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  1. Critically ill patients with respiratory failure undergoing bronchoscopy have an increased risk of hypoxaemia-related complications. Previous studies have shown that in awake, hypoxaemic patients non-invasive ...

    Authors: Marcel Simon, Stephan Braune, Daniel Frings, Ann-Kathrin Wiontzek, Hans Klose and Stefan Kluge
    Citation: Critical Care 2014 18:712
    Content type: Research Published on:

  2. Cardiogenic shock (CS) is the leading cause of death in patients hospitalized with acute myocardial infarction (AMI). Biomarkers might help in risk stratification and understanding of pathophysiology. Prelimin...

    Authors: Georg Fuernau, Janine Pöss, Daniel Denks, Steffen Desch, Gunnar H Heine, Ingo Eitel, Sarah Seiler, Suzanne de Waha, Sebastian Ewen, Andreas Link, Gerhard Schuler, Volker Adams, Michael Böhm and Holger Thiele
    Citation: Critical Care 2014 18:713
    Content type: Research Published on:

  3. Sepsis and septic shock are leading causes of intensive care unit (ICU) mortality. They are characterized by excessive inflammation, upregulation of procoagulant proteins and depletion of natural anticoagulant...

    Authors: Emily Rimmer, Brett L Houston, Anand Kumar, Ahmed M Abou-Setta, Carol Friesen, John C Marshall, Gail Rock, Alexis F Turgeon, Deborah J Cook, Donald S Houston and Ryan Zarychanski
    Citation: Critical Care 2014 18:699
    Content type: Research Published on:

  4. Liberal and overaggressive use of vasopressors during the initial period of shock resuscitation may compromise organ perfusion and worsen outcome. When transiently applying the concept of permissive hypotensio...

    Authors: Andreas Brunauer, Andreas Koköfer, Otgon Bataar, Ilse Gradwohl-Matis, Daniel Dankl and Martin W Dünser
    Citation: Critical Care 2014 18:719
    Content type: Research Published on:

  5. Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an emerging acute kidney injury (AKI) biomarker. We evaluated the performance of urinary TIMP-2 in an adult mixed ICU by comparison with other biomarkers tha...

    Authors: Tetsushi Yamashita, Kent Doi, Yoshifumi Hamasaki, Takehiro Matsubara, Takeshi Ishii, Naoki Yahagi, Masaomi Nangaku and Eisei Noiri
    Citation: Critical Care 2014 18:716
    Content type: Research Published on:

  6. Acute kidney injury (AKI) is a frequently occurring complication in ICU patients and is associated with decreased short- and long-term survival. Gammelager and colleagues showed that AKI patients are at increa...

    Authors: Wim Vandenberghe and Eric AJ Hoste
    Citation: Critical Care 2014 18:703
    Content type: Commentary Published on:

  9. The aim of this study was to conduct a meta-analysis to determine whether percutaneous tracheostomy (PT) techniques are advantageous over surgical tracheostomy (ST), and if one PT technique is superior to the ...

    Authors: Christian Putensen, Nils Theuerkauf, Ulf Guenther, Maria Vargas and Paolo Pelosi
    Citation: Critical Care 2014 18:544
    Content type: Research Published on:

  12. The aim of this study was to examine whether albumin reduced mortality when employed for the resuscitation of adult patients with severe sepsis and septic shock compared with crystalloid by meta-analysis.

    Authors: Jing-Yuan Xu, Qi-Hong Chen, Jian-Feng Xie, Chun Pan, Song-Qiao Liu, Li-Wei Huang, Cong-Shan Yang, Ling Liu, Ying-Zi Huang, Feng-Mei Guo, Yi Yang and Hai-Bo Qiu
    Citation: Critical Care 2014 18:702
    Content type: Research Published on:

  14. Fever is associated with a poor outcome in severely brain-injured patients, and its control is one of the therapies used in this condition. But, fever suppression may promote infection, and severely brain-inju...

    Authors: Yoann Launey, Nicolas Nesseler, Audren Le Cousin, Fanny Feuillet, Ronan Garlantezec, Yannick Mallédant and Philippe Seguin
    Citation: Critical Care 2014 18:689
    Content type: Research Published on:

  15. Critically ill patients with sepsis are prone to develop cardiac dysrhythmias, most commonly atrial fibrillation (AF). Systemic inflammation, circulating stress hormones, autonomic dysfunction, and volume shif...

    Authors: Sanne Kuipers, Peter MC Klein Klouwenberg and Olaf L Cremer
    Citation: Critical Care 2014 18:688
    Content type: Research Published on:

  16. Early protein and energy feeding in critically ill patients is heavily debated and early protein feeding hardly studied.

    Authors: Peter JM Weijs, Wilhelmus GPM Looijaard, Albertus Beishuizen, Armand RJ Girbes and Heleen M Oudemans-van Straaten
    Citation: Critical Care 2014 18:701
    Content type: Research Published on:

  17. Hyponatremia is a marker of poor prognosis in patients with cirrhosis. This analysis aimed to assess if hyponatremia also has prognostic value in patients with acute-on-chronic liver failure (ACLF), a syndrome...

    Authors: Andrés Cárdenas, Elsa Solà, Ezequiel Rodríguez, Rogelio Barreto, Isabel Graupera, Marco Pavesi, Faouzi Saliba, Tania Mara Welzel, Javier Martinez-Gonzalez, Thierry Gustot, Mauro Bernardi, Vicente Arroyo and Pere Ginès
    Citation: Critical Care 2014 18:700
    Content type: Research Published on:

  18. To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality. We hypothesised that if TXA reduces mortality by decreasing blood...

    Authors: Ian Roberts, David Prieto-Merino and Daniela Manno
    Citation: Critical Care 2014 18:685
    Content type: Research Published on:

  19. Because of its resistance profiles, Pseudomonas aeruginosa remains probably one of the challenging bacteria responsible for ventilator-associated pneumonia in the ICU. Nevertheless, a much better understanding of...

    Authors: Bruno François
    Citation: Critical Care 2014 18:669
    Content type: Commentary Published on:

  20. Pseudomonas aeruginosa uses a complex type III secretion system to inject the toxins ExoS, ExoT, ExoU, and ExoY into the cytosol of target eukaryotic cells. This system is regulated by the exoenzyme S regulon and...

    Authors: Teiji Sawa, Masaru Shimizu, Kiyoshi Moriyama and Jeanine P Wiener-Kronish
    Citation: Critical Care 2014 18:668
    Content type: Review Published on:

  22. Apart from its complex functionality, the brain is a robust thermodynamic machine; the tissue metabolic rate is high and it is thermally shielded by a skull. Therefore, if there is no high-volume blood flow to...

    Authors: Joseph Donnelly and Marek Czosnyka
    Citation: Critical Care 2014 18:693
    Content type: Commentary Published on:

  23. Vitamin D deficiency is common in critically ill patients, and was reported to be associated with adverse outcomes. However, the effect of vitamin D deficiency on mortality in critically ill patients remains u...

    Authors: Yan-Peng Zhang, You-Dong Wan, Tong-Wen Sun, Quan-Cheng Kan and Le-Xin Wang
    Citation: Critical Care 2014 18:684
    Content type: Research Published on:

  24. The role of reactive carbonyl species, such as methylglyoxal (MG), has been overlooked within the context of the sepsis syndrome. The aims of this study were to assess the impact of MG formation in different i...

    Authors: Thorsten Brenner, Thomas Fleming, Florian Uhle, Stephan Silaff, Felix Schmitt, Eduardo Salgado, Alexis Ulrich, Stefan Zimmermann, Thomas Bruckner, Eike Martin, Angelika Bierhaus, Peter P Nawroth, Markus A Weigand and Stefan Hofer
    Citation: Critical Care 2014 18:683
    Content type: Research Published on:

  25. The scope of extracorporeal membrane oxygenation (ECMO) is expanding; however, optimal drug prescription during ECMO remains a developing science. Currently, there are no clear guidelines for antibiotic dosing...

    Authors: Kiran Shekar, John F Fraser, Fabio Silvio Taccone, Susan Welch, Steven C Wallis, Daniel V Mullany, Jeffrey Lipman and Jason A Roberts
    Citation: Critical Care 2014 18:565
    Content type: Research Published on:

  26. The combination of Adenosine (A), lidocaine (L) and Mg2+ (M) (ALM) has demonstrated cardioprotective and resuscitative properties in models of cardiac arrest and hemorrhagic shock. This study evaluates whether AL...

    Authors: Asger Granfeldt, Hayley L Letson, Geoffrey P Dobson, Wei Shi, Jakob Vinten-Johansen and Else Tønnesen
    Citation: Critical Care 2014 18:682
    Content type: Research Published on:

  29. Assessment of respiratory system compliance (Crs) can be used for individual optimization of positive end-expiratory pressure (PEEP). However, in patients with spontaneous breathing activity, the conventional met...

    Authors: Tobias H Becher, Simon Bui, Günther Zick, Daniel Bläser, Dirk Schädler, Norbert Weiler and Inéz Frerichs
    Citation: Critical Care 2014 18:679
    Content type: Research Published on:

  30. Low plasma glutamine concentration at ICU admission is associated with unfavorable outcomes. The prediction of plasma glutamine concentration after ICU discharge on outcomes has not been characterized. In the ...

    Authors: Marie Smedberg, Johanna Nordmark Grass, Linn Pettersson, Åke Norberg, Olav Rooyackers and Jan Wernerman
    Citation: Critical Care 2014 18:677
    Content type: Research Published on:

  31. Brain midline shift (MLS) is a life-threatening condition that requires urgent diagnosis and treatment. We aimed to validate bedside assessment of MLS with Transcranial Sonography (TCS) in neurosurgical ICU pa...

    Authors: Julie Motuel, Isaure Biette, Mohamed Srairi, Ségolène Mrozek, Matt M Kurrek, Patrick Chaynes, Christophe Cognard, Olivier Fourcade and Thomas Geeraerts
    Citation: Critical Care 2014 18:676
    Content type: Research Published on:

  34. Iron as an element is a double-edged sword, essential for living but also potentially toxic through the generation of oxidative stress. The recent study by Chen and colleagues in Critical Care reminds us of this ...

    Authors: Sigismond Lasocki, Thomas Gaillard and Emmanuel Rineau
    Citation: Critical Care 2014 18:678
    Content type: Commentary Published on:

  35. Extracorporeal membrane oxygenation (ECMO) is used in critically ill patients presenting acute cardiac and/or pulmonary dysfunctions, who are at high risk of developing acute kidney injury and fluid overload. ...

    Authors: Han Chen, Rong-Guo Yu, Ning-Ning Yin and Jian-Xin Zhou
    Citation: Critical Care 2014 18:675
    Content type: Research Published on:

  36. Several studies have reported the presence of electroencephalography (EEG) abnormalities or altered evoked potentials (EPs) during sepsis. However, the role of these tests in the diagnosis and prognostic asses...

    Authors: Koji Hosokawa, Nicolas Gaspard, Fuhong Su, Mauro Oddo, Jean-Louis Vincent and Fabio Silvio Taccone
    Citation: Critical Care 2014 18:674
    Content type: Research Published on:

  38. In Europe, vitamin D deficiency is highly prevalent varying between 40% and 60% in the healthy general adult population. The consequences of vitamin D deficiency for sepsis and outcome in critically ill patien...

    Authors: Kim de Haan, AB Johan Groeneveld, Hilde RH de Geus, Mohamud Egal and Ard Struijs
    Citation: Critical Care 2014 18:660
    Content type: Research Published on:

  39. Appropriate management of analgo-sedation in the intensive care unit (ICU) is associated with improved patient outcomes. Our objectives were: a) to describe utilization of analgo-sedation regimens and strategi...

    Authors: Barbara Sneyers, Pierre-François Laterre, Marc M Perreault, Dominique Wouters and Anne Spinewine
    Citation: Critical Care 2014 18:655
    Content type: Research Published on:

  40. Achievement of optimal vancomycin exposure is crucial to improve the management of patients with life-threatening infections caused by susceptible Gram-positive bacteria and is of particular concern in patient...

    Authors: João Pedro Baptista, Jason A Roberts, Eduardo Sousa, Ricardo Freitas, Nuno Deveza and Jorge Pimentel
    Citation: Critical Care 2014 18:654
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2019 23:228

  41. The purpose of the study was to verify the efficacy of using internal jugular vein (IJV) size and distensibility as a reliable index of fluid responsiveness in mechanically ventilated patients with sepsis.

    Authors: Fabio Guarracino, Baldassarre Ferro, Francesco Forfori, Pietro Bertini, Luana Magliacano and Michael R Pinsky
    Citation: Critical Care 2014 18:647
    Content type: Research Published on:

  42. Recent experimental and clinical studies have indicated the cardioprotective role of sildenafil during ischemia/reperfusion injury. The aim of this study was to determine, by obtaining metabolic evidence from ...

    Authors: Qian Zhang, Wei Yuan, Guoxing Wang, Junyuan Wu, Miaomiao Wang and ChunSheng Li
    Citation: Critical Care 2014 18:641
    Content type: Research Published on:

  44. The aim of this study was to develop consensus recommendations on safety parameters for mobilizing adult, mechanically ventilated, intensive care unit (ICU) patients.

    Authors: Carol L Hodgson, Kathy Stiller, Dale M Needham, Claire J Tipping, Megan Harrold, Claire E Baldwin, Scott Bradley, Sue Berney, Lawrence R Caruana, Doug Elliott, Margot Green, Kimberley Haines, Alisa M Higgins, Kirsi-Maija Kaukonen, Isabel Anne Leditschke, Marc R Nickels…
    Citation: Critical Care 2014 18:658
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535