biomarkers of infection, inflammation and coagulation. CAP is a well characterized disease, ...
This article is part of a Supplement: Volume 12 Supplement 6
Despite effective antibiotic therapy, about one-third of patients admitted to an intensive care unit (ICU) with severe community-acquired pneumonia (CAP) and organ dysfunction die within a month. This high dea...
This article is part of a Supplement: Volume 12 Supplement 6
Patients with severe infections almost invariably exhibit evidence of activation of the coagulation system. The lungs are amongst the most frequently affected organs during severe infection and sepsis. The abu...
This article is part of a Supplement: Volume 12 Supplement 6
Mortality in patients with community-acquired pneumonia (CAP) who require intubation or support with inotropes in an intensive care unit setting remains extremely high (up to 50%). Systematic use of objective ...
This article is part of a Supplement: Volume 12 Supplement 6
This article is part of a Supplement: Volume 12 Supplement 6
Critical illness polyneuropathy (CIP) and myopathy (CIM) are major complications of severe critical illness and its management. CIP/CIM prolongs weaning from mechanical ventilation and physical rehabilitation ...
Bacteria communicate extensively with each other and employ a communal approach to facilitate survival in hostile environments. A hierarchy of cell-to-cell signaling pathways regulates bacterial growth, metabo...
The present commentary provides a brief overview of the evolving literature on glycemic management in critically ill patients. Recent interventional studies have been plagued by high rates of severe hypoglycem...
Acute kidney injury occurs in approximately one-quarter to one-third of patients with major burn injury. Apart from the usual suspects – such as older age, severity of burn injury, sepsis and multiple organ dy...
Link and colleagues present a pilot study investigating platelet function and platelet numbers in patients with cardiogenic shock and acute kidney failure undergoing continuous venovenous haemodialysis. Their ...
Electronic patient records are becoming more common in critical care. As their design and implementation are optimized for single users rather than for groups, we aimed to understand the differences in interac...
The endothelial specific angiopoietin (Ang)-Tie2 ligand-receptor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis. Binding of circulating Ang-1 to the Tie...
Acute lung injury (ALI) may arise both after sepsis and non-septic inflammatory conditions and is often associated with the release of fatty acids, including oleic acid (OA). Infusion of OA has been used exten...
Functional residual capacity (FRC) reference values are obtained from spontaneous breathing patients, and are measured in the sitting or standing position. During mechanical ventilation FRC is determined by th...
The Erratum to this article has been published in Critical Care 2009 13:430
The Acute Kidney Injury Network proposed a new classification for acute kidney injury (AKI) distinguishing between three stages. We applied the criteria to a large intensive care unit (ICU) population and eval...
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
This article is part of a Supplement: Volume 12 Supplement 5
Critical Care