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  1. We conducted a prospective observational study in cardiac arrest survivors treated with mild induced hypothermia, evaluating different platelet function tests at hypo- and normothermia. We also investigated th...

    Authors: Thomas Kander, Josef Dankiewicz, Hans Friberg and Ulf Schött
    Citation: Critical Care 2014 18:495
  2. ICU-acquired weakness (ICUAW) complicates the disease course of critically ill patients. Inflammation and acute-phase response occur directly within myocytes and contribute to ICUAW. We observed that tripartit...

    Authors: Franziska Schmidt, Melanie Kny, Xiaoxi Zhu, Tobias Wollersheim, Kathleen Persicke, Claudia Langhans, Doerte Lodka, Christian Kleber, Steffen Weber-Carstens and Jens Fielitz
    Citation: Critical Care 2014 18:545
  3. Prompt treatment of severe sepsis in the Emergency Department reduces deaths, but the role of prehospital fluid resuscitation is unknown. We sought to determine the risk-adjusted association between prehospita...

    Authors: Christopher W Seymour, Colin R Cooke, Susan R Heckbert, John A Spertus, Clifton W Callaway, Christian Martin-Gill, Donald M Yealy, Thomas D Rea and Derek C Angus
    Citation: Critical Care 2014 18:533
  4. The early detection and treatment of sepsis are the most important factors in improving the outcome of patients with this condition. However, many patients admitted to hospital experience a long delay in the d...

    Authors: Paul E Marik
    Citation: Critical Care 2014 18:529
  5. The pathophysiology of endotoxemia-induced acute kidney injury (AKI) is characterized by an intense activation of the host immune system and renal resident cells by lipopolysaccharide (LPS) and derived proinfl...

    Authors: Giuseppe Castellano, Alessandra Stasi, Angelica Intini, Margherita Gigante, Anna Maria Di Palma, Chiara Divella, Giuseppe Stefano Netti, Clelia Prattichizzo, Paola Pontrelli, Antonio Crovace, Francesco Staffieri, Enrico Fiaccadori, Nicola Brienza, Giuseppe Grandaliano, Giovanni Pertosa and Loreto Gesualdo
    Citation: Critical Care 2014 18:520
  6. The understanding of coagulopathies in trauma has increased interest in thromboelastography (TEG®) and thromboelastometry (ROTEM®), which promptly evaluate the entire clotting process and may guide blood produ...

    Authors: Luis Teodoro Da Luz, Bartolomeu Nascimento, Ajith Kumar Shankarakutty, Sandro Rizoli and Neill KJ Adhikari
    Citation: Critical Care 2014 18:518
  7. Prolonged conventional cardiopulmonary resuscitation (CCPR) is associated with a poor prognosis in out-of-hospital cardiac arrest (OHCA) patients. Alternative methods can be needed to improve the outcome in pa...

    Authors: Su Jin Kim, Jae Seung Jung, Jae Hyoung Park, Jong Su Park, Yun Sik Hong and Sung Woo Lee
    Citation: Critical Care 2014 18:535
  8. Circulating histones have been identified as mediators of damage in animal models of sepsis and in patients with trauma-associated lung injury. Despite existing controversies on actual histone concentrations, ...

    Authors: Michael Liembo Ekaney, Gordon Philipp Otto, Maik Sossdorf, Christoph Sponholz, Michael Boehringer, Wolfgang Loesche, Daniel Rittirsch, Arne Wilharm, Oliver Kurzai, Michael Bauer and Ralf Alexander Claus
    Citation: Critical Care 2014 18:543
  9. As the threat of international terrorism rises, there is an increasing requirement to provide evidence-based information and training for the emergency personnel who will respond to terrorist incidents. Curren...

    Authors: Julian Thompson, Marius Rehn, Hans Morten Lossius and David Lockey
    Citation: Critical Care 2014 18:521
  10. The psychological impact of critical illness on a patient can be severe, and frequently results in acute distress as well as psychological morbidity after leaving hospital. A UK guideline states that patients ...

    Authors: Dorothy M Wade, Matthew Hankins, Deborah A Smyth, Elijah E Rhone, Michael G Mythen, David CJ Howell and John A Weinman
    Citation: Critical Care 2014 18:519
  11. There is substantial variability in the preoperative use of intraaortic balloon pumps (IABPs) in patients undergoing coronary artery bypass grafting post myocardial infarction. The objective of this study is t...

    Authors: Pey-Jen Yu, Hugh A Cassiere, Sophia L Dellis, Nina Kohn, Frank Manetta and Alan R Hartman
    Citation: Critical Care 2014 18:531
  12. Regulatory agencies in North America and Europe recently re-evaluated the safety of metoclopramide. This re-evaluation resulted in recommendations and restrictions in order to minimise the risk of neurological...

    Authors: Y Gert van der Meer, Willem A Venhuizen, Daren K Heyland and Arthur RH van Zanten
    Citation: Critical Care 2014 18:502
  13. The prognostic significance of conversion from nonshockable to shockable rhythms in patients with initial nonshockable rhythms who experience out-of-hospital cardiac arrest (OHCA) remains unclear. We hypothesi...

    Authors: Yoshikazu Goto, Tetsuo Maeda and Yumiko Nakatsu-Goto
    Citation: Critical Care 2014 18:528
  14. There are little data about patients with cardiogenic shock (CS) who survive the early phase of acute myocardial infarction (AMI). The aim of this study was to assess long-term (5-year) mortality among early s...

    Authors: Nadia Aissaoui, Etienne Puymirat, Tabassome Simon, Eric Bonnefoy-Cudraz, Denis Angoulvant, Francois Schiele, Hakim Benamer, Philippe Quandalle, Fabrice Prunier, Eric Durand, Laurence Berard, Didier Blanchard and Nicolas Danchin
    Citation: Critical Care 2014 18:516
  15. Long-term ventilated intensive care patients frequently require tracheostomy. Although overall risks are low, serious immediate and late complications still arise. Real-time ultrasound guidance has been propos...

    Authors: Máté Rudas, Ian Seppelt, Robert Herkes, Robert Hislop, Dorrilyn Rajbhandari and Leonie Weisbrodt
    Citation: Critical Care 2014 18:514
  16. Patients with severe acute kidney injury (AKI) who are hospitalized at centers that do not provide renal replacement therapy (RRT) are frequently subjected to inter-hospital transfer for the provision of RRT. ...

    Authors: Paul Kudlow, Karen EA Burns, Neill KJ Adhikari, Benjamin Bell, David J Klein, Bin Xie, Jan O Friedrich and Ron Wald
    Citation: Critical Care 2014 18:513
  17. The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect of genetic deficiency of the en...

    Authors: Ciro Coletta, Katalin Módis, Gábor Oláh, Attila Brunyánszki, Daniela S Herzig, Edward R Sherwood, Zoltán Ungvári and Csaba Szabo
    Citation: Critical Care 2014 18:511
  18. Numerous factors interfere with the ability to achieve optimal pharmacokinetic and pharmacodynamic targets and this has been associated with greater mortality and lower cure rates. The recent study by Zoller a...

    Authors: Guy A Richards and Adrian J Brink
    Citation: Critical Care 2014 18:525
  19. In a previous report, we demonstrated a favorable trend for supplementation with antithrombin (AT) concentrate at a dosage of 3,000 IU/day over 1,500 IU/day for the treatment of sepsis-associated disseminated ...

    Authors: Toshiaki Iba, Daizoh Saitoh, Hideo Wada and Hidesaku Asakura
    Citation: Critical Care 2014 18:497
  20. Sodium bicarbonate (SBIC) was reported to be a promising approach to prevent cardiac surgery-associated acute kidney injury (CSA-AKI). However, the results remain controversial. We conducted a systematic revie...

    Authors: Hong-Tao Tie, Ming-Zhu Luo, Ming-Jing Luo, Min Zhang, Qing-Chen Wu and Jing-Yuan Wan
    Citation: Critical Care 2014 18:517
  21. Assist in unison to the patient’s inspiratory neural effort and feedback-controlled limitation of lung distension with neurally adjusted ventilatory assist (NAVA) may reduce the negative effects of mechanical ...

    Authors: David Berger, Stefan Bloechlinger, Jukka Takala, Christer Sinderby and Lukas Brander
    Citation: Critical Care 2014 18:499
  22. We sought to investigate whether treatment of subnormal (<70%) central venous oxygen saturation (ScvO2) with inotropes or red blood cell (RBC) transfusion during early goal-directed therapy (EGDT) for septic shoc...

    Authors: Dustin G Mark, John W Morehouse, Yun-Yi Hung, Mamata V Kene, Andrew R Elms, Vincent Liu, Dustin W Ballard and David R Vinson
    Citation: Critical Care 2014 18:496
  23. Immobilization of hindlimb muscles in a shortened position results in an accelerated rate of inactivity-induced muscle atrophy and contractile dysfunction. Similarly, prolonged controlled mechanical ventilatio...

    Authors: Catherine SH Sassoon, Ercheng Zhu, Liwei Fang, Gary C Sieck and Scott K Powers
    Citation: Critical Care 2014 18:494
  24. Endotoxemia and the systemic inflammatory response syndrome have a significant impact on post-surgery outcome, particularly in the elderly. The cytokine response to endotoxin is altered by aging. We tested the...

    Authors: Hanan Slimani, Yufeng Zhai, Nasser G Yousif, Lihua Ao, Qingchun Zeng, David A Fullerton and Xianzhong Meng
    Citation: Critical Care 2014 18:527
  25. When alveoli collapse the traction forces exerted on their walls by adjacent expanded units may increase and concentrate. These forces may promote its re-expansion at the expense of potentially injurious stres...

    Authors: Jaime Retamal, Bruno Curty Bergamini, Alysson R Carvalho, Fernando A Bozza, Gisella Borzone, João Batista Borges, Anders Larsson, Göran Hedenstierna, Guillermo Bugedo and Alejandro Bruhn
    Citation: Critical Care 2014 18:505
  26. There is overwhelming evidence that sepsis and septic shock are associated with hyperlactatemia (sepsis-associated hyperlactatemia (SAHL)). SAHL is a strong independent predictor of mortality and its presence ...

    Authors: Mercedes Garcia-Alvarez, Paul Marik and Rinaldo Bellomo
    Citation: Critical Care 2014 18:503
  27. In a previous issue of Critical Care, Lorente and colleagues reported the results of a prospective observational study aiming at evaluating the effect of continuous control of cuff pressure (Pcuff ) on the incide...

    Authors: Anahita Rouzé, Emmanuelle Jaillette and Saad Nseir
    Citation: Critical Care 2014 18:512
  28. The aim of this study was to evaluate the diagnostic and prognostic value of presepsin in patients with severe sepsis and septic shock during the first week of ICU treatment.

    Authors: Michael Behnes, Thomas Bertsch, Dominic Lepiorz, Siegfried Lang, Frederik Trinkmann, Martina Brueckmann, Martin Borggrefe and Ursula Hoffmann
    Citation: Critical Care 2014 18:507
  29. Unfractionated heparin (UFH) is the anticoagulant of choice for extracorporeal membrane oxygenation (ECMO), but bivalirudin can be used as an alternative. The purpose of the present study is to investigate the...

    Authors: Marco Ranucci, Ekaterina Baryshnikova, Giuseppe Isgrò, Concetta Carlucci, Mauro Cotza, Giovanni Carboni and Andrea Ballotta
    Citation: Critical Care 2014 18:504
  30. Hyperglycemia is a marker of poor prognosis in severe brain injuries. There is currently little data regarding the effects of intensive insulin therapy (IIT) on neurological recovery.

    Authors: Raphaël Cinotti, Carole Ichai, Jean-Christophe Orban, Pierre Kalfon, Fanny Feuillet, Antoine Roquilly, Bruno Riou, Yvonnick Blanloeil, Karim Asehnoune and Bertrand Rozec
    Citation: Critical Care 2014 18:498
  31. Delirium is a frequent complication after cardiac surgery. Although various risk factors for postoperative delirium have been identified, the relationship between nocturnal breathing disorders and delirium has...

    Authors: Jens Roggenbach, Marvin Klamann, Rebecca von Haken, Thomas Bruckner, Matthias Karck and Stefan Hofer
    Citation: Critical Care 2014 18:477
  32. The TraumaRegister DGUâ„¢ (TR-DGU) has used the Revised Injury Severity Classification (RISC) score for outcome adjustment since 2003. In recent years, however, the observed mortality rate has fallen to about 2%...

    Authors: Rolf Lefering, Stefan Huber-Wagner, Ulrike Nienaber, Marc Maegele and Bertil Bouillon
    Citation: Critical Care 2014 18:476
  33. Echocardiographic indices based on respiratory variations of superior and inferior vena cavae diameters (ΔSVC and ΔIVC, respectively) have been proposed as predictors of fluid responsiveness in mechanically ve...

    Authors: Hélène Charbonneau, Béatrice Riu, Matthieu Faron, Arnaud Mari, Matt M Kurrek, Jean Ruiz, Thomas Geeraerts, Olivier Fourcade, Michèle Genestal and Stein Silva
    Citation: Critical Care 2014 18:473
  34. Patients with severe acute exacerbations of asthma often receive inappropriate antibiotic treatment. We aimed to determine whether serum procalcitonin (PCT) levels can effectively and safely reduce antibiotic ...

    Authors: Wei Long, Li-juan Li, Gao-zhong Huang, Xue-min Zhang, Yi-cui Zhang, Jian-guo Tang, Yu Zhang and Gang Lu
    Citation: Critical Care 2014 18:471
  35. Dengue shock syndrome (DSS) fluid resuscitation by following the World Health Organization (WHO) guideline usually required large volumes of Ringer lactate (RL) that might induce secondary fluid overload. Our ...

    Authors: Dadang H Somasetia, Tatty E Setiati, Azhali M Sjahrodji, Ponpon S Idjradinata, Djatnika Setiabudi, Hubert Roth, Carole Ichai, Eric Fontaine and Xavier M Leverve
    Citation: Critical Care 2014 18:466
  36. Acute kidney injury (AKI) is a common and feared complication of sepsis. The pathogenesis of sepsis-induced AKI is largely unknown, and therapeutic interventions are mainly supportive. In the present study, we...

    Authors: Johan Fenhammar, Mats Rundgren, Kjell Hultenby, Jakob Forestier, Micael Taavo, Ellinor Kenne, Eddie Weitzberg, Stefan Eriksson, Volkan Ozenci, Annika Wernerson and Robert Frithiof
    Citation: Critical Care 2014 18:488
  37. Sepsis and other infections are associated with late cardiovascular events. Although persistent inflammation is implicated, a causal relationship has not been established. We tested whether sepsis causes vascu...

    Authors: Ata Murat Kaynar, Sachin Yende, Lin Zhu, Daniel R Frederick, Robin Chambers, Christine L Burton, Melinda Carter, Donna Beer Stolz, Brittani Agostini, Alyssa D Gregory, Shanmugam Nagarajan, Steven D Shapiro and Derek C Angus
    Citation: Critical Care 2014 18:469
  38. The most common cause of acute kidney injury (AKI) in hospitalized patients is sepsis. However, the molecular pathways and mechanisms that mediate septic AKI are not well defined. Experiments performed over th...

    Authors: Eric D Morrell, John A Kellum, Núria M Pastor-Soler and Kenneth R Hallows
    Citation: Critical Care 2014 18:501
  39. Whether red blood cell (RBC) transfusion is beneficial remains controversial. In both retrospective and prospective evaluations, transfusion has been associated with adverse, neutral, or protective effects. Th...

    Authors: Andre Dejam, Brian E Malley, Mengling Feng, Federico Cismondi, Shinhyuk Park, Saira Samani, Zahra Aziz Samani, Duane S Pinto and Leo Anthony Celi
    Citation: Critical Care 2014 18:487
  40. Little is known about oxyhemoglobin (oxy-Hb) levels in the cerebral tissue during the development of anoxic and ischemic brain injury. We hypothesized that the estimated cerebral oxy-Hb level, a product of Hb ...

    Authors: Kei Hayashida, Kei Nishiyama, Masaru Suzuki, Takayuki Abe, Tomohiko Orita, Noritoshi Ito and Shingo Hori
    Citation: Critical Care 2014 18:500