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6923 result(s) for 'sepsis' within Critical Care

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  1. Delirium, an acute and fluctuating disturbance of consciousness and cognition, is a common manifestation of acute brain dysfunction in critically ill patients, occurring in up to 80% of the sickest intensive c...

    Authors: Timothy D Girard, Pratik P Pandharipande and E Wesley Ely
    Citation: Critical Care 2008 12(Suppl 3):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 12 Supplement 3

  2. The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after ...

    Authors: Jakub Fronczek, Kamil Polok, Dylan W. de Lange, Christian Jung, Michael Beil, Andrew Rhodes, Jesper Fjølner, Jacek Górka, Finn H. Andersen, Antonio Artigas, Maurizio Cecconi, Steffen Christensen, Michael Joannidis, Susannah Leaver, Brian Marsh, Alessandro Morandi…
    Citation: Critical Care 2021 25:231
    Content type: Research Published on:

  3. Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) represent leading causes of trauma-induced mortality, especially when co-occurring in pre-hospital settings where standard...

    Authors: Andrew R. Mayer, Andrew B. Dodd, Julie G. Rannou-Latella, David D. Stephenson, Rebecca J. Dodd, Josef M. Ling, Carissa J. Mehos, Cidney R. Robertson-Benta, Sharvani Pabbathi Reddy, Rachel E. Kinsler, Meghan S. Vermillion, Andrew P. Gigliotti, Veronik Sicard, Amy L. Lloyd, Erik B. Erhardt, Jessica M. Gill…
    Citation: Critical Care 2021 25:428
    Content type: Research Published on:

  4. Biofilm formation on endotracheal tubes (ETTs) is an early and frequent event in mechanically ventilated patients. The biofilm is believed to act as a reservoir for infecting microorganisms and thereby contrib...

    Authors: Hulda R. Thorarinsdottir, Thomas Kander, Anna Holmberg, Sarunas Petronis and Bengt Klarin
    Citation: Critical Care 2020 24:382
    Content type: Research Published on:

  5. Single- (SL) and double-lumen (DL) catheters are used in clinical practice for veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. However, information is lacking regarding the effects of the c...

    Authors: Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M. Johnson, Sandro Gelsomino and Daniel Herr
    Citation: Critical Care 2021 25:107
    Content type: Research Published on:

  6. COVID-19-related ARDS has unique features when compared with ARDS from other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host response within the lung are sparse. The object...

    Authors: Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot and Pierre-Emmanuel Charles
    Citation: Critical Care 2020 24:632
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2021 25:143

  7. Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well tolerated, but rare serious complications may occur in some patients receiving VPA chronically, including haemorrhagic pancreatiti...

    Authors: Philippe ER Lheureux, Andrea Penaloza, Soheil Zahir and Mireille Gris
    Citation: Critical Care 2005 9:431
    Content type: Review Published on:

  9. Intensive care unit-acquired weakness (ICU-AW) is common in survivors of critical illness, resulting in global weakness and functional deficit. Although ICU-AW is well described subjectively in the literature,...

    Authors: Evelyn J Corner, Neil Soni, Jonathan M Handy and Stephen J Brett
    Citation: Critical Care 2014 18:R55
    Content type: Research Published on:

  10. While the Glasgow coma scale (GCS) is one of the strongest outcome predictors, the current classification of traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormo...

    Authors: Cecilia A. I. Åkerlund, Anders Holst, Nino Stocchetti, Ewout W. Steyerberg, David K. Menon, Ari Ercole and David W. Nelson
    Citation: Critical Care 2022 26:228
    Content type: Research Published on:

  11. Inhaled nitric oxide (INO) allows selective pulmonary vasodilation in acute respiratory distress syndrome and improves PaO2 by redistribution of pulmonary blood flow towards better ventilated parenchyma. One-thir...

    Authors: Sebastien Trachsel, Ginette Deby-Dupont, Edwige Maurenbrecher, Monique Nys, Maurice Lamy and Göran Hedenstierna
    Citation: Critical Care 2008 12:R131
    Content type: Research Published on:

  12. Serum B-type natriuretic peptide (BNP) is frequently elevated after subarachnoid hemorrhage (SAH), but whether this high BNP level is related to transient elevation of left ventricular filling pressure (LVFP) ...

    Authors: Eric Meaudre, Christophe Jego, Nadia Kenane, Ambroise Montcriol, Henry Boret, Philippe Goutorbe, Gilbert Habib and Bruno Palmier
    Citation: Critical Care 2009 13:R76
    Content type: Research Published on:

  13. Acute kidney injury (AKI) is a frequent complication of cardiopulmonary bypass (CPB). The lack of early biomarkers has impaired our ability to intervene in a timely manner. We previously showed in a small coho...

    Authors: Catherine L Dent, Qing Ma, Sudha Dastrala, Michael Bennett, Mark M Mitsnefes, Jonathan Barasch and Prasad Devarajan
    Citation: Critical Care 2007 11:R127
    Content type: Research Published on:

  14. The term Pulmonary–renal syndrome refers to the combination of diffuse alveolar haemorrhage and rapidly progressive glomerulonephritis. A variety of mechanisms such as those involving antiglomerular basement m...

    Authors: Spyros A Papiris, Effrosyni D Manali, Ioannis Kalomenidis, Giorgios E Kapotsis, Anna Karakatsani and Charis Roussos
    Citation: Critical Care 2007 11:213
    Content type: Review Published on:

  15. Diagnosis of severe influenza pneumonia remains challenging because of a lack of correlation between the presence of influenza virus and clinical status. We conducted gene-expression profiling in the whole blo...

    Authors: Grant P Parnell, Anthony S McLean, David R Booth, Nicola J Armstrong, Marek Nalos, Stephen J Huang, Jan Manak, Wilson Tang, Oi-Yan Tam, Stanley Chan and Benjamin M Tang
    Citation: Critical Care 2012 16:R157
    Content type: Research Published on:

  16. Stress-induced hyperglycaemia is prevalent in critical care. Control of blood glucose levels to within a 4.4 to 6.1 mmol/L range or below 7.75 mmol/L can reduce mortality and improve clinical outcomes. The Spe...

    Authors: JGeoffrey Chase, Geoffrey Shaw, Aaron Le Compte, Timothy Lonergan, Michael Willacy, Xing-Wei Wong, Jessica Lin, Thomas Lotz, Dominic Lee and Christopher Hann
    Citation: Critical Care 2008 12:R49
    Content type: Research Published on:

  17. In acute lung injury, repair of the damaged alveolar-capillary barrier is an essential part of recovery. Endostatin is a 20 to 28 kDa proteolytic fragment of the basement membrane collagen XVIII, which has bee...

    Authors: Gavin D Perkins, Nazim Nathani, Alex G Richter, Daniel Park, Murali Shyamsundar, Ritva Heljasvaara, Taina Pihlajaniemi, Mav Manji, W Tunnicliffe, Danny McAuley, Fang Gao and David R Thickett
    Citation: Critical Care 2009 13:R52
    Content type: Research Published on:

  18. Procalcitonin (PCT) and C-reactive protein (CRP) were previously shown to have value for the detection of secondary infections in critically ill COVID-19 patients. However, since the introduction of immunomodu...

    Authors: Emma J. Kooistra, Miranda van Berkel, Noortje F. van Kempen, Celine R. M. van Latum, Niklas Bruse, Tim Frenzel, Maarten J. W. van den Berg, Jeroen A. Schouten, Matthijs Kox and Peter Pickkers
    Citation: Critical Care 2021 25:281
    Content type: Research Published on:

  19. Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-dose ente...

    Authors: Paul E. Wischmeyer, Danielle E. Bear, Mette M. Berger, Elisabeth De Waele, Jan Gunst, Stephen A. McClave, Carla M. Prado, Zudin Puthucheary, Emma J. Ridley, Greet Van den Berghe and Arthur R. H. van Zanten
    Citation: Critical Care 2023 27:261
    Content type: Review Published on:

  20. Acute kidney injury following surgery incurs significant mortality with no proven preventative therapy. We investigated whether the α2 adrenoceptor agonist dexmedetomidine (Dex) provides protection against ischem...

    Authors: Jianteng Gu, Pamela Sun, Hailin Zhao, Helena R Watts, Robert D Sanders, Niccolo Terrando, Peiyuan Xia, Mervyn Maze and Daqing Ma
    Citation: Critical Care 2011 15:R153
    Content type: Research Published on:

  21. Distinguishing pulmonary edema due to acute lung injury (ALI) or the acute respiratory distress syndrome (ARDS) from hydrostatic or cardiogenic edema is challenging in critically ill patients. B-type natriuret...

    Authors: Joseph E Levitt, Ajeet G Vinayak, Brian K Gehlbach, Anne Pohlman, William Van Cleve, Jesse B Hall and John P Kress
    Citation: Critical Care 2008 12:R3
    Content type: Research Published on:

  22. Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with chan...

    Authors: Pieter R Tuinman, Alexander P Vlaar, Alexander D Cornet, Jorrit J Hofstra, Marcel Levi, Joost CM Meijers, Albertus Beishuizen, Marcus J Schultz, AB Johan Groeneveld and Nicole P Juffermans
    Citation: Critical Care 2011 15:R59
    Content type: Research Published on:

  24. Gravimetric validation of single-indicator extravascular lung water (EVLW) and normal EVLW values has not been well studied in humans thus far. The aims of this study were (1) to validate the accuracy of EVLW ...

    Authors: Takashi Tagami, Shigeki Kushimoto, Yasuhiro Yamamoto, Takahiro Atsumi, Ryoichi Tosa, Kiyoshi Matsuda, Renpei Oyama, Takanori Kawaguchi, Tomohiko Masuno, Hisao Hirama and Hiroyuki Yokota
    Citation: Critical Care 2010 14:R162
    Content type: Research Published on:

  25. The prognosis of patients who are admitted in a comatose state following successful resuscitation after cardiac arrest remains uncertain. Although the introduction of therapeutic hypothermia (TH) and improveme...

    Authors: Fabio Silvio Taccone, Tobias Cronberg, Hans Friberg, David Greer, Janneke Horn, Mauro Oddo, Sabino Scolletta and Jean-Louis Vincent
    Citation: Critical Care 2014 18:202
    Content type: Review Published on:

  26. This study aims at comparing the very short-term effects of conventional and noisy (variable) pressure support ventilation (PSV) in mechanically ventilated patients with acute hypoxemic respiratory failure.

    Authors: Peter M Spieth, Andreas Güldner, Robert Huhle, Alessandro Beda, Thomas Bluth, Dierk Schreiter, Max Ragaller, Birgit Gottschlich, Thomas Kiss, Samir Jaber, Paolo Pelosi, Thea Koch and Marcelo Gama de Abreu
    Citation: Critical Care 2013 17:R261
    Content type: Research Published on:

  27. The use of the furosemide stress test (FST) as an acute kidney injury (AKI) severity marker has been described in several trials. However, the diagnostic performance of the FST in predicting AKI progression ha...

    Authors: Jia-Jin Chen, Chih-Hsiang Chang, Yen-Ta Huang and George Kuo
    Citation: Critical Care 2020 24:202
    Content type: Research Published on:

  28. Prone positioning (PP) homogenizes ventilation distribution and may limit ventilator-induced lung injury (VILI) in patients with moderate to severe acute respiratory distress syndrome (ARDS). The static and dy...

    Authors: Christoph Boesing, Joerg Krebs, Alice Marguerite Conrad, Matthias Otto, Grietje Beck, Manfred Thiel, Patricia R. M. Rocco, Thomas Luecke and Laura Schaefer
    Citation: Critical Care 2024 28:82
    Content type: Research Published on:

  29. Despite studies demonstrating benefit, patients with femoral vascular catheters placed for continuous renal replacement therapy are frequently restricted from mobilization. No researchers have reported filter ...

    Authors: Yi Tian Wang, Terry P Haines, Paul Ritchie, Craig Walker, Teri A Ansell, Danielle T Ryan, Phaik-Sim Lim, Sanjiv Vij, Rebecca Acs, Nigel Fealy and Elizabeth H Skinner
    Citation: Critical Care 2014 18:R161
    Content type: Research Published on:

  30. The incidence of deep venous thrombosis (DVT) related to a central venous catheter varies considerably in ICUs depending on the population included. The aim of this study was to determine subclavian central ve...

    Authors: Ariane Gentile, Laurent Petit, Françoise Masson, Vincent Cottenceau, Josseline Bertrand-Barat, Geneviève Freyburger, Catherine Pinaquy, Alain Léger, Jean-François Cochard and François Sztark
    Citation: Critical Care 2013 17:R103
    Content type: Research Published on:

  31. This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at

    Authors: Annemijn H. Jonkman, Heder J. de Vries and Leo M. A. Heunks
    Citation: Critical Care 2020 24:104
    Content type: Review Published on:

    The Correction to this article has been published in Critical Care 2024 28:94

  32. Acute kidney injury (AKI) develops mostly in the context of critical illness and multiple organ failure, characterized by alterations in substrate use, insulin resistance, and hypercatabolism. Optimal nutritio...

    Authors: Michaël P Casaer, Dieter Mesotten and Miet RC Schetz
    Citation: Critical Care 2008 12:222
    Content type: Review Published on:

  33. Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit (ICU) f...

    Authors: Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar…
    Citation: Critical Care 2021 25:25
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2021 25:130

  34. Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-...

    Authors: Zhilin Zeng, Haijing Yu, Huilong Chen, Weipeng Qi, Liang Chen, Guang Chen, Weiming Yan, Tao Chen, Qin Ning, Meifang Han and Di Wu
    Citation: Critical Care 2020 24:525
    Content type: Research Published on:

  35. We assessed the prognostic accuracy of the standardized electroencephalography (EEG) patterns (“highly malignant,” “malignant,” and “benign”) according to the EEG timing (early vs. late) and investigated the E...

    Authors: Youn-Jung Kim, Min-Jee Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Dong Hoon Lee and Won Young Kim
    Citation: Critical Care 2021 25:398
    Content type: Research Published on:

  36. Hypotension following out-of-hospital cardiac arrest (OHCA) may cause secondary brain injury and increase mortality rates. Current guidelines recommend avoiding hypotension. However, the optimal blood pressure...

    Authors: Peter J. McGuigan, Elisa Giallongo, Bronagh Blackwood, James Doidge, David A. Harrison, Alistair D. Nichol, Kathryn M. Rowan, Manu Shankar-Hari, Markus B. Skrifvars, Karen Thomas and Danny F. McAuley
    Citation: Critical Care 2023 27:4
    Content type: Research Published on:

    The Publisher Correction to this article has been published in Critical Care 2023 27:169

    The Matters Arising to this article has been published in Critical Care 2023 27:423

    The Matters Arising to this article has been published in Critical Care 2023 27:404

  38. Several measurements have been used to predict the success of weaning from mechanical ventilation; however, their efficacy varies in different studies. In recent years, diaphragmatic ultrasound has been used f...

    Authors: Henry M. Parada-Gereda, Adriana L. Tibaduiza, Alejandro Rico-Mendoza, Daniel Molano-Franco, Victor H. Nieto, Wanderley A. Arias-Ortiz, Purificación Perez-Terán and Joan R. Masclans
    Citation: Critical Care 2023 27:174
    Content type: Perspective Published on:

  39. Liver failure patients might be at risk for citrate accumulation during continuous venovenous hemodialysis (CVVHD) with regional citrate anticoagulation. The aim of this study was to investigate the predictive...

    Authors: Caroline Schultheiß, Bernd Saugel, Veit Phillip, Philipp Thies, Sebastian Noe, Ulrich Mayr, Bernhard Haller, Henrik Einwächter, Roland M Schmid and Wolfgang Huber
    Citation: Critical Care 2012 16:R162
    Content type: Research Published on:

  40. Pulmonary microbial diversity may be influenced by biotic or abiotic conditions (e.g., disease, smoking, invasive mechanical ventilation (MV), etc.). Specially, invasive MV may trigger structural and physiolog...

    Authors: Chang Liu, Kang Wu, Tianyu Sun, Bin Chen, Yaxing Yi, Ruotong Ren, Lixin Xie and Kun Xiao
    Citation: Critical Care 2022 26:252
    Content type: Review Published on:

  41. Patients with community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU) have high mortality rates during the acute infection and up to ten years thereafter. Recommendations from internationa...

    Authors: Luis Felipe Reyes, Esteban Garcia, Elsa D. Ibáñez-Prada, Cristian C. Serrano-Mayorga, Yuli V. Fuentes, Alejandro Rodríguez, Gerard Moreno, Alirio Bastidas, Josep Gómez, Angélica Gonzalez, Christopher R. Frei, Leo Anthony Celi, Ignacio Martin-Loeches and Grant Waterer
    Citation: Critical Care 2023 27:212
    Content type: Research Published on:

  42. Trauma is a leading cause of mortality and morbidity, with traumatic brain injury (TBI) and uncontrolled hemorrhage responsible for the majority of these deaths. Recombinant activated factor VIIa (rFVIIa) is b...

    Authors: Yoram Kluger, Bruno Riou, Rolf Rossaint, Sandro B Rizoli, Kenneth David Boffard, Philip Iau Tsau Choong, Brian Warren and Michael Tillinger
    Citation: Critical Care 2007 11:R85
    Content type: Research Published on:

  43. Subsyndromal delirium (SSD) is a frequent condition and has been commonly described as an intermediate stage between delirium and normal cognition. However, the true frequency of SSD and its impact on clinical...

    Authors: Rodrigo B. Serafim, Marcio Soares, Fernando A. Bozza, José R. Lapa e Silva, Felipe Dal-Pizzol, Maria Carolina Paulino, Pedro Povoa and Jorge I. F. Salluh
    Citation: Critical Care 2017 21:179
    Content type: Research Published on:

  44. The aim of this study was to assess how mean systemic pressure (Psm) and resistance to venous return (Rvr) behave during passive leg raising (PLR) in cases of fluid responsiveness and fluid unresponsiveness.

    Authors: Laurent Guérin, Jean-Louis Teboul, Romain Persichini, Martin Dres, Christian Richard and Xavier Monnet
    Citation: Critical Care 2015 19:411
    Content type: Research Published on:

  45. Glutamine has been launched as a conditionally indispensible amino acid for the critically ill. Supplementation has been recommended in guidelines from international societies. Although data have been presente...

    Authors: Marie Smedberg and Jan Wernerman
    Citation: Critical Care 2016 20:361
    Content type: Viewpoint Published on:

  47. There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim of this study was to identify markers for IHD weaning in critically ill patients with acute kid...

    Authors: Julien Aniort, Ali Ait Hssain, Bruno Pereira, Elisabeth Coupez, Pierre Antoine Pioche, Christophe Leroy, Anne Elisabeth Heng, Bertrand Souweine and Alexandre Lautrette
    Citation: Critical Care 2016 20:43
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:154

  48. The proportion of survivors of acute respiratory failure is growing; yet, many do not regain full function and require prolonged admission in an acute or post-acute care facility. Little is known about their t...

    Authors: Anna Neumeier, Amy Nordon-Craft, Dan Malone, Margaret Schenkman, Brendan Clark and Marc Moss
    Citation: Critical Care 2017 21:190
    Content type: Research Published on:

  50. Indirect calorimetry allows the determination of energy expenditure in critically ill patients by measuring oxygen consumption (VO2) and carbon dioxide production (VCO2). Recent studies have demonstrated variable...

    Authors: Martin Sundström Rehal, Erik Fiskaare, Inga Tjäder, Åke Norberg, Olav Rooyackers and Jan Wernerman
    Citation: Critical Care 2016 20:54
    Content type: Research Published on:

    The Erratum to this article has been published in Critical Care 2016 20:104

    The Commentary to this article has been published in Critical Care 2016 20:138

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Critical Care

ISSN: 1364-8535