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  2. Theoretically, high-frequency oscillatory ventilation (HFOV) achieves all goals of a lung-protective ventilatory mode and seems ideal for the treatment of adult patients with acute respiratory distress syndrom...

    Authors: Chun-Ta Huang, Hsien-Ho Lin, Sheng-Yuan Ruan, Meng-Sui Lee, Yi-Ju Tsai and Chong-Jen Yu
    Citation: Critical Care 2014 18:R102
    Content type: Research Published on:

  4. In the previous issue of Critical Care, Mori and colleagues demonstrate that glutamine supplementation in mechanically ventilated patients as part of parenteral nutrition increases plasma glutamine concentration ...

    Authors: Heleen M Oudemans-van Straaten and Arthur RH van Zanten
    Citation: Critical Care 2014 18:143
    Content type: Commentary Published on:

  5. Low plasma selenium concentrations are frequent in critically ill patients. However, whether this is due to systemic inflammation, a deficient nutritional state or both is still not clear. We aimed to determin...

    Authors: Simone Brasil de Oliveira Iglesias, Heitor Pons Leite, Ângela Tavares Paes, Susyane Vieira de Oliveira and Roseli Oselka Saccardo Sarni
    Citation: Critical Care 2014 18:R101
    Content type: Research Published on:

  6. Acute kidney injury (AKI) following acute myocardial infarction (AMI) is associated with unfavorable prognosis. Endothelial activation and injury were found to play a critical role in the development of both A...

    Authors: Kuan-Liang Liu, Kuang-Tso Lee, Chih-Hsiang Chang, Yung-Chang Chen, Shu-Min Lin and Pao-Hsien Chu
    Citation: Critical Care 2014 18:R100
    Content type: Research Published on:

  7. Acute respiratory distress syndrome (ARDS) continues to have significant mortality and morbidity. The only intervention proven to reduce mortality is the use of lung-protective mechanical ventilation strategie...

    Authors: Marianne Fitzgerald, Jonathan Millar, Bronagh Blackwood, Andrew Davies, Stephen J Brett, Daniel F McAuley and James J McNamee
    Citation: Critical Care 2014 18:222
    Content type: Review Published on:

  8. The objective of this study was to describe the pharmacokinetics of vancomycin in ICU patients and to examine whether contemporary antibiotic dosing results in concentrations that have been associated with fav...

    Authors: Stijn Blot, Despoina Koulenti, Murat Akova, Matteo Bassetti, Jan J De Waele, George Dimopoulos, Kirsi-Maija Kaukonen, Claude Martin, Philippe Montravers, Jordi Rello, Andrew Rhodes, Therese Starr, Steven C Wallis, Jeffrey Lipman and Jason A Roberts
    Citation: Critical Care 2014 18:R99
    Content type: Research Published on:

  11. Blunt chest wall trauma accounts for over 15% of all trauma admissions to Emergency Departments worldwide. Reported mortality rates vary between 4 and 60%. Management of this patient group is challenging as a ...

    Authors: Ceri Elisabeth Battle, Hayley Hutchings, Simon Lovett, Omar Bouamra, Sally Jones, Aruni Sen, James Gagg, David Robinson, Jake Hartford-Beynon, Jeremy Williams and Adrian Evans
    Citation: Critical Care 2014 18:R98
    Content type: Research Published on:

  12. Severe sepsis is a major healthcare problem and the early initiation of antimicrobials is one of the few measures associated with improved outcomes. However, antibiotic overuse is an increasing problem in crit...

    Authors: Jorge IF Salluh, Vandack Nobre and Pedro Povoa
    Citation: Critical Care 2014 18:142
    Content type: Commentary Published on:

  14. Despite recent advances in the management of septic shock, mortality remains unacceptably high. Earlier initiation of key therapies including appropriate antimicrobials and fluid resuscitation appears to reduc...

    Authors: Vance Beck, Dan Chateau, Gregory L Bryson, Amarnath Pisipati, Sergio Zanotti, Joseph E Parrillo and Anand Kumar
    Citation: Critical Care 2014 18:R97
    Content type: Research Published on:

  15. Tailoring interventions to address identified barriers to change may be an effective strategy to implement guidelines and improve practice. However, there is inadequate data to inform the optimal method or lev...

    Authors: Naomi E Cahill, Lauren Murch, Deborah Cook and Daren K Heyland
    Citation: Critical Care 2014 18:R96
    Content type: Research Published on:

  16. This study compares different parameters derived from electrical impedance tomography (EIT) data to define ‘best’ positive end-expiratory pressure (PEEP) during a decremental PEEP trial in mechanically-ventila...

    Authors: Paul Blankman, Djo Hasan, Groot Jebbink Erik and Diederik Gommers
    Citation: Critical Care 2014 18:R95
    Content type: Research Published on:

  17. Evolution of extracorporeal life support (ECLS) technology has added a new dimension to the intensive care management of acute cardiac and/or respiratory failure in adult patients who fail conventional treatme...

    Authors: Kiran Shekar, Daniel V Mullany, Bruce Thomson, Marc Ziegenfuss, David G Platts and John F Fraser
    Citation: Critical Care 2014 18:219
    Content type: Review Published on:

  18. Elevated plasma B-type natriuretic peptide (BNP) levels in patients with critical sepsis (severe sepsis and septic shock) may indicate septic cardiomyopathy. However, multiple heterogeneous conditions may also...

    Authors: John Papanikolaou, Demosthenes Makris, Maria Mpaka, Eleni Palli, Paris Zygoulis and Epaminondas Zakynthinos
    Citation: Critical Care 2014 18:R94
    Content type: Research Published on:

  20. Ultrasound guidance has emerged as an adjunct for central vein catheterization in both adults and children. However, the use of ultrasound guidance for radial arterial catheterization has not been well establi...

    Authors: Wan-Jie Gu, Hong-Tao Tie, Jing-Chen Liu and Xian-Tao Zeng
    Citation: Critical Care 2014 18:R93
    Content type: Research Published on:

  22. Selenoenzymes can modulate the extent of oxidative stress, which is recognized as a key feature of septic shock. The pathophysiologic role of erythrocyte selenium concentration in patients with septic shock re...

    Authors: Nara Aline Costa, Ana Lúcia Gut, José Alexandre Coelho Pimentel, Silvia Maria Franciscato Cozzolino, Paula Schmidt Azevedo, Ana Angélica Henrique Fernandes, Bertha Furlan Polegato, Suzana Erico Tanni, Rafael Dezen Gaiolla, Leonardo Antonio Mamede Zornoff, Sergio Alberto Rupp de Paiva and Marcos Ferreira Minicucci
    Citation: Critical Care 2014 18:R92
    Content type: Research Published on:

  23. The study was designed to assess the impact of fluid loading on lung aeration, oxygenation and hemodynamics in patients with septic shock and acute respiratory distress syndrome (ARDS).

    Authors: Fabiola Prior Caltabeloti, Antoine Monsel, Charlotte Arbelot, Hélène Brisson, Qin Lu, Wen-Jie Gu, Guang-Ju Zhou, José O C Auler Jr and Jean-Jacques Rouby
    Citation: Critical Care 2014 18:R91
    Content type: Research Published on:

  24. The high incidence of multidrug-resistant (MDR) bacteria among patients admitted to ICUs has determined an increase of tigecycline (TGC) use for the treatment of severe infections. Many concerns have been rais...

    Authors: Gennaro De Pascale, Luca Montini, Mariano Alberto Pennisi, Valentina Bernini, Riccardo Maviglia, Giuseppe Bello, Teresa Spanu, Mario Tumbarello and Massimo Antonelli
    Citation: Critical Care 2014 18:R90
    Content type: Research Published on:

  25. Cerebral glucose metabolism and energy production are affected by serum glucose levels. Systemic glucose variability has been shown to be associated with poor outcome in critically ill patients. The objective ...

    Authors: Pedro Kurtz, Jan Claassen, Raimund Helbok, J Michael Schmidt, Luis Fernandez, Mary Presciutti, R Morgan Stuart, E Sander Connolly, Kiwon Lee, Neeraj Badjatia and Stephan A Mayer
    Citation: Critical Care 2014 18:R89
    Content type: Research Published on:

  28. We developed a protocol to initiate surgical source control immediately after admission (early source control) and perform initial resuscitation using early goal-directed therapy (EGDT) for gastrointestinal (G...

    Authors: Takeo Azuhata, Kosaku Kinoshita, Daisuke Kawano, Tomonori Komatsu, Atsushi Sakurai, Yasutaka Chiba and Katsuhisa Tanjho
    Citation: Critical Care 2014 18:R87
    Content type: Research Published on:

  31. Both patient- and context-specific factors may explain the conflicting evidence regarding glucose control in critically ill patients. Blood glucose variability appears to correlate with mortality, but this var...

    Authors: Michael J Lanspa, Justin Dickerson, Alan H Morris, James F Orme, John Holmen and Eliotte L Hirshberg
    Citation: Critical Care 2014 18:R86
    Content type: Research Published on:

  34. Acute respiratory distress syndrome (ARDS) is a major cause of mortality in intensive care units. Patients with ARDS often require parenteral nutrition with lipid emulsions as essential components. Besides bei...

    Authors: Matthias Hecker, Juliane Ott, Christoph Sondermann, Martina Barbara Schaefer, Martin Obert, Andreas Hecker, Rory E Morty, Istvan Vadasz, Susanne Herold, Bernhard Rosengarten, Martin Witzenrath, Werner Seeger and Konstantin Mayer
    Citation: Critical Care 2014 18:R85
    Content type: Research Published on:

  35. The study aimed to determine the impact of treatment frequency, hospital size, and capability on mortality of patients admitted after cardiac arrest for postresuscitation care to different intensive care units.

    Authors: Andreas Schober, Michael Holzer, Helene Hochrieser, Martin Posch, Rene Schmutz and Philipp Metnitz
    Citation: Critical Care 2014 18:R84
    Content type: Research Published on:

  36. The world has experienced some very large shifts in the epidemiology of carbon monoxide poisoning, but it remains one of the most important toxicological global causes of morbidity and mortality. The diagnosis...

    Authors: Angela L Chiew and Nicholas A Buckley
    Citation: Critical Care 2014 18:221
    Content type: Review Published on:

  37. Ventilator-associated pneumonia (VAP) is the most commonly acquired infection in intensive care units (ICU). Its outcome is related, at least in part, to the host’s response. Statins have anti-inflammatory eff...

    Authors: Rémi Bruyere, Clara Vigneron, Sébastien Prin, André Pechinot, Jean-Pierre Quenot, Serge Aho, Laurent Papazian and Pierre-Emmanuel Charles
    Citation: Critical Care 2014 18:R83
    Content type: Research Published on:

  38. Heparin is safe and prevents venous thromboembolism in critical illness. We aimed to determine the guideline concordance for thromboprophylaxis in critically ill patients and its predictors, and to analyze fac...

    Authors: François Lauzier, John Muscedere, Éric Deland, Demetrios Jim Kutsogiannis, Michael Jacka, Diane Heels-Ansdell, Mark Crowther, Rodrigo Cartin-Ceba, Michael J Cox, Nicole Zytaruk, Denise Foster, Tasnim Sinuff, France Clarke, Patrica Thompson, Steven Hanna and Deborah Cook
    Citation: Critical Care 2014 18:R82
    Content type: Research Published on:

  39. For patients presenting with acute brain injury (such as traumatic brain injury, subarachnoid haemorrhage and stroke), the diagnosis and identification of intracerebral lesions and evaluation of the severity, ...

    Authors: Ségolène Mrozek, Julien Dumurgier, Giuseppe Citerio, Alexandre Mebazaa and Thomas Geeraerts
    Citation: Critical Care 2014 18:220
    Content type: Review Published on:

  40. In vitamin K antagonist (VKA)-treated patients with severe hemorrhage, guidelines recommend prompt VKA reversal with prothrombin complex concentrate (PCC) and vitamin K. The aim of this observational cohort st...

    Authors: Karim Tazarourte, Bruno Riou, Benjamin Tremey, Charles-Marc Samama, Éric Vicaut and Bernard Vigué
    Citation: Critical Care 2014 18:R81
    Content type: Research Published on:

  41. Septic shock is the most severe manifestation of sepsis. It is characterized as a hypotensive cardiovascular state associated with multiorgan dysfunction and metabolic disturbances. Management of septic shock ...

    Authors: Fabio Guarracino, Baldassare Ferro, Andrea Morelli, Pietro Bertini, Rubia Baldassarri and Michael R Pinsky
    Citation: Critical Care 2014 18:R80
    Content type: Research Published on:

  42. The aim of this study was to determine if there are differences between patients with pre-existing left ventricular dysfunction and those with normal antecedent left ventricular function during a sepsis episod...

    Authors: Daniel R Ouellette and Sadia Z Shah
    Citation: Critical Care 2014 18:R79
    Content type: Research Published on:

  44. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury (AKI), and levels reflect severity of disease in critically ill patients. However, continuous venovenous hemofiltration (...

    Authors: Louise Schilder, S Azam Nurmohamed, Pieter M ter Wee, Nanne J Paauw, Armand RJ Girbes, Albertus Beishuizen, Robert HJ Beelen and AB Johan Groeneveld
    Citation: Critical Care 2014 18:R78
    Content type: Research Published on:

  45. The use of a system for continuous control of endotracheal tube cuff pressure reduced the incidence of ventilator-associated pneumonia (VAP) in one randomized controlled trial (RCT) with 112 patients but not i...

    Authors: Leonardo Lorente, María Lecuona, Alejandro Jiménez, Lisset Lorenzo, Isabel Roca, Judith Cabrera, Celina Llanos and María L Mora
    Citation: Critical Care 2014 18:R77
    Content type: Research Published on:

  46. The potential benefit of parenteral glutamine (GLN) supplementation has been one of the most commonly studied nutritional interventions in the critical care setting. The aim of this systematic review was to in...

    Authors: Paul E Wischmeyer, Rupinder Dhaliwal, Michele McCall, Thomas R Ziegler and Daren K Heyland
    Citation: Critical Care 2014 18:R76
    Content type: Research Published on:

  48. Research into therapeutic hypothermia following traumatic brain injury has been characterised by small trials of poor methodological quality, producing variable results. The Cochrane review, published in 2009,...

    Authors: Samantha Crossley, Jenny Reid, Rachel McLatchie, Judith Hayton, Clair Clark, Margaret MacDougall and Peter JD Andrews
    Citation: Critical Care 2014 18:R75
    Content type: Research Published on:

  50. The predisposition, infection, response and organ dysfunction (PIRO) staging system was designed as a stratification tool to deal with the inherent heterogeneity of septic patients. The present study was condu...

    Authors: Yun-Xia Chen and Chun-Sheng Li
    Citation: Critical Care 2014 18:R74
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535