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Albumin is a frequently prescribed drug in hospitalized patients, and its effect on clinical outcomes has been scrutinized in recent years. Data from meta-analyses has suggested harm related to albumin therapy...
Storage time and residual leukocytes in red blood cell (RBC) units may be deleterious by increasing the accumulation of leukocyte-derived cytokines and by raising the adhesion of RBCs to endothelium. Leukodepl...
Small-volume resuscitation of critically ill patients with hyperoncotic albumin offers a number of theoretical advantages, such as increasing intravascular volume in excess of the volume of fluid administered ...
Excessive inflammatory responses and impaired oxygen utilization because of microcirculatory failure are implicated in septic shock. Recent studies have pointed out some beneficial effects in the treatment of ...
Several recent reports have highlighted the utility of transcutaneous electrical muscle stimulation to preserve muscle mass and strength in ICU patients. Specifically, Serafim Nanas and colleagues report a sig...
Appropriate timing of treatment assumes particular importance in critical care. Lange and colleagues recently reported on the time course of the different nitric oxide synthase (NOS) isoforms, nitrosative stre...
The original article was published in Critical Care 2023 27:374
The original article was published in Critical Care 2023 27:480
Analyzing medical records of 979 patients with severe sepsis or septic shock provided some evidence that...
In order to determine the type and incidence of pulmonary complications associated with the placement of narrow-bore enteral feeding tubes we conducted a prospective, descriptive study in the multidisciplinary...
This article is part of a Supplement: Volume 16 Supplement 1
'Every day' clinical conundrums are all too infrequently addressed in the mainstream literature, but in the past few months two reports attempted to tackle the thorny problem of the occult cervical spine injur...
The Surviving Sepsis Campaign guidelines suggest targeting a mean arterial...
Liver transplantation has been reported to initiate increases in procalcitonin levels, in the absence of bacterial infection. The results of a study investigating the course of procalcitonin levels over severa...
The Letter to this article has been published in Critical Care 2020 24:363
The Letter to this article has been published in Critical Care 2020 24:226
It is heavily debated whether or not treatment with hydroxyethyl starch 130/0.4 contributes to the development of acute kidney failure in patients with severe sepsis. In the previous issue of Critical Care, Mulle...
This article is part of a Supplement: Volume 18 Supplement 2
Mortality is still the most assessed outcome in the critically ill patient and is routinely used as the primary end-point in intervention trials, cohort studies, and benchmarking analysis. Despite this, intere...
Tissue hypoxia is a common end product of circulatory shock and a primary target for resuscitation efforts. In this issue Podbregar and Mozina show that thenar tissue O2 saturation (StO2) and mixed venous O2 satu...
Vitamin K-dependent proteins are not only essential regulators of blood coagulation. A recent paper in Critical Care...describes the levels of the vitamin K-dependent GAS6 and the soluble form of its receptor Axl...
The detection of endotoxemia may provide a clue to the cause of sepsis or may indicate translocation of endotoxin from...Critical Care, evaluated the use of a whole blood EAA in a medical–surgical intensive care ...
Childbirth is a major event in the lives of mothers and their families. Critical illness in pregnancy is uncommon but may arise from conditions unique to pregnancy, conditions exacerbated by pregnancy and coin...
Severe sepsis continues to lead to critical illness. Few...
N-terminal pro brain natriuretic peptide (NT-proBNP) is a cardiac biomarker that has recently shown to be of diagnostic value in a diagnosis of decompensated heart failure, acute coronary syndromes and other cond...
A recent multicentre observational study examined the effect of emergency intubation on central venous oxygen saturation (SCVo2) in critically ill patients. The main finding was that SCVo2 significantly increases...
Ventilator-associated pneumonia is a familiar foe in intensive care units, but those associated with Pseudomonas aeruginosa have a particularly adverse impact on outcome. Correct antibiotic therapy and a novel en...
This article is part of a Supplement: Volume 18 Supplement 2
Many studies have demonstrated that prompt appropriate treatment for the critically ill patient improves outcome. Moving patients to the best place for instituting care, however, is not always associated with ...
Critical Care