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  1. New biomarkers are needed to assess the severity of necrotizing soft tissue infection (NSTI) at an early stage and to individualize treatment strategies. We assessed pentraxin-3 (PTX3) as a marker of disease s...

    Authors: Marco Bo Hansen, Lars Simon Rasmussen, Peter Garred, Daniel Bidstrup, Martin Bruun Madsen and Ole Hyldegaard
    Citation: Critical Care 2016 20:40
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:173

  3. Stress hyperglycaemia (SHG) is a common complication in sepsis associated with poor outcome. Chemerin is an adipocytokine associated with inflammation and impaired glucose homeostasis in metabolic diseases suc...

    Authors: Paul Horn, Uta Barbara Metzing, Ricardo Steidl, Bernd Romeike, Falk Rauchfuß, Christoph Sponholz, Daniel Thomas-Rüddel, Katrin Ludewig, Andreas L. Birkenfeld, Utz Settmacher, Michael Bauer, Ralf Alexander Claus and Christian von Loeffelholz
    Citation: Critical Care 2016 20:39
    Content type: Research Published on:

  4. Acute kidney injury (AKI) occurs frequently and adversely affects patient and kidney outcomes, especially when its severity increases from stage 1 to stages 2 or 3. Early interventions may counteract such dete...

    Authors: Jorien De Loor, Johan Decruyenaere, Kristel Demeyere, Lieve Nuytinck, Eric AJ Hoste and Evelyne Meyer
    Citation: Critical Care 2016 20:38
    Content type: Research Published on:

  5. Mechanical ventilation with a tidal volume (VT) of 6 mL/kg/predicted body weight (PBW), to maintain plateau pressure (Pplat) lower than 30 cmH2O, does not completely avoid the risk of ventilator induced lung inju...

    Authors: Vito Fanelli, Marco V. Ranieri, Jordi Mancebo, Onnen Moerer, Michael Quintel, Scott Morley, Indalecio Moran, Francisco Parrilla, Andrea Costamagna, Marco Gaudiosi and Alain Combes
    Citation: Critical Care 2016 20:36
    Content type: Research Published on:

    The Commentary to this article has been published in Critical Care 2016 20:130

  6. Various noninvasive microscopic camera technologies have been used to visualize the sublingual microcirculation in patients. We describe a comprehensive approach to bedside in vivo sublingual microcirculation ...

    Authors: Michael J. Massey and Nathan I. Shapiro
    Citation: Critical Care 2016 20:35
    Content type: Review Published on:

  10. Protein S100β (PS100 β) and neuron specific enolase (NSE) have been described as biological markers of neuronal damage. The purpose of our study was to assess the prognosis thresholds of these biomarkers in su...

    Authors: Hervé Quintard, Sébastien Leduc, Patricia Ferrari, Isabelle Petit and Carole Ichai
    Citation: Critical Care 2016 20:33
    Content type: Research Published on:

  11. Culture of catheter hubs and skin surrounding the catheter entry site has a negative predictive value for catheter tip colonization. However, manipulation of the hub for culture requires the hubs to be swabbed...

    Authors: María Jesús Pérez-Granda, María Guembe, Raquel Cruces, José María Barrio and Emilio Bouza
    Citation: Critical Care 2016 20:32
    Content type: Research Published on:

  12. While early pneumonia is common in patients after out-of-hospital cardiac arrest (OHCA), little is known about the impact of pneumonia and the optimal timing of antibiotic therapy after OHCA.

    Authors: Kristian Hellenkamp, Sabrina Onimischewski, Jochen Kruppa, Martin Faßhauer, Alexander Becker, Helmut Eiffert, Mark Hünlich, Gerd Hasenfuß and Rolf Wachter
    Citation: Critical Care 2016 20:31
    Content type: Research Published on:

  14. The effects of neuromuscular electrical stimulation (NMES) in critically ill patients after cardiothoracic surgery are unknown. The objectives were to investigate whether NMES prevents loss of muscle layer thi...

    Authors: Arabella Fischer, Matthias Spiegl, Klaus Altmann, Andreas Winkler, Anna Salamon, Michael Themessl-Huber, Mohamed Mouhieddine, Eva Maria Strasser, Arno Schiferer, Tatjana Paternostro-Sluga and Michael Hiesmayr
    Citation: Critical Care 2016 20:30
    Content type: Research Published on:

  15. Beta-lactam antibiotics form the backbone of treatment for Gram-negative pneumonia in mechanically ventilated patients in the intensive care unit. However, this beta-lactam antibiotic backbone is increasingly ...

    Authors: Matteo Bassetti, Tobias Welte and Richard G. Wunderink
    Citation: Critical Care 2016 20:19
    Content type: Review Published on:

  17. Patients receiving intravenous thrombolysis (IVT) for acute ischemic stroke are at risk of developing complications, commonly necessitating admission to an intensive care unit (ICU). At present, most IVT is ad...

    Authors: Roland Faigle, Elisabeth B. Marsh, Rafael H. Llinas, Victor C. Urrutia and Rebecca F. Gottesman
    Citation: Critical Care 2016 20:26
    Content type: Research Published on:

  18. Two clinical scoring systems, the status epilepticus severity score (STESS) and the epidemiology-based mortality score in status epilepticus (EMSE), are used to predict mortality in patients with status epilep...

    Authors: Bong Su Kang, Dong Wook Kim, Kwang Ki Kim, Hye Jin Moon, Young-Soo Kim, Hyun Kyung Kim, Seo-Young Lee, Yong Seo Koo, Jung-Won Shin, Jangsup Moon, Jun-Sang Sunwoo, Jung-Ick Byun, Yong Won Cho, Ki-Young Jung, Kon Chu and Sang Kun Lee
    Citation: Critical Care 2016 20:25
    Content type: Research Published on:

  20. The outcomes of patients admitted to the intensive care unit (ICU) for acute manifestation of small-vessel vasculitis are poorly reported. The aim of the present study was to determine the mortality rate and p...

    Authors: Antoine Kimmoun, Elisabeth Baux, Vincent Das, Nicolas Terzi, Patrice Talec, Pierre Asfar, Stephan Ehrmann, Guillaume Geri, Steven Grange, Nadia Anguel, Alexandre Demoule, Anne Sophie Moreau, Elie Azoulay, Jean-Pierre Quenot, Julie Boisramé-Helms, Guillaume Louis…
    Citation: Critical Care 2016 20:27
    Content type: Research Published on:

  22. Aneurysmal subarachnoid haemorrhage is a neurological syndrome with complex systemic complications. The rupture of an intracranial aneurysm leads to the acute extravasation of arterial blood under high pressur...

    Authors: Airton Leonardo de Oliveira Manoel, Alberto Goffi, Tom R. Marotta, Tom A. Schweizer, Simon Abrahamson and R. Loch Macdonald
    Citation: Critical Care 2016 20:21
    Content type: Review Published on:

  24. Assessment of pulmonary edema is a key factor in monitoring and guidance of therapy in critically ill patients. To date, methods available at the bedside for estimating the physiologic correlate of pulmonary e...

    Authors: Constantin J. C. Trepte, Charles R. Phillips, Josep Solà, Andy Adler, Sebastian A. Haas, Michael Rapin, Stephan H. Böhm and Daniel A. Reuter
    Citation: Critical Care 2016 20:18
    Content type: Research Published on:

  25. Critical illness and the problems faced after ICU discharge do not only affect the patient, it also negatively impacts patients’ informal caregivers. There is no review which summarizes all types of burden rep...

    Authors: Ilse van Beusekom, Ferishta Bakhshi-Raiez, Nicolette F. de Keizer, Dave A. Dongelmans and Marike van der Schaaf
    Citation: Critical Care 2016 20:16
    Content type: Research Published on:

  27. Despite appropriate therapy, Candida bloodstream infections are associated with a mortality rate of approximately 40 %. In animal models, impaired immunity due to T cell exhaustion has been implicated in fungal s...

    Authors: Andrej Spec, Yuichiro Shindo, Carey-Ann D. Burnham, Strother Wilson, Enyo A. Ablordeppey, Evan R. Beiter, Katherine Chang, Anne M. Drewry and Richard S. Hotchkiss
    Citation: Critical Care 2016 20:15
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:191

  29. Patients with subarachnoid haemorrhage (SAH) frequently develop cardiac complications in the acute phase after the bleeding. Although a number of studies have shown that increased levels of cardiac biomarkers ...

    Authors: Jonatan Oras, Christina Grivans, Andreas Bartley, Bertil Rydenhag, Sven-Erik Ricksten and Helene Seeman-Lodding
    Citation: Critical Care 2016 20:11
    Content type: Research Published on:

  30. The aim of the present study was to investigate the incidence of adverse events (AEs) during intra-hospital transport (IHT) of critically ill patients and evaluate the risk factors associated with these events.

    Authors: Liu Jia, Hongliang Wang, Yang Gao, Haitao Liu and Kaijiang Yu
    Citation: Critical Care 2016 20:12
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:84

  31. High serum lactate is associated with increased mortality in septic shock patients. Metformin alters lactate metabolism, and may affect its prognostic value. We compared, between metformin users and nonusers, ...

    Authors: Keren Doenyas-Barak, Ilia Beberashvili, Ronit Marcus and Shai Efrati
    Citation: Critical Care 2016 20:10
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:158

    The Letter to this article has been published in Critical Care 2016 20:127

  33. Leukocyte-mediated pulmonary inflammation is a key pathophysiological mechanism involved in acute respiratory distress syndrome (ARDS). Massive sequestration of leukocytes in the pulmonary microvasculature is ...

    Authors: Pascal Preira, Jean-Marie Forel, Philippe Robert, Paulin Nègre, Martine Biarnes-Pelicot, Francois Xeridat, Pierre Bongrand, Laurent Papazian and Olivier Theodoly
    Citation: Critical Care 2016 20:8
    Content type: Research Published on:

  34. Evidence suggests that EMS-physician-guided cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrest (OOHCA) may be associated with improved outcomes, yet randomized controlled trials are not avai...

    Authors: Bernd W. Böttiger, Michael Bernhard, Jürgen Knapp and Peter Nagele
    Citation: Critical Care 2016 20:4
    Content type: Research Published on:

  35. Glutamine is one of the conditionally essential free amino acids with multiple biological functions. Its supplementation to parenteral nutrition has been widely used for the management of complications in inte...

    Authors: Alberto Leguina-Ruzzi
    Citation: Critical Care 2016 20:7
    Content type: Commentary Published on:

    The Erratum to this article has been published in Critical Care 2016 20:24

  36. Electrical impedance tomography (EIT) is a non-invasive bedside tool which allows an individualized ventilator strategy by monitoring tidal ventilation and lung aeration. EIT can be performed at different cran...

    Authors: Jan Karsten, Thomas Stueber, Nicolas Voigt, Eckhard Teschner and Hermann Heinze
    Citation: Critical Care 2016 20:3
    Content type: Research Published on:

  37. Critical illness following head injury is associated with a hypermetabolic state but there are insufficient epidemiological data describing acute nutrition delivery to this group of patients. Furthermore, ther...

    Authors: Lee-anne S. Chapple, Marianne J. Chapman, Kylie Lange, Adam M. Deane and Daren K. Heyland
    Citation: Critical Care 2016 20:6
    Content type: Research Published on:

  38. Bleeding after cardiac surgery requiring surgical reexploration and blood component transfusion is associated with increased morbidity and mortality. Although prothrombin complex concentrate (PCC) has been use...

    Authors: Giangiuseppe Cappabianca, Giovanni Mariscalco, Fausto Biancari, Daniele Maselli, Francesca Papesso, Marzia Cottini, Sandro Crosta, Simona Banescu, Aamer B. Ahmed and Cesare Beghi
    Citation: Critical Care 2016 20:5
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:63

  39. Prolonged controlled mechanical ventilation depresses diaphragmatic efficiency. Assisted modes of ventilation should improve it. We assessed the impact of pressure support ventilation versus neurally adjusted ven...

    Authors: Rosa Di mussi, Savino Spadaro, Lucia Mirabella, Carlo Alberto Volta, Gabriella Serio, Francesco Staffieri, Michele Dambrosio, Gilda Cinnella, Francesco Bruno and Salvatore Grasso
    Citation: Critical Care 2016 20:1
    Content type: Research Published on:

  40. The aim of extracorporeal albumin dialysis (ECAD) is to reduce endogenous toxins accumulating in liver failure. To date, ECAD is conducted mainly with the Molecular Adsorbents Recirculating System (MARS). Howe...

    Authors: Christoph Sponholz, Katja Matthes, Dina Rupp, Wolf Backaus, Sebastian Klammt, Diana Karailieva, Astrid Bauschke, Utz Settmacher, Matthias Kohl, Mark G. Clemens, Steffen Mitzner, Michael Bauer and Andreas Kortgen
    Citation: Critical Care 2016 20:2
    Content type: Research Published on:

    The Letter to this article has been published in Critical Care 2016 20:156

  41. Great white sharks are responsible for about 10 cases of death annually worldwide, as compared with millions of deaths caused by sepsis. However, the basic principles of avoiding shark attacks and fighting sep...

    Authors: Martin Westphal and Tim Kampmeier
    Citation: Critical Care 2015 19(Suppl 3):S11
    Content type: Review Published on:

    This article is part of a Supplement: Volume 19 Supplement 3

  42. There have really been no single, major, advances in critical care medicine since the specialty came into existence. There has, however, been a gradual, continuous improvement in the process of care over the y...

    Authors: Jean-Louis Vincent and Jacques Creteur
    Citation: Critical Care 2015 19(Suppl 3):S10
    Content type: Review Published on:

    This article is part of a Supplement: Volume 19 Supplement 3

  44. Evidence based medicine is an attempt to optimize the medical decision process through methods primarily based on evidence coming from meta-analyses, systematic reviews, and randomized controlled trials ("evid...

    Authors: Luciano Gattinoni, Eleonora Carlesso and Alessandro Santini
    Citation: Critical Care 2015 19(Suppl 3):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 19 Supplement 3

  45. Over the last 10 years we have significantly reduced hospital mortality from sepsis and critical illness. However, the evidence reveals that over the same period we have tripled the number of patients being se...

    Authors: Paul E Wischmeyer and Inigo San-Millan
    Citation: Critical Care 2015 19(Suppl 3):S6
    Content type: Review Published on:

    This article is part of a Supplement: Volume 19 Supplement 3

  46. This review emphasizes the benefits of parenteral nutrition (PN) in critically ill patients, when prescribed for relevant indications, in adequate quantities, and in due time.

    Authors: Taku Oshima and Claude Pichard
    Citation: Critical Care 2015 19(Suppl 3):S5
    Content type: Review Published on:

    This article is part of a Supplement: Volume 19 Supplement 3

  48. Developments in recent years have placed powerful new tools of diagnosis, therapy, and communication at the disposal of medicine in general, and of critical care in particular. The art of healing requires not ...

    Authors: John J Marini
    Citation: Critical Care 2015 19(Suppl 3):S3
    Content type: Review Published on:

    This article is part of a Supplement: Volume 19 Supplement 3

  50. Medical practice is rooted in our dependence on the best available evidence from incremental scientific experimentation and rigorous clinical trials. Progress toward determining the true worth of ongoing pract...

    Authors: John J Marini, Luciano Gattinoni, Can Ince, Sibylle Kozek-Langenecker, Ravindra L Mehta, Claude Pichard, Martin Westphal, Paul Wischmeyer and Jean-Louis Vincent
    Citation: Critical Care 2015 19(Suppl 3):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 19 Supplement 3

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Critical Care

ISSN: 1364-8535