- Poster presentation
- Open Access
Can N-terminal pro-B-type natriuretic peptide and troponin T predict ICU and hospital mortality in patients with septic shock?
© BioMed Central Ltd 2006
- Published: 21 March 2006
- Left Ventricle
- Septic Shock
- Severe Sepsis
- Natriuretic Peptide
- Prognostic Marker
The counter-regulatory neurohormone N-terminal pro-B-type natriuretic peptide (NT-proBNP) is predominantly released from the left ventricle in response to increasing wall tension and is a useful prognostic marker in patients with-established cardiac failure . Myocardial dysfunction commonly occurs in septic patients. Cardiac biomarkers, including NT-proBNP, have been shown to be predicators of mortality in unselected critically ill patients .
To evaluate the role of NT-proBNP and troponin T (TnT) as predictors of mortality in patients with severe sepsis and septic shock.
A prospective observational study was carried out on patients admitted to a noncardiothoracic tertiary ICU within 24 hours of the development of severe sepsis or septic shock. Plasma samples were taken on all patients on admission. NT-proBNP and TnT were determined using commercially available assays. Data were compared after logarithmic transformation, where appropriate.
ICU and hospital outcomes related to admission NT-proBNP and TnT levels
NT-pro-BNP and TnT are frequently elevated in severe sepsis. However admission values are not prognostic markers of ICU and hospital survival.