Articles
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Citation: Critical Care 2010 14:326
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Year in review 2009: Critical Care - cardiac arrest, trauma and disasters
During 2009, Critical Care published nine papers on various aspects of resuscitation, prehospital medicine, trauma care and disaster response. One article demonstrated that children as young as 9 years of age can...
Citation: Critical Care 2010 14:242 -
Year in review 2009: Critical Care- nephrology
We summarize original research in the field of critical care nephrology accepted or published in 2009 in Critical Care or, when considered relevant or directly linked to this research, in other journals. Four mai...
Citation: Critical Care 2010 14:241 -
Year in review 2009: Critical Care- infection
In 2009 Critical Care provided important and clinically relevant research data for management and prevention of infections in critically ill patients. The present review summarises the results of these observatio...
Citation: Critical Care 2010 14:240 -
Year in review 2009: Critical Care - shock
The research papers on shock that have been published in Critical Care throughout 2009 are related to four major subjects: first, alterations of heart function and, second, the role of the sympathetic central ner...
Citation: Critical Care 2010 14:239 -
Year in review 2009: Critical Care - metabolism
Novel insights into the metabolic alterations of critical illness were published in Critical Care in 2009. The association between early hypoglycaemia/high glycemic variability and poor outcome was confirmed. Imp...
Citation: Critical Care 2010 14:238 -
Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study
V2-receptor (V2R) stimulation potentially aggravates sepsis-induced vasodilation, fluid accumulation and microvascular thrombosis. Therefore, the present study was performed to determine the effects of a first-li...
Citation: Critical Care 2010 14:R200 -
Collaborative effects of bystander-initiated cardiopulmonary resuscitation and prehospital advanced cardiac life support by physicians on survival of out-of-hospital cardiac arrest: a nationwide population-based observational study
There are inconsistent data about the effectiveness of prehospital physician-staffed advanced cardiac life support (ACLS) on the outcomes of out-of-hospital cardiac arrest (OHCA). Furthermore, the relative imp...
Citation: Critical Care 2010 14:R199 -
Preventing severe hypoxia during emergent intubation: is nasopharyngeal oxygenation the answer?
Critically ill patients requiring emergent endotracheal intubation are at risk for life-threatening hypoxemia during the intubation procedure, particularly when the patient is apneic and not receiving any supp...
Citation: Critical Care 2010 14:1005 -
Early norepinephrine resuscitation of life-threatening hypotensive septic shock: it can do the job, but at what cost?
Citation: Critical Care 2010 14:450 -
Effect of oral beta-blocker on short and long-term mortality in patients with acute respiratory failure: results from the BASEL-II-ICU study
Acute respiratory failure (ARF) is responsible for about one-third of intensive care unit (ICU) admissions and is associated with adverse outcomes. Predictors of short- and long-term outcomes in unselected ICU...
Citation: Critical Care 2010 14:R198 -
Bench-to-bedside review: Hypercapnic acidosis in lung injury - from 'permissive' to 'therapeutic'
Modern ventilation strategies for patients with acute lung injury and acute respiratory distress syndrome frequently result in hypercapnic acidosis (HCA), which is regarded as an acceptable side effect ('permi...
Citation: Critical Care 2010 14:137 -
Increased HMGB1 expression and release by mononuclear cells following surgical/anesthesia trauma
High mobility group box 1 (HMGB1) is a key mediator of inflammation that is actively secreted by macrophages and/or passively released from damaged cells. The proinflammatory role of HMGB1 has been demonstrate...
Citation: Critical Care 2010 14:R197 -
Acidemia does not affect outcomes of patients with acute cardiogenic pulmonary edema treated with continuous positive airway pressure
A lack of data exists in the literature evaluating acidemia on admission as a favorable or negative prognostic factor in patients with acute cardiogenic pulmonary edema (ACPE) treated with non-invasive continu...
Citation: Critical Care 2010 14:R196 -
Cost-consequence analysis of remifentanil-based analgo-sedation vs. conventional analgesia and sedation for patients on mechanical ventilation in the Netherlands
Hospitals are increasingly forced to consider the economics of technology use. We estimated the incremental cost-consequences of remifentanil-based analgo-sedation (RS) vs. conventional analgesia and sedation ...
Citation: Critical Care 2010 14:R195 -
Delirium and mortality risk prediction: a story in evolution
Citation: Critical Care 2010 14:449 -
Calculation of the normal range of extravascular lung water
Citation: Critical Care 2010 14:448 -
Effect of histamine-2-receptor antagonists versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients: a meta-analysis of 10 randomized controlled trials
We conducted a meta-analysis in order to investigate the effect of histamine-2-receptor antagonists (H2RA) versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients in the intensive care u...
Citation: Critical Care 2010 14:R194 -
Central venous O2 saturation and venous-to-arterial CO2 difference as complementary tools for goal-directed therapy during high-risk surgery
Central venous oxygen saturation (ScvO2) is a useful therapeutic target in septic shock and high-risk surgery. We tested the hypothesis that central venous-to-arterial carbon dioxide difference (P(cv-a)CO2), a gl...
Citation: Critical Care 2010 14:R193 -
Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit
Absolute lymphocytopenia has been reported as a predictor of bacteremia in medical emergencies. Likewise, the neutrophil-lymphocyte count ratio (NLCR) has been shown a simple promising method to evaluate syste...
Citation: Critical Care 2010 14:R192 -
Hyperoncotic colloids and acute kidney injury: a meta-analysis of randomized trials
It has been hypothesized that hyperoncotic colloids might contribute to acute kidney injury (AKI). However, the validity of this hypothesis remains unclear.
Citation: Critical Care 2010 14:R191 -
Resistin is associated with mortality in patients with traumatic brain injury
Recently, we reported that high levels of resistin are present in the peripheral blood of patients with intracerebral hemorrhage and are associated with a poor outcome. However, not much is known regarding the...
Citation: Critical Care 2010 14:R190 -
Can we afford open-ended ICU care? Yes we can, but ...
Citation: Critical Care 2010 14:447 -
Beta-lactam antibiotics in continuous infusion in critically ill patients
Citation: Critical Care 2010 14:446 -
The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury
Acute lung injury (ALI) is an inflammatory disorder of pulmonary or extrapulmonary origin. We have previously demonstrated that netrin-1 dampens murine ALI, and in an attempt to advance this finding into futur...
Citation: Critical Care 2010 14:R189 -
The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill
Glucagon-like peptide-1 (GLP-1), a principal mediator of the postprandial insulinotropic response in health, has a half-life of minutes. The saliva of the Gila monster contains exendin-4, a structural analogue...
Citation: Critical Care 2010 14:1004 -
GAS6 in systemic inflammatory diseases: with and without infection
Vitamin K-dependent proteins are not only essential regulators of blood coagulation. A recent paper in Critical Care describes the levels of the vitamin K-dependent GAS6 and the soluble form of its receptor Axl i...
Citation: Critical Care 2010 14:1003 -
A balanced view of balanced solutions
The present review of fluid therapy studies using balanced solutions versus isotonic saline fluids (both crystalloids and colloids) aims to address recent controversy in this topic. The change to the acid-base...
Citation: Critical Care 2010 14:325 -
Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic data
Two recent systematic reviews evaluating intensive insulin therapy (IIT) in critically ill patients grouped randomized controlled trials (RCTs) by type of intensive care unit (ICU). The more recent review foun...
Citation: Critical Care 2010 14:324 -
Too cold may not be so cool: spontaneous hypothermia as a marker of poor outcome after cardiac arrest
In a recent issue of Critical Care, den Hartog and colleagues show an association between spontaneous hypothermia, defined by an admission body temperature <35°C, and poor outcome in patients with coma after card...
Citation: Critical Care 2010 14:1002 -
Nebulized heparin reduces levels of pulmonary coagulation activation in acute lung injury
Citation: Critical Care 2010 14:445 -
Bench-to-bedside review: Circulating microparticles - a new player in sepsis?
In sepsis, inflammation and thrombosis are both the cause and the result of interactions between circulating (for example, leukocytes and platelets), endothelial and smooth muscle cells. Microparticles are pro...
Citation: Critical Care 2010 14:236 -
Severe burn injury in europe: a systematic review of the incidence, etiology, morbidity, and mortality
Burn injury is a serious pathology, potentially leading to severe morbidity and significant mortality, but it also has a considerable health-economic impact. The aim of this study was to describe the European ...
Citation: Critical Care 2010 14:R188 -
Comparing different thrombolytic dosing regimens for treatment of acute pulmonary embolism
Citation: Critical Care 2010 14:323 -
Cost and mortality prediction using polymerase chain reaction pathogen detection in sepsis: evidence from three observational trials
Delays in adequate antimicrobial treatment contribute to high cost and mortality in sepsis. Polymerase chain reaction (PCR) assays are used alongside conventional cultures to accelerate the identification of m...
Citation: Critical Care 2010 14:R186 -
Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units
Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients.
Citation: Critical Care 2010 14:R185 -
Clinical review: mechanical circulatory support for cardiogenic shock complicating acute myocardial infarction
Acute myocardial infarction is one of the 10 leading reasons for admission to adult critical care units. In-hospital mortality for this condition has remained static in recent years, and this is related primar...
Citation: Critical Care 2010 14:235 -
Treatment of euvolemic hyponatremia in the intensive care unit by urea
Hyponatremia in the intensive care unit (ICU) is most commonly related to inappropriate secretion of antidiuretic hormone (SIADH). Fluid restriction is difficult to apply in these patients. We wanted to report...
Citation: Critical Care 2010 14:R184 -
Open lung approach associated with high-frequency oscillatory or low tidal volume mechanical ventilation improves respiratory function and minimizes lung injury in healthy and injured rats
To test the hypothesis that open lung (OL) ventilatory strategies using high-frequency oscillatory ventilation (HFOV) or controlled mechanical ventilation (CMV) compared to CMV with lower positive end-expirato...
Citation: Critical Care 2010 14:R183 -
The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
Previous reports suggest that endothelial activation is an important process in sepsis pathogenesis. We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ...
Citation: Critical Care 2010 14:R182 -
Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery
Interleukin-6 (IL-6) is a proinflammatory cytokine that increases early in the serum of patients with acute kidney injury (AKI). The aim of this study was to determine whether urine IL-6 is an early biomarker ...
Citation: Critical Care 2010 14:R181 -
Clinical review: Oxygen as a signaling molecule
Molecular oxygen is obviously essential for conserving energy in a form useable for aerobic life; however, its utilization comes at a cost - the production of reactive oxygen species (ROS). ROS can be highly d...
Citation: Critical Care 2010 14:234 -
Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial
Prolonged mechanical ventilation has the potential to aggravate or initiate pulmonary inflammation and cause lung damage through fibrin deposition. Heparin may reduce pulmonary inflammation and fibrin depositi...
Citation: Critical Care 2010 14:R180 -
Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation
Hyperglycemia and insulin resistance are well-known features of critical illness and impact the mortality rate, especially in sepsis. Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is...
Citation: Critical Care 2010 14:R179 -
Inhibition of monocyte chemoattractant protein-1 prevents diaphragmatic inflammation and maintains contractile function during endotoxemia
Respiratory muscle weakness is common in sepsis patients. Proinflammatory mediators produced during sepsis have been implicated in diaphragmatic contractile dysfunction, but the role of chemokines has not been...
Citation: Critical Care 2010 14:R187 -
Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults
Established biomarkers for the diagnosis of sepsis are procalcitonin, interleukin 6, and C-reactive protein. Although sepsis evokes changes of coagulation and fibrinolysis, it is unknown whether thromboelastom...
Citation: Critical Care 2010 14:R178 -
A novel model of common Toll-like receptor 4- and injury-induced transcriptional themes in human leukocytes
An endotoxin challenge, sepsis, and injury/trauma, trigger significant changes in human peripheral blood leukocytes (PBL) gene expression. In this study, we have sought to test the hypothesis that the Toll-lik...
Citation: Critical Care 2010 14:R177 -
Withholding selective decontamination of the digestive tract from critically ill patients must now surely be ethically questionable given the vast evidence base
Citation: Critical Care 2010 14:443 -
Continuous glucose monitors prove highly accurate in critically ill children
Hyperglycemia is associated with increased morbidity and mortality in critically ill patients and strict glycemic control has become standard care for adults. Recent studies have questioned the optimal targets...
Citation: Critical Care 2010 14:R176 -
Variations in the length of stay of intensive care unit nonsurvivors in three scandinavian countries
The length of stay (LOS) in intensive care unit (ICU) nonsurvivors is not often reported, but represents an important indicator of the use of resources. LOS in ICU nonsurvivors may also be a marker of cultural...
Citation: Critical Care 2010 14:R175
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- ISSN: 1364-8535 (electronic)