Open Access

Impedance cardiography (electrical velocimetry) and transthoracic echocardiography for non-invasive cardiac output monitoring in pediatric intensive care patients: a prospective single-center observational study

  • Martin Ernst Blohm1Email author,
  • Denise Obrecht1,
  • Jana Hartwich1, 2,
  • Goetz Christoph Mueller3,
  • Jan Felix Kersten4,
  • Jochen Weil3 and
  • Dominique Singer1
Critical Care201418:603

https://doi.org/10.1186/s13054-014-0603-0

Received: 4 May 2014

Accepted: 20 October 2014

Published: 19 November 2014

Abstract

Introduction

Electrical velocimetry (EV) is a type of impedance cardiography, and is a non-invasive and continuously applicable method of cardiac output monitoring. Transthoracic echocardiography (TTE) is non-invasive but discontinuous.

Methods

We compared EV with TTE in pediatric intensive care patients in a prospective single-center observational study. Simultaneous, coupled, left ventricular stroke volume measurements were performed by EV using an Aesculon® monitor and TTE (either via trans-aortic valve flow velocity time integral [EVVTI], or via M-mode [EVMM]). H0: bias was less than 10% and the mean percentage error (MPE) was less than 30% in Bland–Altman analysis between EV and TTE. If appropriate, data were logarithmically transformed prior to Bland–Altman analysis.

Results

A total of 72 patients (age: 2 days to 17 years; weight: 0.8 to 86 kg) were analyzed. Patients were divided into subgroups: organ transplantation (OTX, n =28), sepsis or organ failure (SEPSIS, n =16), neurological patients (NEURO, n =9), and preterm infants (PREM, n =26); Bias/MPE for EVVTI was 7.81%/26.16%. In the EVVTI subgroup analysis for OTX, NEURO, and SEPSIS, bias and MPE were within the limits of H0, whereas the PREM subgroup had a bias/MPE of 39.00%/46.27%. Bias/MPE for EVMM was 8.07%/37.26% where the OTX and NEURO subgroups were within the range of H0, but the PREM and SEPSIS subgroups were outside the range. Mechanical ventilation, non-invasive continuous positive airway pressure ventilation, body weight, and secondary abdominal closure were factors that significantly affected comparison of the methods.

Conclusions

This study shows that EV is comparable with aortic flow-based TTE for pediatric patients.

Introduction

In the 1960s, impedance cardiography was developed to monitor cardiac output (CO) [1]. This method is based on a change in resistance during the cardiac cycle to a transcutaneously applied electrical AC voltage, and is used to calculate left ventricular stroke volume (LVSV), and thus CO. After several modifications to the algorithm [1]-[5], impedance cardiography (that is, electrical velocimetry (EV)) devices have become commercially available. There is conflicting evidence on the use of EV in the literature [6]-[12], and the technique is not yet widely used clinically.

This study evaluated continuously applicable and non-invasive EV and compared it with discontinuously applicable and non-invasive transthoracic echocardiography (TTE). We compared LVSV measurements with EV and TTE in pediatric and neonatal patients, and analyzed parameters that affected comparison of the methods.

Materials and methods

Study design

This single-center observational study aimed to validate EV compared with TTE in pediatric intensive care patients with normal cardiac biventricular anatomy. LVSV was simultaneously measured by EV and TTE. Equivalence of EV and TTE was assumed if Bland–Altman analysis had bias <10% and mean percentage error (MPE) <30% regarding LVSV measurement by EV compared with TTE (H0) [13].

Electrical velocimetry measurements

An Aesculon® monitor (CE 0123; Osypka Medical, Berlin, Germany) was used to record EV. The electrode position of four RedDot® neonatal ECG radiolucent prewired monitoring electrodes (3M Health Care, Neuss, Germany) was chosen as recommended by the manufacturer. The analyzed heart beats were recorded simultaneously by TTE on the Aesculon® monitor. The signal that was generated by the Aesculon® monitor for EV LVSV measurements was accepted if the green signal quality bar indicated a reliable signal.

Transthoracic echocardiography measurements

For echocardiography, either the GE Medical Systems Vivid 7 (CE 0470; GE Healthcare, Munich, Germany) or the GE Healthcare Technologies Logiq P5 (CE 0459; GE Healthcare) ultrasound machine was used. LVSV by TTE was calculated using two different methods [14],[15]. In one method, LVSV was calculated based on measurement of the flow velocity time integral (VTI) measured over the aortic valve (measured from an apical four-chamber view with angle correction, if necessary) multiplied by the area of the aortic valve:
LVSV = aortic valve area × V T I
where the aortic valve diameter was determined by triplicate measurements of the internal diameter of the aortic valve hinge points:
Aortic valve area = 0.5 × diameter 2 × 3.14

In the other method, LVSV was based on M-mode measurement in the long parasternal axis, using the internal algorithm of the echocardiography machine based on the Teichholz equation [16]. For these M-mode measurements, a single beat was simultaneously measured in triplicate by TTE and EV.

Setting

Three consecutive heart beats for VTI measurements or a single beat for the M-mode measurement were simultaneously recorded with the corresponding identical EV beats. All of the TTE measurements were performed by a single operator (MEB).

Patients and sample characteristics

Pediatric and neonatal patients treated at the University Medical Center Hamburg–Eppendorf (UKE) in the pediatric and neonatal ICUs were eligible. This study was approved by the ethics committee of the Chamber of Physicians Hamburg, Germany. This study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. National laws were observed. Parental written informed consent was obtained prior to data collection.

Data collection and statistics

The distribution of data was graphically assessed. Right-skewed data were logarithmically transformed prior to statistical analysis. The intra-class correlation for repeated measurements on the same day in individual patients was high (97% for comparison of EV versus the LVSV measurement based on the VTI over the aortic valve (EVVTI), 98% for comparison of EV versus the LVSV determination by M-mode echocardiogram (EVMM)). Data were therefore combined into 285 measurement pairs (EV vs. TTE) by averaging the LVSV measured by each method in an individual patient, thus representing a single day of measurement in a single patient (n = 146 EVVTI combined data points, n = 139 EVMM combined data points). Agreement between the EV and TTE methods was assessed by means of Bland–Altman plots [17],[18]. The MPE was computed as:
M P E = precision / mean E V + mean T T E / 2
where precision was defined as the two-standard-deviation method difference [13],[17],[19]. True precision for EV (TPEV) was calculated based on the following equation [20],[21]:
T P E V = M P E 2 precision T T E 2
A mixed-model analysis (analysis of covariance) was performed to identify the effects of persistent ductus arteriosus (PDA), persistent foramen ovale, the combination of PDA and persistent foramen ovale, non-invasive continuous positive airway pressure (CPAP) ventilation, any form of ventilation, use of catecholamines, outcome, body weight, secondary abdominal closure, sex, and heart rate on EV and TTE. Post-hoc power analysis was performed and the least significant change was calculated [20],[22]:
Minimum change that needs t o be measured b y a device t o recognize a real change = precision × 2

The trend-following characteristic over repeated measurements was determined using Kendall's coefficient of concordance. The statistical significance level was set to 0.05. SPSS version 20.0 (IBM, Armonk, NY, USA) was used for all statistical analyses.

Results

The study cohort included 72 pediatric intensive care patients (39 girls and 33 boys). The patients were classified into four subgroups: solid organ transplantation (OTX subgroup, n = 28: liver, n = 24; kidney, n = 2; combined liver and kidney transplant, n = 2), sepsis or other organ failure (SEPSIS subgroup, n = 16), acute neurological patients (NEURO subgroup, n = 9), and preterm infants (PREM subgroup, n = 26; gestational age 25 + 5 weeks to 34 + 5 weeks). Some patients (n = 7) could be classified into two subgroups (NEURO and SEPSIS, n = 5; OTX and SEPSIS, n = 2). In these 72 patients, 855 paired measurements of LVSV by EV and TTE (EVVTI, 438 paired measurements; EVMM, 417 paired measurements) were recorded with two sets of measurements on two separate days in most cases. In some patients, up to six sets of measurements were taken on separate occasions during their stay in the ICU. As described above, data were combined into 146 EVVTI data points and 139 EVMM data points, each representing a pair of measurements of echocardiography versus impedance cardiography on a single day in an individual patient. Table 1 presents detailed information on the patient and sample characteristics.
Table 1

Patient and sample characteristics of electrical velocimetry versus transthoracic echocardiography, based on 855 paired measurements

Characteristic

Total

OTX

SEPSIS

NEURO

PREM

Patients in each group ( n )

72

28

16

9

26

Paired measurements ( n )

855

372

213

96

243

Number of measurement days per patient (mean)

1.98

2.20

2.05

1.56

1.60

Weight (kg) (median/mean, range)

7.2/15.96 (0.84 to 86.00)

10.0/18.64 (2.06 to 86.00)

23.0/26.23 (2.06 to 60.00)

14.5/18.90 (3.10 to 45.00)

1.67/1.66 (0.84 to 2.40)

Age (years) (median/mean, range)

0.78/4.19 (0.01 to 17.87)

1.56/4.76 (0.05 to 17.87)

7.10/7.66 (0.16 to 17.87)

2.89/4.16 (0.04 to 11.12)

0.03/0.04 (0.01 to 0.11)

Use of inotropes (%)

29.47

37.27

50.47

50.00

0.00

Mechanical ventilation via endotracheal intubation (%)

39.30

46.11

51.89

93.75

4.94

Any form of respiratory support (that is, non-invasive CPAP or ET tube) (%)

51.58

49.33

54.72

93.75

43.21

Secondary closure of the abdomen (%)

7.37

16.94

2.83

0.00

0.00

ICU survival rate (%)

85.61

91.96

75.94

50.00

100.00

Data are shown for the whole pediatric cohort and for subgroups. CPAP, continuous positive airway pressure; ET, endotracheal; NEURO, acute neurological patients subgroup; OTX, solid organ transplantation subgroup; PREM, preterm infants subgroup; SEPSIS, sepsis or other organ failure subgroup.

The mean cardiac index was 4.0 l/(minute*m2) by EV, compared with 4.2 l/(minute*m2) by LVSV measurement based on the VTI over the aortic valve and with 4.5 l/(minute*m2) by LVSV determination by M-mode echocardiogram. Because the study included two separate TTE methods compared with EV (based on transaortic flow measurement (EVVTI) and M-mode measurement (EVMM)) the results are presented separately for these two study arms. There was a highly significant (P <0.001) positive Pearson correlation of LVSV measurements by EV and TTE for the whole cohort (EVVTI, r = 0.934; EVMM, r = 0.896) and for subgroup analyses for OTX subgroup (EVVTI, r = 0.929; EVMM, r = 0.869), SEPSIS subgroup (EVVTI, r = 0.911; EVMM, r = 0.863) NEURO subgroup (EVVTI, r = 0.955; EVMM, r = 0.899), and PREM subgroup (EVVTI, r = 0.786; EVMM, r = 0.728).

Bland–Altman plots for EVVTI and EVMM are shown in Figures 1 and 2. Outlying data points were not excluded from the Bland–Altman analysis. Reasons for the outliers are mentioned in Discussion. Bias and MPE are presented in Table 2. For EVVTI, the whole cohort and all subgroups (except for PREM subgroup) were within the cutoff levels of H0. For EVMM, data were within the limits of H0 only for OTX and NEURO subgroups, and outside the limits of H0 for the whole cohort and the other subgroups.
Figure 1

Bland–Altman plot for comparison of left ventricular stroke volume measured by electrical velocimetry versus the transthoracic echocardiography velocity time integral. Each data point represents combined paired measurements in an individual patient that were measured on separate occasions (146 combined paired measurements, logarithmic scale). Bias and two standard deviations (2SD) are shown as reference lines. EV, electrical velocimetry; LVSV, left ventricular stroke volume; MPE, mean percentage error; TTE, transthoracic echocardiography; VTI, velocity time integral.

Figure 2

Bland–Altman plot for comparison of left ventricular stroke volume measured by electrical velocimetry versus the transthoracic echocardiography M-mode. Each data point represents combined paired measurements in an individual patient measured on separate occasions (139 combined paired measurements, logarithmic scale). Bias and two standard deviations (2SD) are shown as reference lines. EV, electrical velocimetry; LVSV, left ventricular stroke volume; MPE, mean percentage error; TTE, transthoracic echocardiography.

Table 2

Comparison of measurement of left ventricular stroke volume by electrical velocimetry versus transthoracic echocardiography using Bland–Altman analysis

Study arm

Group

Number of patients/ measurements

Bias (%)

MPE (%)

EVVTI

All

72/146

7.81

26.16

OTX

28/65

5.05

23.03

SEPSIS

16/36

2.62

26.82

NEURO

9/16

6.98

14.79

PREM

26/41

39.00

46.27

EVMM

All

72/139

8.07

37.26

OTX

28/59

5.04

28.96

SEPSIS

16/35

2.57

43.53

NEURO

9/16

6.65

27.10

PREM

26/40

39.53

42.80

Data were analyzed for subgroups. EVMM, electrical velocimetry versus the transthoracic echocardiography M-mode; EVVTI, electrical velocimetry versus the transthoracic echocardiography velocity time integral; MPE, mean percentage error; NEURO, acute neurological patients subgroup; OTX, solid organ transplantation subgroup; PREM, preterm infants subgroup; SEPSIS, sepsis or other organ failure subgroup.

The trend of the relative differences in LVSV measurements over separate measurement occasions between the two methods is shown in Figure 3. There was no correlation between the relative differences and the times of individual measurements (r = 0.101, P = 0.24), and this was observed for the whole cohort and for combined data points with separate analyses for EVVTI and EVMM.
Figure 3

Trend of left ventricular stroke volume measurements using electrical velocimetry versus measurements based on the velocity time integral over the aortic valve. Percentage difference in repeated left ventricular stroke volume (LVSV) measurements between methods in individual patients on serial measurement days. Box plots show the median, standard deviation, and outliers (136 combined measurement points were included; outliers from Figure 1 were excluded). Note the constant average direction of bias over repeated measurement days. TTE, echocardiography; EV, electrical velocimetry; VTI, velocity time integral.

Kendall’s coefficient of concordance (to assess trend monitoring quality) did show a highly significant (P < 0.001) concordance of the relative bias of 97% for EVVTI and 100% for EVMM. Looking at the three repetitive measurements on individual measurement days, the concordance for separate measurement days was 96% for EVVTI and 89% for EVVM.

The average precision of TTE in transaortic flow measurements was 7.97% and that in M-mode measurements was 7.42% based on the calculation described by Cecconi and colleagues [20] with lower precision in the PREM subgroup (LVSV measurement based on the VTI over the aortic valve 29.55%/LVSV determination by M-mode echocardiogram 25.07%). TPEV was 24.92% for EVVTI and 36.51% for EVMM. Subgroup analysis for EVVTI showed a better TPEV for the more homogeneous patient subgroups OTX (22.22%) and NEURO (12.12%) compared with SEPSIS (26.75%) and PREM (35.60%). Post-hoc power analysis showed that the sample size was sufficient to detect a percentage difference in LVSV measurements of 9% for EVVTI and 12% for EVMM (at power = 0.8 and P = 0.05).

A mixed-model analysis was performed to identify parameters affecting any differences between EV and TTE (Table 3). A significant effect (for one or both of the comparisons EVVTI and EVMM) was observed for weight, secondary abdominal closure, endotracheal mechanical ventilation, and non-invasive nasal CPAP ventilation in the PREM subgroup. There tended to be an effect of sex on differences between EV and TTE (P = 0.062). Heart rate, outcome, and catecholamine use did not lead to a significant effect on differences between EV and TTE. In the PREM subgroup, CPAP ventilation (37% of the data points in the PREM subgroup were measured with CPAP) significantly (P = 0.022) affected EVVTI, but this effect was not observed for EVMM. For isolated PDA (5% of the data points for the PREM subgroup were with PDA) a trend was observed (P = 0.077 in EVVTI), but there was no effect of PDA in EVMM. There was no significant effect of a persistent foramen ovale in the PREM subgroup.
Table 3

Possible parameters that affect differences in EVVTI and EVMM using mixed-model analysis

Parameter

Study arm

Effect on difference of methods (%)

P value

(95% limits of agreement)

Non-invasive CPAP in PREM

EVVTI

40.1 (34.6/46.4)

0.022

 

EVMM

31.6 (26.6/37.6)

0.732

Ventilation via ET tube

EVVTI

5.0 (4.3/5.9)

0.017

 

EVMM

4.7 (4.0/5.7)

0.069

Body weight

EVVTI

9.5 (6.4/7.5)

<0.001

EVMM

11.5 (9.7/13.5)

<0.001

Secondary abdominal closure

EVVTI

5.2 (4.4/6.1)

0.272

EVMM

6.9 (5.5/8.7)

0.002

CPAP, continuous positive airway pressure; ET, endotracheal; EVMM, electrical velocimetry versus the transthoracic echocardiography M-mode; EVVTI, electrical velocimetry versus the transthoracic echocardiography velocity time integral; PREM, preterm infants subgroup.

Discussion

The main result of the study was good agreement for Bland–Altman analysis for EVVTI, with an acceptably low bias <10%, and MPE <30% [13] in the whole cohort and in the OTX, NEURO, and SEPSIS subgroups. However, bias and MPE in the PREM subgroup were above the accepted range. For EVMM, bias was within the range of H0 except in the PREM subgroup. For EVVM, MPE was above the range of H0 in the whole cohort and the PREM and SEPSIS subgroups (not OTX and NEURO) (Table 2).

A theoretical TPEV could be calculated because two imprecise CO monitoring methods (EV and TTE) were compared [19]-[21]. In our study, this TPEV was based on combined data points with triplicate measurements. TPEV was better for the OTX and NEURO subgroups than for the less homogeneous subgroups SEPSIS and PREM. These findings are consistent with other validation studies on EV. Acceptable equivalence was reported [13] when comparing EV with other CO monitoring methods in homogeneous adult biventricular patients [9] and homogeneous pediatric patient groups [23],[24]. Non-equivalence of EV compared with other methods (mostly due to a high MPE) has been reported in studies with homogeneous and heterogenic pediatric patient cohorts [21],[25]-[29], with an effect of left-to-right shunts and ventricular septal defects on the compared methods [27], as well as in adult studies with heterogenic patient cohorts [11],[12],[30]-[32].

Transthoracic impedance is affected by air and fluid content in the chest. Changes in fluid content in the chest by pleural effusion, cardiac congestion, alterations in the size of cardiac chambers (for example, because of valvular insufficiency), or increased air content (for example, by application of CPAP or mechanical ventilation) affect basic impedance, and thus calculation of LVSV by EV. Changes in blood content or blood flow alter the size of the cardiac cycle-related change in impedance (for example, in cardiac valve insufficiency or in the presence of a relevant PDA). The outliers in the Bland–Altman plots in Figures 1 and 2 had one or several of the abovementioned factors limiting signal quality in EV (for example, Patient A had mitral endocarditis with mitral insufficiency (grade 4), Patient B was on high-frequency oscillation after bone marrow transplantation, and Patients C, D, and E all had organ transplant with abdominal patch closure or a large intraabdominal tumor prior to liver transplantation). These findings are consistent with a previous study showing a significant effect of extravascular lung water on impedance cardiography [33].

Mixed-model analysis was performed on parameters that theoretically affect the true LVSV and CO and/or impedance cardiography measurements. Parameters that affected differences between the methods of EV and TTE in this study were body weight, mechanical ventilation, and non-invasive CPAP ventilation. Inotropic support or outcome did not affect differences between EV and TTE. The parameter with the strongest effect was non-invasive CPAP ventilation, which contributed to 40.1% of the difference using EVVTI in the PREM subgroup. This result and our finding that PDA was present in only 5% of PREM measurements may have been the reason why PDA did not reach significance (P = 0.077) in the PREM group. A previous study compared CO by EV versus TTE in 28 preterm neonates, and showed that the difference between the methods was 4% for ventilated infants and 2.5% for nonventilated infants [23]. This previous finding is in accordance with the current study, which demonstrated an effect of ventilation on comparison of the methods.

Theoretical limitations of the study

To achieve a simultaneously paired LVSV measurement of identical heart beats by EV and TTE, the echocardiography used in the present study was only in a single plane rather than in two opposing planes. The precision of TTE in this study might therefore not have been as good as 30%, which has been reported in the literature [19]. However, the precision of TTE might have been better than the MPE of 36% reported in children for systems with blind Doppler probe positioning [34],[35]. The precision of TTE in this study was calculated as approximately 8%. Additionally, the precision of TTE was not homogeneous and depended on patient subgroups with lower precision, particularly in the PREM subgroup, contributing to higher bias and MPE in that subgroup.

Another limitation of the study may be due to variation in LVSV during the respiratory cycle. Our study used paired measurements irrespective of the respiratory cycle, and did not take into account that the variation in stroke volume was between 10 and 30% in most cases. In vigorously breathing neonates, the variation was as high as 40% (as indicated by the Aesculon® monitor). The variation in stroke volume during the respiratory cycle is a problem for any method of determining CO [26],[30],[36],[37]. Theoretically, variation in stroke volume should equally affect EV and TTE.

Previous studies have shown a significant effect of extravascular lung water on impedance cardiography CO measurements based on the Sramek–Bernstein equation compared with CO by thermodilution [33]. This implies that heterogenic patients with different amounts of extravascular lung water (as in this study) have heterogenic EV measurements, and this will affect comparison of EV and TTE.

Trend monitoring

To base goal-directed therapy on a monitoring tool such as EV CO measurement, the capacity of the applied method for determining a trend is important [20],[38] (that is, the ability of the method to detect a change in CO over time). Figure 3, which shows repeated measurements over time, demonstrates that the average direction of bias between EV and TTE remained positive or negative with repeated measurements. The high Kendall’s concordance mathematically supports this visual estimate of the constancy of the bias both for repetitive tests on the same day and on different days. By increasing the sampling interval with more measurements or more heart beats, the MPE between the two compared methods will become less (that is, precision will improve) [20],[22]. The least significant change is defined as the minimum change that needs to be measured by a device to recognize a real change [22]. According to the equation for calculating the least significant change, the minimum percentage of LVSV change detected by EV in this study was 11.3% (sampling interval of three heart beats). After five measurement cycles (equivalent to 15 heart beats), the least significant change for EV would theoretically [22] become 5%. This implies that at a heart rate of 60 beats/minute EV would theoretically be able to detect a 5% change in LVSV within 15 seconds of averaged measurement. This short time response to a relatively small change in LVSV implies good tracking properties of the EV method [38]. Other continuous CO monitoring devices, including non-invasive devices (for example, continuous Doppler-based systems) [34],[35] and invasive devices (for example, transpulmonary thermodilution methods combined with pulse contour analysis) [11],[12], normally average multiple cardiac cycles for more accurate continuous monitoring. Because EV is a non-invasive and continuously applicable method, combined measurement cycles averaging LVSV and CO over multiple heart beats are technically possible. This averaging would also equalize variation in stroke volume during the respiratory cycle. EV therefore appears to be suitable for monitoring trends. The advantages of non-invasiveness and continuity of EV, with a low bias compared with TTE, may outweigh the relatively low precision of this method.

In summary, LVSV measurements by EV and TTE were not different in pediatric intensive care patients if LVSV was determined by TTE using transaortic flow (EVVTI). This finding was observed for the whole cohort and for the subgroups OTX, NEURO, and SEPSIS, but not for the PREM subgroup. This equivalence could not be demonstrated because of a high MPE for EV and TTE if LVSV was determined by M-mode (EVMM), except in the OTX and NEURO subgroups. The poorer agreement between EV and TTE in the PREM subgroup may be related to the fact that nasal CPAP was the main parameter that affected differences between the methods. Because the average direction of bias between EV and TTE with repeated measurements in the same patients remained constant, EV appears to be a suitable method for following trends in CO.

Conclusions

Because of partial or good agreement between the two methods EV and TTE for determining LVSV (depending on the group of patients), EV appears to be suitable for determination of CO in children. The advantage of continuous applicability theoretically facilitates the possibility of monitoring of CO trends by EV.

Key messages

In this study, stroke volume measurements based on EV and echocardiographic transaortic flow were not different in pediatric intensive care patients.

In preterm infants, there was a difference between the two methods, but LVSV measurements were significantly correlated.

The main factors that affected comparison between EV and echocardiography were any form of ventilation and body weight.

EV appears to be suitable for monitoring trends in pediatric patients.

Authors’ contributions

MEB designed the study, carried out the echocardiography measurements in all of the patients, was involved in data acquisition and data analysis, and prepared the manuscript. DO and JH were responsible for simultaneous EV measurements, data acquisition, data management, data analysis, and manuscript preparation. GCM and JW were involved in impedance cardiography, data analysis, and substantially contributed to manuscript preparation. JFK, a statistician, provided substantial input for data analysis and developed the mixed-model analysis. DS helped to design the study and substantially contributed to data analysis and manuscript preparation. All authors read and approved the manuscript.

Abbreviations

CO: 

cardiac output

CPAP: 

continuous positive airway pressure

EV: 

electrical velocimetry (impedance cardiography)

EVMM: 

comparison of electrical velocimetry versus the transthoracic echocardiography M-mode

EVVTI: 

comparison of electrical velocimetry versus the transthoracic echocardiography velocity time integral

LVSV: 

left ventricular stroke volume

MPE: 

mean percentage error

NEURO: 

neurological patient group

OTX: 

solid organ transplantation patient group

PDA: 

persistent ductus arteriosus

PREM: 

preterm infant patient group

SEPSIS: 

sepsis or organ failure patient group

TPEV

true precision for electrical velocimetry

TTE: 

transthoracic echocardiography

VTI: 

velocity time integral

Declarations

Acknowledgments

The authors wish to thank the patients and their parents for participating in this study, and the nursing team and other staff, especially Mark Tini, for their support. The funding for this study was provided by the hospital.

Authors’ Affiliations

(1)
Department of Pediatrics, Division of Neonatology and Pediatric Intensive Care, University Medical Center Hamburg-Eppendorf
(2)
Department of Neurology, Elbe Kliniken Stade
(3)
Department of Pediatric Cardiology, University Medical Center Hamburg-Eppendorf
(4)
Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf

References

  1. Kubicek WG, Karnegis JN, Patterson RP, Witsoe DA, Mattson RH: Development and evaluation of an impedance cardiac output system. Aerosp Med. 1966, 37: 1208-1212.Google Scholar
  2. Sramek BB, Welter LO: Recent developments in electrical transthoracic impedance resulting in real-time monitoring of cardiac output [abstract]. Anesthesiology. 1982, 57: A178-10.1097/00000542-198209001-00178.View ArticleGoogle Scholar
  3. Bernstein DP: A new stroke volume equation for thoracic electrical bioimpedance: theory and rationale. Crit Care Med. 1986, 14: 904-909. 10.1097/00003246-198610000-00017.View ArticleGoogle Scholar
  4. Osypka MJ, Bernstein DP: Electrophysiologic principles and theory of stroke volume determination by thoracic electrical bioimpedance. Review. AACN Clin Issues. 1999, 10: 385-399. 10.1097/00044067-199908000-00008.View ArticleGoogle Scholar
  5. Bernstein DP: Stroke volume equation for impedance cardiography: citation correction. Intensive Care Med. 2007, 33: 923-10.1007/s00134-007-0613-3.View ArticleGoogle Scholar
  6. Raaijmakers E, Faes TJ, Scholten RJ, Goovaerts HG, Heethaar RM: A meta-analysis of three decades of validating thoracic impedance cardiography. Crit Care Med. 1999, 27: 1203-1213. 10.1097/00003246-199906000-00053.View ArticleGoogle Scholar
  7. Summers RL, Shoemaker WC, Peacock WF, Ander DS, Coleman TG: Bench to bedside: electrophysiologic and clinical principles of noninvasive hemodynamic monitoring using impedance cardiography. Acad Emerg Med. 2003, 10: 669-680. 10.1111/j.1553-2712.2003.tb00054.x.View ArticleGoogle Scholar
  8. Van De Water JM, Miller TW, Vogel RL, Mount BE, Dalton ML: Impedance cardiography: the next vital sign technology?. Chest. 2003, 123: 2028-2033. 10.1378/chest.123.6.2028.View ArticleGoogle Scholar
  9. Schmidt C, Theilmeier G, Van Aken H, Korsmeier P, Wirtz SP, Berendes E, Hoffmeier A, Meissner A: Comparison of electrical velocimetry and transoesophageal Doppler echocardiography for measuring stroke volume and cardiac output. Br J Anaesth. 2005, 95: 603-610. 10.1093/bja/aei224.View ArticleGoogle Scholar
  10. Gujjar AR, Muralidhar K, Banakal S, Gupta R, Sathyaprabha TN, Jairaj PS: Non-invasive cardiac output by transthoracic electrical bioimpedence in post-cardiac surgery patients: comparison with thermodilution method. J Clin Monit Comput. 2008, 22: 175-180. 10.1007/s10877-008-9119-y.View ArticleGoogle Scholar
  11. Peyton PJ, Chong SW: Minimally invasive measurement of cardiac output during surgery and critical care: a meta-analysis of accuracy and precision. Anesthesiology. 2010, 113: 1220-1235. 10.1097/ALN.0b013e3181ee3130.View ArticleGoogle Scholar
  12. Peyton PJ, Chon JW: Minimally invasive measurement of cardiac output during surgery and critical care: a meta-analysis of accuracy and precision: erratum. Anesthesiology. 2012, 116: 973-10.1097/ALN.0b013e31824ef294.View ArticleGoogle Scholar
  13. Critchley LA, Critchley JA: A meta-analysis of studies using bias and precision statistics to compare cardiac output measurement techniques. Clin Monit Comput. 1999, 15: 85-91. 10.1023/A:1009982611386.View ArticleGoogle Scholar
  14. Lai WW, Geva T, Shirali GS, Frommelt PC, Humes RA, Brook MM, Pignatelli RH, Rychik J: Guidelines and standards for performance of a pediatric echocardiogram: a report from the task force of the pediatric council of the American Society of Echocardiography. J Am Soc Echocardiogr. 2006, 19: 1413-1430. 10.1016/j.echo.2006.09.001.View ArticleGoogle Scholar
  15. Turner MA: Doppler-based hemodynamic monitoring: a minimally invasive alternative. AACN Clin Issues. 2003, 14: 220-231. 10.1097/00044067-200305000-00011.View ArticleGoogle Scholar
  16. Teichholz LE, Kreulen T, Herman MV, Gorlin R: Problems in echocardiographic volume determinations: echocardiographic–angiographic correlations in the presence of absence of asynergy. Am J Cardiol. 1976, 37: 7-11. 10.1016/0002-9149(76)90491-4.View ArticleGoogle Scholar
  17. Bland JM, Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986, 1: 307-310. 10.1016/S0140-6736(86)90837-8.View ArticleGoogle Scholar
  18. Bland JM, Altman DG: Agreement between methods of measurement with multiple observations per individual. J Biopharm Stat. 2007, 17: 571-582. 10.1080/10543400701329422.View ArticleGoogle Scholar
  19. Chew MS, Poelaert J: Accuracy and repeatability of pediatric cardiac output measurement using Doppler: 20-year review of the literature. Review. Intensive Care Med. 2003, 29: 1889-1894. 10.1007/s00134-003-1967-9.View ArticleGoogle Scholar
  20. Cecconi M, Rhodes A, Poloniecki J, Della Rocca G, Grounds RM: Bench-to-bedside review: the importance of the precision of the reference technique in method comparison studies – with specific reference to the measurement of cardiac output. Crit Care. 2009, 13: 201-10.1186/cc7129.View ArticleGoogle Scholar
  21. Noori S, Drabu B, Soleymani S, Seri I: Continuous non-invasive cardiac output measurements in the neonate by electrical velocimetry: a comparison with echocardiography. Arch Dis Child Fetal Neonatal Ed. 2012, 97: F340-F343. 10.1136/fetalneonatal-2011-301090.View ArticleGoogle Scholar
  22. Whitley E, Ball J: Statistics review 4: sample size calculations. Crit Care. 2002, 6: 335-341. 10.1186/cc1521.View ArticleGoogle Scholar
  23. Grollmuss O, Gonzalez P: Non-invasive cardiac output measurement in low and very low birth weight infants: a method comparison. Front Pediatr. 2014, 25: 16-Google Scholar
  24. Grollmuss O, Demontoux S, Capderou A, Serraf A, Belli E: Electrical velocimetry as a tool for measuring cardiac output in small infants after heart surgery. Intensive Care Med. 2012, 38: 1032-1039. 10.1007/s00134-012-2530-3.View ArticleGoogle Scholar
  25. Blohm ME, Hartwich J, Obrecht D, Miller G, Weil J, Singer D: Left ventricular stroke volume measurement by impedance cardiography correlates with echocardiography in neonates [abstract]. Crit Care. 2012, 16: 225-10.1186/cc10832.View ArticleGoogle Scholar
  26. Nusmeier A, van der Hoeven JG, Lemson J: Cardiac output monitoring in pediatric patients. Review. Expert Rev Med Devices. 2010, 7: 503-517. 10.1586/erd.10.19.View ArticleGoogle Scholar
  27. Norozi K, Beck C, Osthaus WA, Wille I, Wessel A, Bertram H: Electrical velocimetry for measuring cardiac output in children with congenital heart disease. Br J Anaesth. 2008, 100: 88-94. 10.1093/bja/aem320.View ArticleGoogle Scholar
  28. Tomaske M, Knirsch W, Kretschmar O, Woitzek K, Balmer C, Schmitz A, Bauersfeld U, Weiss M: Cardiac output measurement in children: comparison of Aesculon cardiac output monitor and thermodilution. Br J Anaesth. 2008, 100: 517-520. 10.1093/bja/aen024.View ArticleGoogle Scholar
  29. Tomaske M, Knirsch W, Kretschmar O, Balmer C, Woitzek K, Schmitz A, Bauersfeld U, Weiss M: Evaluation of the Aesculon cardiac output monitor by subxiphoidal Doppler flow measurement in children with congenital heart defects. Eur J Anaesthesiol. 2009, 26: 412-415. 10.1097/EJA.0b013e3283240438.View ArticleGoogle Scholar
  30. Engoren M, Barbee D: Comparison of cardiac output determined by bioimpedance, thermodilution, and the Fick method. Am J Crit Care. 2005, 14: 40-45.Google Scholar
  31. Raue W, Swierzy M, Koplin G, Schwenk W: Comparison of electrical velocimetry and transthoracic thermodilution technique for cardiac output assessment in critically ill patients. Eur J Anaesthesiol. 2009, 26: 1067-1071. 10.1097/EJA.0b013e32832bfd94.View ArticleGoogle Scholar
  32. Heringlake M, Handke U, Hanke T, Eberhardt F, Schumacher J, Gehring H, Heinze H: Lack of agreement between thermodilution and electrical velocimetry cardiac output measurements. Intensive Care Med. 2007, 33: 2168-2172. 10.1007/s00134-007-0828-3.View ArticleGoogle Scholar
  33. Raaijmakers E, Faes TJ, Kunst PW, Bakker J, Rommes JH, Goovaerts HG, Heethaar RM: The influence of extravascular lung water on cardiac output measurements using thoracic impedance cardiography. Physiol Meas. 1998, 19: 491-499. 10.1088/0967-3334/19/4/004.View ArticleGoogle Scholar
  34. Chong SW, Peyton PJ: A meta-analysis of the accuracy and precision of the ultrasonic cardiac output monitor (USCOM). Anaesthesia. 2012, 67: 1266-1271. 10.1111/j.1365-2044.2012.07311.x.View ArticleGoogle Scholar
  35. Knirsch W, Kretschmar O, Tomaske M, Stutz K, Nagdyman N, Balmer C, Schmitz A, Béttex D, Berger F, Bauersfeld U, Weiss M: Cardiac output measurement in children: comparison of the ultrasound cardiac output monitor with thermodilution cardiac output measurement. Intensive Care Med. 2008, 34: 1060-1064. 10.1007/s00134-008-1030-y.View ArticleGoogle Scholar
  36. Gonzalez J, Delafosse C, Fartoukh M, Capderou A, Straus C, Zelter M, Derenne J-P, Similowski T: Comparison of bedside measurement of cardiac output with the thermodilution method and the Fick method in mechanically ventilated patients. Crit Care. 2003, 7: 171-178. 10.1186/cc1848.View ArticleGoogle Scholar
  37. Pinsky MR: Why measure cardiac output?. Crit Care. 2003, 7: 114-116. 10.1186/cc1863.View ArticleGoogle Scholar
  38. Squara P, Cecconi M, Rhodes A, Singer M, Chiche JD: Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices. Intensive Care Med. 2009, 35: 1801-1808. 10.1007/s00134-009-1570-9.View ArticleGoogle Scholar

Copyright

© Blohm et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.