Articles
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Citation: Critical Care 2015 19:446
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PEEP titration during prone positioning for acute respiratory distress syndrome
No major trial evaluating prone positioning for acute respiratory distress syndrome (ARDS) has incorporated a high-positive end-expiratory pressure (high-PEEP) strategy despite complementary physiological rati...
Citation: Critical Care 2015 19:436 -
European trauma guideline compliance assessment: the ETRAUSS study
Haemorrhagic shock is the leading cause of preventable death in trauma patients. The 2013 European trauma guidelines emphasise a comprehensive, multidisciplinary, protocol-based approach to trauma care. The ai...
Citation: Critical Care 2015 19:423 -
Accuracy of intracranial pressure monitoring: systematic review and meta-analysis
Intracranial pressure (ICP) measurement is used to tailor interventions and to assist in formulating the prognosis for traumatic brain injury patients. Accurate data are therefore essential. The aim of this st...
Citation: Critical Care 2015 19:420 -
Association of perioperative intravenous fluid strategy with acute kidney injury following off-pump coronary artery bypass surgery
Citation: Critical Care 2015 19:419 -
Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock?
Severe systemic inflammatory response to infection results in severe sepsis and septic shock, which are the leading causes of death in critically ill patients. Septic shock is characterised by refractory hypot...
Citation: Critical Care 2015 19:418 -
Does inferior vena cava respiratory variability predict fluid responsiveness in spontaneously breathing patients?
We have almost no information concerning the value of inferior vena cava (IVC) respiratory variations in spontaneously breathing ICU patients (SBP) to predict fluid responsiveness.
Citation: Critical Care 2015 19:400 -
Extracorporeal therapies in pediatric severe sepsis: findings from the pediatric health-care information system
Pediatric severe sepsis (PSS) continues to be a major health problem. Extracorporeal therapies (ETs), defined as extracorporeal membrane oxygenation (ECMO) and RRenal replacement therapyenal replacement therap...
Citation: Critical Care 2015 19:397 -
Erratum to: Development of the Post Cardiac Surgery (POCAS) prognostic score
Citation: Critical Care 2015 19:395 -
Extracorporeal decarboxylation in patients with severe traumatic brain injury and ARDS enables effective control of intracranial pressure
Acute respiratory distress syndrome (ARDS) with concomitant impairment of oxygenation and decarboxylation represents a complex problem in patients with increased intracranial pressure (ICP). Permissive hyperca...
Citation: Critical Care 2015 19:381 -
Diagnostic accuracy of C-reactive protein and procalcitonin in suspected community-acquired pneumonia adults visiting emergency department and having a systematic thoracic CT scan
Community-acquired pneumonia (CAP) requires prompt treatment, but its diagnosis is complex. Improvement of bacterial CAP diagnosis by biomarkers has been evaluated using chest X-ray infiltrate as the CAP gold ...
Citation: Critical Care 2015 19:366 -
Faulty risk-of-bias assessment in a meta-analysis of hydroxyethyl starch for nonseptic ICU patients
Citation: Critical Care 2015 19:357 -
Incidence and predisposing factors for the development of disturbed glucose metabolism and DIabetes mellitus AFter Intensive Care admission: the DIAFIC study
Elevated blood glucose levels during intensive care unit (ICU) stay, so-called stress hyperglycaemia (SH), is a common finding. Its relation with a future diabetes risk is unclear. Our objective was to determi...
Citation: Critical Care 2015 19:355 -
Dehydroepiandrosterone sulphate: diabolical hormone or epiphenomenon in aneurysmal subarachnoid hemorrhage?
Inflammation is purported to play an important role in the clinical course of subarachnoid hemorrhage. The current study by Höllig et al. entails using dehydroepiandrosterone sulfate, a hormone that inhibits k...
Citation: Critical Care 2015 19:352 -
Dynamics of end expiratory lung volume after changing positive end-expiratory pressure in acute respiratory distress syndrome patients
Lung recruitment maneuvers followed by an individually titrated positive end-expiratory pressure (PEEP) are the key components of the open lung ventilation strategy in acute respiratory distress syndrome (ARDS...
Citation: Critical Care 2015 19:340 -
Echocardiography for adult patients supported with extracorporeal membrane oxygenation
Venoarterial (VA) and venovenous (VV) extracorporeal membrane oxygenation (ECMO) support is increasingly being used in recent years in the adult population. Owing to the underlying disease precipitating severe...
Citation: Critical Care 2015 19:326 -
The accuracy of presepsin (sCD14-ST) for the diagnosis of sepsis in adults: a meta-analysis
The early diagnosis of sepsis remains a challenge. Recently, soluble cluster of differentiation 14 subtype (sCD14-ST), also known as presepsin, has been identified as a potential biomarker of sepsis. We perfor...
Citation: Critical Care 2015 19:323 -
Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study
A clinical suspicion of infection is mandatory for diagnosing sepsis in patients with a systemic inflammatory response syndrome. Yet, the accuracy of categorizing critically ill patients presenting to the inte...
Citation: Critical Care 2015 19:319 -
The role of previously unmeasured organic acids in the pathogenesis of severe malaria
Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria.
Citation: Critical Care 2015 19:317 -
Predictors for mechanical ventilation and short-term prognosis in patients with Guillain-Barré syndrome
Guillain-Barré syndrome (GBS) is an immune-mediated disorder of the peripheral nervous system. Respiratory failure requiring mechanical ventilation (MV) is a serious complication of GBS. Identification of modi...
Citation: Critical Care 2015 19:310 -
Adequate antibiotic therapy prior to ICU admission in patients with severe sepsis and septic shock reduces hospital mortality
In patients with severe sepsis and septic shock as cause of Intensive Care Unit (ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy initiated before ICU admission.
Citation: Critical Care 2015 19:302 -
Importance of a registered and structured protocol when conducting systematic reviews: comments about nebulized antibiotics for ventilator-associated pneumonia
Citation: Critical Care 2015 19:298 -
Long-term quality of life in critically ill patients with acute kidney injury treated with renal replacement therapy: a matched cohort study
Acute kidney injury (AKI) is a common complication in intensive care unit (ICU) patients and is associated with increased morbidity and mortality. We compared long-term outcome and quality of life (QOL) in ICU...
Citation: Critical Care 2015 19:289 -
One-year survival and resource use after critical illness: impact of organ failure and residual organ dysfunction in a cohort study in Brazil
In this study, we evaluated the impacts of organ failure and residual dysfunction on 1-year survival and health care resource use using Intensive Care Unit (ICU) discharge as the starting point.
Citation: Critical Care 2015 19:269 -
A positive fluid balance is an independent prognostic factor in patients with sepsis
Intravenous fluid administration is an essential component of sepsis management, but a positive fluid balance has been associated with worse prognosis. We analyzed whether a positive fluid balance and its pers...
Citation: Critical Care 2015 19:251 -
Higher colistin dose during continuous renal replacement therapy: look before leaping!
Citation: Critical Care 2015 19:235 -
An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance
Pseudomonas aeruginosa nosocomial pneumonia (Pa-NP) is associated with considerable morbidity, prolonged hospitalization, increased costs, and mortality.
Citation: Critical Care 2015 19:219 -
A comprehensive method to develop a checklist to increase safety of intra-hospital transport of critically ill patients
Transport of critically ill patients from the Intensive Care Unit (ICU) to other departments for diagnostic or therapeutic procedures is often a necessary part of the critical care process. Transport of critic...
Citation: Critical Care 2015 19:214 -
Mixed colloids and acute kidney injury: a case of selection bias?
Citation: Critical Care 2015 19:207 -
High-frequency oscillation ventilation for hypercapnic failure of conventional ventilation in pulmonary acute respiratory distress syndrome
High-frequency oscillation ventilation (HFOV) is regarded as particularly lung protective. Recently, HFOV has been shown to be not beneficial for acute respiratory distress syndrome (ARDS) patients in general....
Citation: Critical Care 2015 19:201 -
Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis
Kallistatin levels in the circulation are reduced in patients with sepsis and liver disease. Transgenic mice expressing kallistatin are resistant to lipopolysaccharide (LPS)-induced mortality. Here, we investi...
Citation: Critical Care 2015 19:200 -
When do confounding by indication and inadequate risk adjustment bias critical care studies? A simulation study
In critical care observational studies, when clinicians administer different treatments to sicker patients, any treatment comparisons will be confounded by differences in severity of illness between patients. ...
Citation: Critical Care 2015 19:195 -
Do alcohol use disorders impact on long term outcomes from intensive care?
There is limited evidence regarding the impact of alcohol use disorders on long term outcomes from intensive care. The aims of this study were to analyse the nature and complications of alcohol related admissi...
Citation: Critical Care 2015 19:185 -
The administration of dextrose during in-hospital cardiac arrest is associated with increased mortality and neurologic morbidity
Dextrose may be used during cardiac arrest resuscitation to prevent or reverse hypoglycemia. However, the incidence of dextrose administration during cardiac arrest and the association of dextrose administrati...
Citation: Critical Care 2015 19:160 -
Fluid overload at start of continuous renal replacement therapy is associated with poorer clinical condition and outcome: a prospective observational study on the combined use of bioimpedance vector analysis and serum N-terminal pro-B-type natriuretic peptide measurement
It is unclear whether the fluid status, as determined by bioimpedance vector analysis (BIVA) combined with serum N-terminal pro-B-type natriuretic peptides (NT-pro-BNP) measurement, is associated with treatmen...
Citation: Critical Care 2015 19:135 -
Mechanical ventilation modes for respiratory distress syndrome in infants: a systematic review and network meta-analysis
The effects of different mechanical ventilation (MV) modes on mortality outcome in infants with respiratory distress syndrome (RDS) are not well known.
Citation: Critical Care 2015 19:108 -
Cooling techniques for targeted temperature management post-cardiac arrest
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at
Citation: Critical Care 2015 19:103 -
Why intensivists want chest radiographs
Citation: Critical Care 2015 19:100 -
Closed-loop assisted versus manual goal-directed fluid therapy during high-risk abdominal surgery: a case–control study with propensity matching
Goal-directed fluid therapy strategies have been shown to benefit moderate- to high-risk surgery patients. Despite this, these strategies are often not implemented. The aim of this study was to assess a closed...
Citation: Critical Care 2015 19:94 -
Efficacy and safety of 6% hydroxyethyl starch 130/0.4 (Voluven) for perioperative volume replacement in children undergoing cardiac surgery: a propensity-matched analysis
Six percent hydroxyethyl starch (HES) 130/0.4 is considered an alternative to human albumin (HA) and crystalloids for volume replacement in children undergoing cardiac surgery. In this large propensity-matched...
Citation: Critical Care 2015 19:87 -
Superior vena cava drainage improves upper body oxygenation during veno-arterial extracorporeal membrane oxygenation in sheep
Differential hypoxia is a pivotal problem in patients with femoral veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) support. Despite recognition of differential hypoxia and attempts to deliver mor...
Citation: Critical Care 2015 19:68 -
Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation
Dexmedetomidine was shown in two European randomized double-blind double-dummy trials (PRODEX and MIDEX) to be non-inferior to propofol and midazolam in maintaining target sedation levels in mechanically venti...
Citation: Critical Care 2015 19:67 -
Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction
The objective was to compare the impact of three assistance levels of different modes of mechanical ventilation; neurally adjusted ventilatory assist (NAVA), proportional assist ventilation (PAV), and pressure...
Citation: Critical Care 2015 19:56 -
Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury
Sepsis refers to severe systemic inflammation leading to acute lung injury (ALI) and death. Introducing novel therapies can reduce the mortality in ALI. Osteopontin (OPN), a secretory glycoprotein produced by ...
Citation: Critical Care 2015 19:53 -
Neurally adjusted ventilatory assist (NAVA) allows patient-ventilator synchrony during pediatric noninvasive ventilation: a crossover physiological study
The need for intubation after a noninvasive ventilation (NIV) failure is frequent in the pediatric intensive care unit (PICU). One reason is patient-ventilator asynchrony during NIV. Neurally adjusted ventilat...
Citation: Critical Care 2015 19:44 -
Propofol, midazolam, vancomycin and cyclosporine therapeutic drug monitoring in extracorporeal membrane oxygenation circuits primed with whole human blood
As a result of drug sequestration and increased volume of distribution, the extracorporeal membrane oxygenation (ECMO) procedure might lead to a decrease in drug concentrations during a patient’s treatment. Th...
Citation: Critical Care 2015 19:40 -
Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?
The aim of this study was to explore the impact of augmented creatinine clearance and differing minimum inhibitory concentrations (MIC) on piperacillin pharmacokinetic/pharmacodynamic (PK/PD) target attainment...
Citation: Critical Care 2015 19:28 -
Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice
Lung-protective ventilation reduced acute respiratory distress syndrome (ARDS) mortality. To minimize ventilator-induced lung injury (VILI), tidal volume is limited, high plateau pressures are avoided, and pos...
Citation: Critical Care 2015 19:23 -
Reintubation in critically ill patients: procedural complications and implications for care
In critically ill patients, re-intubation is common and may be a high-risk procedure. Anticipating a difficult airway and identifying high-risk patients can allow time for life-saving preparation. Unfortunatel...
Citation: Critical Care 2015 19:12 -
Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit
Septic shock is a major life-threatening condition in critically ill patients and it is well known that early recognition of septic shock and expedient initiation of appropriate treatment improves patient outc...
Citation: Critical Care 2015 19:11
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- ISSN: 1364-8535 (electronic)