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Citation: Critical Care 2022 26:353
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Spontaneous pneumomediastinum: a surrogate of P-SILI in critically ill COVID-19 patients
Spontaneous pneumomediastinum (SP) has been described early during the COVID-19 pandemic in large series of patients with severe pneumonia, but most patients were receiving invasive mechanical ventilation (IMV...
Citation: Critical Care 2022 26:350 -
Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis
Several biomarkers have been proposed to predict the occurrence of acute kidney injury (AKI); however, their efficacy varies between different trials. The aim of this study was to compare the predictive perfor...
Citation: Critical Care 2022 26:349 -
High-flow nasal cannula versus non-invasive ventilation for acute hypercapnic respiratory failure in adults: a systematic review and meta-analysis of randomized trials
Non-invasive ventilation (NIV) with bi-level positive pressure ventilation is a first-line intervention for selected patients with acute hypercapnic respiratory failure. Compared to conventional oxygen therapy...
Citation: Critical Care 2022 26:348 -
Daily fluctuations in kidney function in critically ill adults
Citation: Critical Care 2022 26:347 -
The ICU Bridge Program: volunteers bridging medicine and people together
The intensive care unit (ICU) is an emotionally taxing environment. Patients and family members are at an increased risk of long-term physical and psychological consequences of critical illness, known collecti...
Citation: Critical Care 2022 26:346 -
Hyperoxia during venoarterial ECMO: Culprit or co-variate? A comment from the BLENDER investigators
Citation: Critical Care 2022 26:345 -
A universal predictive and mechanistic urinary peptide signature in acute kidney injury
The delayed diagnosis of acute kidney injury (AKI) episodes and the lack of specificity of current single AKI biomarkers hamper its management. Urinary peptidome analysis may help to identify early molecular c...
Citation: Critical Care 2022 26:344 -
Corticotropin-stimulated steroid profiles to predict shock development and mortality in sepsis: From the HYPRESS study
Steroid profiles in combination with a corticotropin stimulation test provide information about steroidogenesis and its functional reserves in critically ill patients.
Citation: Critical Care 2022 26:343 -
PSP is a promising biomarker of sepsis; however, potential elimination by RRT must be considered
Citation: Critical Care 2022 26:342 -
A genome-wide association study of survival in patients with sepsis
Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene v...
Citation: Critical Care 2022 26:341 -
Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study
Previously identified phenotypes of acute respiratory distress syndrome (ARDS) have been limited by a disregard for temporal dynamics. We aimed to identify longitudinal phenotypes in ARDS to test the prognosti...
Citation: Critical Care 2022 26:340 -
Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is one of most common comorbidities in acute respiratory distress syndrome (ARDS). There are few specific studies on the appropriate ventilation strategy for patien...
Citation: Critical Care 2022 26:339 -
Use of an innovative cuff pressure control and subglottic secretions drainage system in COVID-19 ARDS patients undergoing pronation
We conducted a proof of concept study where Anapnoguard endotracheal tubes and its control unit were used in 15 patients with COVID-19 acute respiratory distress syndrome. Anapnoguard system provides suction, ...
Citation: Critical Care 2022 26:338 -
Public awareness and knowledge of sepsis: a cross-sectional survey of adults in Canada
Sepsis is a life-threatening complication of the body’s response to infection. The financial, medical, and psychological costs of sepsis to individuals and to the healthcare system are high. Most sepsis cases ...
Citation: Critical Care 2022 26:337 -
How symptoms of prolonged grief disorder, posttraumatic stress disorder, and depression relate to each other for grieving ICU families during the first two years of bereavement
Bereaved ICU family surrogates are at risk of comorbid prolonged grief disorder (PGD), posttraumatic stress disorder (PTSD), and depression. Knowledge about temporal relationships between PGD, PTSD, and depres...
Citation: Critical Care 2022 26:336 -
Public-access defibrillation and favorable neurological outcome after out-of-hospital cardiac arrest during the COVID-19 pandemic in Japan
Early public-access defibrillation (PAD) effectively improves the outcomes of out-of-hospital cardiac arrests (OHCA), but several strategies implemented to prevent the spread of coronavirus disease 2019 (COVID...
Citation: Critical Care 2022 26:335 -
Negative pressure ventilation protects the brain
Citation: Critical Care 2022 26:334 -
Proenkephalin A 119–159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis of the ELAIN trial
Renal replacement therapy (RRT) remains the key rescue therapy for critically ill patients with severe acute kidney injury (AKI). However, there are currently no tools available to predict successful liberatio...
Citation: Critical Care 2022 26:333 -
Future without delirium: not quite there yet but we can start by prescribing touch
Citation: Critical Care 2022 26:332 -
Hyperoxia in patients on venoarterial extracorporeal membrane oxygenation
Citation: Critical Care 2022 26:331 -
Extracorporeal versus conventional cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: a secondary analysis of the Prague OHCA trial
Survival rates in refractory out-of-hospital cardiac arrest (OHCA) remain low with conventional advanced cardiac life support (ACLS). Extracorporeal life support (ECLS) implantation during ongoing resuscitatio...
Citation: Critical Care 2022 26:330 -
Wearable ultrasound and provocative hemodynamics: a view of the future
Citation: Critical Care 2022 26:329 -
Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients
Steroids have been shown to reduce inflammation, hypoxic pulmonary vasoconstriction (HPV) and lung edema. Based on evidence from clinical trials, steroids are widely used in severe COVID-19. However, the effec...
Citation: Critical Care 2022 26:328 -
Higher PEEP in intubated COVID-19-associated ARDS patients? We are not sure
Citation: Critical Care 2022 26:327 -
Virtual and augmented reality in critical care medicine: the patient’s, clinician’s, and researcher’s perspective
Virtual reality (VR) and augmented reality (AR) are aspiring, new technologies with increasing use in critical care medicine. While VR fully immerses the user into a virtual three-dimensional space, AR adds ov...
Citation: Critical Care 2022 26:326 -
Comparison of continuous versus intermittent enteral feeding in critically ill patients: a systematic review and meta-analysis
The enteral route is commonly utilised to support the nutritional requirements of critically ill patients. However, there is paucity of data guiding clinicians regarding the appropriate method of delivering th...
Citation: Critical Care 2022 26:325 -
Effects of rapid fluid infusion on hemoglobin concentration: a systematic review and meta-analysis
Rapid fluid administration may decrease hemoglobin concentration (Hb) by a diluting effect, which could limit the increase in oxygen delivery (DO2) expected with a positive response to fluid challenge in critical...
Citation: Critical Care 2022 26:324 -
Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxem...
Citation: Critical Care 2022 26:323 -
Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study
We have previously shown that iatrogenic dehydration is associated with a shift to organic osmolyte production in the general ICU population. The aim of the present investigation was to determine the validity ...
Citation: Critical Care 2022 26:322 -
Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study
Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine. We hypothesized that in critically ill adults, the response to N-for...
Citation: Critical Care 2022 26:321 -
An area under the concentration–time curve threshold as a predictor of efficacy and nephrotoxicity for individualizing polymyxin B dosing in patients with carbapenem-resistant gram-negative bacteria
Evidence supports therapeutic drug monitoring of polymyxin B, but clinical data for establishing an area under the concentration–time curve across 24 h at steady state (AUCss,24 h) threshold are still limited. Th...
Citation: Critical Care 2022 26:320 -
Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study
The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients.
Citation: Critical Care 2022 26:319 -
Early versus delayed enteral nutrition in mechanically ventilated patients with circulatory shock: statistics fallacy of logistic regression model
Citation: Critical Care 2022 26:318 -
Hospital change to mixed lipid emulsion from soybean oil-based lipid emulsion for parenteral nutrition in hospitalized and critically ill adults improves outcomes: a pre–post-comparative study
Early data suggest use of a mixed lipid emulsion (LE) with a soybean oil reduction strategy in parenteral nutrition (PN) may improve clinical outcomes. Duke University Hospital made a full switch to a Soybean ...
Citation: Critical Care 2022 26:317 -
Individualizing mechanical ventilation: titration of driving pressure to pulmonary elastance through Young’s modulus in an acute respiratory distress syndrome animal model
Mechanical ventilation increases the risk of lung injury (VILI). Some authors propose that the way to reduce VILI is to find the threshold of driving pressure below which VILI is minimized. In this study, we p...
Citation: Critical Care 2022 26:316 -
Algorithmic fairness audits in intensive care medicine: artificial intelligence for all?
Citation: Critical Care 2022 26:315 -
Integrating electrical impedance tomography and transpulmonary pressure monitoring to personalize PEEP in hypoxemic patients undergoing pressure support ventilation
Monitoring with electrical impedance tomography (EIT) during a decremental PEEP trial has been used to identify the PEEP that yields the optimal balance of pulmonary overdistension and collapse. This method is...
Citation: Critical Care 2022 26:314 -
Early hyperoxia and 28-day mortality in patients on venoarterial ECMO support for refractory cardiogenic shock: discussion about potential confounding factors
Citation: Critical Care 2022 26:313 -
Delivery decision in pregnant women rescued by ECMO for severe ARDS: a retrospective multicenter cohort study
Although rarely addressed in the literature, a key question in the care of critically pregnant women with severe acute respiratory distress syndrome (ARDS), especially at the time of extracorporeal membrane ox...
Citation: Critical Care 2022 26:312 -
Microcirculatory alterations in critically ill COVID-19 patients analyzed using artificial intelligence
The sublingual microcirculation presumably exhibits disease-specific changes in function and morphology. Algorithm-based quantification of functional microcirculatory hemodynamic variables in handheld vital mi...
Citation: Critical Care 2022 26:311 -
Ten areas for ICU clinicians to be aware of to help retain nurses in the ICU
Shortage of nurses on the ICU is not a new phenomenon, but has been exacerbated by the COVID-19 pandemic. The underlying reasons are relatively well-recognized, and include excessive workload, moral distress, ...
Citation: Critical Care 2022 26:310 -
PEEP, p-values, and pulmonary mechanics; don’t throw the baby out with the bathwater
Citation: Critical Care 2022 26:309 -
Renaissance of glucocorticoids in critical care in the era of COVID-19: ten urging questions
The 40-year-old experience with glucocorticosteroids (GCs) in the context of severe infections is complex and troublesome. Recently, however, a clear indication for GCs in severe COVID-19 has been established....
Citation: Critical Care 2022 26:308 -
Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors
Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mort...
Citation: Critical Care 2022 26:307 -
Optimized diagnosis-based comorbidity measures for all-cause mortality prediction in a national population-based ICU population
We aimed to optimize prediction of long-term all-cause mortality of intensive care unit (ICU) patients, using quantitative register-based comorbidity information assessed from hospital discharge diagnoses prio...
Citation: Critical Care 2022 26:306 -
Doppler study of portal vein and renal venous velocity predict the appropriate fluid response to diuretic in ICU: a prospective observational echocardiographic evaluation
Fluid overload and venous congestion are associated with morbi-mortality in the ICU (intensive care unit). Administration of diuretics to correct the fluid balance is common, although there is no strong relati...
Citation: Critical Care 2022 26:305 -
Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults
The composition of the digestive microbiota may be associated with outcome and infections in patients admitted to the intensive care unit (ICU). The dominance by opportunistic pathogens (such as Enterococcus) has...
Citation: Critical Care 2022 26:300 -
Early intubation and patient-centered outcomes in septic shock
Citation: Critical Care 2022 26:299 -
The best PEEP or the optimal PEEP or the piece PEEP of the mechanical power puzzle?
Citation: Critical Care 2022 26:298
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- ISSN: 1364-8535 (electronic)