Skip to content


Critical Care

Volume 12 Supplement 5

Sepsis 2008

Open Access

Effects of hydroxyethyl starch and gelatin solutions on renal function in surgical intensive care unit patients

  • Christiane Hartog1,
  • Franziska Schabinski1,
  • Janaina Oishi1,
  • Fabio Tuche1,
  • Alain Luy1,
  • Yasser Sakr1,
  • Donald Bredle2 and
  • Konrad Reinhart1
Critical Care200812(Suppl 5):P16

Published: 18 November 2008


Renal FailureGelatinSevere SepsisHospital MortalityCumulative Dose


There is continuing concern regarding adverse renal effects of colloid solutions in ICU patients.


To compare two colloids, hydroxyethyl starch (HES 6% 130/.04) and gelatin 4%, on renal function in ICU patients.


A before–after study of surgical ICU patients. Consecutive patients admitted from January to June 2005 formed Group HES, with HES as the standard colloid of choice. Patients admitted from January to June 2006 formed Group GEL, with gelatin as the primary colloid administered.


There were 1,383 patients in Group HES and 1,528 in Group GEL; 118 and 87 patients, respectively, had severe sepsis. There were some differences between groups in comorbidities and surgical procedures for the patients overall; however, these characteristics were more closely matched in the subset of severe sepsis patients. The incidence of renal failure and the ICU and hospital mortalities were similar in the two groups. In multivariate analysis, cumulative doses >33 ml/kg of either HES (odds ratio = 1.85, 95% confidence interval = 1.01 to 3.41, P < 0.001) or gelatin (odds ratio = 1.99, 95% confidence interval = 1.05 to 3.79, P = 0.035) were associated with higher risk of renal failure. In severe sepsis, hospital mortality tended to be higher in Group HES than in Group GEL (43% vs. 31%, P = 0.076). Patients with severe sepsis who received a cumulative dose >33 ml/kg of either colloid had a higher incidence of renal failure, which reached statistical significance for the HES group.


Moderate cumulative doses of modern HES or gelatin solutions are associated with higher risk for acute renal failure. These solutions should be used with caution, especially in severe sepsis, until their safety can be demonstrated.

Authors’ Affiliations

Department of Anesthesiology and Intensive Care, Friedrich-Schiller-University Hospital, Jena, Germany
Department of Kinesiology, University of Wisconsin, Eau Claire, USA


© Hartog et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd.