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Transpulmonary thermodilution-derived cardiac function index identifies cardiac dysfunction in acute heart failure and septic patients: an observational study
Critical Care volume 13, Article number: R133 (2009)
Abstract
Introduction
There is limited clinical experience with the single-indicator transpulmonary thermodilution (pulse contour cardiac output, or PiCCO) technique in critically ill medical patients, particularly in those with acute heart failure (AHF). Therefore, we compared the cardiac function of patients with AHF or sepsis using the pulmonary artery catheter (PAC) and the PiCCO technology.
Methods
This retrospective observational study was conducted in the medical intensive care unit of a university hospital. Twelve patients with AHF and nine patients with severe sepsis or septic shock had four simultaneous hemodynamic measurements by PAC and PiCCO during a 24-hour observation period. Comparisons between groups were made with the use of the Mann-Whitney U test. Including all measurements, correlations between data pairs were established using linear regression analysis and are expressed as the square of Pearson's correlation coefficients (r2).
Results
Compared to septic patients, AHF patients had a significantly lower cardiac index, cardiac function index (CFI), global ejection fraction, mixed venous oxygen saturation (SmvO2) and pulmonary vascular permeability index, but higher pulmonary artery occlusion pressure. All patients with a CFI less than 4.5 per minute had an SmvO2 not greater than 70%. In both groups, the CFI correlated with the left ventricular stroke work index (sepsis: r2 = 0.30, P < 0.05; AHF: r2 = 0.23, P < 0.05) and cardiac power (sepsis: r2 = 0.39, P < 0.05; AHF: r2 = 0.45, P < 0.05).
Conclusions
In critically ill medical patients, assessment of cardiac function using transpulmonary thermodilution technique is an alternative to the PAC. A low CFI identifies cardiac dysfunction in both AHF and septic patients.
Introduction
Several studies have suggested that there is no clear benefit, or that there may even be harm, in using a pulmonary artery catheter (PAC) in critically ill patients [1–4]. As a result, the use of PAC decreased substantially over the last decade [5]. However, PAC is still recommended for the hemodynamic monitoring of critically ill patients with heart failure [6] because it allows the assessment of the pulmonary artery occlusion pressure (PAOP), which may provide information on left ventricular function [7]. As an alternative to the more invasive PAC, the use of the transpulmonary thermodilution method (pulse contour cardiac output, or PiCCO) has been suggested [8]. The PiCCO monitor measures cardiac output (CO) and the global end-diastolic volume indexed for body surface area (GEDVI) as well as parameters of cardiac performance such as the cardiac function index (CFI) and the global ejection fraction (GEF). It also provides an estimate of extravascular lung water (EVLW) and calculates the pulmonary vascular permeability index (PVPI) [9–11], which allows the differentiation between a hydrostatic and a permeability type of pulmonary edema [12, 13]. Volumetric parameters better estimate preload than central venous pressure or PAOP [8, 10, 11, 14], and EVLW monitoring is of prognostic relevance [15–18]. A recent study suggested that guiding fluid and catecholamine therapy by an algorithm based on GEDVI and EVLW reduces postoperative vasopressor and catecholamine requirements in cardiac surgery patients [19].
The PiCCO method has been validated mainly in surgical patients and, to a lesser extent, in patients with sepsis [14, 20–22]. However, there is still limited clinical experience with PiCCO-derived parameters of cardiac function and volume status in critically ill medical patients, particularly in those with acute heart failure (AHF) [8]. Therefore, we retrospectively analysed a series of simultaneous measurements by PiCCO and PAC in patients with AHF, severe sepsis, or septic shock.
Materials and methods
Study design
The study was performed at the 12-bed medical intensive care unit (ICU) of the University Hospital Zurich, Switzerland. Approval was given by our Institutional Review Board. Due to the retrospective nature of the analysis, the need for informed consent was waived. Twenty-one patients (15 males and 6 females) with circulatory failure monitored with a PAC were included in the study. Treatment was directed by the clinicians in charge of the patients. In 17 patients (81%), PAC was inserted within 1 day after ICU admission. After initial hemodynamic stabilisation but before removal of the PAC, the arterial line was switched to a PiCCO catheter in order to have less invasive continuous monitoring of CO for vasopressor weaning and fluid management. This provided a unique opportunity of simultaneous monitoring with the two methods during a 24-hour period. During this period, the dosage of vasoactive drugs was progressively decreased and volume was substituted or removed according to the clinical treatment strategy. Simultaneous recordings started 2 days (interquartile range [IQR] 1 to 4 days) after ICU admission. In each patient, four consecutive measurements were performed before PAC removal. Median (IQR) time intervals from baseline to the second and third measurements were 5 (4 to 8) and 13 (9 to 16) hours, respectively. All four measurements were realised after 19 (14 to 22) hours. A total of 84 simultaneous hemodynamic measurements were recorded and finally analysed.
Patient characteristics
Severe sepsis was defined according to the published guidelines as systemic inflammatory response syndrome with infection associated with organ dysfunction [23]. AHF was diagnosed in the presence of an underlying heart disease and congestive heart failure, pulmonary edema, or cardiogenic shock [6]. Diagnosis of AHF was based on clinical signs of congestion (dyspnea, orthopnea, rales, or elevated jugular venous pressure), low CO with organ hypoperfusion, and bilateral alveolar consolidations on chest x-ray. Echocardiography and coronary angiography were performed only when clinically indicated. The severity of illness was described by the Simplified Acute Physiology Score (SAPS II) as calculated with the worst values within 24 hours following ICU admission [24].
AHF and severe sepsis or septic shock were diagnosed in 12 and 9 patients, respectively. Baseline characteristics on ICU admission are shown in Table 1. Coronary heart disease was present in 7 patients with AHF. Other underlying heart diseases included dilatative cardiomyopathy (n = 2), non-compaction cardiomyopathy (n = 1), valvular heart disease (n = 1), and congenital heart disease (n = 1). Cardiac imaging by echocardiography or coronary angiography or both was available in all heart failure patients except in two with known ischemic heart disease. The septic patients suffered from proven bacterial infection, namely pneumonia (n = 6), abdominal infection (n = 1), urogenital tract infection (n = 1), and puerperal sepsis (n = 1). Twelve patients (57%) required norepinephrine (0.1 to 0.3 μg/kg per minute), 13 patients (62%) needed inotropic support with dobutamine (1.5 to 6 μg/kg per minute), milrinone, or levosimendan, and 6 patients (29%) received intravenous vasodilatators such as nitroglycerin or nesiritide. Furthermore, 16 patients (76%) were mechanically ventilated, and 11 patients (52%) had renal replacement therapy by continuous veno-venous hemofiltration.
Hemodynamic measurements
A continuous CO thermodilution PAC (model VIP 139F75; Edwards Lifesciences LLC, Irvine, CA, USA) was inserted via a central vein into the right pulmonary artery. Correct placement of the catheter was checked by appropriate pressure traces and fluoroscopy. The PAC was used for measurements of pulmonary artery pressure, PAOP, and cardiac index. Special care was taken to define the zero reference at midchest level and to perform measurements at end-expiration. Continuous assessment of CO was measured using the modified thermodilution technique provided by the PAC manufacturer and described elsewhere [25, 26].
A thermister-tipped arterial PiCCO catheter (Pulsiocath 5F, 20 cm, PV2015L20; Pulsion Medical Systems AG, Munich, Germany) was placed in the descending aorta and connected to a bedside PiCCO plus monitor. Cardiac index and volumetric variables were measured with the single-indicator transpulmonary thermodilution technique. The PiCCO values were obtained by repeated injections of 15- or 20-mL boluses of ice-cold normal saline via a central line. The mean value of three consecutive measurements was used for analysis. If the difference between the three obtained values for cardiac index was greater than 10%, two additional measurements were performed subsequently. Finally, the mean of all consecutive measurements was used.
By means of the thermodilution curve, the PiCCO calculates CO by the modified Stewart-Hamilton equation, the mean transit time (MTt), and the exponential downslope time (DSt) of the curve. The product of CO times MTt gives the intrathoracic thermal volume (ITTV) [12, 27]. The product of CO times the DSt gives the pulmonary thermal volume (PTV) [12, 28, 29]. The difference between ITTV and PTV is called global end-diastolic volume (GEDV), or GEDVI if indexed for the body surface area.
Stroke volume (SV) is calculated by dividing CO by heart rate. A 'global' ejection fraction (GEF) can be obtained by dividing SV by a quarter of GEDV. Similarly, dividing CO by the preload parameter GEDV gives an indicator of cardiac systolic function, the so-called CFI. Both GEF and CFI may provide information on left ventricular systolic function [30]. In patients with shock and multi-organ failure, GEF and CFI correlated closely with left ventricular fractional area of change using echocardiography [30].
The PiCCO method and definitions of intrathoracic blood volume and EVLW are described in more detail elsewhere [31]. For this study, EVLW was indexed to predicted body weight (ELWI), as proposed by Phillips and colleagues [16].
The ratio of EVLW to pulmonary blood volume is used as an index of pulmonary vascular permeability (PVPI). Additionally, we calculated the ratio of EVLW indexed for body weight to GEDVI (that is, ELWI/GEDVI × 102) as another index of pulmonary vascular permeability [13].
In addition to mean arterial pressure (MAP), heart rate, continuous CO, and right atrial pressure, the following hemodynamic parameters were simultaneously recorded four times in each patient: cardiac index by both methods, mixed venous oxygen saturation (SmvO2), left ventricular stroke work index (LVSWI), PAOP, GEDVI, CFI, GEF, ELWI, and PVPI. For each recording, all variables were determined within 10 minutes. LVSWI was calculated by the formula SVI × (MAP – PAOP) × 0.0136, where SVI denotes SV index (SV divided by body surface area). For comparison purposes, we also calculated cardiac power (CP) using the formula CP = MAP × CO/451. The CP has been described as a valuable marker of outcome in patients with cardiogenic shock [32–34]. Definitions are provided in Table 2.
Statistical analysis
Clinical data were collected from the patients' charts, anonymised, and entered into a computerised database. Medians, 25th–75th percentiles (IQR), or percentages were calculated for the overall sample and subgroups. Comparisons between groups were made with the use of the Mann-Whitney U test or the Fisher exact test, as appropriate. Repeated measures within groups were compared with a Wilcoxon signed rank sum test. Including all consecutive hemodynamic measurements per patient, correlations between data pairs were established using linear regression analysis and are expressed as the square of Pearson's correlation coefficients (r2). To investigate the relationship between the cardiac index measured by PAC and PiCCO, bias and limits of agreement of data pairs were calculated as described by Bland and Altman [35]. Bias represents the systemic error between the two methods. Upper and lower limits of agreement, calculated as mean bias ± two standard deviations, define the range in which 95% of the differences are expected. The percentage error was calculated as 100 × (CO indexed for body surface area [CI] by PiCCO - CI by PAC)/[(CI by PiCCO + CI by PAC)/2], as proposed by Rödig and colleagues [36]. All analyses were performed using SPSS version 12.0 for Windows (SPSS Inc., Chicago, IL, USA). Statistical significance was defined as P values of below 0.05, and all hypothesis testing was two-tailed.
Results
The clinical characteristics of the two study groups are described above. Net fluid balance during the 24-hour observation period was +2,066 (375 to 2,749) mL in septic patients as compared with +60 (-596 to 1,622) mL in patients with AHF (P = 0.11). ICU lengths of stay were 17 (14 to 30) days in septic patients and 12 (5 to 19) days in AHF patients (P = 0.13). Overall ICU mortality rates were 44% (4/9) among patients with sepsis and 25% (3/12) among those with AHF (P = 0.40).
Hemodynamic measurements
Measurement of PAOP was unavailable in two AHF patients, and the SmvO2 was missing in another AHF patient. Hemodynamic measurements obtained at the first and fourth recordings are shown in Table 3. Between the first and the forth measurements, hemodynamic variables remained nearly unchanged. Exceptions were LVSWI (increase in septic patients), PAOP and GEDVI (decrease in AHF patients), and SmvO2 (increase in AHF patients). According to the mild changes during the observation period, we pooled the results within each group for further correlation purposes (Table 4). In comparison with patients with AHF, those with sepsis had higher cardiac index, CP, LVSWI, SmvO2, CFI, GEF, PVPI, and ELWI/GEDVI ratio but a lower PAOP. ELWI was higher in patients with sepsis, but this trend did not reach statistical significance (P = 0.09).
A Bland-Altman analysis of cardiac index measurements by PiCCO and PAC resulted in a mean bias of 0.19 L/minute per square metre. Limits of agreement were -0.97 and 1.35 L/minute per square metre. The median percentage error of comparisons was 2.5%. It was within 15% for 68% of comparisons between CI by PiCCO and CI by PAC. In septic patients, r2 between the two cardiac indexes was 0.81 (P < 0.001) compared with 0.58 in patients with AHF (P < 0.001).
Comparisons between CFI and other markers of cardiac performance (CP and LVSWI) are displayed in Figure 1. Figure 1 demonstrates the significant correlation between CFI and LVSWI (sepsis: r2 = 0.30, P = 0.001; AHF: r2 = 0.23, p = 0.002) as well as CFI and CP (sepsis: r2 = 0.39, P < 0.001; AHF: r2 = 0.45, P < 0.001) in both patient groups. In Figures 1a and 1b, the CFI values of four septic patients with depressed cardiac function can easily be identified. The correlations between GEF and LVSWI (sepsis: r2 = 0.26, P = 0.001; AHF: r2 = 0.18, P = 0.006) plus GEF and CP (sepsis: r2 = 0.22, P = 0.004; AHF: r2 = 0.13, P = 0.01), as shown in Figure 2, were comparable to the corresponding CFI correlations in Figure 1. The overall correlation between CFI and GEF was r2 = 0.81 (P < 0.001). Figure 3 shows the relationships between CFI and PAOP and between CFI and SmvO2. It demonstrates the significant negative correlation between CFI and PAOP (r2 = -0.18, P = 0.006) in AHF patients but not in patients with sepsis (P = 0.89). On the other hand, CFI was significantly correlated with SmvO2 in septic patients (r2 = 0.22, P = 0.004) but not in those with heart failure (P = 0.26).
All AHF patients had an SmvO2 of not more than 70% and a CFI of less than 4.5 per minute, except one suffering from congenital heart disease, who presented with low central venous oxygen saturation and shock. In this patient (classified as AHF because of her history), PAC showed a CI of 3.6 L/minute per square metre and an SmvO2 of 68%. PiCCO revealed a CFI of at least 4.5 per minute in two of four measurements and a GEF of greater than 20% in all four measurements.
All septic patients with cardiac dysfunction (CFI of less than 4.5 per minute) had an SmvO2 of not more than 70%. Among those with a CFI of at least 4.5 per minute, 1 patient had four SmvO2 values of less than 70%, most likely because of hypovolemia. The remaining four points of less than 70% (2 patients) were associated with an arterial oxygen saturation of below 92% (Figure 3b).
PAOP did not correlate with ELWI and PVPI either in septic or in heart failure patients (Figure 4). Five of 12 patients with AHF and 6 of 9 with sepsis had at least one PVPI value of greater than 3.0, indicating that PVPI may not discriminate between heart failure and sepsis. No correlations were found between PAOP and GEDVI (data not shown).
Discussion
The results of the present study indicate that in patients with AHF and severe sepsis or septic shock the PiCCO-derived cardiac function parameters, namely CFI and GEF, are valuable and comparable to the more classic PAC-derived parameters such as CP and LVSWI and are better than PAOP and SmvO2. In patients with sepsis, the PVPI and the ratio of ELWI to GEDVI were only slightly higher than in those with AHF, which suggests an increased pulmonary vascular permeability in the latter group. Elevated ELWI despite a relatively low PAOP for patients with AHF supports this assumption.
Our results confirm that PiCCO-derived CO measurements parallel values obtained by PAC [20, 37, 38]. In addition to previous reports from surgical and septic patients, our data prove that this is also the case for critically ill medical patients presenting with AHF and a low CO. The systemic error (bias) of CO measurements between PiCCO and PAC was considerably lower in our medical ICU population. As previously reported, CO is usually slightly overestimated when measured in the aorta compared with the pulmonary artery [20, 39].
SmvO2 is considered a surrogate marker of CO in several conditions [40]. In our study, we found that SmvO2 correlated with CFI in patients with sepsis but not in those with AHF. All patients presenting with AHF had an SmvO2 of below 70%. Among the septic patients with a CFI of greater than 4.5 per minute, three had SmvO2 measurements of below 70%. This observation is in line with the hypothesis that SmvO2 has a low sensitivity and specificity for the detection of myocardial dysfunction in patients with distributive shock [41–43]. Our results favour CO measurements over SmvO2 assessments for the monitoring of cardiac performance in septic patients.
PAC-derived LVSWI and particularly CP, the product of CO and MAP, are predictors of outcome in cardiogenic shock patients [32–34]. In our study, we found a good correlation between CFI and both LVSWI and CP, independently of whether patients had sepsis or AHF. Of note, the median left ventricular ejection fractions were below 30% in heart failure patients and normal in septic patients. The PiCCO parameters CFI and GEF have previously been shown to be reliable markers of left ventricular function when compared with echocardiographic assessments [27] and left ventricular dP/dt max [44]. Interestingly, CFI and GEF identified a subpopulation of septic patients with a myocardial function as poor as in AHF patients. The CFI cutoff level for a depressed myocardial function in our septic population was between 4 and 5 per minute, which is in agreement with the results of a recent study indicating that a CFI of less than 4 per minute estimated a left ventricular fractional area of change of less than 40% with a sensitivity of 86% and a specificity of 88% [30].
In AHF patients but not in septic patients, PAOP was negatively correlated with CFI, suggesting that PAOP in heart failure is a marker of myocardial dysfunction. This is in line with earlier results in patients with acute myocardial infarction [45], in which a PAOP of at least 18 mm Hg was associated with an increased mortality [46]. Caution is recommended when using PAOP as a surrogate marker of cardiac function because PAOP depends on left ventricular filling volume and compliance. Hence, the relationship between the left ventricular filling pressure and volume is not linear [47]. Therefore, other pressure-independent hemodynamic markers of cardiac function such as CFI, GEF, or CP are superior. The results of our study in septic and AHF patients suggest that CFI adequately reflects cardiac function and may be preferred to PAOP, LVSWI, and CP.
Consistent with previous studies in heart failure [8] and septic [48, 49] patients, PAOP correlated neither with GEDVI nor with EVLW. In contrast to a recent study performed in patients with hydrostatic pulmonary edema and acute lung injury/acute respiratory distress syndrome (ALI/ARDS) [13], we could not find a significant difference in GEDVI and EVLW between heart failure and septic patients. However, we found a lower PVPI and ELWI/GEDVI ratio in patients with AHF than in those with sepsis. This is in accordance with the hydrostatic origin of pulmonary edema in the former group. In our septic patients, GEDVI was higher and ELWI and PVPI were both lower than in the patients with ALI/ARDS reported by Monnet and colleagues [13]. This difference may be explained by lower pulmonary vascular permeability and milder pulmonary edema in our patients. The PaO2/FiO2 (partial arterial oxygen pressure/inspired oxygen fraction) ratios were an average of 165 mm Hg in our septic patients and 118 mm Hg in patients with ALI/ARDS reported by Monnet and colleagues. In our AHF patients, PVPI and the ELWI/GEDVI ratio were surprisingly high, suggesting an increased pulmonary vascular permeability in addition to an elevated left ventricular filling pressure. These results add further evidence against the use of PAOP as the only criterion to differentiate between a hydrostatic and a permeability type of pulmonary edema [12, 50, 51].
The number of patients limits the results of our study. However, consistently using four measurements per patient in a condition close to a steady state over a short observation period of an average of 19 hours, 2 days after ICU admission, at least partially compensated for this limitation. Moreover, consecutive measurements in the same patients may have multiplied the number of errors. However, as seen in Tables 3 and 4, the IQRs for a single variable between the four sets of measurements and within the groups were small. Thus, our measurements made in two different and well-characterised clinical conditions probably give a realistic hemodynamic picture of the two populations, allowing a fair comparison between PiCCO and PAC. Another important point is that some of the investigated parameters are mathematically coupled. For example, LVSWI, CFI, and CP are all linked to SV. Similarly, GEDV is the preload index for both CFI and GEF. This fact might explain at least some of the significant correlations found in this study.
Conclusions
The results of our study indicate that hemodynamic variables derived from the transpulmonary thermodilution method allow hemodynamic characterisation of patients with AHF and sepsis. In particular, a low CFI and GEF identified cardiac dysfunction in patients with AHF and in patients with severe sepsis or septic shock. Prospective studies are now needed to demonstrate that the PiCCO technology is superior to a standard of care based on the current recommendations for hemodynamic monitoring and management in shock [40, 52].
Key messages
-
Pulse contour cardiac output (PiCCO)-derived cardiac output measurements parallel values obtained by pulmonary artery catheter, even in critically ill medical patients presenting with a low cardiac output.
-
The PiCCO-derived cardiac function index and global ejection fraction are valuable parameters of cardiac function in patients with acute heart failure and severe sepsis or septic shock.
Abbreviations
- AHF:
-
acute heart failure
- ALI/ARDS:
-
acute lung injury/acute respiratory distress syndrome
- CFI:
-
cardiac function index
- CI:
-
cardiac output indexed for body surface area
- CO:
-
cardiac output
- CP:
-
cardiac power
- DSt:
-
exponential downslope time
- ELWI:
-
extravascular lung water indexed for predicted body weight
- EVLW:
-
extravascular lung water
- GEDV:
-
global end-diastolic volume
- GEDVI:
-
global end-diastolic volume indexed for body surface area
- GEF:
-
global ejection fraction
- ICU:
-
intensive care unit
- IQR:
-
interquartile range
- ITTV:
-
intrathoracic thermal volume
- LVSWI:
-
left ventricular stroke work index
- MAP:
-
mean arterial pressure
- MTt:
-
mean transit time
- PAC:
-
pulmonary artery catheter
- PAOP:
-
pulmonary artery occlusion pressure
- PiCCO:
-
pulse contour cardiac output
- PTV:
-
pulmonary thermal volume
- PVPI:
-
pulmonary vascular permeability index
- SmvO2:
-
mixed venous oxygen saturation
- SV:
-
stroke volume
- SVI:
-
stroke volume indexed for body surface area.
References
Binanay C, Califf RM, Hasselblad V, O'Connor CM, Shah MR, Sopko G, Stevenson LW, Francis GS, Leier CV, Miller LW: Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial. JAMA 2005, 294: 1625-1633. 10.1001/jama.294.13.1625
Rhodes A, Cusack RJ, Newman PJ, Grounds RM, Bennett ED: A randomised, controlled trial of the pulmonary artery catheter in critically ill patients. Intensive Care Med 2002, 28: 256-264. 10.1007/s00134-002-1206-9
Richard C, Warszawski J, Anguel N, Deye N, Combes A, Barnoud D, Boulain T, Lefort Y, Fartoukh M, Baud F, Boyer A, Brochard L, Teboul JL: Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2003, 290: 2713-2720. 10.1001/jama.290.20.2713
Harvey S, Harrison DA, Singer M, Ashcroft J, Jones CM, Elbourne D, Brampton W, Williams D, Young D, Rowan K: Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet 2005, 366: 472-477. 10.1016/S0140-6736(05)67061-4
Wiener RS, Welch HG: Trends in the use of the pulmonary artery catheter in the United States, 1993–2004. JAMA 2007, 298: 423-429. 10.1001/jama.298.4.423
Nieminen MS, Bohm M, Cowie MR, Drexler H, Filippatos GS, Jondeau G, Hasin Y, Lopez-Sendon J, Mebazaa A, Metra M, Rhodes A, Swedberg K, Priori SG, Garcia MA, Blanc JJ, Budaj A, Cowie MR, Dean V, Deckers J, Burgos EF, Lekakis J, Lindahl B, Mazzotta G, Morais J, Oto A, Smiseth OA, Garcia MA, Dickstein K, Albuquerque A, Conthe P, et al.: Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. Eur Heart J 2005, 26: 384-416. 10.1093/eurheartj/ehi044
Crexells C, Chatterjee K, Forrester JS, Dikshit K, Swan HJ: Optimal level of filling pressure in the left side of the heart in acute myocardial infarction. N Engl J Med 1973, 289: 1263-1266.
Bindels AJ, Hoeven JG, Meinders AE: Pulmonary artery wedge pressure and extravascular lung water in patients with acute cardiogenic pulmonary edema requiring mechanical ventilation. Am J Cardiol 1999, 84: 1158-1163. 10.1016/S0002-9149(99)00527-5
Lichtwarck-Aschoff M, Zeravik J, Pfeiffer UJ: Intrathoracic blood volume accurately reflects circulatory volume status in critically ill patients with mechanical ventilation. Intensive Care Med 1992, 18: 142-147. 10.1007/BF01709237
Sakka SG, Bredle DL, Reinhart K, Meier-Hellmann A: Comparison between intrathoracic blood volume and cardiac filling pressures in the early phase of hemodynamic instability of patients with sepsis or septic shock. J Crit Care 1999, 14: 78-83. 10.1016/S0883-9441(99)90018-7
Michard F, Alaya S, Zarka V, Bahloul M, Richard C, Teboul JL: Global end-diastolic volume as an indicator of cardiac preload in patients with septic shock. Chest 2003, 124: 1900-1908. 10.1378/chest.124.5.1900
Isakow W, Schuster DP: Extravascular lung water measurements and hemodynamic monitoring in the critically ill: bedside alternatives to the pulmonary artery catheter. Am J Physiol Lung Cell Mol Physiol 2006, 291: L1118-1131. 10.1152/ajplung.00277.2006
Monnet X, Anguel N, Osman D, Hamzaoui O, Richard C, Teboul JL: Assessing pulmonary permeability by transpulmonary thermodilution allows differentiation of hydrostatic pulmonary edema from ALI/ARDS. Intensive Care Med 2007, 33: 448-453. 10.1007/s00134-006-0498-6
Della Rocca G, Costa GM, Coccia C, Pompei L, Di Marco P, Pietropaoli P: Preload index: pulmonary artery occlusion pressure versus intrathoracic blood volume monitoring during lung transplantation. Anesth Analg 2002, 95: 835-843. 10.1097/00000539-200210000-00009
Sakka SG, Klein M, Reinhart K, Meier-Hellmann A: Prognostic value of extravascular lung water in critically ill patients. Chest 2002, 122: 2080-2086. 10.1378/chest.122.6.2080
Phillips CR, Chesnutt MS, Smith SM: Extravascular lung water in sepsis-associated acute respiratory distress syndrome: indexing with predicted body weight improves correlation with severity of illness and survival. Crit Care Med 2008, 36: 69-73. 10.1097/01.CCM.0000295314.01232.BE
Kuzkov VV, Kirov MY, Sovershaev MA, Kuklin VN, Suborov EV, Waerhaug K, Bjertnaes LJ: Extravascular lung water determined with single transpulmonary thermodilution correlates with the severity of sepsis-induced acute lung injury. Crit Care Med 2006, 34: 1647-1653. 10.1097/01.CCM.0000218817.24208.2E
Martin GS, Eaton S, Mealer M, Moss M: Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit Care 2005, 9: R74-82. 10.1186/cc3025
Goepfert MS, Reuter DA, Akyol D, Lamm P, Kilger E, Goetz AE: Goal-directed fluid management reduces vasopressor and catecholamine use in cardiac surgery patients. Intensive Care Med 2007, 33: 96-103. 10.1007/s00134-006-0404-2
Sakka SG, Reinhart K, Meier-Hellmann A: Comparison of pulmonary artery and arterial thermodilution cardiac output in critically ill patients. Intensive Care Med 1999, 25: 843-846. 10.1007/s001340050962
Gust R, Gottschalk A, Bauer H, Bottiger BW, Bohrer H, Martin E: Cardiac output measurement by transpulmonary versus conventional thermodilution technique in intensive care patients after coronary artery bypass grafting. J Cardiothorac Vasc Anesth 1998, 12: 519-522. 10.1016/S1053-0770(98)90093-3
Sakka SG, Ruhl CC, Pfeiffer UJ, Beale R, McLuckie A, Reinhart K, Meier-Hellmann A: Assessment of cardiac preload and extravascular lung water by single transpulmonary thermodilution. Intensive Care Med 2000, 26: 180-187. 10.1007/s001340050043
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003, 29: 530-538.
Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993, 270: 2957-2963. 10.1001/jama.270.24.2957
Yelderman M: Continuous measurement of cardiac output with the use of stochastic system identification techniques. J Clin Monit 1990, 6: 322-332. 10.1007/BF02842492
Boldt J, Menges T, Wollbruck M, Hammermann H, Hempelmann G: Is continuous cardiac output measurement using thermodilution reliable in the critically ill patient? Crit Care Med 1994, 22: 1913-1918.
Meier P, Zierler KL: On the theory of the indicator-dilution method for measurement of blood flow and volume. J Appl Physiol 1954, 6: 731-744.
Newman EV, Merrell M, Genecin A, Monge C, Milnor WR, McKeever WP: The dye dilution method for describing the central circulation. An analysis of factors shaping the time-concentration curves. Circulation 1951, 4: 735-746.
Carter SA, Swan HJ, Wood EH: Time and concentration components of indicator-dilution curves recorded following central injections of dye in normal human subjects. Circulation 1959, 19: 430-439.
Combes A, Berneau JB, Luyt CE, Trouillet JL: Estimation of left ventricular systolic function by single transpulmonary thermodilution. Intensive Care Med 2004, 30: 1377-1383.
Katzenelson R, Perel A, Berkenstadt H, Preisman S, Kogan S, Sternik L, Segal E: Accuracy of transpulmonary thermodilution versus gravimetric measurement of extravascular lung water. Crit Care Med 2004, 32: 1550-1554. 10.1097/01.CCM.0000130995.18334.8B
Fincke R, Hochman JS, Lowe AM, Menon V, Slater JN, Webb JG, LeJemtel TH, Cotter G: Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a report from the SHOCK trial registry. J Am Coll Cardiol 2004, 44: 340-348. 10.1016/j.jacc.2004.03.060
Cotter G, Moshkovitz Y, Kaluski E, Milo O, Nobikov Y, Schneeweiss A, Krakover R, Vered Z: The role of cardiac power and systemic vascular resistance in the pathophysiology and diagnosis of patients with acute congestive heart failure. Eur J Heart Fail 2003, 5: 443-451. 10.1016/S1388-9842(03)00100-4
Mendoza DD, Cooper HA, Panza JA: Cardiac power output predicts mortality across a broad spectrum of patients with acute cardiac disease. Am Heart J 2007, 153: 366-370. 10.1016/j.ahj.2006.11.014
Bland JM, Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986, 1: 307-310.
Rödig G, Prasser C, Keyl C, Liebold A, Hobbhahn J: Continuous cardiac output measurement: pulse contour analysis vs thermodilution technique in cardiac surgical patients. Br J Anaesth 1999, 82: 525-530.
Goedje O, Hoeke K, Lichtwarck-Aschoff M, Faltchauser A, Lamm P, Reichart B: Continuous cardiac output by femoral arterial thermodilution calibrated pulse contour analysis: comparison with pulmonary arterial thermodilution. Crit Care Med 1999, 27: 2407-2412. 10.1097/00003246-199911000-00014
Della Rocca G, Costa MG, Pompei L, Coccia C, Pietropaoli P: Continuous and intermittent cardiac output measurement: pulmonary artery catheter versus aortic transpulmonary technique. Br J Anaesth 2002, 88: 350-356. 10.1093/bja/88.3.350
Ostergaard M, Nielsen J, Rasmussen JP, Berthelsen PG: Cardiac output – pulse contour analysis vs. pulmonary artery thermodilution. Acta Anaesthesiol Scand 2006, 50: 1044-1049. 10.1111/j.1399-6576.2006.01080.x
Antonelli M, Levy M, Andrews PJ, Chastre J, Hudson LD, Manthous C, Meduri GU, Moreno RP, Putensen C, Stewart T, Torres A: Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27–28 April 2006. Intensive Care Med 2007, 33: 575-590. 10.1007/s00134-007-0531-4
Ho BC, Bellomo R, McGain F, Jones D, Naka T, Wan L, Braitberg G: The incidence and outcome of septic shock patients in the absence of early-goal directed therapy. Crit Care 2006, 10: R80. 10.1186/cc4918
Perel A, Segal E: Management of sepsis. N Engl J Med 2007, 356: 1178. author reply 1181–1172 10.1056/NEJMc063207
Shapiro NI, Howell MD, Talmor D, Lahey D, Ngo L, Buras J, Wolfe RE, Weiss JW, Lisbon A: Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med 2006, 34: 1025-1032. 10.1097/01.CCM.0000206104.18647.A8
Lichtwarck-Aschoff M, Leucht S, Kisch HW, Zimmermann G, Blumel G, Pfeiffer UJ: Monitoring of right ventricular function using a conventional slow response thermistor catheter. Intensive Care Med 1994, 20: 348-353. 10.1007/BF01720907
Forrester JS, Diamond G, Chatterjee K, Swan HJ: Medical therapy of acute myocardial infarction by application of hemodynamic subsets (first of two parts). N Engl J Med 1976, 295: 1356-1362.
Shell WE, DeWood MA, Peter T, Mickle D, Prause JA, Forrester JS, Swan HJ: Comparison of clinical signs and hemodynamic state in the early hours of transmural myocardial infarction. Am Heart J 1982, 104: 521-528. 10.1016/0002-8703(82)90222-8
Pinsky MR: Clinical significance of pulmonary artery occlusion pressure. Intensive Care Med 2003, 29: 175-178.
Boussat S, Jacques T, Levy B, Laurent E, Gache A, Capellier G, Neidhardt A: Intravascular volume monitoring and extravascular lung water in septic patients with pulmonary edema. Intensive Care Med 2002, 28: 712-718. 10.1007/s00134-002-1286-6
Spohr F, Hettrich P, Bauer H, Haas U, Martin E, Bottiger BW: Comparison of two methods for enhanced continuous circulatory monitoring in patients with septic shock. Intensive Care Med 2007, 33: 1805-1810. 10.1007/s00134-007-0703-2
Abraham E, Matthay MA, Dinarello CA, Vincent JL, Cohen J, Opal SM, Glauser M, Parsons P, Fisher CJ Jr, Repine JE: Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med 2000, 28: 232-235. 10.1097/00003246-200001000-00039
Schuster DP: Identifying patients with ARDS: time for a different approach. Intensive Care Med 1997, 23: 1197-1203. 10.1007/s001340050486
Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36: 296-327. 10.1097/01.CCM.0000298158.12101.41
Acknowledgements
AR was supported by a personal grant from the Siegenthaler Foundation (Zurich, Switzerland). This study was performed in the University Hospital of Zurich (Switzerland). The authors are indebted to the medical and nursing ICU staff for taking care of the patients.
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MM is a member of the Pulsion Medical Systems AG Medical Advisory Board. He received reimbursements for travel costs by the company for attending advisory board meetings and giving talks on several occasions. He received no grants for this study. The other authors declare that they have no competing interests.
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SR was responsible for data collection, carried out the statistical analysis, contributed to the interpretation of data, and drafted and revised the manuscript. AR carried out the statistical analysis, contributed to the interpretation of data, and revised the manuscript. MM developed the study design, coordinated data collection, helped to carry out the statistical analysis and interpretation of data, and revised the manuscript. All authors read and approved the final manuscript.
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Ritter, S., Rudiger, A. & Maggiorini, M. Transpulmonary thermodilution-derived cardiac function index identifies cardiac dysfunction in acute heart failure and septic patients: an observational study. Crit Care 13, R133 (2009). https://doi.org/10.1186/cc7994
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DOI: https://doi.org/10.1186/cc7994