Articles
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Citation: Critical Care 2014 18(Suppl 1):P475
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Development of key performance indicators for renal replacement therapy in adult intensive care to guide safe and cost-effective therapy
Citation: Critical Care 2014 18(Suppl 1):P396 -
Role of the rapid shallow breathing index to predict the success of mechanical ventilator liberation in acute respiratory failure
Citation: Critical Care 2014 18(Suppl 1):P300 -
Mechanisms underlying the lung-protective effects of FLow- controlled EXpiration
Citation: Critical Care 2014 18(Suppl 1):P296 -
Association between DNA haplogroups and severe sepsis in patients who underwent major surgery
Citation: Critical Care 2014 18(Suppl 1):P224 -
Lactate quartile concentration and prognosis in severe sepsis and septic shock
Citation: Critical Care 2014 18(Suppl 1):P176 -
Another brick in the wall of needs for invasive ventilation?
Ventilator-induced lung injury and ventilator-induced diaphragmatic dysfunction are major complications in mechanically ventilated patients with acute respiratory failure. Invasive ventilation adds a further b...
Citation: Critical Care 2014 18:122 -
Separating signal from noise: the challenge of identifying useful biomarkers in sepsis
Sepsis diagnosis remains based largely on clinical presentation despite significant advances in the understanding of underlying pathophysiology and host-pathogen interactions. The systematic review article by ...
Citation: Critical Care 2014 18:121 -
Eculizumab treatment of atypical haemolytic uraemic syndrome: results from the largest prospective clinical trial to date
Citation: Critical Care 2014 18(Suppl 1):P105 -
Factors affecting the clinical response to National Early Warning score triggers
Citation: Critical Care 2014 18(Suppl 1):P45 -
Calorie intake and patient outcomes in severe acute kidney injury: findings from The Randomized Evaluation of Normal vs. Augmented Level of Replacement Therapy (RENAL) study trial
Current practice in the delivery of caloric intake (DCI) in patients with severe acute kidney injury (AKI) receiving renal replacement therapy (RRT) is unknown. We aimed to describe calorie administration in p...
Citation: Critical Care 2014 18:R45 -
The ethical dimension in published animal research in critical care: the dark side of our moon
The replacement, refinement, and reduction (3Rs) guidelines are the cornerstone of animal welfare practice for medical research. Nowadays, no animal research can be performed without being approved by an anima...
Citation: Critical Care 2014 18:120 -
Selective decontamination: no oracle needed
Citation: Critical Care 2014 18:417 -
Fluid therapy in patients with brain injury: what does physiology tell us?
Citation: Critical Care 2014 18:119 -
The ‘availability’ bias: underappreciated but with major potential implications
Many biases have been described that potentially introduce prejudice or a systemic error into a study that would favor one outcome versus another. One major source of bias has, so far, been underappreciated: t...
Citation: Critical Care 2014 18:118 -
Percutaneous dilatational tracheostomy: mostly safe, but do benefits outweigh risks?
Percutaneous dilatational tracheostomies have become one of the most frequently performed surgical procedures in the ICU, and are believed to offer a variety of advantages over open tracheostomies, including i...
Citation: Critical Care 2014 18:117 -
Should we breathe quiet or noisy?
External noise is introduced by computer-generated random levels of pressure assistance during noisy pressure support ventilation (PSV). In patients, noisy PSV was associated with higher tidal volume variabili...
Citation: Critical Care 2014 18:116 -
Procalcitonin for diagnosis of bacterial pneumonia in critically ill patients during 2009 H1N1 influenza pandemic: a prospective cohort study, systematic review and individual patient data meta-analysis
Procalcitonin (PCT) is helpful for diagnosing bacterial infections. The diagnostic utility of PCT has not been examined thoroughly in critically ill patients with suspected H1N1 influenza.
Citation: Critical Care 2014 18:R44 -
Thoracic ultrasonography versus chest radiography for detection of pneumothoraces: challenges in deriving and interpreting summary diagnostic accuracy estimates
Citation: Critical Care 2014 18:416 -
Renal replacement therapy for critically ill patients: an intermittent continuity
Choice of the right renal replacement therapy for severe acute kidney injury in critically ill patients has been investigated many times in the last two decades. Although some questions have been answered, in ...
Citation: Critical Care 2014 18:115 -
Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study
Current sepsis guidelines recommend antimicrobial treatment (AT) within one hour after onset of sepsis-related organ dysfunction (OD) and surgical source control within 12 hours. The objective of this study wa...
Citation: Critical Care 2014 18:R42 -
Soluble platelet-endothelial cell adhesion molecule-1, a biomarker of ventilator-induced lung injury
Endothelial cell injury is an important component of acute lung injury. Platelet-endothelial cell adhesion molecule-1 (PECAM1) is a transmembrane protein that connects endothelial cells to one another and can ...
Citation: Critical Care 2014 18:R41 -
The brain-enriched microRNA miR-124 in plasma predicts neurological outcome after cardiac arrest
Early prognostication after successful cardiopulmonary resuscitation is difficult, and there is a need for novel methods to estimate the extent of brain injury and predict outcome. In this study, we evaluated ...
Citation: Critical Care 2014 18:R40 -
Effect of glomerular filtration rate impairment on diagnostic performance of neutrophil gelatinase-associated lipocalin and B-type natriuretic peptide as markers of acute cardiac and renal failure in chronic kidney disease patients
Cardio-renal syndromes are characterized by the impairment of cardiac and renal functions. Plasma and urinary neutrophil gelatinase-associated lipocalin (NGAL), and plasma B-type natriuretic peptide (BNP) are ...
Citation: Critical Care 2014 18:R39 -
Long live dynamic parameters!
Citation: Critical Care 2014 18:413 -
Colistin dosing for treatment of multidrug-resistant Pseudomonasin critically ill patients - please, be adequate!
Citation: Critical Care 2014 18:412 -
Do men perform better than women in trauma?
In recent decades, numerous studies have compared survival according to gender of patients admitted to general hospitals and particularly to intensive care units. In a previous issue of Critical Care, Schoeneberg...
Citation: Critical Care 2014 18:114 -
Early mobilization of patients receiving extracorporeal membrane oxygenation: a retrospective cohort study
Critical illness is a well-recognized cause of neuromuscular weakness and impaired physical functioning. Physical therapy (PT) has been demonstrated to be safe and effective for critically ill patients. The im...
Citation: Critical Care 2014 18:R38 -
Malignant hyperthermia in the intensive care setting
Citation: Critical Care 2014 18:411 -
Development of a simple score to predict outcome for unresponsive wakefulness syndrome
Accurate assessment of prognosis for patients with unresponsive wakefulness syndrome (UWS; formerly vegetative state) may help clinicians and families guide the type and intensity of therapy; however, there is...
Citation: Critical Care 2014 18:R37 -
Cytomegalovirus reactivation in critically ill burn patients: it’s time to worry about it!
Citation: Critical Care 2014 18:410 -
Equipment in anaesthesia and critical care
Citation: Critical Care 2014 18:304 -
Residents learning ultrasound-guided catheterization are not sufficiently skilled to use landmarks
Ultrasound-guided (UG) technique is the recommended procedure for central venous catheterization (CVC). However, as ultrasound may not be available in emergency situations, guidelines also propose that physici...
Citation: Critical Care 2014 18:R36 -
Human factors play a vital role in the outcome of percutaneous dilatational tracheostomy
Citation: Critical Care 2014 18:409 -
Implementing evidence-based practice in the neuroscience intensive care unit
Citation: Critical Care 2014 18:303 -
Clinical monitoring of peripheral perfusion: there is more to learn
Irrespective of initiating factors, the peripheral circulation shows two general phases during the development and treatment of shock. Most published reports support earlier knowledge that the peripheral circu...
Citation: Critical Care 2014 18:113 -
Incretins and the intensivist: what are they and what does an intensivist need to know about them?
Hyperglycaemia occurs frequently in the critically ill, even in those patients without a history of diabetes. The mechanisms underlying hyperglycaemia in this group are complex and incompletely defined. In hea...
Citation: Critical Care 2014 18:205 -
Choosing wisely - when to mend a broken heart with ECMO?
Refractory cardiac shock in the cardiac surgical intensive care unit confers significant morbidity and mortality. Extracorporeal membrane oxygenation (ECMO) has become a common intervention for refractory card...
Citation: Critical Care 2014 18:112 -
Avoidable statistical pitfalls in analyzing length of stay in intensive care units or hospitals
Citation: Critical Care 2014 18:408 -
Feasibility and reliability of an automated controller of inspired oxygen concentration during mechanical ventilation
Hypoxemia and high fractions of inspired oxygen (FiO2) are concerns in critically ill patients. An automated FiO2 controller based on continuous oxygen saturation (SpO2) measurement was tested. Two different SpO2
Citation: Critical Care 2014 18:R35 -
Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults
Sepsis is a severe and life-threatening systemic inflammatory response to infection that affects all populations and age groups. The pathophysiology of sepsis is associated with aberrant interaction between le...
Citation: Critical Care 2014 18:204 -
Early hemodynamic resuscitation in septic shock: understanding and modifying oxygen delivery
In a previous issue of Critical Care, researchers have focused on the venous-to-arterial carbon dioxide difference (Pv-aCO2) as a surrogate marker for systemic perfusion in patients with septic shock. Although th...
Citation: Critical Care 2014 18:111 -
Skeletal muscle mass and mortality - but what about functional outcome?
We have known for over a decade that critical illness survivors suffer from significant functional disability after hospital discharge. Muscle wasting is a major contributor to this disability, occurring early...
Citation: Critical Care 2014 18:110 -
Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis
The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin (ADM) plays a central role in initiating the hyperdynamic response during the early stages of sepsis. Pi...
Citation: Critical Care 2014 18:R34 -
Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study
Microvascular alterations impair tissue oxygenation during sepsis. A red blood cell (RBC) transfusion increases oxygen (O2) delivery but rarely improves tissue O2 uptake in patients with sepsis. Possible causes i...
Citation: Critical Care 2014 18:R33 -
Circulating neutrophil counts and mortality in septic shock
Citation: Critical Care 2014 18:407 -
Preventing deaths related to percutaneous tracheostomy: safety is never too much!
Citation: Critical Care 2014 18:406 -
Fever in sepsis: is it cool to be hot?
Changes in body temperature are a characteristic feature of sepsis. The study by Kushimoto and colleagues in a recent issue of Critical Care demonstrates that hypothermia is a very important manifestation of infe...
Citation: Critical Care 2014 18:109 -
Predicting outcome in patients with sepsis: new biomarkers for old expectations
Early prediction of the outcome of patients with sepsis could be helpful in guiding therapies but remains challenging. Presepsin, a new sepsis biomarker whose elevation as early as day 1 is well correlated wit...
Citation: Critical Care 2014 18:108 -
Incidence and diagnosis of ventilator-associated tracheobronchitis in the intensive care unit: an international online survey
Several aspects of ventilator-associated tracheobronchitis (VAT)—including diagnostic criteria, overlap with ventilator-associated pneumonia (VAP), and appropriate treatment regimens—remain poorly defined. The...
Citation: Critical Care 2014 18:R32
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- ISSN: 1364-8535 (electronic)