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  2. Although much feared by clinicians, the ability to produce ketones has allowed humans to withstand prolonged periods of starvation. At such times, ketones can supply up to 50% of basal energy requirements. Mor...

    Authors: Hayden White and Balasubramanian Venkatesh
    Citation: Critical Care 2011 15:219
    Content type: Review Published on:

  4. Cell death is a central event in the pathogenesis of sepsis and is reflected by circulating nucleosomes. Circulating nucleosomes were suggested to play an important role in inflammation and were demonstrated t...

    Authors: Femke Stephan, Jan A Hazelzet, Ingrid Bulder, Marja A Boermeester, JW Olivier van Till, Tom van der Poll, Walter A Wuillemin, Lucien A Aarden and Sacha Zeerleder
    Citation: Critical Care 2011 15:R110
    Content type: Research Published on:

  5. Systemic inflammation (for example, following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 s...

    Authors: Alexander Koch, Lutz Hamann, Matthias Schott, Olaf Boehm, Dirk Grotemeyer, Muhammed Kurt, Carsten Schwenke, Ralf R Schumann, Stefan R Bornstein and Kai Zacharowski
    Citation: Critical Care 2011 15:R109
    Content type: Research Published on:

  6. Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care. We carried out a multicentre study of coagulopathy in intensive care units (ICUs) and here desc...

    Authors: Simon J Stanworth, Timothy S Walsh, Robin J Prescott, Robert J Lee, Douglas M Watson and Duncan Wyncoll
    Citation: Critical Care 2011 15:R108
    Content type: Research Published on:

  7. Whether the hydrogen sulfide (H2S)-induced metabolic depression observed in awake rodents exists in larger species is controversial. Therefore, Derwall and colleagues exposed anesthetized and ventilated sheep to ...

    Authors: Katja Wagner, Michael Georgieff, Pierre Asfar, Enrico Calzia, Markus W Knöferl and Peter Radermacher
    Citation: Critical Care 2011 15:146
    Content type: Commentary Published on:

  8. Terblanche and colleagues add to the ongoing controversy over the role, if any, for statins in patients with sepsis. The authors note that statins fail to prevent progression to organ dysfunction in critically...

    Authors: Jonathon Dean Truwit
    Citation: Critical Care 2011 15:145
    Content type: Commentary Published on:

  9. The present study examined the median survival, life expectancies, and cumulative incidence rate (CIR) of patients undergoing prolonged mechanical ventilation (PMV) stratified by different underlying diseases.

    Authors: Mei-Chuan Hung, Hsin-Ming Lu, Likwang Chen, Fu-Chang Hu, Soa-Yu Chan, Yuan-Horng Yan, Po-Sheng Fan, Ming-Shian Lin, Cheng-Ren Chen, Lu-Cheng Kuo, Chong-Jen Yu and Jung-Der Wang
    Citation: Critical Care 2011 15:R107
    Content type: Research Published on:

  13. Although numerous studies have linked extremes of weight with poor outcome in adult intensive care patients, the effect of weight on intensive care outcome has not previously been reported in the pediatric pop...

    Authors: Andrew Numa, John McAweeney, Gary Williams, John Awad and Hari Ravindranathan
    Citation: Critical Care 2011 15:R106
    Content type: Research Published on:

  14. Long-term outcomes of elderly patients after medical ICU care are little known. The aim of the study was to evaluate functional status and quality of life of elderly patients 12 months after discharge from a m...

    Authors: Emilio Sacanella, Joan Manel Pérez-Castejón, Josep Maria Nicolás, Ferran Masanés, Marga Navarro, Pedro Castro and Alfonso López-Soto
    Citation: Critical Care 2011 15:R105
    Content type: Research Published on:

  15. Vitamin D deficiency is encountered frequently in critically ill patients and might be harmful. Current nutrition guidelines recommend very low vitamin D doses. The objective of this trial was to evaluate the ...

    Authors: Karin Amrein, Harald Sourij, Gerit Wagner, Alexander Holl, Thomas R Pieber, Karl Heinz Smolle, Tatjana Stojakovic, Christian Schnedl and Harald Dobnig
    Citation: Critical Care 2011 15:R104
    Content type: Research Published on:

  16. In pulmonary embolism (PE) without hemodynamic compromise, the prognostic value of right ventricular (RV) dysfunction as measured by echocardiography, computed tomography (CT) or biological (natriuretic peptid...

    Authors: Guillaume Coutance, Emmanuelle Cauderlier, Javed Ehtisham, Michèle Hamon and Martial Hamon
    Citation: Critical Care 2011 15:R103
    Content type: Research Published on:

  17. The number of patients requiring prolonged mechanical ventilation (PMV) is likely to increase. Transferring patients to specialised weaning units may improve outcomes and reduce costs. The aim of this study wa...

    Authors: Nazir I Lone and Timothy S Walsh
    Citation: Critical Care 2011 15:R102
    Content type: Research Published on:

  22. Our purpose was to study whether the time to target temperature correlates with neurologic outcome in patients after cardiac arrest with restoration of spontaneous circulation treated with therapeutic mild hyp...

    Authors: Moritz Haugk, Christoph Testori, Fritz Sterz, Maximilian Uranitsch, Michael Holzer, Wilhelm Behringer and Harald Herkner
    Citation: Critical Care 2011 15:R101
    Content type: Research Published on:

  24. Fluid resuscitation is a cornerstone of intensive care unit patient care, but prediction of the cardiovascular response remains difficult, despite many efforts in clinical research. The concept of responders a...

    Authors: Didier Payen
    Citation: Critical Care 2011 15:139
    Content type: Commentary Published on:

  40. The study by Yang and colleagues examined 81 patients with septic shock due to pneumonia, along with 20 patients with pneumonia without organ dysfunction. Their major findings were that circulating levels of s...

    Authors: Nathan I Shapiro and William C Aird
    Citation: Critical Care 2011 15:135
    Content type: Commentary Published on:

  41. To estimate the incidence of intensive care unit (ICU)-acquired bloodstream infection (BSI) and its independent effect on hospital mortality.

    Authors: John R Prowle, Jorge E Echeverri, E Valentina Ligabo, Norelle Sherry, Gopal C Taori, Timothy M Crozier, Graeme K Hart, Tony M Korman, Barrie C Mayall, Paul DR Johnson and Rinaldo Bellomo
    Citation: Critical Care 2011 15:R100
    Content type: Research Published on:

  42. Septic shock remains a major health care problem worldwide. Sepsis-induced immune alterations are thought to play a major role in patients' mortality and susceptibility to nosocomial infections. Programmed dea...

    Authors: Caroline Guignant, Alain Lepape, Xin Huang, Hakim Kherouf, Laure Denis, Françoise Poitevin, Christophe Malcus, Aurélie Chéron, Bernard Allaouchiche, François Gueyffier, Alfred Ayala, Guillaume Monneret and Fabienne Venet
    Citation: Critical Care 2011 15:R99
    Content type: Research Published on:

  48. Due to resource limitations, few critical care interventions have been rigorously evaluated with adequately powered randomized clinical trials (RCTs). There is a need to improve the efficiency of RCTs in criti...

    Authors: Daren K Heyland, John Muscedere, John Drover, Xuran Jiang and Andrew G Day
    Citation: Critical Care 2011 15:R98
    Content type: Research Published on:

  49. Climate change and environmental stewardship are phrases that have been defining the past few decades and promoting change in our societies. The sensitivities of intensive care as a specialty make the process ...

    Authors: Martin Chapman and Alison Chapman
    Citation: Critical Care 2011 15:302
    Content type: Viewpoint Published on:

  50. CD40 Ligand (CD40L) and its soluble counterpart (sCD40L) are proteins that exhibit prothrombotic and proinflammatory properties on binding to their cell surface receptor CD40. The results of small clinical stu...

    Authors: Leonardo Lorente, María M Martín, Nerea Varo, Juan María Borreguero-León, Jordi Solé-Violán, José Blanquer, Lorenzo Labarta, César Díaz, Alejandro Jiménez, Eduardo Pastor, Felipe Belmonte, Josune Orbe, José A Rodríguez, Eduardo Gómez-Melini, José M Ferrer-Agüero, José Ferreres…
    Citation: Critical Care 2011 15:R97
    Content type: Research Published on:
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Critical Care

ISSN: 1364-8535